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1. 发明授权

US06643591B1 Use of computational and experimental data to model organic compound reactivity in cytochrome P450 mediated reactions and to optimize the design of pharmaceuticals 有权
标题翻译：使用计算和实验数据来模拟细胞色素P450介导的反应中的有机化合物反应性并优化药物的设计
公开(公告)号：US06643591B1
公开(公告)日：2003-11-04
申请号：US09368511
申请日：1999-08-05
申请人： Kenneth R. Korzekwa , Jeffrey P. Jones , Lee Ann Higgins
发明人： Kenneth R. Korzekwa , Jeffrey P. Jones , Lee Ann Higgins
IPC分类号： G06N700
CPC分类号： G01N33/6803 , C12Q1/26 , G01N2333/795 , G01N2333/80 , G01N2333/90245 , G06F19/12 , G06F19/16
摘要： The present invention is directed to the use of computational and other experimental data in the design of new pharmaceuticals, and in predicting the metabolism and toxicological profiles thereof. Computational and other information is used to further understand drug metabolism and toxicology, particulary in relation to monooxygenase enzymes, such as those of the CYP system, that are involved in drug metabolism. Information derived according to the practice of the invention is useful in determining the clearance or half-life of drugs, and the nature and toxicity of byproducts resulting from their metabolism. The invention provides novel and powerful new approaches to drug design.
摘要翻译：本发明涉及计算和其他实验数据在新药物设计中的应用，以及在预测其新陈代谢和毒理学特征。计算和其他信息用于进一步了解药物代谢和毒理学，特别是与单加氧酶相关的，例如参与药物代谢的CYP系统的那些。根据本发明的实践得到的信息可用于确定药物的清除率或半衰期，以及由其代谢产生的副产物的性质和毒性。本发明提供了新的和强大的药物设计新方法。

2. 发明授权

US06625547B1 Relative rates of cytochrome p450 metabolism 失效
公开(公告)号：US06625547B1
公开(公告)日：2003-09-23
申请号：US09613875
申请日：2000-07-10
申请人： Kenneth R. Korzekwa , Jeffrey P. Jones
发明人： Kenneth R. Korzekwa , Jeffrey P. Jones
IPC分类号： G06G758
CPC分类号： G06F19/16 , C12Q1/26 , G01N33/6803 , G01N2333/795 , G01N2333/80 , G01N2333/90245 , G06F19/12
摘要： Reactive sites on a substrate molecule, typically a drug, may be identified and the relative rates of their metabolism by the CYP enzymes may be determined. Determining these relative rates is an important factor in determining the absolute rate of metabolism of the individual sites and the substrate molecule as a whole. This information is also a critical factor in determining whether and how the substrate can be redesigned to improve its ADME/PK properties. In this regard, it is particularly important to know how the relative rates compare to the rate of a non-metabolic side reaction (branch pathway) such as water generation and regeneration of the substrate.

3. 发明申请

US20110105816A1 Production of Aromatics from Methane 有权
标题翻译：从甲烷生产芳烃
公开(公告)号：US20110105816A1
公开(公告)日：2011-05-05
申请号：US12985789
申请日：2011-01-06
申请人： Neeraj Sangar , Larry L. Iaccino , Jeffrey P. Jones
发明人： Neeraj Sangar , Larry L. Iaccino , Jeffrey P. Jones
IPC分类号： C07C15/02
CPC分类号： C07C2/76 , C07C2521/04 , C07C2521/08 , C07C2523/06 , C07C2523/28 , C07C2523/30 , C07C2523/36 , C07C2529/40 , C10G50/00 , C10G2300/1025 , C10G2400/30
摘要： In a process for converting methane to aromatic hydrocarbons, a feed containing methane is contacted with a dehydrocyclization catalyst in a reaction zone under conditions effective to convert the methane to aromatic hydrocarbons. The reaction zone is contained within a reactor and the reactor or an internal component of the reactor has at least one surface that is chemically exposed to the feed and is formed from a refractory material that exhibits a carbon uptake (mass of carbon absorbed per unit of exposed metal surface area) of less than 25 g/m2 when exposed to mixture of 50 vol % methane and 50 vol % H2 at 900° C. for 168 hours.
摘要翻译：在将甲烷转化为芳族烃的方法中，在有效将甲烷转化为芳族烃的条件下，含有甲烷的进料在反应区与脱氢环化催化剂接触。反应区包含在反应器内，反应器或反应器的内部组分具有化学暴露于进料的至少一个表面，并且由表现出碳吸收的耐火材料形成（每单位面积吸收的碳的质量暴露的金属表面积）当暴露于50体积％甲烷和50体积％H 2的混合物在900℃下168小时时小于25g / m 2。

4. 发明授权

US08906511B2 Alumina forming bimetallic tube and method of making and using 有权
标题翻译：氧化铝形成双金属管及其制造和使用方法
公开(公告)号：US08906511B2
公开(公告)日：2014-12-09
申请号：US13271808
申请日：2011-10-12
申请人： ChangMin Chun , D. Samuel Deutsch , James E. Feather , Jeffrey P. Jones , David B. Spicer
发明人： ChangMin Chun , D. Samuel Deutsch , James E. Feather , Jeffrey P. Jones , David B. Spicer
IPC分类号： F16L9/147 , B05D3/06 , B05D3/10 , B05D3/14 , B05D3/12 , C23C26/00 , H05H1/24 , F16L9/02 , B22F5/10 , B22F7/06 , B32B15/01 , C22C19/05 , C22C30/00 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/40 , C22C38/48 , F28F19/06 , F28F21/08 , C22C1/04 , F28D21/00
CPC分类号： F16L9/02 , B22F5/106 , B22F7/06 , B32B15/011 , B32B15/013 , B32B15/015 , C22C1/0433 , C22C19/05 , C22C19/058 , C22C30/00 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/40 , C22C38/48 , F28D2021/0059 , F28F19/06 , F28F21/083
摘要： Provided is a bimetallic tube for transport of hydrocarbon feedstocks in a petrochemical process unit and/or refinery process unit, including: i) an outer tube layer being formed from a steam cracker alloy including at least 18.0 wt. % Cr and at least 10.0 wt. % Ni; ii) an inner tube layer being formed from an alumina forming bulk alloy including 5.0 to 10.0 wt. % of Al, 18.0 wt. % to 25.0 wt. % Cr, less than 0.5 wt. % Si, and at least 35.0 wt. % Fe with the balance being Ni, wherein the inner tube layer is formed plasma powder welding the alumina forming bulk alloy on the inner surface of the outer tube layer; and iii) an oxide layer formed on the surface of the inner tube layer, wherein the oxide layer is substantially comprised of alumina, chromia, silica, mullite, spinels, or mixtures thereof.
摘要翻译：提供了一种用于在石化工艺单元和/或炼油工艺单元中输送烃原料的双金属管，包括：i）由蒸汽裂化器合金形成的外管层，其包含至少18.0wt。％Cr和至少10.0wt。％Ni; ii）内管层，其由包含5.0至10.0重量％的氧化铝形成块状合金形成。％的Al，18.0wt。％至25.0wt。％Cr，小于0.5wt。％Si，和至少35.0wt。％Fe，余量为Ni，其中内管层形成等离子体粉末，将氧化铝形成体合金焊接在外管层的内表面上; 以及iii）形成在所述内管层的表面上的氧化物层，其中所述氧化物层基本上由氧化铝，氧化铬，二氧化硅，莫来石，尖晶石或其混合物组成。

5. 发明授权

US07893308B2 Production of aromatics from methane 有权
标题翻译：从甲烷生产芳烃
公开(公告)号：US07893308B2
公开(公告)日：2011-02-22
申请号：US11891752
申请日：2007-08-13
申请人： Neeraj Sangar , Larry L. Iaccino , Jeffrey P. Jones
发明人： Neeraj Sangar , Larry L. Iaccino , Jeffrey P. Jones
IPC分类号： C07C2/52
CPC分类号： C07C2/76 , C07C2521/04 , C07C2521/08 , C07C2523/06 , C07C2523/28 , C07C2523/30 , C07C2523/36 , C07C2529/40 , C10G50/00 , C10G2300/1025 , C10G2400/30
摘要： In a process for converting methane to aromatic hydrocarbons, a feed containing methane is contacted with a dehydrocyclization catalyst in a reaction zone under conditions effective to convert the methane to aromatic hydrocarbons. The reaction zone is contained within a reactor and the reactor or an internal component of the reactor has at least one surface that is chemically exposed to the feed and is formed from a refractory material that exhibits a carbon uptake (mass of carbon absorbed per unit of exposed metal surface area) of less than 25 g/m2 when exposed to mixture of 50 vol % methane and 50 vol % H2 at 900° C. for 168 hours.
摘要翻译：在将甲烷转化为芳族烃的方法中，在有效将甲烷转化为芳族烃的条件下，含有甲烷的进料在反应区与脱氢环化催化剂接触。反应区包含在反应器内，反应器或反应器的内部组分具有化学暴露于进料的至少一个表面，并且由表现出碳吸收的耐火材料形成（每单位面积吸收的碳的质量暴露的金属表面积）当暴露于50体积％甲烷和50体积％H 2的混合物在900℃下168小时时小于25g / m 2。

6. 发明申请

US20110257455A1 Apparatus And Methods For Utilizing Heat Exchanger Tubes 有权
标题翻译：使用热交换器管的装置和方法
公开(公告)号：US20110257455A1
公开(公告)日：2011-10-20
申请号：US12762910
申请日：2010-04-19
申请人： David B. Spicer , Jeffrey P. Jones
发明人： David B. Spicer , Jeffrey P. Jones
IPC分类号： C07C4/04 , B01J19/00 , B21D53/02 , F28F1/00 , F28F21/08
CPC分类号： B01J19/02 , B01J19/0073 , B01J19/2425 , B01J2219/00157 , B01J2219/00247 , B01J2219/0218 , B01J2219/0236 , B01J2219/0286 , C10G9/20 , C10G9/203 , C10G9/36 , C10G2300/807 , C10G2400/20 , F28D7/16 , F28F2265/26 , Y10T29/4935
摘要： In one aspect, the present techniques include a heat exchange apparatus including: a) a body comprising an interior cavity, the body including: a first surface and a second surface defining at least a portion of the body and the first surface positioned exterior with respect to the second surface and the interior cavity, and the second surface positioned exterior with respect to the interior cavity and interior with respect to the first surface; b) a first conduit for conveying a fluid to the body; c) a second conduit in fluid communication with the first conduit wherein the second conduit is positioned at least partially within the interior cavity of the body; and d) a joint between the first conduit and the second conduit, wherein the joint moves between a first location and a second location based on the temperature within the interior cavity, wherein at least one of said first location and said second location is positioned intermediate the first surface and the second surface.
摘要翻译：在一个方面，本技术包括热交换装置，其包括：a）包括内腔的主体，所述主体包括：第一表面和第二表面，所述第一表面和第二表面限定所述主体的至少一部分，并且所述第一表面相对于并且所述第二表面相对于所述内腔定位在外部并且相对于所述第一表面位于内部; b）用于将流体输送到身体的第一导管; c）与所述第一管道流体连通的第二导管，其中所述第二导管至少部分地定位在所述主体的内腔内; 以及d）所述第一管道和所述第二管道之间的接头，其中所述接头基于所述内部空腔内的温度在第一位置和第二位置之间移动，其中所述第一位置和所述第二位置中的至少一个位于中间第一表面和第二表面。

7. 发明授权

US07924984B2 Method and system for determining physical location of emergency service callers on a packet switched network 有权
标题翻译：用于确定分组交换网络上的紧急业务呼叫者的物理位置的方法和系统
公开(公告)号：US07924984B2
公开(公告)日：2011-04-12
申请号：US11553947
申请日：2006-10-27
申请人： Lance A. Tatman , Jeffrey P. Jones
发明人： Lance A. Tatman , Jeffrey P. Jones
IPC分类号： H04M11/00
CPC分类号： H04M11/04 , H04L12/2856 , H04L12/2881 , H04L41/0213 , H04L41/12
摘要： Pluggable communication modules, e.g. SFP, XFP, XENPAK, on a service provider's packet switched network will include network monitoring capability, e.g. Intelligent Pluggable Modules. The Intelligent Pluggable Modules are configured to detect emergency calls. When an emergency call is detected, the module notifies a software application of the detected call, including the Media Access Controller (MAC) address of the caller. The application then queries the network equipment, typically the Digital Subscriber Line Access Multiplexer for the ingress port of the MAC address using a protocol such as SNMP. Upon receipt, the service provider's customer database is then queried for the physical port location corresponding to the MAC address. The management station then sends the physical location into the existing 911 system.
摘要翻译：可插拔通信模块，例如 SFP，XFP，XENPAK在服务提供商的分组交换网络上将包括网络监控能力，例如，智能可插拔模块智能可插拔模块配置为检测紧急呼叫。当检测到紧急呼叫时，模块向软件应用通知检测到的呼叫，包括呼叫者的媒体接入控制器（MAC）地址。应用程序然后使用诸如SNMP的协议来查询网络设备，通常是用于MAC地址的入口端口的数字用户线路接入复用器。接收到后，就会查询与MAC地址对应的物理端口位置的服务提供商的客户数据库。然后，管理站将物理位置发送到现有的911系统。

8. 发明授权

US5060229A Serial transport frame format method 失效
标题翻译：串行传输帧格式方法
公开(公告)号：US5060229A
公开(公告)日：1991-10-22
申请号：US351458
申请日：1989-05-12
申请人： Raymond E. Tyrrell , Stephen C. Dunning , Richard J. Sanders, Jr. , Claude M. Hurlocker , Michael J. Gingell , Jeffrey P. Jones
发明人： Raymond E. Tyrrell , Stephen C. Dunning , Richard J. Sanders, Jr. , Claude M. Hurlocker , Michael J. Gingell , Jeffrey P. Jones
IPC分类号： H04J3/12 , H04J3/16
CPC分类号： H04J3/1611 , H04J3/12
摘要： A serial transport frame format is described which transfers data between two locations. The serial transport frame format comprises a fixed number of channels per frame, each channel having a predetermined size. One channel per frame contains frame synchronization information and each channel which conveys data, contains a first portion for the transfer of data and a second portion which contains associated control information.
摘要翻译：描述了在两个位置之间传送数据的串行传输帧格式。串行传输帧格式包括每帧固定数量的信道，每个信道具有预定的大小。每帧一个通道包含帧同步信息，并且传送数据的每个通道包含用于传送数据的第一部分和包含关联控制信息的第二部分。

9. 发明授权

US07951985B2 Production of aromatics from methane 有权
公开(公告)号：US07951985B2
公开(公告)日：2011-05-31
申请号：US12985789
申请日：2011-01-06
申请人： Neeraj Sangar , Larry L. Iaccino , Jeffrey P. Jones
发明人： Neeraj Sangar , Larry L. Iaccino , Jeffrey P. Jones
IPC分类号： C07C2/52
CPC分类号： C07C2/76 , C07C2521/04 , C07C2521/08 , C07C2523/06 , C07C2523/28 , C07C2523/30 , C07C2523/36 , C07C2529/40 , C10G50/00 , C10G2300/1025 , C10G2400/30
摘要： In a process for converting methane to aromatic hydrocarbons, a feed containing methane is contacted with a dehydrocyclization catalyst in a reaction zone under conditions effective to convert the methane to aromatic hydrocarbons. The reaction zone is contained within a reactor and the reactor or an internal component of the reactor has at least one surface that is chemically exposed to the feed and is formed from a refractory material that exhibits a carbon uptake (mass of carbon absorbed per unit of exposed metal surface area) of less than 25 g/m2 when exposed to mixture of 50 vol % methane and 50 vol % H2 at 900° C. for 168 hours.

10. 发明授权

US07338645B2 Method and system for reducing decomposition byproducts in a methanol to olefin reactor system 有权
标题翻译：降低甲醇与烯烃反应器系统中分解副产物的方法和系统
公开(公告)号：US07338645B2
公开(公告)日：2008-03-04
申请号：US10761745
申请日：2004-01-21
申请人： Jeffrey P. Jones , Kenneth Ray Clem , Stephen N. Vaughn , Teng Xu , Jeffrey L. White
发明人： Jeffrey P. Jones , Kenneth Ray Clem , Stephen N. Vaughn , Teng Xu , Jeffrey L. White
IPC分类号： B01J19/26 , B01J8/00 , C07C1/20
CPC分类号： C22C19/05 , B01J4/002 , B01J19/02 , B01J19/26 , B01J2219/00119 , B01J2219/00155 , B01J2219/00252 , B01J2219/0218 , B01J2219/0236 , C07C1/20 , C22C19/058 , C22C30/00 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/50 , Y02P30/42 , Y10S585/92 , Y10S585/923 , C07C11/02
摘要： Disclosed is a method and system for reducing the formation of metal catalyzed side-reaction byproducts formed in the feed vaporization and introduction system of a methanol to olefin reactor system by forming and/or coating one or more of the heating devices, feed lines or feed introduction nozzles of/with a material that is resistant to the formation of metal catalyzed side reaction byproducts. The invention also may include monitoring and/or maintaining the temperature of at least a portion of the feed vaporization and introduction system and/or of the feedstock contained therein below about 400° C., 350° C., 300° C., 250° C., 200° C. or below about 150° C. The temperature can be maintained in the desired range by jacketing at least a portion of the feed vaporization and introduction system, such as at least a portion of the feed introduction nozzle, with a thermally insulating material or by implementing a cooling system.
摘要翻译：公开了用于通过形成和/或涂覆一种或多种加热装置，进料管线或进料来减少在甲醇至烯烃反应器系统的进料蒸发和引入系统中形成的金属催化的副反应副产物的形成的方法和系统引入具有耐金属催化副反应副产物形成材料的喷嘴。本发明还可以包括监测和/或维持进料蒸发和引入系统和/或其中所含原料的至少一部分的温度低于约400℃，350℃，300℃，250℃ ℃，200℃或低于约150℃。通过夹套至少一部分进料蒸发和引入系统（例如进料引入喷嘴的至少一部分）可将温度保持在所需范围内，具有绝热材料或通过实施冷却系统。

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