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1. 发明授权

US5589502A Baccatin derivatives and processes for preparing the same 失效
标题翻译：浆果赤霉素衍生物及其制备方法
公开(公告)号：US5589502A
公开(公告)日：1996-12-31
申请号：US558772
申请日：1995-11-15
申请人： Kenji Tsujihara , Tomiki Hashiyama , Motoaki Ohashi , Noriyuki Nakanishi
发明人： Kenji Tsujihara , Tomiki Hashiyama , Motoaki Ohashi , Noriyuki Nakanishi
IPC分类号： C07D263/04 , C07D263/06 , C07D305/14 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , A61K31/335
CPC分类号： C07D263/04 , C07D263/06 , C07D305/14 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12
摘要： A compound represented by the formula [I]: ##STR1## wherein R.sup.3 represents a lower alkanoyl group; R.sup.4 represents a substituted or unsubstituted benzoyl group; ring A represents a substituted or unsubstituted cyclopropane ring; X represents a single bond or a group represented by --O--, --S-- or --NH--; R represents a substituted or unsubstituted lower alkyl group (wherein said lower alkyl group may have a cycloalkyl moiety), a substituted or unsubstituted aryl group or a substituted or unsubstituted aromatic heterocyclic group; E represents hydrogen atom or a group represented by --CO(CH.sub.2).sub.n ZY; Y represents a residue obtained from an amino acid or a dipeptide by removing hydroxyl group in one carboxyl group therefrom (wherein amino group existing in said residue may be protected, and carboxyl group existing in said residue may be esterified or amidated); Z represents a group represented by the formula of --O-- or --NH--; and n represents 1, 2, 3, 4, 5 or 6, or a pharmaceutically acceptable salt thereof. Said compounds have excellent antitumor activity so that they are useful in the prophylaxis or treatment of a wide range of tumors such as breast cancer, ovary cancer, lung cancer, malignant melanoma and the like.
摘要翻译：由式[I]表示的化合物：其中R 3表示低级烷酰基; R4表示取代或未取代的苯甲酰基; 环A表示取代或未取代的环丙烷环; X表示单键或由-O - ， - S-或-NH-表示的基团; R表示取代或未取代的低级烷基（其中所述低级烷基可以具有环烷基部分），取代或未取代的芳基或取代或未取代的芳族杂环基; E表示氢原子或由-CO（CH 2）n ZY表示的基团; Y表示通过从其中除去一个羧基中的羟基从氨基酸或二肽获得的残基（其中存在于所述残基中的氨基可被保护，并且所述残基中存在的羧基可被酯化或酰胺化）; Z表示由式-O-或-NH-表示的基团; 和n表示1,2,3,4,5或6或其药学上可接受的盐。所述化合物具有优异的抗肿瘤活性，因此它们可用于预防或治疗广泛范围的肿瘤如乳腺癌，卵巢癌，肺癌，恶性黑素瘤等。

2. 发明授权

US5677470A Baccatin derivatives and processes for preparing the same 失效
标题翻译：浆果赤霉素衍生物及其制备方法
公开(公告)号：US5677470A
公开(公告)日：1997-10-14
申请号：US480052
申请日：1995-06-07
申请人： Kenji Tsujihara , Tomiki Hashiyama , Naoyuki Harada , Kunihiko Ozaki , Motoaki Ohashi , Noriyuki Nakanishi , Tetsuo Yamaguchi
发明人： Kenji Tsujihara , Tomiki Hashiyama , Naoyuki Harada , Kunihiko Ozaki , Motoaki Ohashi , Noriyuki Nakanishi , Tetsuo Yamaguchi
IPC分类号： C07D305/14 , C07D407/12 , C07D409/12
CPC分类号： C07D407/12 , A61K47/48038 , C07D305/14 , C07D409/12 , Y02P20/55
摘要： Disclosed are 13.alpha.-(3-substituted-2-hydroxypropionyloxy)baccatin compounds represented by the formula: ##STR1## wherein R.sup.1 represents a lower alkanoyl group or a protective group for hydroxy group; R.sup.2 represents a protective group for hydroxy group; R.sup.3 represents a lower alkanoyl group; R.sup.4 represents a substituted or unsubstituted benzoyl group; X represents a substituted or unsubstituted aryl group, a substituted or unsubstituted lower alkenyl group, or a substituted or unsubstituted lower alkynyl group; and A' represents a halogen atom, azido group or amino group, and processes for preparing the same.
摘要翻译：公开了由下式表示的13α-（3-取代-2-羟基丙酰氧基）浆果赤霉素化合物：其中R1代表低级烷酰基或羟基保护基; R2表示羟基的保护基; R3表示低级烷酰基; R4表示取代或未取代的苯甲酰基; X表示取代或未取代的芳基，取代或未取代的低级烯基或取代或未取代的低级炔基; A'表示卤素原子，叠氮基或氨基，及其制备方法。

3. 发明授权

US5608073A Baccatin derivatives and processes for preparing the same 失效
标题翻译：浆果赤霉素衍生物及其制备方法
公开(公告)号：US5608073A
公开(公告)日：1997-03-04
申请号：US673580
申请日：1996-07-01
申请人： Kenji Tsujihara , Tomiki Hashiyama , Motoaki Ohashi , Noriyuki Nakanishi
发明人： Kenji Tsujihara , Tomiki Hashiyama , Motoaki Ohashi , Noriyuki Nakanishi
IPC分类号： C07D263/04 , C07D263/06 , C07D305/14 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12
CPC分类号： C07D263/04 , C07D263/06 , C07D305/14 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12
摘要： A compound represented by the formula [I]: ##STR1## wherein R.sup.3 represents a lower alkanoyl group; R.sup.4 represents a substituted or unsubstituted benzoyl group; ring A represents a substituted or unsubstituted cyclopropane ring; X represents a single bond or a group represented by --O--,--S-- or --NH--, R represents a substituted or unsubstituted lower alkyl group (wherein said lower alkyl group may have a cycloalkyl moiety), a substituted or unsubstituted aryl group or a substituted or unsubstituted aromatic heterocyclic group; E represents hydrogen atom or a group represented by --CO(CH.sub.2).sub.n ZY; Y represents a residue obtained from an amino acid or a dipeptide by removing hydroxyl group in one carboxyl group therefrom (wherein amino group existing in said residue may be protected, and carboxyl group existing in said residue may be esterified or amidated); Z represents a group represented by the formula of --O-- or --NH--; and n represents 1, 2, 3, 4, 5 or 6, or a pharmaceutically acceptable salt thereof. Said compounds have excellent antitumor activity so that they are useful in the prophylaxis or treatment of a wide range of tumors such as breast cancer, ovary cancer, lung cancer, malignant melanoma and the like.
摘要翻译：由式[I]表示的化合物：其中R 3表示低级烷酰基; R4表示取代或未取代的苯甲酰基; 环A表示取代或未取代的环丙烷环; X表示单键或由-O - ， - S-或-NH-表示的基团，R表示取代或未取代的低级烷基（其中所述低级烷基可具有环烷基部分），取代或未取代的芳基或取代或未取代的芳族杂环基; E表示氢原子或由-CO（CH 2）n ZY表示的基团; Y表示通过从其中除去一个羧基中的羟基从氨基酸或二肽获得的残基（其中存在于所述残基中的氨基可被保护，并且所述残基中存在的羧基可被酯化或酰胺化）; Z表示由式-O-或-NH-表示的基团; 和n表示1,2,3,4,5或6或其药学上可接受的盐。所述化合物具有优异的抗肿瘤活性，因此它们可用于预防或治疗广泛范围的肿瘤如乳腺癌，卵巢癌，肺癌，恶性黑素瘤等。

4. 发明授权

US08862272B2 Reagent preparation apparatus, reagent preparation system, and reagent preparation method 有权
标题翻译：试剂制备装置，试剂制备系统和试剂制备方法
公开(公告)号：US08862272B2
公开(公告)日：2014-10-14
申请号：US13197371
申请日：2011-08-03
申请人： Yutaka Ikeda , Noriyuki Nakanishi
发明人： Yutaka Ikeda , Noriyuki Nakanishi
IPC分类号： G05B21/00 , G01N1/38 , G01N35/10
CPC分类号： G01N1/38 , G01N35/1002
摘要： A reagent preparation apparatus for supplying a reagent, prepared by mixing a high concentration reagent and purified water supplied from a purified water production device, to a sample measurement device for measuring a sample using the prepared reagent, the reagent preparation apparatus comprising: a reagent preparation unit for preparing the reagent by mixing the high concentration reagent and the purified water supplied from the purified water production device; and a controller, communicably connected to the purified water production device, for controlling the purified water production device to continue producing the purified water until a predetermined time has elapsed from when the purified water production device starts the production of the purified water.Also, a reagent preparation system and a reagent preparation method.
摘要翻译：一种试剂调制装置，用于将通过将高浓度试剂和从净化水生成装置供给的净化水混合而制备的试剂供给到使用所制备的试剂测量样品的样品测量装置，所述试剂制备装置包括：试剂制备通过混合高浓度试剂和从纯化水生产装置供给的净化水来制备试剂的单元; 以及与净化水生产装置可通信地连接的控制器，用于控制净化水生产装置继续生产净化水，直到净化水生产装置开始净化水的生产经过预定时间。另外，也可以使用试剂调制系统和试剂调制方法。

5. 发明申请

US20110311396A1 REAGENT PREPARATION APPARATUS AND SPECIMEN PROCESSING SYSTEM 有权
标题翻译：试剂制备装置和样品加工系统
公开(公告)号：US20110311396A1
公开(公告)日：2011-12-22
申请号：US13218956
申请日：2011-08-26
申请人： Tomoyuki Asahara , Kouichi Ookubo , Noriyuki Nakanishi
发明人： Tomoyuki Asahara , Kouichi Ookubo , Noriyuki Nakanishi
IPC分类号： G01N1/28 , B01L99/00
CPC分类号： G01N35/10 , G01N35/00663 , G01N35/00732 , G01N35/0092 , G01N2035/00465 , G01N2035/00673
摘要： This reagent preparation apparatus prepares a reagent supplied to a measurement portion measuring a specimen with the reagent. The reagent is prepared from a first liquid and a second liquid different from the first liquid. The reagent preparation apparatus comprises a reagent preparation portion preparing the reagent and a control portion acquiring reagent information related to the reagent prepared by the reagent preparation portion, acquiring supply time information related to a time when the reagent prepared by the reagent preparation portion was supplied to the measurement portion and outputting the reagent information and the supply time information.
摘要翻译：该试剂调制装置准备用试剂供给到测定试样的测定部的试剂。试剂由不同于第一液体的第一液体和第二液体制备。试剂调制装置包括准备试剂的试剂调制部和获取与试剂调制部制备的试剂有关的试剂信息的控制部，获取与由试剂调制部制备的试剂供给时间相关的供给时间信息测量部分并输出试剂信息和供给时间信息。

6. 发明授权

US5712662A Pressure sensitive resistor cell and method for detecting threshold value of stylus used therewith 失效
标题翻译：压敏电阻单元及用于检测触针的阈值的方法
公开(公告)号：US5712662A
公开(公告)日：1998-01-27
申请号：US595913
申请日：1996-02-06
申请人： Minekazu Miyazaki , Noriyuki Nakanishi
发明人： Minekazu Miyazaki , Noriyuki Nakanishi
IPC分类号： G06F3/045 , G06F3/033 , G06F3/041 , G06F3/048 , G09G5/00
CPC分类号： G06F3/045
摘要： A simple-structured pressure sensitive resistor cell which permits the setting of a stylus pressure detecting threshold value VT and a stylus pressure detecting threshold value setting method therefor. A midtap T of a series connection of two or more resistors R1, R2 is connected to an input terminal of an A/D converter and a potential voltage divided by the resistors at the midtap T is defined as the stylus pressure detecting threshold value VT. Therefore, the stylus pressure detecting threshold value VT can be adjusted simply by changing the resistance value of either one of the resistors.
摘要翻译：一种简单结构的压敏电阻单元，其允许设置触针压力检测阈值VT和用于其的触笔压力检测阈值设定方法。两个或更多个电阻器R1，R2的串联连接的中间抽头T连接到A / D转换器的输入端子，并且将由中间抽头T上的电阻器分压的电位电压定义为触笔压力检测阈值VT。因此，可以通过改变电阻器中的任一个的电阻值来简单地调整触针压力检测阈值VT。

7. 发明授权

US5618699A Plant virus vector, plasmid, process for expression of foreign gene and process for obtaining foreign gene product 失效
标题翻译：植物病毒载体，质粒，外源基因表达过程和获得外源基因产物的方法
公开(公告)号：US5618699A
公开(公告)日：1997-04-08
申请号：US313127
申请日：1994-11-30
申请人： Hiroshi Hamamoto , Yoshinori Sugiyama , Noriaki Nakagawa , Eiji Hashida , Suguru Tsuchimoto , Noriyuki Nakanishi , Yuji Matsunaga , Yoshimi Okada
发明人： Hiroshi Hamamoto , Yoshinori Sugiyama , Noriaki Nakagawa , Eiji Hashida , Suguru Tsuchimoto , Noriyuki Nakanishi , Yuji Matsunaga , Yoshimi Okada
IPC分类号： C07K14/81 , C12N15/40 , C12N15/82 , C12N15/83 , C12N15/62
CPC分类号： C12N15/8257 , C07K14/8103 , C12N15/8203 , C12N15/8216 , C12N15/8242 , C07K2319/00
摘要： The present invention relates to a plant virus vector comprising a foreign gene linked downstream of a coat protein gene of tobacco mosaic virus via a nucleotide sequence which cause the readthrough, and a plasmid which is transcribed to provide the vector, as well as a process for expression of a foreign gene in a plant by inoculating the plant with the vector.In addition, the present invention relates to a process for efficiently recovering a foreign gene product produced in a plant as virions.
摘要翻译： PCT No.PCT / JP93 / 00408 Sec。 371日期1994年11月30日 102（e）1994年11月30日日期PCT 1993年3月31日PCT公布。公开号WO93 / 20217 日期：1993年10月14日本发明涉及包含外源基因的植物病毒载体，所述外源基因通过引导重读的核苷酸序列连接到烟草花叶病毒的外壳蛋白基因的下游，以及转录以提供载体的质粒为以及通过用载体接种植物来在植物中表达外源基因的方法。此外，本发明涉及一种有效回收植物中产生的外源基因产物作为病毒粒子的方法。

8. 发明授权

US09316660B2 Reagent preparation apparatus and specimen processing system 有权
标题翻译：试剂制备装置和样品处理系统
公开(公告)号：US09316660B2
公开(公告)日：2016-04-19
申请号：US13218956
申请日：2011-08-26
申请人： Tomoyuki Asahara , Kouichi Ookubo , Noriyuki Nakanishi
发明人： Tomoyuki Asahara , Kouichi Ookubo , Noriyuki Nakanishi
IPC分类号： G01N1/28 , B01L99/00 , G01N35/10 , G01N35/00
CPC分类号： G01N35/10 , G01N35/00663 , G01N35/00732 , G01N35/0092 , G01N2035/00465 , G01N2035/00673
摘要： This reagent preparation apparatus prepares a reagent supplied to a measurement portion measuring a specimen with the reagent. The reagent is prepared from a first liquid and a second liquid different from the first liquid. The reagent preparation apparatus comprises a reagent preparation portion preparing the reagent and a control portion acquiring reagent information related to the reagent prepared by the reagent preparation portion, acquiring supply time information related to a time when the reagent prepared by the reagent preparation portion was supplied to the measurement portion and outputting the reagent information and the supply time information.
摘要翻译：该试剂调制装置准备供给试剂的测定部的试剂。试剂由不同于第一液体的第一液体和第二液体制备。试剂调制装置包括准备试剂的试剂调制部和获取与试剂调制部制备的试剂有关的试剂信息的控制部，获取与由试剂调制部制备的试剂供给时间相关的供给时间信息测量部分并输出试剂信息和供给时间信息。

9. 发明申请

US20120237400A1 REAGENT PREPARATION APPARATUS AND SAMPLE PROCESSING APPARATUS 有权
标题翻译：试剂制备装置和样品加工装置
公开(公告)号：US20120237400A1
公开(公告)日：2012-09-20
申请号：US13417886
申请日：2012-03-12
申请人： Yutaka Ikeda , Noriyuki Nakanishi
发明人： Yutaka Ikeda , Noriyuki Nakanishi
IPC分类号： G01N1/28 , G01N27/00
CPC分类号： G01N35/00663 , G01N35/00613 , G01N35/00712 , G01N2035/00673 , Y10T436/12 , Y10T436/25
摘要： The present invention is a reagent preparation apparatus, comprising: a reagent preparation unit configured to prepare a reagent for processing a sample; a measuring unit configured to measure a property of the reagent prepared by the reagent preparation unit; a waste section configured to discard the prepared reagent when a measurement result by the measuring unit does not meet a predetermined condition; and a controller configured to control a reagent preparation operation of the reagent preparation unit, wherein the controller controls the reagent preparation unit to stop the reagent preparation operation when a number of times of discarding a reagent has reached a predetermined plurality of times.
摘要翻译：本发明是一种试剂调制装置，其特征在于，包括：试剂调制单元，其被配置为制备用于处理样品的试剂; 测量单元，被配置为测量由所述试剂调制单元制备的试剂的性质; 当所述测量单元的测量结果不满足预定条件时，废弃部分被配置为丢弃所述准备的试剂; 以及控制器，其被配置为控制所述试剂调制单元的试剂调制操作，其中，所述控制器控制所述试剂调制单元停止试剂准备操作，所述试剂停留次数达到预定次数。

10. 发明申请

US20100248208A1 REAGENT PREPARING DEVICE, REAGENT PREPARING METHOD, AND SPECIMEN PROCESSING SYSTEM 审中-公开
标题翻译：试剂制备装置，试剂制备方法和样品处理系统
公开(公告)号：US20100248208A1
公开(公告)日：2010-09-30
申请号：US12748768
申请日：2010-03-29
申请人： Koichi Okubo , Noriyuki Nakanishi , Masahiko Oguro , Tomoyuki Asahara , Takayuki Nakajima
发明人： Koichi Okubo , Noriyuki Nakanishi , Masahiko Oguro , Tomoyuki Asahara , Takayuki Nakajima
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： G01N35/1002 , G01N35/00663
摘要： A reagent preparing device capable of supplying a predetermined reagent, which includes a first liquid and a second liquid different from the first liquid, to a measurement section for measuring a specimen using the reagent, comprising: a pressure generator for generating pressure to transfer liquid; a reagent preparing section for executing a preparation operation of the predetermined reagent using the pressure generated by the pressure generator; and a controller configured for performing operations comprising: determining whether or not the reagent preparing section is executing the preparation operation, and controlling the generation of the pressure by the pressure generator according to the determination result, is disclosed. A reagent preparing method and a specimen processing system are also disclosed.
摘要翻译：一种能够将包含第一液体和与第一液体不同的第二液体的预定试剂供给到使用试剂测定试样的测定部的试剂调制装置，其特征在于，包括：压力发生器，其产生用于输送液体的压力; 试剂调制部，用于使用由压力发生器产生的压力执行预定试剂的制备操作; 以及控制器，其被配置为执行操作，包括：确定所述试剂准备部是否正在执行所述准备操作，并且根据所述确定结果来控制由所述压力发生器产生的压力。还公开了一种试剂制备方法和试样处理系统。

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