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1. 发明授权

US5629198A Anti-HIV agent 失效
标题翻译：抗艾滋病毒药物
公开(公告)号：US5629198A
公开(公告)日：1997-05-13
申请号：US175438
申请日：1994-01-12
申请人： Kenji Mizumoto , Hiroshi Tsuboi , Hideki Miyajima , Hiroshi Fujimoto , Katsumi Ajisaka , Yukio Fujiki , Hajime Tsunoo
发明人： Kenji Mizumoto , Hiroshi Tsuboi , Hideki Miyajima , Hiroshi Fujimoto , Katsumi Ajisaka , Yukio Fujiki , Hajime Tsunoo
IPC分类号： A61K31/40 , A61K31/555 , A61K38/00 , A61K47/48 , C07D487/22 , C07K14/765 , A61K39/00 , C07K1/00 , G01N33/53 , G01N33/564
CPC分类号： C07D487/22 , A61K31/40 , A61K31/555 , A61K47/48238 , C07K14/765 , A61K38/00 , Y10S435/974 , Y10S435/975
摘要： The invention relates to an anti-HIV agent comprising, as an active ingredient, at least one porphyrin derivative selected from the following derivatives (A) and (B):(A) porphyrins modified with a compound selected from carbodiimides, alkylenediamines and alcohols; and(B) complexes of a plasma protein or a chemically modified plasma protein and a porphyrin which may have been modified with a compound selected from carbodiimides, alkylenediamines and alcohols.This anti-HIV agent is excellent in killing effect on HIV-infected cells, inhibitory effect on cytopathy due to HIV infection and HIV-replication inhibiting effect, and high in safety.
摘要翻译： PCT No.PCT / JP92 / 00977 Sec。 371日期：1994年1月12日 102（e）日期1994年1月12日PCT提交1992年7月31日PCT公布。出版物WO93 / 03035 日本特开1993-1985号本发明涉及含有选自以下衍生物（A）和（B）中的至少一种卟啉衍生物作为活性成分的抗HIV剂：（A）用选自碳二亚胺的化合物改性的卟啉，亚烷基二胺和醇; 和（B）可以用选自碳二亚胺，亚烷基二胺和醇的化合物修饰的血浆蛋白或化学修饰的血浆蛋白和卟啉的复合物。该抗HIV剂对HIV感染细胞的杀伤效果优异，对HIV感染的细胞病变和HIV复制抑制作用的抑制作用，安全性高。

2. 发明授权

US5972914A Remedies for liver diseases 失效
标题翻译：肝病治疗
公开(公告)号：US5972914A
公开(公告)日：1999-10-26
申请号：US118866
申请日：1998-07-20
申请人： Hajime Sasaki , Atsushi Nemoto , Hisae Kume , Hiroshi Tsuboi , Kenji Mizumoto , Naommy Takahashi , Masayuki Uchida
发明人： Hajime Sasaki , Atsushi Nemoto , Hisae Kume , Hiroshi Tsuboi , Kenji Mizumoto , Naommy Takahashi , Masayuki Uchida
IPC分类号： A61K31/13 , A61K31/66
CPC分类号： A61K31/661 , A61K31/13
摘要： The present invention discloses a method for the treatment of liver diseases, comprising administering an effective amount of an aminoalcohol of the following formula (1) or a salt thereof: ##STR1## wherein R.sup.1 represents a hydrogen atom or a phosphono group, R.sup.2 represents a hydrogen atom or a group --(CH.sub.2).sub.n --OR.sup.1, and n represents an integer between 2 and 5 inclusive. The present invention also relates to the use of the compound in the manufacture of a remedy for the treatment of liver diseases. This compound exhibits hepatocyte proliferation activity and liver disorder restoring effect, and thus is useful for the treatment of acute hepatitis, chronic hepatitis, hepatic cirrhosis, etc.
摘要翻译：本发明公开了一种治疗肝病的方法，其包括给予有效量的下式（1）的氨基醇或其盐：其中R1表示氢原子或膦酰基，R2表示氢原子或基团 - （CH 2）n -OR 1，n表示2〜5的整数。本发明还涉及该化合物在制备用于治疗肝脏疾病的治疗药物中的用途。该化合物显示肝细胞增殖活性和肝脏疾病恢复作用，因此可用于治疗急性肝炎，慢性肝炎，肝硬化等。

3. 发明授权

US5916924A Remedies for liver diseases 失效
标题翻译：肝病治疗
公开(公告)号：US5916924A
公开(公告)日：1999-06-29
申请号：US971267
申请日：1997-11-17
申请人： Hajime Sasaki , Atsushi Nemoto , Hisae Kume , Hiroshi Tsuboi , Kenji Mizumoto , Naommy Takahashi , Masayuki Uchida
发明人： Hajime Sasaki , Atsushi Nemoto , Hisae Kume , Hiroshi Tsuboi , Kenji Mizumoto , Naommy Takahashi , Masayuki Uchida
IPC分类号： A61K31/13
CPC分类号： A61K31/661 , A61K31/13
摘要： The present invention discloses a method for the treatment of liver diseases, comprising administering an effective amount of an aminoalcohol of the following formula (1) or a salt thereof: ##STR1## wherein R.sup.1 represents a hydrogen atom or a phosphono group, R.sup.2 represents a hydrogen atom or a group--(CH.sub.2).sub.n --OR.sup.1, and n represents an integer between 2 and 5 inclusive. The present invention also relates to the use of the compound in the manufacture of a remedy for the treatment of liver diseases. This compound exhibits hepatocyte proliferation activity and liver disorder restoring effect, and thus is useful for the treatment of acute hepatitis, chronic hepatitis, hepatic cirrhosis, etc.
摘要翻译：本发明公开了一种治疗肝病的方法，其包括给予有效量的下式（1）的氨基醇或其盐：其中R1表示氢原子或膦酰基，R2表示氢原子或基团 - （CH 2）n -OR 1，n表示2〜5的整数。本发明还涉及该化合物在制备用于治疗肝脏疾病的治疗药物中的用途。该化合物显示肝细胞增殖活性和肝脏疾病恢复作用，因此可用于治疗急性肝炎，慢性肝炎，肝硬化等。

4. 发明授权

US08612057B2 Control of water discharge system by reflected wave detection threshold(s) 有权
标题翻译：通过反射波检测阈值控制排水系统
公开(公告)号：US08612057B2
公开(公告)日：2013-12-17
申请号：US12809251
申请日：2008-12-17
申请人： Kensuke Murata , Masayuki Nagaishi , Katsuhisa Tsuchiya , Shoichi Tsuiki , Masami Tsujita , Hiroshi Tsuboi
发明人： Kensuke Murata , Masayuki Nagaishi , Katsuhisa Tsuchiya , Shoichi Tsuiki , Masami Tsujita , Hiroshi Tsuboi
IPC分类号： G05D7/00 , E03C1/05 , F16K31/02
CPC分类号： E03C1/05 , E03C1/057 , G01S7/415 , G01S13/50 , G01S13/88 , Y10T137/8158
摘要： A water discharge system capable of preventing a mistaken detection to surely perform the stop of water discharge or continue the start of water discharge is provided. The water discharge system includes: a water discharge unit; a sensor unit configured to obtain information about an object to be detected through a reflected wave of a radiated radio wave; a control unit configured to control the start of water discharge from the water discharge unit based on a detective signal from the sensor unit; and a storage mechanics. The sensor unit is installed so that at least part of a radiated radio wave comes into contact with a discharged water flow discharged from the water discharge unit and receives the reflected wave reflected by the discharged water flow, and the control unit determines a state of the discharged water flow by checking a relationship between a first threshold set larger than amplitude of oscillation around a reference value of the detective signal in a water flow state in which only the start of water discharge from the water discharge unit is performed and amplitude of the detective signal received by the sensor unit.
摘要翻译：提供了能够防止错误检测以确定地执行排水停止或继续开始排水的排水系统。排水系统包括：排水单元; 传感器单元，被配置为通过辐射无线电波的反射波获得关于要检测的对象的信息; 控制单元，被配置为基于来自所述传感器单元的检测信号来控制从所述排水单元开始排水; 和存储机制。传感器单元被安装成使得辐射无线电波的至少一部分与从排水单元排出的排出水流接触并接收由排出水流反射的反射波，并且控制单元确定通过检查在仅执行来自排水单元的排水开始的水流状态下的检测信号的基准值周围的振荡振幅周围的第一阈值与检测器的振幅之间的关系，信号由传感器单元接收。

5. 发明申请

US20100316618A1 LACTIC ACID BACTERIUM HAVING EFFECT OF LOWERING BLOOD URIC ACID LEVEL 有权
标题翻译：具有降低血液尿酸水平的影响的乳酸杆菌
公开(公告)号：US20100316618A1
公开(公告)日：2010-12-16
申请号：US12745006
申请日：2008-11-27
申请人： Hiroshi Tsuboi , Noriko Kaneko , Akina Satou , Akinori Kume , katsunori Kimura
发明人： Hiroshi Tsuboi , Noriko Kaneko , Akina Satou , Akinori Kume , katsunori Kimura
IPC分类号： A61K35/74 , C12N1/20 , C12P1/04 , A61P7/00
CPC分类号： C12R1/225 , A23C9/1234 , A23L33/135 , A23Y2220/37 , A61K35/747
摘要： The present invention provides lactic acid bacteria which are suitable for use for dietary products and pharmaceuticals, and which can suppress the increase of blood uric acid level.Various types of lactic acid bacteria were cultured in the presence of a purine, the amount of the purine consumed and the amount of purine degradation products produced were measured, and several lactic acid bacteria showing remarkable purine-decomposing ability were selected. Lactic acid bacteria that were assessed to have high purine-decomposing ability according to the above-mentioned selection were orally administered to rats reared on purine-containing feed, the general status and serum uric acid level of the rats were measured, and the effect of lactic acid bacteria administration on serum uric acid levels was examined. As a result, lactic acid bacteria that significantly suppress the increase of serum uric acid levels, Lactobacillus gasseri OLL2922, were found.
摘要翻译：本发明提供适用于饮食品和药物的乳酸菌，可抑制血液中尿酸水平的升高。在嘌呤存在下培养各种类型的乳酸菌，测定嘌呤消耗量和产生的嘌呤降解产物量，选择显示出显着的嘌呤分解能力的几种乳酸菌。对含有嘌呤的饲料饲养的大鼠口服给予根据上述选择被评估为具有高嘌呤分解能力的乳酸菌，测定大鼠的一般状态和血清尿酸水平，检测乳酸菌对血清尿酸水平的影响。结果发现，显着抑制血清尿酸水平升高的乳酸菌，加氏乳杆菌（Lactobacillus gasseri）OLL2922。

6. 发明授权

US6113378A Mold for drum-shaped magnetic core 失效
标题翻译：鼓形磁芯模具
公开(公告)号：US6113378A
公开(公告)日：2000-09-05
申请号：US862703
申请日：1997-05-23
申请人： Hiroshi Tsuboi , Toshinori Okamoto , Kunio Kojima
发明人： Hiroshi Tsuboi , Toshinori Okamoto , Kunio Kojima
IPC分类号： B30B11/02 , B30B11/04 , B29C43/02
CPC分类号： B30B11/04 , B30B11/027
摘要： A mold for molding a drum shaped magnetic core having two flanges connected by a coil winding core portion. The mold includes a die defining a cylindrical cavity having an inner diameter substantially equal to an outer diameter of the flanges. A pair of die inserts are movable in an orthogonal direction relative to the cylindrical cavity and define a diameter of the coil winding core portion of the drum shaped magnetic core. The diameter of the coil winding core portion is smaller than the outer diameter of the flanges. An upper punch and a lower punch are inserted into the cylindrical cavity from a corresponding end opening of the mold such that each forms a flange. A central punch is disposed coaxially within one of the punches to form the coil winding core portion.
摘要翻译：一种用于模制鼓形磁芯的模具，其具有通过线圈绕组芯部分连接的两个凸缘。模具包括限定具有基本上等于凸缘的外径的内径的圆柱形腔的模具。一对模插件可以相对于圆柱形空腔在正交方向上移动，并且限定鼓形磁芯的线圈绕组芯部分的直径。线圈绕芯部分的直径小于凸缘的外径。上冲头和下冲头从模具的对应的端部开口插入到圆柱形腔中，使得每个形成凸缘。中心冲头同轴地布置在一个冲头内以形成线圈卷绕芯部分。

7. 发明授权

US5625911A Apparatus for sampling urine 失效
标题翻译：尿液取样装置
公开(公告)号：US5625911A
公开(公告)日：1997-05-06
申请号：US537760
申请日：1996-01-19
申请人： Chiaki Nakayama , Kuniaki Shinohara , Naoki Sato , Hiroshi Tsuboi
发明人： Chiaki Nakayama , Kuniaki Shinohara , Naoki Sato , Hiroshi Tsuboi
IPC分类号： A47K13/00 , A61B10/00 , E03D9/00 , G01N1/10 , G01N33/483 , G01N33/493 , E03D11/00 , A61B5/00
CPC分类号： G01N33/493 , A61B10/007
摘要： A method and an apparatus (30) for sampling urine at a toilet (10) equipped with a standard water closet bowl fixture (12). An elongated, curved, urine sampling trough (32) having a U-shaped cross-section is used. For sampling of urine, the sampling trough (32) is positioned in the vertical central plane (46) of the toilet bowl fixture in such a manner that it extends obliquely between the upper front region and the bottom region of the inner space of the bowl (14). As the urine sampling trough (32) covers a substantial length in the vertical direction as well as in the fore-and-aft direction, the urine column hits on the sampling trough even when the trajectory of urine column is fluctuated in the vertical or fore-and-aft direction, whereby urine is effectively sampled. As the urine sampling trough is elongated and curved, it can be readily stored under the toilet seat when not in use.
摘要翻译： PCT No.PCT / JP95 / 00259 Sec。 371日期1996年1月19日 102（e）日期1996年1月19日PCT提交1995年2月23日PCT公布。公开号WO95 / 23337 日期1995年8月31日一种用于在配备有标准洗手间碗具（12）的马桶（10）上抽尿的方法和装置（30）。使用具有U形横截面的细长弯曲的尿液采样槽（32）。为了取样尿液，采样槽（32）以这样的方式定位在马桶装置的垂直中心平面（46）中，使其在碗的内部空间的上部前部区域和底部区域之间倾斜地延伸（14）。当尿液采样槽（32）在垂直方向和前后方向上覆盖相当长的长度时，即使当尿液柱的轨迹在垂直或前方波动时，尿液塔也会在取样槽上撞击后方向，从而有效地抽取尿液。当尿液采样槽细长且弯曲时，可以在不使用时容易地储存在马桶座下。

8. 发明授权

US5184359A Stool-type apparatus for sampling and assay of urine with swingable carriage 失效
标题翻译：用于采用可移动运输的尿液取样和测定的STOOL型装置
公开(公告)号：US5184359A
公开(公告)日：1993-02-09
申请号：US748211
申请日：1991-08-22
申请人： Naoki Tsukamura , Kiyoshi Alyfuku , Yuzuru Nakamura , Yoshiki Hiruta , Hiroshi Tsuboi
发明人： Naoki Tsukamura , Kiyoshi Alyfuku , Yuzuru Nakamura , Yoshiki Hiruta , Hiroshi Tsuboi
IPC分类号： A61B5/022 , A61B10/00
CPC分类号： A61B5/02241 , A61B10/0051 , A61B10/007
摘要： A toilet system (10) with urine assay function is disclosed which comprises a toilet stool (12) having a toilet bowl (14) and a small urine-sampling cavity (52). A frame (42) is mounted on the toilet stool to support a testing sheet handling and transfer mechanism (30) which comprises a swingable carriage (46) and a slidable arm (50) supported by the carriage for linear telescoping movement. The carriage is swingable about a vertical axis (48) between a first position in which the carriage is oriented toward the sampling cavity and a second position in which the carriage is oriented to a lateral side of the stool wherein a disposal station is provided.The toilet system enables the use of testing sheets (32) which are made from water insoluble materials.Various other embodiments are also disclosed.The system provides a high degree of reliability of analysis.

9. 发明申请

US20120308539A1 LACTIC ACID BACTERIA HAVING ACTION OF LOWERING BLOOD URIC ACID LEVEL 有权
标题翻译：具有降低血液尿酸水平的乳酸菌
公开(公告)号：US20120308539A1
公开(公告)日：2012-12-06
申请号：US13544756
申请日：2012-07-09
申请人： Hiroshi Tsuboi , Noriko Kaneko , Akina Satou , Yoshinobu Tsuchiya
发明人： Hiroshi Tsuboi , Noriko Kaneko , Akina Satou , Yoshinobu Tsuchiya
IPC分类号： C12N1/20 , A61P1/00 , A61K35/74
CPC分类号： A23C9/1234 , A23C9/1238 , A23L33/135 , A23V2002/00 , A23Y2220/61 , A61K35/747 , C12R1/225 , A23V2200/30
摘要： Various types of lactic acid bacteria were cultured in the presence of a purine, the amount of the purine consumed and the amount of purine degradation products produced were measured, and several lactic acid bacteria showing remarkable purine-decomposing ability were selected. Lactic acid bacteria that were assessed to have high purine-decomposing ability according to the above-mentioned selection were orally administered to rats reared on purine-containing feed, the general status and serum uric acid level of the rats were measured, and the effect of lactic acid bacteria administration on serum uric acid levels was examined. As a result, lactic acid bacteria that significantly suppress the increase of serum uric acid levels, Lactobacillus gasseri OLL2959 and Lactobacillus oris OLL2779, were found.
摘要翻译：在嘌呤存在下培养各种类型的乳酸菌，测定嘌呤消耗量和产生的嘌呤降解产物量，选择显示出显着的嘌呤分解能力的几种乳酸菌。对含有嘌呤的饲料饲养的大鼠口服给予根据上述选择被评估为具有高嘌呤分解能力的乳酸菌，测定大鼠的一般状态和血清尿酸水平，检测乳酸菌对血清尿酸水平的影响。结果发现显着抑制血清尿酸水平升高的乳酸菌，加氏乳杆菌OLL2959和乳酸杆菌OLL2779。

10. 发明授权

US08171578B2 Water discharge system 有权
标题翻译：排水系统
公开(公告)号：US08171578B2
公开(公告)日：2012-05-08
申请号：US12182990
申请日：2008-07-30
申请人： Masami Tsujita , Tomoyuki Abe , Naoki Kabe , Hiroshi Tsuboi , Masayuki Nagaishi , Katsuhisa Tsuchiya , Shoichi Tsuiki , Kensuke Murata
发明人： Masami Tsujita , Tomoyuki Abe , Naoki Kabe , Hiroshi Tsuboi , Masayuki Nagaishi , Katsuhisa Tsuchiya , Shoichi Tsuiki , Kensuke Murata
IPC分类号： E03C1/05
CPC分类号： E03C1/057 , G01S13/56 , G01S13/582 , G01S13/88
摘要： There is provided a water discharge system. A water discharge system includes a water discharge portion; a sensor unit which acquires movement information about an object based on a radiated electric wave, and outputs a detecting signal; and a control unit which controls water discharge of the water discharge portion based on the detecting signal. When it is detected that the object is decelerated to a first threshold velocity or less, the control unit controls the water discharge portion to start the water discharge.
摘要翻译：提供排水系统。排水系统包括排水部分; 传感器单元，其基于辐射电波获取关于对象的移动信息，并输出检测信号; 以及控制单元，其基于检测信号来控制排水部的排水。当检测到物体减速到第一阈值速度或更小时，控制单元控制排水部分开始排水。

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