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1. 发明申请

US20100316618A1 LACTIC ACID BACTERIUM HAVING EFFECT OF LOWERING BLOOD URIC ACID LEVEL 有权
标题翻译：具有降低血液尿酸水平的影响的乳酸杆菌
公开(公告)号：US20100316618A1
公开(公告)日：2010-12-16
申请号：US12745006
申请日：2008-11-27
申请人： Hiroshi Tsuboi , Noriko Kaneko , Akina Satou , Akinori Kume , katsunori Kimura
发明人： Hiroshi Tsuboi , Noriko Kaneko , Akina Satou , Akinori Kume , katsunori Kimura
IPC分类号： A61K35/74 , C12N1/20 , C12P1/04 , A61P7/00
CPC分类号： C12R1/225 , A23C9/1234 , A23L33/135 , A23Y2220/37 , A61K35/747
摘要： The present invention provides lactic acid bacteria which are suitable for use for dietary products and pharmaceuticals, and which can suppress the increase of blood uric acid level.Various types of lactic acid bacteria were cultured in the presence of a purine, the amount of the purine consumed and the amount of purine degradation products produced were measured, and several lactic acid bacteria showing remarkable purine-decomposing ability were selected. Lactic acid bacteria that were assessed to have high purine-decomposing ability according to the above-mentioned selection were orally administered to rats reared on purine-containing feed, the general status and serum uric acid level of the rats were measured, and the effect of lactic acid bacteria administration on serum uric acid levels was examined. As a result, lactic acid bacteria that significantly suppress the increase of serum uric acid levels, Lactobacillus gasseri OLL2922, were found.
摘要翻译：本发明提供适用于饮食品和药物的乳酸菌，可抑制血液中尿酸水平的升高。在嘌呤存在下培养各种类型的乳酸菌，测定嘌呤消耗量和产生的嘌呤降解产物量，选择显示出显着的嘌呤分解能力的几种乳酸菌。对含有嘌呤的饲料饲养的大鼠口服给予根据上述选择被评估为具有高嘌呤分解能力的乳酸菌，测定大鼠的一般状态和血清尿酸水平，检测乳酸菌对血清尿酸水平的影响。结果发现，显着抑制血清尿酸水平升高的乳酸菌，加氏乳杆菌（Lactobacillus gasseri）OLL2922。

2. 发明授权

US08541223B2 Lactic acid bacteria having action of lowering blood uric acid level 有权
公开(公告)号：US08541223B2
公开(公告)日：2013-09-24
申请号：US13544756
申请日：2012-07-09
申请人： Hiroshi Tsuboi , Noriko Kaneko , Akina Satou , Yoshinobu Tsuchiya
发明人： Hiroshi Tsuboi , Noriko Kaneko , Akina Satou , Yoshinobu Tsuchiya
IPC分类号： C12N1/20
CPC分类号： A23C9/1234 , A23C9/1238 , A23L33/135 , A23V2002/00 , A23Y2220/61 , A61K35/747 , C12R1/225 , A23V2200/30
摘要： Various types of lactic acid bacteria were cultured in the presence of a purine, the amount of the purine consumed and the amount of purine degradation products produced were measured, and several lactic acid bacteria showing remarkable purine-decomposing ability were selected. Lactic acid bacteria that were assessed to have high purine-decomposing ability according to the above-mentioned selection were orally administered to rats reared on purine-containing feed, the general status and serum uric acid level of the rats were measured, and the effect of lactic acid bacteria administration on serum uric acid levels was examined. As a result, lactic acid bacteria that significantly suppress the increase of serum uric acid levels, Lactobacillus gasseri OLL2959 and Lactobacillus oris OLL2779, were found.

3. 发明授权

US08460918B2 Lactic acid bacteria having action of lowering blood uric acid level 有权
标题翻译：乳酸菌具有降低血尿酸水平的作用
公开(公告)号：US08460918B2
公开(公告)日：2013-06-11
申请号：US12745007
申请日：2007-11-29
申请人： Hiroshi Tsuboi , Noriko Kaneko , Akina Satou , Yoshinobu Tsuchiya
发明人： Hiroshi Tsuboi , Noriko Kaneko , Akina Satou , Yoshinobu Tsuchiya
IPC分类号： C12N1/20
CPC分类号： A23C9/1234 , A23C9/1238 , A23L33/135 , A23V2002/00 , A23Y2220/61 , A61K35/747 , C12R1/225 , A23V2200/30
摘要： Various types of lactic acid bacteria were cultured in the presence of a purine, the amount of the purine consumed and the amount of purine degradation products produced were measured, and several lactic acid bacteria showing remarkable purine-decomposing ability were selected. Lactic acid bacteria that were assessed to have high purine-decomposing ability according to the above-mentioned selection were orally administered to rats reared on purine-containing feed, the general status and serum uric acid level of the rats were measured, and the effect of lactic acid bacteria administration on serum uric acid levels was examined. As a result, lactic acid bacteria that significantly suppress the increase of serum uric acid levels, Lactobacillus gasseri OLL2959 and Lactobacillus oris OLL2779, were found.
摘要翻译：在嘌呤存在下培养各种类型的乳酸菌，测定嘌呤消耗量和产生的嘌呤降解产物量，选择显示出显着的嘌呤分解能力的几种乳酸菌。对含有嘌呤的饲料饲养的大鼠口服给予根据上述选择被评估为具有高嘌呤分解能力的乳酸菌，测定大鼠的一般状态和血清尿酸水平，检测乳酸菌对血清尿酸水平的影响。结果发现显着抑制血清尿酸水平升高的乳酸菌，加氏乳杆菌OLL2959和乳酸杆菌OLL2779。

4. 发明授权

US08389266B2 Lactic acid bacterium having effect of lowering blood uric acid level 有权
标题翻译：具有降低血液尿酸水平的作用的乳酸菌
公开(公告)号：US08389266B2
公开(公告)日：2013-03-05
申请号：US12745006
申请日：2008-11-27
申请人： Hiroshi Tsuboi , Noriko Kaneko , Akina Satou , Akinori Kume , Katsunori Kimura
发明人： Hiroshi Tsuboi , Noriko Kaneko , Akina Satou , Akinori Kume , Katsunori Kimura
IPC分类号： C12N1/20
CPC分类号： C12R1/225 , A23C9/1234 , A23L33/135 , A23Y2220/37 , A61K35/747
摘要： The present invention provides lactic acid bacteria which are suitable for use for dietary products and pharmaceuticals, and which can suppress the increase of blood uric acid level. Various types of lactic acid bacteria were cultured in the presence of a purine, the amount of the purine consumed and the amount of purine degradation products produced were measured, and several lactic acid bacteria showing remarkable purine-decomposing ability were selected. Lactic acid bacteria that were assessed to have high purine-decomposing ability according to the above-mentioned selection were orally administered to rats reared on purine-containing feed, the general status and serum uric acid level of the rats were measured, and the effect of lactic acid bacteria administration on serum uric acid levels was examined. As a result, lactic acid bacteria that significantly suppress the increase of serum uric acid levels, Lactobacillus gasseri OLL2922, were found.
摘要翻译：本发明提供适用于饮食品和药物的乳酸菌，可抑制血液中尿酸水平的升高。在嘌呤存在下培养各种类型的乳酸菌，测定嘌呤消耗量和产生的嘌呤降解产物量，选择显示出显着的嘌呤分解能力的几种乳酸菌。对含有嘌呤的饲料饲养的大鼠口服给予根据上述选择被评估为具有高嘌呤分解能力的乳酸菌，测定大鼠的一般状态和血清尿酸水平，检测乳酸菌对血清尿酸水平的影响。结果发现，显着抑制血清尿酸水平升高的乳酸菌，加氏乳杆菌（Lactobacillus gasseri）OLL2922。

5. 发明申请

US20110014168A1 LACTIC ACID BACTERIA HAVING ACTION OF LOWERING BLOOD URIC ACID LEVEL 有权
标题翻译：具有降低血液尿酸水平的乳酸菌
公开(公告)号：US20110014168A1
公开(公告)日：2011-01-20
申请号：US12745007
申请日：2007-11-29
申请人： Hirosi Tsuboi , Noriko Kaneko , Akina Satou , Yoshinobu Tsuchiya
发明人： Hirosi Tsuboi , Noriko Kaneko , Akina Satou , Yoshinobu Tsuchiya
IPC分类号： A61K35/74 , C12N1/20 , A61P1/00
CPC分类号： A23C9/1234 , A23C9/1238 , A23L33/135 , A23V2002/00 , A23Y2220/61 , A61K35/747 , C12R1/225 , A23V2200/30
摘要： Various types of lactic acid bacteria were cultured in the presence of a purine, the amount of the purine consumed and the amount of purine degradation products produced were measured, and several lactic acid bacteria showing remarkable purine-decomposing ability were selected. Lactic acid bacteria that were assessed to have high purine-decomposing ability according to the above-mentioned selection were orally administered to rats reared on purine-containing feed, the general status and serum uric acid level of the rats were measured, and the effect of lactic acid bacteria administration on serum uric acid levels was examined. As a result, lactic acid bacteria that significantly suppress the increase of serum uric acid levels, Lactobacillus gasseri OLL2959 and Lactobacillus oris OLL2779, were found.
摘要翻译：在嘌呤存在下培养各种类型的乳酸菌，测定嘌呤消耗量和产生的嘌呤降解产物量，选择显示出显着的嘌呤分解能力的几种乳酸菌。对含有嘌呤的饲料饲养的大鼠口服给予根据上述选择被评估为具有高嘌呤分解能力的乳酸菌，测定大鼠的一般状态和血清尿酸水平，检测乳酸菌对血清尿酸水平的影响。结果发现显着抑制血清尿酸水平增加的乳酸菌，加氏乳杆菌OLL2959和乳酸杆菌OLL2779。

6. 发明申请

US20120308539A1 LACTIC ACID BACTERIA HAVING ACTION OF LOWERING BLOOD URIC ACID LEVEL 有权
标题翻译：具有降低血液尿酸水平的乳酸菌
公开(公告)号：US20120308539A1
公开(公告)日：2012-12-06
申请号：US13544756
申请日：2012-07-09
申请人： Hiroshi Tsuboi , Noriko Kaneko , Akina Satou , Yoshinobu Tsuchiya
发明人： Hiroshi Tsuboi , Noriko Kaneko , Akina Satou , Yoshinobu Tsuchiya
IPC分类号： C12N1/20 , A61P1/00 , A61K35/74
CPC分类号： A23C9/1234 , A23C9/1238 , A23L33/135 , A23V2002/00 , A23Y2220/61 , A61K35/747 , C12R1/225 , A23V2200/30
摘要： Various types of lactic acid bacteria were cultured in the presence of a purine, the amount of the purine consumed and the amount of purine degradation products produced were measured, and several lactic acid bacteria showing remarkable purine-decomposing ability were selected. Lactic acid bacteria that were assessed to have high purine-decomposing ability according to the above-mentioned selection were orally administered to rats reared on purine-containing feed, the general status and serum uric acid level of the rats were measured, and the effect of lactic acid bacteria administration on serum uric acid levels was examined. As a result, lactic acid bacteria that significantly suppress the increase of serum uric acid levels, Lactobacillus gasseri OLL2959 and Lactobacillus oris OLL2779, were found.
摘要翻译：在嘌呤存在下培养各种类型的乳酸菌，测定嘌呤消耗量和产生的嘌呤降解产物量，选择显示出显着的嘌呤分解能力的几种乳酸菌。对含有嘌呤的饲料饲养的大鼠口服给予根据上述选择被评估为具有高嘌呤分解能力的乳酸菌，测定大鼠的一般状态和血清尿酸水平，检测乳酸菌对血清尿酸水平的影响。结果发现显着抑制血清尿酸水平升高的乳酸菌，加氏乳杆菌OLL2959和乳酸杆菌OLL2779。

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