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1. 发明授权

US07163965B2 Process for producing porous composite materials 有权
标题翻译：生产多孔复合材料的方法
公开(公告)号：US07163965B2
公开(公告)日：2007-01-16
申请号：US10492300
申请日：2002-05-01
申请人： Shinichi Sotome , Toshimasa Uemura , Junzo Tanaka , Masanori Kikuchi , Kenichi Shinomiya , Soichiro Itoh , Tetsuya Tateishi
发明人： Shinichi Sotome , Toshimasa Uemura , Junzo Tanaka , Masanori Kikuchi , Kenichi Shinomiya , Soichiro Itoh , Tetsuya Tateishi
IPC分类号： A61L27/00 , A61L27/52
CPC分类号： A61L27/56 , A61L27/46 , C08L89/06
摘要： This invention relates to a process for producing porous and composite materials comprising steps of: freezing a complex containing at least one calcium salt selected from calcium carbonate, calcium phosphate, and hydroxyapatite and collagen, at least a part of which is gelatinized; and then lyophilizing the resultant. The porous and composite materials obtained by the method of the present invention have large pore diameters, high porosities, and adequate mechanical strengths and biodegradability. Thus, they are suitable for implants such as bone fillers, drug carriers for sustained-release, and the like.
摘要翻译：本发明涉及一种生产多孔和复合材料的方法，包括以下步骤：冷冻含有至少一种选自碳酸钙，磷酸钙和羟基磷灰石的钙盐的复合物和至少部分胶凝的胶原蛋白; 然后将所得物冷冻干燥。通过本发明的方法获得的多孔和复合材料具有大的孔径，高孔隙率和足够的机械强度和生物降解性。因此，它们适用于诸如骨填料，持续释放的药物载体等植入物。

2. 发明授权

US06887272B2 Artificial pyramid 有权
标题翻译：人造金字塔
公开(公告)号：US06887272B2
公开(公告)日：2005-05-03
申请号：US10468010
申请日：2002-02-20
申请人： Kenichi Shinomiya , Soichiro Itoh , Junzo Tanaka , Masanori Kikuchi
发明人： Kenichi Shinomiya , Soichiro Itoh , Junzo Tanaka , Masanori Kikuchi
IPC分类号： A61L27/00 , A61B17/80 , A61F2/44 , A61L27/46 , A61L27/58 , A61F2/28 , A61F13/00
CPC分类号： A61L27/56 , A61B17/80 , A61F2/44 , A61L27/46 , A61L2430/38 , C08L89/06
摘要： Disclosed is an artificial vertebra having a bone-marrow regenerating function, comprising a hydroxyapatite (HAp)/collagen (Col) composite body formed by pressure-dehydrating a coprecipitate of hydroxyapatite and collagen to have a nanocomposite structure in which HAp particles are conjugated along a Col fiber while aligned each of the c-axes of the HAp particles along the Col fiber. The HAp/Col composite body is formed with a perforated aperture for allowing a blood vessel and an osteogenic cell to intrude thereinto. The present invention also provides a biodecomposable/bioabsorbable support for fixing an artificial vertebra, comprising a polylactic acid plate prepared by injection-molding molten polylactic acid and then extrusion-molding the injection-molded polylactic acid in such a manner that it is draw-oriented in a uniaxial direction. The plate has four corner regions each formed with a screw hole for fixing the plate to vertebral bodies.
摘要翻译：公开了一种具有骨髓再生功能的人造椎骨，其包含羟磷灰石（HAp）/胶原（Col）复合体，其通过将羟基磷灰石和胶原的共沉淀物进行压力脱水而形成，以具有纳米复合结构，其中HAp颗粒沿着 Col纤维同时沿着Col纤维排列HAp颗粒的每个c轴。 HAp / Col复合体形成有穿孔，用于允许血管和成骨细胞侵入其中。本发明还提供了一种用于固定人造椎骨的生物可组合/生物吸收性支撑体，其包括通过注射熔融聚乳酸制备的聚乳酸板，然后以注射成型聚乳酸的方式使其成为拉伸取向在单轴方向。该板具有四个拐角区域，每个角部区域形成有用于将板固定到椎体的螺钉孔。

3. 发明申请

US20050004242A1 Method for preparing porous composite material 有权
标题翻译：多孔复合材料的制备方法
公开(公告)号：US20050004242A1
公开(公告)日：2005-01-06
申请号：US10492300
申请日：2002-05-01
申请人： Shinichi Sotome , Toshimasa Uemura , Junzo Tanaka , Masanori Kikuchi , Kenichi Shinomiya , Soichiro Itoh , Tetsuya Tateishi
发明人： Shinichi Sotome , Toshimasa Uemura , Junzo Tanaka , Masanori Kikuchi , Kenichi Shinomiya , Soichiro Itoh , Tetsuya Tateishi
IPC分类号： A61L27/46 , A61L27/56 , C08J9/26
CPC分类号： A61L27/56 , A61L27/46 , C08L89/06
摘要： This invention relates to a process for producing porous and composite materials comprising steps of: freezing a complex containing at least one calcium salt selected from calcium carbonate, calcium phosphate, and hydroxyapatite and collagen, at least a part of which is gelatinized; and then lyophilizing the resultant. The porous and composite materials obtained by the method of the present invention have large pore diameters, high porosities, and adequate mechanical strengths and biodegradability. Thus, they are suitable for implants such as bone fillers, drug carriers for sustained-release, and the like.
摘要翻译：本发明涉及一种生产多孔和复合材料的方法，包括以下步骤：冷冻含有至少一种选自碳酸钙，磷酸钙和羟基磷灰石的钙盐的复合物和至少部分胶凝的胶原蛋白; 然后将所得物冷冻干燥。通过本发明的方法获得的多孔和复合材料具有大的孔径，高孔隙率和足够的机械强度和生物降解性。因此，它们适用于诸如骨填料，持续释放的药物载体等植入物。

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