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1. 发明授权

US5834512A Prevention and improvement of allergy caused by leucotriene B 4 失效
标题翻译：预防和改善由白三烯B引起的过敏
公开(公告)号：US5834512A
公开(公告)日：1998-11-10
申请号：US688017
申请日：1996-07-29
申请人： Kengo Akimoto , Hiroshi Kawashima , Satomichi Yoshimura , Masashi Matsui , Tomohito Hamazaki , Shigeki Sawazaki , Norio Nakamura
发明人： Kengo Akimoto , Hiroshi Kawashima , Satomichi Yoshimura , Masashi Matsui , Tomohito Hamazaki , Shigeki Sawazaki , Norio Nakamura
IPC分类号： A23L1/30 , A61K31/20 , A61K31/201 , A61K31/202 , A61K31/23 , A61K31/231 , A61K31/232 , A61P29/00 , A61P37/08 , C07C57/03 , C07C57/12 , C07C69/587
CPC分类号： A61K31/20 , A23L33/12 , A61K31/201 , A61K31/202 , A61K31/231 , A61K31/232
摘要： A composition such as foods, drinks, pharmaceutical composition, for prevention or improvement of allergy, comprising an omega 9 series unsaturated fatty acid such as 6,9-octadecadienoic acid, 8,11-eicosadienoic acid, 5,8,11-eicosatrienoic acid etc.
摘要翻译：包含ω9系列不饱和脂肪酸如6,9-十八碳二烯酸，8,11-二十碳烯酸，5,8,11-二十碳三烯酸的组合物，例如用于预防或改善过敏的食品，饮料，药物组合物等等

2. 发明授权

US5861433A Prevention and improvement of inflammation caused by leucotriene B4 失效
标题翻译：预防和改善由白三烯B4引起的炎症
公开(公告)号：US5861433A
公开(公告)日：1999-01-19
申请号：US568287
申请日：1995-12-06
申请人： Kengo Akimoto , Hiroshi Kawashima , Satomichi Yoshimura , Masashi Matsui , Tomohito Hamazaki , Shigeki Sawazaki , Norio Nakamura
发明人： Kengo Akimoto , Hiroshi Kawashima , Satomichi Yoshimura , Masashi Matsui , Tomohito Hamazaki , Shigeki Sawazaki , Norio Nakamura
IPC分类号： A23L1/30 , A61K31/20 , A61K31/201 , A61K31/202 , A61K31/23 , A61K31/231 , A61K31/232 , A61P29/00 , A61P37/08 , C07C57/03 , C07C57/12 , C07C69/587
CPC分类号： A61K31/20 , A23L33/12 , A61K31/201 , A61K31/202 , A61K31/231 , A61K31/232
摘要： A composition such as foods, drinks, pharmaceutical composition, for prevention or improvement of inflammation such as chronic inflammation, comprising an omega 9 series unsaturated fatty acid such as 6,9-octadecadienoic acid, 8,11-eicosadienoic acid, 5,8,11-eicosatrienoic acid etc.
摘要翻译：包含ω9系列不饱和脂肪酸如6,9-十八碳二烯酸，8,11-二十碳二烯酸，5,8， 11-二十碳三烯酸等

3. 发明授权

US06765020B2 Drugs for prevention and treatment of diseases caused by abnormalities in cartilage tissues 失效
标题翻译：用于预防和治疗由软骨组织异常引起的疾病的药物
公开(公告)号：US06765020B2
公开(公告)日：2004-07-20
申请号：US08817176
申请日：1997-04-07
申请人： Satomichi Yoshimura , Kengo Akimoto , Masashi Matsui
发明人： Satomichi Yoshimura , Kengo Akimoto , Masashi Matsui
IPC分类号： A61K3120
CPC分类号： A61K31/201 , A23L33/12 , A61K31/20 , A61K31/202 , A61K31/231
摘要： Drug or foods and drink for prevention or treatment of diseases caused by abnormalities in cartilage tissues in which said drugs or foods and drinks have omega-9 unsaturated fatty acid as an active ingredient.
摘要翻译：用于预防或治疗由软骨组织异常引起的疾病的药物或食物和饮料，其中所述药物或食品和饮料具有ω-9不饱和脂肪酸作为活性成分。

4. 发明授权

US4826818A Proteinaceous emulsifier, process for preparing same and emulsion type cosmetic compositions containing same 失效
标题翻译：蛋白质乳化剂，其制备方法和含有其的乳液型化妆品组合物
公开(公告)号：US4826818A
公开(公告)日：1989-05-02
申请号：US153561
申请日：1988-02-02
申请人： Kenji Mori , Kazuyoshi Morita , Shizume Takemoto , Hisanao Nagasawa , Yasuhisa Ohtani , Masashi Matsui , Sohichi Arai
发明人： Kenji Mori , Kazuyoshi Morita , Shizume Takemoto , Hisanao Nagasawa , Yasuhisa Ohtani , Masashi Matsui , Sohichi Arai
IPC分类号： A61K8/06 , A61K8/44 , A61K8/64 , A61K8/65 , A61Q1/02 , A61Q19/00 , A61Q19/10 , B01F17/00 , B01F17/28 , B01F17/30 , A01N61/02
CPC分类号： B01F17/005 , A61K8/06 , A61K8/44 , A61K8/64 , A61K8/645 , A61K8/65 , A61Q19/00 , A61Q1/02 , A61Q19/10 , Y10S514/801 , Y10S514/938 , Y10S516/06
摘要： A proteinaceous emulsifier can be obtained by reacting an amino acid ester with a hydrophilic protein in the presence of an endopeptidase to form decomposition products of the hydrophilic protein having a carboxyl end group joined to the amino group of the amino acid ester by amide linkage.This proteinaceous emulsifier has a typical surfactant structure in which a hydrophobic portion consisting of the amino acid ester is attached to the rear end of a hydrophilic portion consisting of the protein, and is characterized by causing little irritation to the skin, exhibiting strong emulsifying power and possessing moisture retention properties. Thus, it is very suitable for use as an emulsifier in various cosmetics such as creams, milky lotions and the like.
摘要翻译： PCT No.PCT / JP84 / 00512 Sec。 371日期1985年6月25日第 102（e）日期1985年6月25日PCT提交1984年10月26日PCT公布。出版物WO85 / 01890 日期：1985年5月9日。蛋白质乳化剂可以通过在内肽酶存在下使氨基酸酯与亲水性蛋白质反应形成具有与氨基酸的氨基连接的羧基端基的亲水性蛋白质的分解产物酯通过酰胺键。这种蛋白质乳化剂具有典型的表面活性剂结构，其中由氨基酸酯组成的疏水部分连接到由蛋白质组成的亲水部分的后端，其特征在于对皮肤几乎没有刺激性，具有很强的乳化力，具有保湿性。因此，它非常适合用作各种化妆品中的乳化剂，例如乳膏，乳白色乳液等。

5. 发明授权

US4369010A Reinforced vehicle frame and tie down eye structure 失效
标题翻译：加强车架和绑扎眼镜结构
公开(公告)号：US4369010A
公开(公告)日：1983-01-18
申请号：US161480
申请日：1980-06-20
申请人： Hisao Ichinose , Shinji Katou , Masashi Matsui , Kouji Hori
发明人： Hisao Ichinose , Shinji Katou , Masashi Matsui , Kouji Hori
IPC分类号： B60D1/14 , B60P3/073 , B62D25/20 , A44B13/00 , B60P7/06 , B61D45/00
CPC分类号： B60D1/488 , B60D1/565 , B60P3/073 , B62D25/209
摘要： A vehicle body structure at mounting portions of tractive or fastening hooks of an automobile comprises U-shaped members welded to vehicle body members whose joint flanges surrounded by the U-shaped members are formed with apertures to reinforce the joint flange by bolts passing through the apertures, thereby preventing separations and cracks in the joint flanges during a transport for a long distance.
摘要翻译：在汽车的牵引或紧固钩的安装部分处的车体结构包括焊接到车体构件的U形构件，其U形构件围绕的接合凸缘形成有孔，以通过穿过孔的螺栓来加强接头凸缘从而防止长距离输送中的接合凸缘中的分离和裂纹。

6. 发明授权

US5126262A Monoclonal antibody 失效
标题翻译：单克隆抗体
公开(公告)号：US5126262A
公开(公告)日：1992-06-30
申请号：US657253
申请日：1991-02-15
申请人： Masashi Matsui , Soldano Ferrone
发明人： Masashi Matsui , Soldano Ferrone
IPC分类号： C07K16/30 , C12N5/20
CPC分类号： C07K16/30 , C07K16/3053
摘要： Specific antibody of the invention is capable of differentiating between malignant and benign tumors, and is obtained by culturing hybridoma cells prepared from tumor cells treated with a certain anti-tumor substance.
摘要翻译：本发明的特异性抗体能够区分恶性和良性肿瘤，并且通过培养由用某种抗肿瘤物质处理的肿瘤细胞制备的杂交瘤细胞获得。

7. 发明授权

US06197811B1 Cytokine production inhibitors 失效
标题翻译：细胞因子生成抑制剂
公开(公告)号：US06197811B1
公开(公告)日：2001-03-06
申请号：US09292961
申请日：1999-04-16
申请人： Martin A. Hayes , David J. Hardick , Jenny S. Tang , Hamish Ryder , Adrian J. Folkes , Toshio Tatsuoka , Masashi Matsui
发明人： Martin A. Hayes , David J. Hardick , Jenny S. Tang , Hamish Ryder , Adrian J. Folkes , Toshio Tatsuoka , Masashi Matsui
IPC分类号： A61K3135
CPC分类号： C07D309/32
摘要： A compound selected from the group consisting of a 5,6-dihydro-&agr;-pyrone of formula (I): wherein bond a is oriented either or ; X is O or NH; R1 is selected from the group consisting of: a group R3(O)C— wherein R3 is selected from the group consisting of: (i) a group of formula R4—CH═CH— wherein R4 is C1-C20 alkyl, C2-C20 alkenyl, an aryl group, or a 5- or 6-membered unsaturated heterocyclic ring containing one or two O, N or S atoms, (ii) C2-C20 alkyl; and (iii) an aryl group or a substituent which is a fused ring system of formula (1) or (2): wherein each of R′ and R″, which are the same or different and may occupy any position on ring a or ring b of said fused ring system, is H or C1-C6 alkyl; a group ArCH2— wherein Ar is an aryl group; and a group R5O—CH2— wherein R5 is C1-C6 alkyl optionally interrupted by one or two O atoms; and R2 is CH3 or, when R1 is a group of formula (A) as defined below, R2 is R6OOC— or R6NOC— wherein R6 is C1-C6 alkyl; and the pharmaceutically and veterinarily acceptable salts and esters thereof; with the exception of compounds wherein bond a is oriented , X is O and R1 is a group of formula (A): wherein R11 and R21 are H when R2 in formula (I) is CO2H or CH3, or one of R11 and R21 is H and the other is OH when R2 in formula (I) is CO2H.
摘要翻译：选自式（I）的5,6-二氢-α-吡喃酮的化合物：其中键合a定向为或; X是O或NH; R1选自：组R3 （O）C-，其中R 3选自：（i）式R 4 -CH = CH-的基团，其中R 4是C 1 -C 20烷基，C 2 -C 20烯基，芳基或5-或含有一个或两个O，N或S原子的6元不饱和杂环，（ii）C 2 -C 20烷基;和（iii）作为式（1）或（2）的稠环体系的芳基或取代基，：其中R'和R“各自相同或不同并且可以占据所述稠环系统的环a或环b上的任何位置是H或C 1 -C 6烷基;基团ArCH 2 - 其中Ar是芳基; 和R5O-CH2-基团，其中R5是任选被一个或两个O原子中断的C 1 -C 6烷基; 并且R 2是CH 3，或者当R 1是如下定义的式（A）的基团时，R 2是R 60 OC-或R 6 NOC - ，其中R 6是C 1 -C 6烷基;和其药学和兽医学上可接受的盐和酯; 除了其中键a取向的化合物的化合物除外，X是O，R1是式（A）的基团：当式（I）中的R 2为CO 2 H或CH 3时，R 11和R 21为H，或者R 11和R 21中的一个为H，另一个为OH，式（I）中的R 2为CO 2 H.

8. 发明授权

US5126253A Cell lines for use in the preparation of hybridoma cells 失效
标题翻译：用于制备杂交瘤细胞的细胞系
公开(公告)号：US5126253A
公开(公告)日：1992-06-30
申请号：US912678
申请日：1986-09-25
申请人： Toshihiro Nakanishi , Masashi Matsui , Kenju Miura , Yoshiaki Fukuda , Teruhisa Noguchi
发明人： Toshihiro Nakanishi , Masashi Matsui , Kenju Miura , Yoshiaki Fukuda , Teruhisa Noguchi
IPC分类号： C07K14/52 , C07K14/57 , C12N5/02 , C12N5/16 , C12P21/08
CPC分类号： C12N5/163 , C07K14/52 , C07K14/57 , Y10S435/948
摘要： A novel cell line for use as a parent for hybridoma preparation is provided. This cell line is derived from tumor cells, in particular human tumor cells, other than those originating from bone marrow cells. A method for establishing this cell line is also provided. By fusing this cell line with cells producing useful physiologically active substances, such as B cells immunized with an antigen, a hybridoma capable of active growth can be prepared. This hybridoma can be cultivated for the production of useful physiologically active substances.
摘要翻译：提供了用作杂交瘤制备的亲本的新型细胞系。该细胞系来自肿瘤细胞，特别是源于骨髓细胞的肿瘤细胞。还提供了建立该细胞系的方法。通过将该细胞系与产生有用的生理活性物质的细胞（例如用抗原免疫的B细胞）融合，可以制备能够活跃生长的杂交瘤。该杂交瘤可用于生产有用的生理活性物质。

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