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1. 发明授权

US5791345A Non-invasive blood analyzer 失效
标题翻译：非侵入性血液分析仪
公开(公告)号：US5791345A
公开(公告)日：1998-08-11
申请号：US565046
申请日：1995-11-30
申请人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa , Yasuhiro Kouchi
发明人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa , Yasuhiro Kouchi
IPC分类号： A61B5/00 , A61B5/026 , G01N15/00 , G01N15/02 , G01N21/53 , A61B1/04
CPC分类号： A61B5/1455 , A61B5/0261 , A61B5/14535 , G01N21/53 , A61B5/14532 , A61B5/14546 , G01N15/0227 , G01N2015/0065 , G01N2021/1791
摘要： A non-invasive blood analyzer is intended to capture images of a prescribed volume of blood in a blood vessel in a non-invasive manner and with a good contrast without collecting blood from a living body. The non-invasive blood analyzer includes a light application device for illuminating a detection region of vessels contained in a part of a living body, an image capturing device for capturing images of the detection region illuminated by the light application device, and an analyzer for analyzing blood components contained in the detection region by processing the images captured by the image capturing device. The image capturing device includes an object lens for converging the reflected light from the detection region. The light application device illuminates the detection region at an incident angle larger than an aperture angle of the object lens with respect to the detection region to provide dark-field illumination.
摘要翻译：非侵入性血液分析仪旨在以非侵入性的方式在血管中捕获规定体积的血液的图像，并且具有良好的对比度而不从活体收集血液。非侵入性血液分析装置包括：照射生物体的一部分容纳的血管的检测区域的照明装置，摄像装置，用于拍摄由光照射装置照射的检测区域的图像;以及分析装置，通过处理由图像捕获装置拍摄的图像，包含在检测区域中的血液成分。图像捕获装置包括用于会聚来自检测区域的反射光的物镜。光应用装置以相对于检测区域大于物镜的孔径角的入射角照射检测区域，以提供暗场照明。

2. 发明授权

US5741213A Apparatus for analyzing blood 失效
标题翻译：用于分析血液的装置
公开(公告)号：US5741213A
公开(公告)日：1998-04-21
申请号：US736822
申请日：1996-10-25
申请人： Yasuhiro Kouchi , Kaoru Asano , Ken Ishihara
发明人： Yasuhiro Kouchi , Kaoru Asano , Ken Ishihara
IPC分类号： A61B5/00 , G06K9/00
CPC分类号： G06K9/00127 , A61B5/0059
摘要： An apparatus for analyzing blood includes an image capturing device for capturing an image including at least one object blood cell and an analyzer for analyzing the captured image as an image F(x, y) in an x-y coordinate system. The analyzer includes an edge calculator for calculating an edge intensity distribution E(x, y) representing an outline of the image F(x, y); a weight memory for storing in advance a weight distribution W(i, j) corresponding to an average outline of the object cell; an assessment value calculator for obtaining an assessment value C (x, y) at each point (x, y) by calculating a degree of correspondence between the edge intensity distribution E (x, y) and the weight distribution W(i, j) for each point (x, y); and an extractor for extracting a point (x, y) at which the assessment value C(x, y) is larger than a predetermined value, thereby determining that the object blood cell is present at the point (x, y). The apparatus is useful as a device for identifying the object blood cell.
摘要翻译：用于分析血液的装置包括用于捕获包括至少一个对象血细胞的图像的图像捕获装置和用于在x-y坐标系统中分析捕获图像作为图像F（x，y）的分析器。分析器包括用于计算表示图像F（x，y）的轮廓的边缘强度分布E（x，y）的边缘计算器。权重存储器，用于预先存储与所述对象单元的平均轮廓对应的权重分布W（i，j）; 评估值计算器，用于通过计算边缘强度分布E（x，y）和权重分布W（i，j）之间的对应度来获得每个点（x，y）处的评估值C（x，y）对于每个点（x，y）; 以及提取器，用于提取评估值C（x，y）大于预定值的点（x，y），从而确定所述对象血细胞存在于所述点（x，y）处。该装置可用作识别对象血细胞的装置。

3. 发明授权

US6061583A Noninvasive blood analyzer 失效
标题翻译：无创血液分析仪
公开(公告)号：US6061583A
公开(公告)日：2000-05-09
申请号：US77743
申请日：1998-06-11
申请人： Ken Ishihara , Kaoru Asano , Yasuhiro Kouchi , Hideo Kusuzawa
发明人： Ken Ishihara , Kaoru Asano , Yasuhiro Kouchi , Hideo Kusuzawa
IPC分类号： A61B5/145 , A61B5/00 , G01N21/47
CPC分类号： A61B5/14535 , A61B5/1455 , A61B5/14552 , A61B5/6826 , A61B5/6838 , G01N21/4795
摘要： A noninvasive blood analyzer is provided which comprises: a light source for illuminating a part of tissues of a living body including a blood vessel; an image pickup section for picking up an image of the illuminated blood vessel and tissues; and an analyzing section for analyzing the picked image; the analyzing section including an extracting section for extracting image density distribution across the blood vessel in the image as an image density profile, a quantifying section for quantifying configurational characteristics of the image density profile, a computing section for computing the concentration of a blood constituent on the basis of the quantified characteristics, and an outputting section for outputting a computation result. The blood analyzer can measure the concentration of blood hemoglobin and the hematocrit in real time with an improved repeatability without blood sampling.
摘要翻译： PCT No.PCT / JP96 / 03894 Sec。 371日期：1998年6月11日 102（e）1998年6月11日PCT PCT 1996年12月27日PCT公布。出版物WO97 / 24066 日期1997年7月10日提供了一种无创血液分析仪，其包括：用于照射包括血管的生物体的一部分组织的光源; 用于拾取照明的血管和组织的图像的图像拾取部分; 以及分析部分，用于分析所拾取的图像; 所述分析部分包括提取部分，用于提取图像中的血管中的图像浓度分布作为图像浓度分布;量化部分，用于量化图像浓度分布的结构特征;计算部分，用于计算血液成分的浓度量化特性的基础，以及用于输出计算结果的输出部分。血液分析仪可以实时测量血红蛋白浓度和血细胞比容，改善重复性，无需采血。

4. 发明授权

US5974338A Non-invasive blood analyzer 失效
标题翻译：非侵入性血液分析仪
公开(公告)号：US5974338A
公开(公告)日：1999-10-26
申请号：US60080
申请日：1998-04-15
申请人： Kaoru Asano , Yasuhiro Kouchi
发明人： Kaoru Asano , Yasuhiro Kouchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14535 , A61B5/1455 , A61B5/14551
摘要： A non-invasive blood analyzer includes a light source unit for irradiating a portion of a living body, the portion including a blood vessel, and includes an image capturing unit for capturing an image of the irradiated portion. An analyzing unit is included for setting an analysis region in the captured image and analyzing a blood vessel portion in the set analysis region. The image capturing unit captures images of the irradiated portion of the living body a plurality of times and the analyzing unit specifies analysis regions including the same blood vessel portions with respect to the captured images. The analyzing unit determines these regions based upon a position of a feature in sequential images and calculates at least one of blood vessel width, blood component concentration and blood component concentration ratio with respect to the blood vessel portion in each specified analysis region.
摘要翻译：非侵入性血液分析仪包括用于照射生物体的一部分的光源单元，该部分包括血管，并且包括用于捕获照射部分的图像的图像捕获单元。包括分析单元，用于设置拍摄图像中的分析区域并分析设定分析区域中的血管部分。图像拍摄单元多次拍摄生物体的照射部分的图像，并且分析单元针对捕获的图像指定包括相同血管部分的分析区域。分析单元基于连续图像中的特征的位置来确定这些区域，并且计算每个指定分析区域中的血管部分的血管宽度，血液成分浓度和血液成分浓度比中的至少一个。

5. 发明申请

US20050170353A1 Gene examination method for judging the onset risk of glaucoma 审中-公开
标题翻译：用于判断青光眼发病风险的基因检查方法
公开(公告)号：US20050170353A1
公开(公告)日：2005-08-04
申请号：US10509595
申请日：2003-03-19
申请人： Kaoru Asano , Takayuki Takahata , Shigehiro Numada , Akinori Masago , Yasuhiro Kouchi
发明人： Kaoru Asano , Takayuki Takahata , Shigehiro Numada , Akinori Masago , Yasuhiro Kouchi
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/156 , G01N33/6887 , G01N2800/168
摘要： To provide a gene examination method for predicting the onset risk of glaucoma based on the relation between a glaucoma-associated gene and the onset of glaucoma, the onset of glaucoma in future is predicted by using as an indication mutations in the gene region involving the code region and/or the upstream region of a glaucoma-associated gene. In the base sequence represented by SEQ ID NO:1, mutation(s) in at least one of the following positions are detected, i.e., the 194-, 199-, 324-, 1051-, 1084-, 1627-, 1685-, 1756-, 1853-, 2830-, 3371-, 4037- and 4364-positions.
摘要翻译：为了提供基于青光眼相关基因与青光眼发生之间的关系来预测青光眼的发病风险的基因检查方法，通过使用涉及代码的基因区域中的指示突变来预测未来的青光眼发作区域和/或青光眼相关基因的上游区域。在由SEQ ID NO：1表示的碱基序列中，检测至少一个以下位置的突变，即194-，199-，324-，1051-，1084-，1627-，1685- ，1756-，1853-，2830-，3371-4037-和4364-位。

6. 发明授权

US06353750B1 Living body inspecting apparatus and noninvasive blood analyzer using the same 有权
标题翻译：生物体检查装置及无创血液分析仪
公开(公告)号：US06353750B1
公开(公告)日：2002-03-05
申请号：US09403551
申请日：1999-10-25
申请人： Rokusaburo Kimura , Kaoru Asano , Hideo Kusuzawa , Yasuhiro Kouchi , Toshiyuki Ozawa
发明人： Rokusaburo Kimura , Kaoru Asano , Hideo Kusuzawa , Yasuhiro Kouchi , Toshiyuki Ozawa
IPC分类号： A61B500
CPC分类号： A61B5/0031 , A61B5/0261 , G06F19/00 , H04B10/532
摘要： The purpose is to fix a portion of a living body, which is an object of measurement, stably without strain and to acquire accurate inspection results with good reproducibility. An apparatus for capturing an image of a living body includes: a base for mounting a portion of a living body to be inspected; two sidewall members capable of holding the mounted portion of the living body therebetween from both sides; a light source section for supplying a light to the portion of the living body held on the base and between the sidewall members; and a light receiving section for detecting optical information from the portion of the living body supplied with the light, and a non-invasive apparatus for living body inspection including the above apparatus for capturing an image of a living body in which the light receiving section includes an image capturing element, and an analyzing section for calculating information on blood flowing through a blood vessel by analyzing an image of a tissue including the blood vessel obtained by the image capturing element.
摘要翻译：目的是将作为测量对象的生物体的一部分稳定地固定而不变形，并以良好的再现性获得精确的检查结果。一种用于捕获生物体图像的装置，包括：用于安装待检查的生物体的一部分的基座; 两侧壁构件能够从两侧保持活体的安装部分; 光源部，用于向保持在基部上的活体和侧壁部件之间的部分供给光; 以及用于从提供有光的生物体的部分检测光学信息的光接收部分，以及用于生物体检查的非侵入性装置，包括用于捕获其中光接收部分包括的生物体的图像的上述装置图像捕获元件和分析部分，用于通过分析包括由图像捕获元件获得的血管的组织的图像来计算关于血管流动的血液的信息。

7. 发明申请

US20060265136A1 Treatment effect prediction system, a treatment effect prediction method, and a computer program product thereof 有权
标题翻译：治疗效果预测系统，治疗效果预测方法及其计算机程序产品
公开(公告)号：US20060265136A1
公开(公告)日：2006-11-23
申请号：US11431594
申请日：2006-05-11
申请人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
发明人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
IPC分类号： G06F19/00 , G06Q50/00
CPC分类号： G06F19/20 , G06F19/00 , G06F19/34 , G06F19/3481 , G06Q50/24 , G16H50/50 , G16H50/70
摘要： A treatment effect prediction system, comprising: a processor; and a memory, under control of the processor, including instructions enabling the processor to carry out operations comprising: determining a patient pathological condition information, which represents a feature of pathological condition of a patient, based on diagnostic data of the patient; accessing a database of stored pathological condition information and corresponding treatment effects occurring when predetermined treatment is provided; and retrieving, from the database, a specific treatment effect corresponding to the one of the stored pathological condition information that is similar to the patient pathological condition information, is disclosed. A treatment effect prediction method and a computer program product thereof are also disclosed.
摘要翻译：一种治疗效果预测系统，包括：处理器; 以及在所述处理器的控制下的存储器，包括使得所述处理器能够执行操作的指令，所述指令基于所述患者的诊断数据来确定患者病理状况信息，其表示患者病理状态的特征; 访问存储的病理状况信息的数据库和提供预定治疗时发生的相应治疗效果; 并且从数据库中检索与存储的病理状况信息相对应的与患者病理状况信息相似的特定治疗效果。还公开了一种治疗效果预测方法及其计算机程序产品。

8. 发明授权

US08065900B2 Method of manufacturing plug used to pierce and roll metal material, method of manufacturing metal pipe and plug used to pierce and roll metal material 有权
标题翻译：制造用于刺穿和轧制金属材料的插头的方法，用于刺穿和轧制金属材料的金属管和塞子的制造方法
公开(公告)号：US08065900B2
公开(公告)日：2011-11-29
申请号：US12533390
申请日：2009-07-31
申请人： Yasuyoshi Hidaka , Naoya Hirase , Yasuhiro Kouchi
发明人： Yasuyoshi Hidaka , Naoya Hirase , Yasuhiro Kouchi
IPC分类号： B21B19/04
CPC分类号： B21B25/00 , B21B19/04 , C23C8/14
摘要： A plug material having a prescribed shape is prepared, the prepared plug material is thermally treated in a heat treatment atmosphere that contains at least 1.0 vol. % oxygen at a heat treatment temperature of at least 950° C. and less than 1050° C. and thus a plug having an oxide scale layer 30 on the surface is manufactured. According to the manufacturing method, pores PO that extend along the surface SF of the plug material are formed under outer scale layer 20 in the oxide scale layer 30, which allows cracks to be more easily propagated in the outer scale layer 20. Therefore, the outer scale layer 20 is more easily peeled off than the conventional one.
摘要翻译：制备具有规定形状的塞子材料，将所制备的塞子材料在包含至少1.0体积％的热处理气氛中进行热处理。在氧化处理温度为至少950℃且低于1050℃的氧气中制造氧，因此制造了表面上具有氧化皮层30的塞子。根据制造方法，在氧化皮层30中的外标尺层20上形成有沿插塞材料的表面SF延伸的孔PO，这允许裂纹在外标尺层20中更容易传播。因此，外标层20比常规剥离更容易。

9. 发明申请

US20110041661A1 Rotary Cutting Tool, Method of Cutting Billet for Manufacturing Seamless Pipe or Tube, and Method of Manufacturing Seamless Pipe or Tube 审中-公开
标题翻译：旋切刀具，切割生产无缝管或管的坯料的方法，以及制造无缝管或管的方法
公开(公告)号：US20110041661A1
公开(公告)日：2011-02-24
申请号：US12934404
申请日：2008-12-15
申请人： Yasuhiro Kouchi , Osamu Kanda
发明人： Yasuhiro Kouchi , Osamu Kanda
IPC分类号： B23D61/02 , B26D3/16 , B21B19/04
CPC分类号： B23D61/02 , B23D45/12 , B23D45/18 , B23D47/02 , Y10T83/04 , Y10T83/9319
摘要： An object of the present invention is to provide a rotary cutting tool, a method of cutting a billet for manufacturing a seamless pipe, and a method of manufacturing the seamless pipe, which are capable of restraining the occurrence of an outer surface flaw on the seamless pipe.A rotary cutting tool 100 in accordance with the present invention has substantially circular shape and is provided with a plurality of blade parts 1 along the outer peripheral portion thereof. The end face 11 on the downstream side in the direction of rotation of the blade part 1 tilts at an angle θ not smaller than 1 degree and not larger than 10 degrees with respect to the thickness direction Y intersecting at right angles to the direction of rotation X.
摘要翻译：本发明的目的是提供一种旋转切削工具，切割用于制造无缝管的坯料的方法以及能够抑制无缝管的外表面缺陷的发生的无缝管的制造方法。管。根据本发明的旋转切削工具100具有大致圆形形状，并且沿其外周部分设置有多个叶片部分1。叶片部1的旋转方向的下游侧的端面11以角度倾斜; 相对于与旋转方向X成直角相交的厚度方向Y不小于1度且不大于10度。

10. 发明申请

US20090177453A1 Medical diagnosis support computer system, computer program, and server computer 审中-公开
标题翻译：医疗诊断支持计算机系统，计算机程序和服务器计算机
公开(公告)号：US20090177453A1
公开(公告)日：2009-07-09
申请号：US12152593
申请日：2008-05-15
申请人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
发明人： Yasuhiro Kouchi , Takeo Saitou , Masayoshi Seike
IPC分类号： G06G7/48 , G06F3/048
CPC分类号： G16H50/50
摘要： A medical diagnosis support computer system for supporting diagnosis of a patient by a doctor, the system comprising: a display device; and a controller in communication with the display device, the controller comprising a processor configured to build a biological model representing biological functions of the patient on a computer, generate pathological condition information of the patient based on the biological model, display a doctor screen and a patient screen in a switchable manner on the display device; wherein the doctor screen is configured to simultaneously display a screen region for displaying the pathological condition information of the patient and a screen region for displaying one or more related information related to the patient; and the patient screen is configured to selectively display a display content between the pathological condition information of the patient and one or more related information related to the patient is disclosed.
摘要翻译：一种用于支持医生对患者的诊断的医疗诊断支持计算机系统，所述系统包括：显示装置; 以及与所述显示装置通信的控制器，所述控制器包括处理器，所述处理器被配置为在计算机上构建表示所述患者的生物功能的生物学模型，基于所述生物模型生成患者的病理状况信息，显示医生屏幕和患者屏幕以可切换的方式在显示装置上; 其中所述医生画面被配置为同时显示用于显示患者的病理状况信息的屏幕区域和用于显示与患者相关的一个或多个相关信息的屏幕区域; 并且患者屏幕被配置为选择性地显示患者的病理状况信息和与患者相关的一个或多个相关信息之间的显示内容。

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