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1. 发明申请

US20090048571A1 Durable Hydrophilic Coating Compositions 有权
标题翻译：耐久亲水性涂料组合物
公开(公告)号：US20090048571A1
公开(公告)日：2009-02-19
申请号：US12191339
申请日：2008-08-14
申请人： Kemal Vatansever Catalan , Carolyn Ann Spitzmueller , Vladimir Gartstein , Matthew Scott Wagner , Dennis Ray Bacon , David S. Salloum , Faiz Feisal Sherman
发明人： Kemal Vatansever Catalan , Carolyn Ann Spitzmueller , Vladimir Gartstein , Matthew Scott Wagner , Dennis Ray Bacon , David S. Salloum , Faiz Feisal Sherman
IPC分类号： A61F13/53 , A01K29/00 , C09D5/00 , C09D129/04 , C09D133/02 , C09D133/08 , C09D175/04 , C09D109/06
CPC分类号： A61L15/42 , A61L15/22 , A61L2400/12
摘要： A durable hydrophilic coating composition is provided comprising a film forming polymer, a wetting agent and from about 0.001% to about 40%, by weight of the composition, of nanoparticles. The nanoparticles are selected from the group consisting of alumina, silica and combinations thereof and have a particle size of from about 1 to about 750 nanometers. The weight ratio of the film forming polymer to the nanoparticles is from about 1:1 to about 1:30. A disposable absorbent article is also disclosed.
摘要翻译：提供了一种持久的亲水涂料组合物，其包含成膜聚合物，润湿剂和按组合物重量计约0.001％至约40％的纳米颗粒。纳米颗粒选自氧化铝，二氧化硅及其组合，其粒度为约1至约750纳米。成膜聚合物与纳米颗粒的重量比为约1:1至约1:30。还公开了一次性吸收制品。

2. 发明授权

US09314544B2 Durable hydrophilic coating compositions 有权
标题翻译：耐久亲水涂料组合物
公开(公告)号：US09314544B2
公开(公告)日：2016-04-19
申请号：US12191339
申请日：2008-08-14
申请人： Kemal Vatansever Catalan , Carolyn Ann Spitzmueller , Vladimir Gartstein , Matthew Scott Wagner , Dennis Ray Bacon , David S. Salloum , Faiz Feisal Sherman
发明人： Kemal Vatansever Catalan , Carolyn Ann Spitzmueller , Vladimir Gartstein , Matthew Scott Wagner , Dennis Ray Bacon , David S. Salloum , Faiz Feisal Sherman
IPC分类号： A61F13/15 , A61F13/20 , A61L15/42 , A61L15/22
CPC分类号： A61L15/42 , A61L15/22 , A61L2400/12
摘要： A durable hydrophilic coating composition is provided comprising a film forming polymer, a wetting agent and from about 0.001% to about 40%, by weight of the composition, of nanoparticles. The nanoparticles are selected from the group consisting of alumina, silica and combinations thereof and have a particle size of from about 1 to about 750 nanometers. The weight ratio of the film forming polymer to the nanoparticles is from about 1:1 to about 1:30. A disposable absorbent article is also disclosed.
摘要翻译：提供了一种持久的亲水涂料组合物，其包含成膜聚合物，润湿剂和按组合物重量计约0.001％至约40％的纳米颗粒。纳米颗粒选自氧化铝，二氧化硅及其组合，其粒度为约1至约750纳米。成膜聚合物与纳米颗粒的重量比为约1:1至约1:30。还公开了一次性吸收制品。

3. 发明授权

US07695814B2 Responsive coated particles comparing hydrophobic and hydrophilic polymers 有权
标题翻译：响应性涂层颗粒包含疏水和亲水聚合物
公开(公告)号：US07695814B2
公开(公告)日：2010-04-13
申请号：US11705836
申请日：2007-02-14
申请人： Vladimir Gartstein , David S. Salloum , Faiz Feisal Sherman , Robert Mikhailovych Lupitskyy , Sergiy Minko , Mikhail Motornov , Roman Bogdanovych Sheparovych
发明人： Vladimir Gartstein , David S. Salloum , Faiz Feisal Sherman , Robert Mikhailovych Lupitskyy , Sergiy Minko , Mikhail Motornov , Roman Bogdanovych Sheparovych
IPC分类号： B32B5/16 , B32B9/04
CPC分类号： C09D183/04 , A61K8/11 , A61K8/25 , A61K8/84 , A61K8/891 , A61K2800/412 , A61K2800/413 , A61K2800/57 , A61Q5/00 , A61Q19/00 , B82Y30/00 , C01P2004/50 , C01P2004/61 , C01P2004/62 , C01P2004/64 , C08K3/36 , C08K9/06 , C09C1/3072 , C09C1/309 , Y10T428/2995 , Y10T428/2998 , Y10T428/31 , Y10T428/31663 , C08L83/04 , C08L2666/20
摘要： A responsive coated particle comprising at least one particle comprising an interfacial surface to which a responsive coating attaches, said responsive coating comprising (a) at least one silicone-based, substantially hydrophobic polymer and (b) at least one substantially hydrophilic polymer wherein said responsive coating particle is in a first state.
摘要翻译：一种响应性涂层颗粒，其包含至少一个包含响应性涂层附着的界面的颗粒，所述响应性涂层包含（a）至少一种基于硅氧烷的基本上疏水的聚合物和（b）至少一种基本上亲水的聚合物，涂层颗粒处于第一状态。

4. 发明授权

US07923106B2 Responsive coated substrates 有权
标题翻译：响应涂层基材
公开(公告)号：US07923106B2
公开(公告)日：2011-04-12
申请号：US11705837
申请日：2007-02-14
申请人： Vladimir Gartstein , David S. Salloum , Faiz Feisal Sherman , Robert Mikhailovych Lupitskyy , Sergiy Minko , Mikhail Motornov , Roman Bogdanovych Sheparovych
发明人： Vladimir Gartstein , David S. Salloum , Faiz Feisal Sherman , Robert Mikhailovych Lupitskyy , Sergiy Minko , Mikhail Motornov , Roman Bogdanovych Sheparovych
IPC分类号： B32B5/16
CPC分类号： C09D183/04 , B05D5/00 , B05D5/04 , B05D5/08 , C08L79/02 , D06M13/332 , D06M15/643 , Y10T428/24942 , Y10T428/254 , Y10T428/2998 , Y10T428/31 , Y10T428/31663 , Y10T428/31721 , C08L2666/20
摘要： A responsive coated substrate, said substrate comprising an interfacial surface to which a responsive coating attaches, said responsive coating comprising (a) at least one silicone-based, substantially hydrophobic polymer and (b) at least one substantially hydrophilic polymer wherein said responsive coating substrate is in a first state; and methods of coating the same.
摘要翻译：响应性涂层基材，所述基材包含响应性涂层附着的界面，所述响应涂层包含（a）至少一种基于硅氧烷的基本疏水的聚合物和（b）至少一种基本上亲水的聚合物，其中所述响应涂层基材处于第一状态; 和涂布方法。

5. 发明授权

US08216190B2 Microstructures for delivering a composition cutaneously to skin 有权
标题翻译：用于将组合物皮肤递送到皮肤的微结构
公开(公告)号：US08216190B2
公开(公告)日：2012-07-10
申请号：US11351818
申请日：2006-02-09
申请人： Vladimir Gartstein , Faiz Feisal Sherman
发明人： Vladimir Gartstein , Faiz Feisal Sherman
IPC分类号： A61M5/00 , A61M31/00 , A61B17/34
CPC分类号： A61M37/0015 , A45D26/0004 , A61B17/205 , A61B17/322 , A61B17/54 , A61B2017/00761 , A61B2017/00765 , A61B2017/320008 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053
摘要： An improved method and apparatus is provided as a system to deliver a composition, preferably a medical or pharmaceutical composition or active, through the stratum corneum of skin, without introducing bleeding or damage to tissue, and absent pain or other trauma. The dimensions and shapes of the microelements are controlled so as to control the penetration depth into the skin. The microelements can be “hollow” such that passageways are created therethrough to allow the composition to flow from a chamber, through the microelements, and into the skin. Alternatively, the microelements can be “solid,” and the composition is applied directly to the skin just before or just after the microelements are applied to the skin surface to create the openings in the stratum corneum.
摘要翻译：提供了一种改进的方法和装置，作为通过皮肤角质层递送组合物，优选医药或药物组合物或活性物质的系统，而不引起对组织的渗血或损伤，以及不存在疼痛或其他创伤。控制微量元素的尺寸和形状以控制进入皮肤的穿透深度。微量元件可以是“中空”的，使得通过其形成以允许组合物从腔室，微量元件流入皮肤。或者，微量元素可以是“固体”，并且组合物在微元件施用于皮肤表面之前或之后直接施用于皮肤以在角质层中产生开口。

6. 发明授权

US07828827B2 Method of exfoliation of skin using closely-packed microstructures 有权
标题翻译：使用紧密堆积的微结构剥离皮肤的方法
公开(公告)号：US07828827B2
公开(公告)日：2010-11-09
申请号：US10155108
申请日：2002-05-24
申请人： Vladimir Gartstein , Faiz Feisal Sherman
发明人： Vladimir Gartstein , Faiz Feisal Sherman
IPC分类号： A61B17/80
CPC分类号： A61M37/0015 , A45D26/0004 , A61B17/205 , A61B17/54 , A61B2017/00761 , A61M2037/003
摘要： An improved method and apparatus is provided as a system to enhance skin appearance and health, in which skin is cleaned (or exfoliated) and conditioned by use of microelements affixed to a base element or hand-held patch. The dimensions of the microelements are controlled so as to remove a certain number of layers of skin cells and to accumulate those skin cells, along with other foreign substances, into areas between the microelements. In addition, a conditioning compound or therapeutic active can be applied to the exfoliated skin to enhance the skin. Moreover, the amount of accumulated skin cells represents a self-limiting maximum quantity that cannot be substantially exceeded regardless of the number of attempts by a user to re-use the microstructure apparatus. Some of the microstructures are designed with very close-packed microelements, which in some cases have flexible substrates.
摘要翻译：提供了一种改进的方法和装置，作为增强皮肤外观和健康的系统，其中皮肤被清洁（或剥离）并通过使用固定在基底元件或手持贴片上的微量元件进行调理。控制微量元素的尺寸以去除一定数量的皮肤细胞层，并将这些皮肤细胞与其它外来物质一起积累在微量元素之间的区域中。此外，调理化合物或治疗活性物质可以施用于剥离的皮肤以增强皮肤。此外，无论使用者重复使用微结构装置的尝试次数多少，累积的皮肤细胞的量代表不能大幅超过的自限制最大量。一些微结构被设计成非常紧密堆积的微量元素，其在一些情况下具有柔性基底。

7. 发明授权

US07261000B2 Methods of assessing characteristics of fibrous substrates and treating fibrous substrates 有权
标题翻译：评估纤维基材特性和处理纤维基材的方法
公开(公告)号：US07261000B2
公开(公告)日：2007-08-28
申请号：US11113468
申请日：2005-04-25
申请人： Faiz Feisal Sherman , Vladimir Gartstein , Helen Rochelle Kemp , Thomas A. Sturgis
发明人： Faiz Feisal Sherman , Vladimir Gartstein , Helen Rochelle Kemp , Thomas A. Sturgis
IPC分类号： G01N3/00
CPC分类号： A61Q5/12 , A61K8/00 , A61Q5/02 , A61Q5/06 , G01N22/04 , G01N33/4833
摘要： A method of assessing damage of a fibrous substrate comprises the steps of: (a) providing said fibrous substrate having a length, a root end, and a tip end; (b) providing a means for assessing substrate moisture content; (c) using said means for assessing substrate moisture content to obtain at least a first measured moisture content value for said fibrous substrate at a first position along the length of said fibrous substrate and a second measured moisture content value for said fibrous substrate at a second position along the length of said fibrous substrate; (d) comparing said measured moisture content values with each other to obtain a measured moisture content differential; and (e) correlating said measured moisture content differential to a substrate damage value for said fibrous substrate. A method of treating a fibrous substrate comprises the steps of: (a) assessing damage of the fibrous substrate according to the method described above to obtain a correlated substrate damage value for the fibrous substrate; (b) using the correlated substrate damage value to select at least one appropriate substrate treatment composition; and (c) applying the appropriate substrate treatment composition to the fibrous substrate.
摘要翻译：评估纤维基质的损伤的方法包括以下步骤：（a）提供具有长度，根端和末端的所述纤维基材; （b）提供评估底物含水量的方法; （c）使用所述用于评估底物含水量的装置，以在沿着所述纤维基材的长度的第一位置处获得至少第一测量的所述纤维基材的水分含量值，并且在第二步中获得用于所述纤维基材的第二测量的水分含量值沿着所述纤维基材的长度的位置; （d）将所测量的水分含量值相互比较以获得测得的含湿量差; 和（e）将所述测得的水分含量差异与所述纤维基质的底物损伤值相关联。处理纤维基材的方法包括以下步骤：（a）根据上述方法评估纤维基材的损伤，以获得纤维基材的相关的基材损伤值; （b）使用相关的底物损伤值来选择至少一种适当的底物处理组合物; 和（c）将合适的底物处理组合物施加到纤维基材上。

8. 发明授权

US06471903B2 Method for manufacturing an intracutaneous microneedle array 有权
标题翻译：用于制造皮内微针阵列的方法
公开(公告)号：US06471903B2
公开(公告)日：2002-10-29
申请号：US09956520
申请日：2001-09-19
申请人： Faiz Feisal Sherman , Vadim Vladimirovich Yuzhakov , Vladimir Gartstein , Grover David Owens
发明人： Faiz Feisal Sherman , Vadim Vladimirovich Yuzhakov , Vladimir Gartstein , Grover David Owens
IPC分类号： B29C3342
CPC分类号： B29C51/082 , A61M37/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B26F1/24 , B29C33/0033 , B29C33/42 , B29C37/0053 , B29C45/2628 , B29C51/00 , B29C2059/023 , B29L2031/7544 , B29L2031/756 , B81B2201/055 , B81C1/00111 , B81C2201/036
摘要： An array of hollow microneedles is constructed of molded plastic, in which a micro-machining technique is used to fabricate the molds used in a plastic microforming process. The molds are detachable and can be re-used. The preferred process for making the plastic arrays of microneedles is a microinjection technique. In the microinjection method, a molten plastic substance is injected between two micro-machined molds that contain microhole and micropillar arrays. Once the desired shape of the microneedle array has been formed, the mold and the plastic material are cooled down. Next, the molds are separated and the plastic microneedle array is detached from the mold structures.
摘要翻译：中空微针阵列由模制塑料构成，其中使用微加工技术来制造在塑料微成形过程中使用的模具。模具是可拆卸的，可以重新使用。用于制造微针的塑料阵列的优选方法是显微注射技术。在显微注射方法中，将熔融塑料物质注入包含微孔和微柱阵列的两个微加工模具之间。一旦已经形成所需的微针阵列形状，就将模具和塑料材料冷却下来。接下来，模具被分离，并且塑料微针阵列与模具结构分离。

9. 发明授权

US06379324B1 Intracutaneous microneedle array apparatus 有权
标题翻译：内皮微针阵列装置
公开(公告)号：US06379324B1
公开(公告)日：2002-04-30
申请号：US09328947
申请日：1999-06-09
申请人： Vladimir Gartstein , Dragan Danilo Nebrigic , Grover David Owens , Faiz Feisal Sherman , Vadim Vladimirovich Yuzhakov
发明人： Vladimir Gartstein , Dragan Danilo Nebrigic , Grover David Owens , Faiz Feisal Sherman , Vadim Vladimirovich Yuzhakov
IPC分类号： A61B1720
CPC分类号： B81C99/0085 , A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150282 , A61B5/150389 , A61B5/150412 , A61B5/150458 , A61B5/150969 , A61B5/150984 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B29L2031/7544 , B29L2031/756 , B81B2201/055
摘要： A first embodiment microneedle array is constructed of silicon and silicon dioxide compounds using MEMS technology and standard microfabrication techniques to create hollow cylindrical individual microneedles. The resulting array of microneedles can penetrate with a small pressure through the stratum corneum of skin to either deliver drugs or to facilitate interstitial fluid sampling through the hollow microneedles into the epidermis. The delivery of drugs and sampling of fluids can be performed by way of passive diffusion (time release), instantaneous injection, or iontophoresis. In a second embodiment, an array of hollow (or solid) microneedles is constructed of plastic or some other type of molded or cast material. An electric field may be used to increase transdermal flow rate, and the microneedles can be effectively combined with the application of an electric field between an anode and cathode attached to the skin which causes a low-level electric current. As a drug delivery system, the microneedle array includes electrodes that apply an electric potential to the skin between the electrode locations. One of the electrode assemblies is filled with an ionized drug, and the charged drug molecules move into the body due to the applied electric potential. As a body-fluid sampling system, the microneedle array also includes electrodes to assist in moving fluid from the body into a receiving chamber, and which further includes a bioelectrochemical sensor to measure the concentration of a particular substance.
摘要翻译：第一实施例微针阵列由硅和二氧化硅化合物构成，使用MEMS技术和标准微加工技术来制造中空圆柱形单个微针。所得的微针阵列可以通过皮肤的角质层穿透小的压力，以递送药物或促进通过空心微针进入表皮的间质液取样。可以通过被动扩散（时间释放），瞬时注射或离子电渗法进行药物的输送和液体取样。在第二实施例中，中空（或固体）微针的阵列由塑料或其它类型的模制或铸造材料构成。可以使用电场来增加透皮流速，并且可以将微针与附着在皮肤上的阳极和阴极之间的电场的施加有效地组合，这导致低电平电流。作为药物递送系统，微针阵列包括在电极位置之间向皮肤施加电位的电极。电极组件中的一个填充有电离药物，并且带电药物分子由于施加的电位而进入体内。作为体液采样系统，微针阵列还包括有助于将流体从身体移动到接收室中的电极，并且还包括用于测量特定物质浓度的生物电化学传感器。

10. 发明授权

US07131987B2 Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation 有权
标题翻译：用于治疗和调理皮肤的微结构和方法，其在剥离期间引起较少的刺激
公开(公告)号：US07131987B2
公开(公告)日：2006-11-07
申请号：US10154686
申请日：2002-05-24
申请人： Faiz Feisal Sherman , Vladimir Gartstein
发明人： Faiz Feisal Sherman , Vladimir Gartstein
IPC分类号： H61M35/00
CPC分类号： A45D26/0004 , A61B17/205 , A61B17/322 , A61B17/54 , A61B2017/00761 , A61B2017/00765 , A61B2017/320008 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053
摘要： An improved method is provided to enhance skin appearance and health, in which skin is cleaned (or exfoliated) and conditioned by use of microelements affixed to a base element or hand-held patch. For the microstructure used in the improved method, the dimensions of the microelements are controlled so as to remove a certain number of layers of skin cells and to accumulate and retain those skin cells, along with other foreign substances, into areas between the microelements. In another embodiment of the improved method, a conditioning compound or therapeutic active can be applied to the exfoliated skin to enhance the skin. Moreover, the amount of skin cells accumulated using the improved method represents a self-limiting maximum quantity that cannot be substantially exceeded regardless of the number of attempts by a user to re-use the microstructure apparatus associated with the improved method. Some of the microelement shapes are purposefully designed with distal ends that exhibit sharp edges rather than sharp tips to reduce skin irritation resulting from use of the improved method.
摘要翻译：提供了一种改进的方法来增强皮肤的外观和健康，其中皮肤被清洁（或剥离）并通过使用固定在基底元件或手持贴片上的微量元件进行调理。对于改进方法中使用的微结构，控制微量元素的尺寸以去除一定数量的皮肤细胞层，并将这些皮肤细胞与其他异物一起积聚并保留在微元件之间的区域中。在改进方法的另一个实施方案中，调理化合物或治疗活性物质可以施用于剥离的皮肤以增强皮肤。此外，使用改进方法累积的皮肤细胞的量代表不能基本超过的自限制最大量，而不管使用者重新使用与改进方法相关联的微结构装置的尝试次数。一些微量元素形状被有目的地设计为具有尖锐边缘而不是尖锐尖端的远端，以减少由于使用改进的方法导致的皮肤刺激。

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