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1. 发明授权

US06555574B1 4-oxybenzopyran derivative 失效
标题翻译： 4-羟基苯并吡喃衍生物
公开(公告)号：US06555574B1
公开(公告)日：2003-04-29
申请号：US10049996
申请日：2002-03-29
申请人： Keizo Tanikawa , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
发明人： Keizo Tanikawa , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
IPC分类号： A61K3135
CPC分类号： C07D405/12 , C07D311/22
摘要： This invention relates to a 4-oxybenzopyran derivative of formula (I) wherein, R1 and R2 represent each independently a hydrogen atom, a C1-6 alkyl group or a phenyl group; R3 represents a hydroxyl group or a C1-6 alkylcarbonyloxy group; R4 represents a hydrogen atom, a C3-6 cycloalkyl group, a C1-6 alkyl group, a C1-6 alkylcarbonyl group, a C1-6 alkylaminocarbonyl group, a di-C1-6 alkylaminocarbonyl group, an aryl group or a heteroaryl group; n represents an integer of 0-4; X represents —C(═O)NR7—, —NR8—, —NHC(═O)NH— or —S(O)2NH—; R5 represents a hydrogen atom or (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), or (l); R6 represents a hydrogen atom, a halogen atom, a nitro group or a cyano group; or a pharmaceutically acceptable salt thereof. And this invention also relates to an antiarrhythmic agent having the prolongation effect of the functional refractory period comprising said compound or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明涉及式（I）的4-氧代苯并吡喃衍生物，其中R1和R2各自独立地表示氢原子，C1-6烷基或苯基; R3表示羟基或C1-6烷基羰基氧基; R 4表示氢原子，C 3-6环烷基，C 1-6烷基，C 1-6烷基羰基，C 1-6烷基氨基羰基，二-C 1-6烷基氨基羰基，芳基或杂芳基 ; n表示0-4的整数; X表示-C（= O）NR 7 - ， - NR 8 - ， - NHC（= O）NH-或-S（O）2 NH-; R5代表氢原子或（a），（b），（c），（d），（e），（f），（g），（h），（i），（j），（k）或（l）; R6表示氢原子，卤素原子，硝基或氰基; 或其药学上可接受的盐。本发明还涉及具有作为活性成分的所述化合物或其药学上可接受的盐的具有功能性不应期的延长作用的抗心律失常药。

2. 发明授权

US06677371B1 4-oxybenzopyran derivative 失效
标题翻译： 4-羟基苯并吡喃衍生物
公开(公告)号：US06677371B1
公开(公告)日：2004-01-13
申请号：US10069002
申请日：2002-03-29
申请人： Keizo Tanikawa , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
发明人： Keizo Tanikawa , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
IPC分类号： A61K3135
CPC分类号： C07D311/22
摘要： This invention relates to a 4-oxybenzopyran derivative of formula (I) wherein, R1 and R2 represent each independently a hydrogen atom, a C1-6 alkyl group or a phenyl group; R3 represents a hydroxyl group or C1-6 alkylcarbonyloxy group; R4 represents a hydrogen atom, a C3-6 cycloalkyl group, a C1-6 alkyl group, a C1-6 alkylcarbonyl group, a C1-6 alkylaminocarbonyl group, a di-C1-6 alkylaminocarbonyl group, an aryl group or a heteroaryl group; R5 represents a hydrogen atom or a C1-6 alkyl group; X is absent or represents C═O or SO2; R6 represents a hydrogen atom, a C1-6 alkyl group or a C3-6 cycloalkyl group; R7 represents a hydrogen atom, a halogen atom, a nitro group or a cyano group; or a pharmaceutically acceptable salt thereof. And this invention also relates to a drug for treating arrhytmia having the prolongation effect on the functional refractory period comprising said compound or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明涉及式（I）的4-氧代苯并吡喃衍生物，其中R 1和R 2各自独立地表示氢原子，C 1-6烷基或苯基; R 3表示羟基或C 1-6烷基羰基氧基; R 4表示氢原子，C 3-6环烷基，C 1-6烷基，C 1-6烷基羰基，C 1-6烷基氨基羰基，二-C 1-6烷基氨基羰基，芳基或杂芳基; R 5表示氢原子或C 1-6烷基; X不存在或表示C = O或SO 2; R 6表示氢原子，C 1-6烷基或C 3-6环烷基; R 7表示氢原子，卤素原子，硝基或氰基; 或其药学上可接受的盐。本发明还涉及一种用于治疗对包含所述化合物或其药学上可接受的盐作为活性成分的具有对功能不应期的延长作用的心律的药物。

3. 发明授权

US06589983B1 Benzopyran derivative 失效
标题翻译：苯并吡喃衍生物
公开(公告)号：US06589983B1
公开(公告)日：2003-07-08
申请号：US10048026
申请日：2002-03-29
申请人： Keizo Tanikawa , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
发明人： Keizo Tanikawa , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
IPC分类号： A61K335
CPC分类号： C07D405/12 , C07D311/68 , C07D311/70
摘要： This invention relates a benzopyran denvative of formula (I) wherein, R1 and R2 represent each independently a hydrogen atom, a (substituted)C1-6 alkyl group or a (substituted)phenyl group,R3 represents a hydroxyl group or C1-6 alkylcarbonyloxy group, R4 represents a hydrogen atom, or R3 and R4 together form a bond, m represents an integer of 0-4, n represents an integer of 0-4, Y is absent, or represents CR11R12 in which R11 and R12 represent each independently a hydrogen atom or a C1-6 alkyl group, R5 represents an aryl group or a (substituted)heteroaryl group,R6 represents a hydrogen atom or a C1-6 alkyl group,R7 represents a hydrogen atom or a C1-6 alkyl group,X is absent, or represents C=O or SO2, R8 represents a hydrogen atom, a (substituted)C1-6 alkyl group or C3-6 cycloalkyl group, and R9 represents a nitro group, etc., or a pharmaceutically acceptable salt thereof. And this invention also relates an antiarrhythmic agent having the prolongation effect on the functional refractory period comprising said compound or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明涉及式（I）的苯并吡喃类抗坏血酸，其中R1和R2各自独立地表示氢原子，（取代的）C1-6烷基或（取代的）苯基，R3表示羟基或C1-6烷基羰氧基基团，R4表示氢原子，或R3和R4一起形成键，m表示0-4的整数，n表示0-4的整数，Y不存在，或表示其中R 11和R 12各自独立地表示的CR 11 R 12 氢原子或C1-6烷基，R5表示芳基或（取代）杂芳基，R6表示氢原子或C1-6烷基，R7表示氢原子或C1-6烷基， X不存在，或表示C = O或SO 2，R 8表示氢原子，（取代的）C 1-6烷基或C 3-6环烷基，R 9表示硝基等，或其药学上可接受的盐。本发明还涉及具有作为活性成分的所述化合物或其药学上可接受的盐具有对功能不应期的延长作用的抗心律失常药。

4. 发明授权

US06486178B1 Indane derivatives 失效
标题翻译：茚满衍生物
公开(公告)号：US06486178B1
公开(公告)日：2002-11-26
申请号：US09701281
申请日：2000-11-28
申请人： Keizo Tanikawa , Kazuhiko Ohrai , Masayuki Sato , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Yamashita
发明人： Keizo Tanikawa , Kazuhiko Ohrai , Masayuki Sato , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Yamashita
IPC分类号： A61K314418
CPC分类号： C07D207/335 , C07C233/44 , C07C233/55 , C07C235/34 , C07C235/38 , C07C235/78 , C07C237/20 , C07C237/22 , C07C255/57 , C07C255/60 , C07C261/04 , C07C275/40 , C07C275/42 , C07C2601/02 , C07C2602/08 , C07D207/337 , C07D209/14 , C07D209/18 , C07D213/38 , C07D213/40 , C07D213/56 , C07D239/26 , C07D295/135 , C07D303/36 , C07D303/38 , C07D303/40 , C07D303/46 , C07D307/52 , C07D307/54 , C07D333/20 , C07D333/24
摘要： The present invention provides medicines for treating cardiac insufficiency which contain as an active ingredient indane derivatives of formula (I) wherein R1 represents hydrogen atom, nitro group, cyano group, C1-6 alkylcarbonylamino, R2 and R3 each independently represent C1-6 alkyl group, R4 represents hydroxyl group or C1-6 alkylcarbonyloxy group or represents a bond or oxygen atom together with R5, R5 represents hydrogen atom or represents a bond or oxygen atom together with R4, R6 represents hydrogen atom, hydroxyl group or NR7R8, n means 0 or an integer of 1 to 4, X represents C═O, CH2, SO2 or NR16, Y represents NR17 when X is C═O, CH2 or SO2 and represents C═O when X is NR16, Z is absent when Y represents NR17 or represents NR18 when Y is C═O, W represents aromatic groups or lactam rings, or pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了治疗心功能不全的药物，其含有作为活性成分的式（I）的二氢化茚衍生物，其中R 1表示氢原子，硝基，氰基，C 1-6烷基羰基氨基，R 2和R 3各自独立地表示C 1-6烷基 R 4表示羟基或C 1-6烷基羰基氧基，或表示键或氧原子连同R 5，R 5表示氢原子，或表示键或氧原子与R 4，R 6表示氢原子，羟基或NR 7 R 8，n表示0 或1〜4的整数，X表示C = O，CH2，SO2或NR16，当X为C = O，CH2或SO2时，Y表示NR17，当X为NR16时，表示C = O，当Y表示NR17时Z不存在或当Y为C = O时表示NR18，W表示芳族基团或内酰胺环，或其药学上可接受的盐。

5. 发明授权

US07041700B2 Substituted benzopyran derivatives against arrhythmia 失效
标题翻译：取代苯并吡喃衍生物抗心律失常
公开(公告)号：US07041700B2
公开(公告)日：2006-05-09
申请号：US10479118
申请日：2002-06-17
申请人： Yoshio Ohara , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
发明人： Yoshio Ohara , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
IPC分类号： A61K31/35
CPC分类号： C07D311/68
摘要： This invention relates to benzopyran derivatives of the formula (1) or the formula (2) wherein R1 and R2 represent independently of each other hydrogen atom or C1-6alkyl group, R3 represents hydroxyl group or C1-6 alkylcarbonyloxy group, R4 represents hydrogen atom or C1-6 alkyl group, R5 represents C1-6 alkyl group substituted with C6-14 aryl group or heteroaryl group, R6 represents C1-6 alkyl group, C1-6 alkoxy group, halogen atom, nitro group, C(O)NH2, C(O)NHR8 or C(O)NR8R9, or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarrhythmic agent
摘要翻译：本发明涉及式（1）或式（2）的苯并吡喃衍生物，其中R 1和R 2各自独立地表示氢原子或C 1-6个烷基，R 3表示羟基或C 1-6烷基羰基氧基，R 4表示氢原子或 C 1-6烷基，R 5表示被C 6-14烷基取代的C 1-6烷基。芳基或杂芳基，R 6表示C 1-6烷基，C 1-6烷氧基，卤素原子，硝基， C（O）NH 2，C（O）NHR 8或C（O）NR 8 R 9，，或其药学上可接受的盐。这些化合物可用作抗心律失常药

6. 发明授权

US06809114B2 4-aminobenzopyran derivatives 失效
标题翻译： 4-氨基苯并吡喃衍生物
公开(公告)号：US06809114B2
公开(公告)日：2004-10-26
申请号：US10466175
申请日：2003-07-14
申请人： Yoshio Ohara , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
发明人： Yoshio Ohara , Kazuhiko Ohrai , Kazufumi Yanagihara , Yukihiro Shigeta , Toru Tsukagoshi , Toru Yamashita
IPC分类号： A61K31335
CPC分类号： C07D311/72 , C07D311/70
摘要： This invention relates to benzopyran derivatives of the formula (I) wherein, R1 and R2 represent each independently a C1-6alkyl group, etc, R3 represents a hydroxyl group, etc, R4 represents a hydrogen atom, etc, R6 represents a hydrogen atom, R7 represents a hydrogen atom, etc, X is absent, or represents C═O, etc, R8 represents a hydrogen atom, a C1-6alkyl group, etc, R9 represents a hydrogen atom or a nitro group, when R9 represents a nitro group, Y represents a C4-8alkylene group, —(CH2)m—CR11R12—(CH2)n— or —(CH2)o—O—(CH2)p—, R5 represents a hydrogen atom, an amino group, a C1-6alkoxy group, a C1-6alkylthio group, a C1-6alkylamino group, a C1-6 alkoxycarbonylamino group, etc, or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarrhythmic agent.
摘要翻译：本发明涉及式（I）的苯并吡喃衍生物，其中R 1和R 2各自独立地为C 1-6烷基等，R 3表示羟基等，R 4表示氢原子等，R 6表示氢原子，R 7表示氢原子等，X不存在，或表示C = O等，R 8表示氢原子，C1- 6烷基等，当R 9表示硝基时，R 9表示氢原子或硝基，Y表示C4-8亚烷基， - （CH2）m-CR11R12 - （CH 2）n - 或 - （CH 2）o O-（CH 2）p - ，R 5表示氢原子，氨基，C 1-6烷氧基，C 1-6烷硫基，C 1-6烷基氨基， C 1-6烷氧基羰基氨基等，或其药学上可接受的盐。这些化合物可用作抗心律失常药。

7. 发明授权

US6066631A Chroman derivatives 失效
标题翻译：色原衍生物
公开(公告)号：US6066631A
公开(公告)日：2000-05-23
申请号：US232645
申请日：1999-01-19
申请人： Keizo Tanikawa , Kazuhiko Ohrai , Masayuki Sato , Toru Yamashita , Kazufumi Yanagihara
发明人： Keizo Tanikawa , Kazuhiko Ohrai , Masayuki Sato , Toru Yamashita , Kazufumi Yanagihara
IPC分类号： C07D311/68 , C07D311/70 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07F7/18 , A61K31/352 , C07D251/00 , C07D405/00 , C07D401/00
CPC分类号： C07D405/04 , C07D311/70 , C07D405/12 , C07D407/12 , C07D409/12 , C07F7/1856
摘要： The present invention relates to chroman derivatives of the formula (I): ##STR1## [wherin R.sup.1 represents a hydrogen atom, a halogen atom, a C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a C.sub.3-6 alkoxymethyl group, etc., R.sup.3 and R.sup.4 each independently represent a hydrogen atom, a C.sub.1-6 alkyl group, etc., R.sup.5 represents a hydroxyl group or a C.sub.1-6 alkylcarbonyloxyl group or forms a bond together with R.sup.5, R.sup.6 represents a hydrogen atom or forms a bond together with R.sup.5, R.sup.7 and R.sup.8 each independently represent a hydrogen atom, a C.sub.1-6 alkyl group, a C.sub.3-6 cycloalkyl group, a phenyl group, etc. n is 0 or an integer of 1, 2, 3 or 4, W represents a phenyl group, etc., X represents C.dbd.O, CH.sub.2, SO.sub.2, etc., Y represents NR.sup.17 (in which R.sup.17 represents a hydrogen atom, a C.sub.1-4 alkyl group, a phenyl group, etc.), etc., Z does not exist or represents CH.sub.2 or NR.sup.18 (R.sup.18 represents a hydrogen atom, a C.sub.1-4 alkyl group, or a phenyl group, etc.)] or their salts.
摘要翻译：本发明涉及式（I）的苯并二氢吡喃衍生物：其中R1表示氢原子，卤素原子，C1-6烷基，C1-6烷氧基，C3-6烷氧基甲基等， R 3和R 4各自独立地表示氢原子，C 1-6烷基等，R 5表示羟基或C 1-6烷基羰氧基，或与R 5一起形成键，R 6表示氢原子或者一起形成键 R5，R7和R8各自独立地表示氢原子，C1-6烷基，C3-6环烷基，苯基等，n为0或1,2,3或4的整数，W表示苯基等，X表示C = O，CH 2，SO 2等，Y表示NR 17（其中R 17表示氢原子，C 1-4烷基，苯基等）等， Z不存在或表示CH2或NR18（R18表示氢原子，C1-4烷基或苯基等）]或其盐。

8. 发明申请

US20090281317A1 3-ETHYLIDENEHYDRAZINO SUBSTITUTED HETEROCYCLIC COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS 失效
标题翻译：作为血栓素受体激活剂的3-乙酰基乙酰胺取代的杂环化合物
公开(公告)号：US20090281317A1
公开(公告)日：2009-11-12
申请号：US11721252
申请日：2005-12-07
申请人： Katsuaki Miyaji , Yukihiro Shigeta , Satoshi Nakano , Shunuske Iwamoto , Yutaka Hirokawa , Hirofumi Ota , Kazufumi Yanagihara , Shingo Owada , Norihisa Ishiwata
发明人： Katsuaki Miyaji , Yukihiro Shigeta , Satoshi Nakano , Shunuske Iwamoto , Yutaka Hirokawa , Hirofumi Ota , Kazufumi Yanagihara , Shingo Owada , Norihisa Ishiwata
IPC分类号： C07D409/12 , C07D333/32
CPC分类号： C07D409/12 , C07D333/32 , C07D401/12
摘要： A compound represented by the formula (1): wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译：由式（1）表示的化合物：其中A，B，R1，L1，R2，L2，L3，Y，L4，R3和X与说明书中定义的相同，互变异构体，前药或药学上可接受的盐化合物或其溶剂合物。

9. 发明授权

US08134013B2 Amide compound and thrombopoietin receptor activator 有权
标题翻译：酰胺化合物和血小板生成素受体激活剂
公开(公告)号：US08134013B2
公开(公告)日：2012-03-13
申请号：US11721786
申请日：2005-12-14
申请人： Katsuaki Myaji , Shunsuke Iwamoto , Satoshi Nakano , Hirofumi Ota , Yukihiro Shigeta , Yutaka Hirokawa , Kazufumi Yanagihara , Koji Toyama , Shingo Owada , Masato Horikawa , Norihisa Ishiwata
发明人： Katsuaki Myaji , Shunsuke Iwamoto , Satoshi Nakano , Hirofumi Ota , Yukihiro Shigeta , Yutaka Hirokawa , Kazufumi Yanagihara , Koji Toyama , Shingo Owada , Masato Horikawa , Norihisa Ishiwata
IPC分类号： C07D409/02 , A61K31/40
CPC分类号： C07D231/18
摘要： The present invention provides compounds useful for prevention, treatment or alleviation of diseases against which activation of the thrombopoietin receptor is effective.A compound represented by the formula (1): wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译：本发明提供了可用于预防，治疗或缓解血小板生成素受体活化有效的疾病的化合物。由式（1）表示的化合物：其中A，B，R1，L1，R2，L2，L3，Y，L4，R3和X与说明书中定义的相同，互变异构体，前药或药学上可接受的盐化合物或其溶剂合物。

10. 发明授权

US07968542B2 Thiophene compounds and thrombopoietin receptor activators 有权
标题翻译：噻吩化合物和血小板生成素受体激活剂
公开(公告)号：US07968542B2
公开(公告)日：2011-06-28
申请号：US11994502
申请日：2006-07-13
申请人： Katsuaki Miyaji , Kazufumi Yanagihara , Yukihiro Shigeta , Shunsuke Iwamoto , Masato Horikawa , Yutaka Hirokawa , Shingo Owada , Satoshi Nakano , Hirofumi Ota , Norihisa Ishiwata
发明人： Katsuaki Miyaji , Kazufumi Yanagihara , Yukihiro Shigeta , Shunsuke Iwamoto , Masato Horikawa , Yutaka Hirokawa , Shingo Owada , Satoshi Nakano , Hirofumi Ota , Norihisa Ishiwata
IPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , A61K31/381 , A61P7/00
CPC分类号： C07D409/14 , C07D333/32 , C07D333/38 , C07D413/14
摘要： A compound represented by the formula (I) (wherein R1, R2, R3 and R4 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译：由式（I）表示的化合物或其溶剂化物，其中R1，R2，R3和R4如说明书中所定义），互变异构体，前药或药学上可接受的盐。

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