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1. 发明授权

US06463326B1 Rate adaptive cardiac rhythm management device using transthoracic impedance 有权
标题翻译：评价自适应心律管理装置使用经胸阻抗
公开(公告)号：US06463326B1
公开(公告)日：2002-10-08
申请号：US09492912
申请日：2000-01-20
申请人： Jesse W. Hartley , Marc H. Cohen , Nicholas J. Stessman , Scott A. Reedstrom , Steven D. Check , James P. Nelson
发明人： Jesse W. Hartley , Marc H. Cohen , Nicholas J. Stessman , Scott A. Reedstrom , Steven D. Check , James P. Nelson
IPC分类号： A61N1365
CPC分类号： A61N1/36521
摘要： A cardiac rhythm management (CRM) device detects transthoracic impedance, extracts ventilation or other information, and adjusts a delivery rate of the CRM therapy accordingly. A four-phase sequence of alternating direction current pulse stimuli is periodically delivered to a patient's thorax. A transthoracic impedance signal is extracted using a weighted demodulation. Signal processing extracts ventilation information and removes cardiac stroke information using an adaptive lowpass filter. The adaptive filter cutoff frequency is based on the patient's heart rate; a higher cutoff frequency is provided for higher heart rates. Peak/valley detection indicates tidal volume, which is integrated to extract minute ventilation (MV). Short and long term averages are formed and compared to establish a MV indicated rate. Rate adjustment ignores MV information when a noise-measurement exceeds a threshold. An interference avoidance circuit delays delivery of the stimuli when telemetry pulses or other interfering signals are detected.
摘要翻译：心律管理（CRM）设备检测经胸阻抗，提取通气或其他信息，并相应地调整CRM治疗的递送率。交替方向电流脉冲刺激的四相序列周期性地递送到患者的胸部。使用加权解调提取经胸阻抗信号。信号处理提取通气信息，并使用自适应低通滤波器去除心脏搏动信息。自适应滤波器截止频率基于患者的心率; 为更高的心率提供更高的截止频率。峰/谷检测表示潮气量，其被集成以提取每分钟通气（MV）。形成短期和长期平均数，并比较建立MV指标利率。当噪声测量超过阈值时，速率调整将忽略MV信息。当检测到遥测脉冲或其他干扰信号时，干扰避免电路延迟了刺激的传递。

2. 发明授权

US6161042A Rate adaptive cardiac rhythm management device using transthoracic impedance 有权
公开(公告)号：US6161042A
公开(公告)日：2000-12-12
申请号：US316690
申请日：1999-05-21
申请人： Jesse W. Hartley , Marc H. Cohen , Nicholas J. Stessman , Scott A. Reedstrom , Steven D. Check , James P. Nelson
发明人： Jesse W. Hartley , Marc H. Cohen , Nicholas J. Stessman , Scott A. Reedstrom , Steven D. Check , James P. Nelson
IPC分类号： A61N1/365
CPC分类号： A61N1/36521
摘要： A cardiac rhythm management (CRM) device detects transthoracic impedance, extracts ventilation or other information, and adjusts a delivery rate of the CRM therapy accordingly. A four-phase sequence of alternating direction current pulse stimuli is periodically delivered to a patient's thorax. A transthoracic impedance signal is extracted using a weighted demodulation. Signal processing extracts ventilation information and removes cardiac stroke information using an adaptive lowpass filter. The adaptive filter cutoff frequency is based on the patient's heart rate; a higher cutoff frequency is provided for higher heart rates. Peak/valley detection indicates tidal volume, which is integrated to extract minute ventilation (MV). Short and long term averages are formed and compared to establish a MV indicated rate. Rate adjustment ignores MV information when a noise-measurement exceeds a threshold. An interference avoidance circuit delays delivery of the stimuli when telemetry pulses or other interfering signals are detected.

3. 发明授权

US06076015A Rate adaptive cardiac rhythm management device using transthoracic impedance 失效
公开(公告)号：US06076015A
公开(公告)日：2000-06-13
申请号：US032731
申请日：1998-02-27
申请人： Jesse W. Hartley , Marc H. Cohen , Nicholas J. Stessman , Scott A. Reedstrom , Steven D. Check , James P. Nelson
发明人： Jesse W. Hartley , Marc H. Cohen , Nicholas J. Stessman , Scott A. Reedstrom , Steven D. Check , James P. Nelson
IPC分类号： A61N1/365
CPC分类号： A61N1/36521
摘要： A cardiac rhythm management (CRM) device detects transthoracic impedance, extracts ventilation or other information, and adjusts a delivery rate of the CRM therapy accordingly. A four-phase sequence of alternating direction current pulse stimuli is periodically delivered to a patient's thorax. A transthoracic impedance signal is extracted using a weighted demodulation. Signal processing extracts ventilation information and removes cardiac stroke information using an adaptive lowpass filter. The adaptive filter cutoff frequency is based on the patient's heart rate; a higher cutoff frequency is provided for higher heart rates. Peak/valley detection indicates tidal volume, which is integrated to extract minute ventilation (MV). Short and long term averages are formed and compared to establish a MV indicated rate. Rate adjustment ignores MV information when a noise-measurement exceeds a threshold. An interference avoidance circuit delays delivery of the stimuli when telemetry pulses or other interfering signals are detected.

4. 发明申请

US20090222055A1 LOW POWER DIGITAL DESIGN FOR DEEP SUBMICRON TECHNOLOGY 失效
标题翻译：低功率数字设计用于深层次级技术
公开(公告)号：US20090222055A1
公开(公告)日：2009-09-03
申请号：US12394693
申请日：2009-02-27
申请人： Paul Huelskamp , Douglas J. Gifford , Scott A. Reedstrom , Keith R. Maile
发明人： Paul Huelskamp , Douglas J. Gifford , Scott A. Reedstrom , Keith R. Maile
IPC分类号： A61N1/362
CPC分类号： A61N1/3931 , A61N1/37
摘要： An apparatus comprises an implantable medical device that includes a storage circuit. The storage circuit includes a first stage circuit configured to receive an input signal and to invert and store information about a data bit received in the input signal, a second stage circuit coupled to the output of the first stage circuit to invert and store information about a data bit received from the first stage circuit, and an error circuit coupled to the output of the first stage circuit and an output of the second stage circuit. The error circuit generates an error indication when the storage circuit outputs match while the first stage circuit and the second stage circuit are in an inactive state.
摘要翻译：一种装置包括可植入医疗装置，其包括存储电路。存储电路包括：第一级电路，被配置为接收输入信号并反相并存储关于在输入信号中接收的数据位的信息;第二级电路，耦合到第一级电路的输出，以反转和存储关于从第一级电路接收的数据位，以及耦合到第一级电路的输出和第二级电路的输出的误差电路。当第一级电路和第二级电路处于非活动状态时，当存储电路输出匹配时，误差电路产生错误指示。

5. 发明授权

US08060204B2 Low power digital design for deep submicron technology 失效
标题翻译：低功耗数字设计深亚微米技术
公开(公告)号：US08060204B2
公开(公告)日：2011-11-15
申请号：US12394693
申请日：2009-02-27
申请人： Paul Huelskamp , Douglas J. Gifford , Scott A. Reedstrom , Keith R. Maile
发明人： Paul Huelskamp , Douglas J. Gifford , Scott A. Reedstrom , Keith R. Maile
IPC分类号： A61N1/00
CPC分类号： A61N1/3931 , A61N1/37
摘要： An apparatus comprises an implantable medical device that includes a storage circuit. The storage circuit includes a first stage circuit configured to receive an input signal and to invert and store information about a data bit received in the input signal, a second stage circuit coupled to the output of the first stage circuit to invert and store information about a data bit received from the first stage circuit, and an error circuit coupled to the output of the first stage circuit and an output of the second stage circuit. The error circuit generates an error indication when the storage circuit outputs match while the first stage circuit and the second stage circuit are in an inactive state.
摘要翻译：一种装置包括可植入医疗装置，其包括存储电路。存储电路包括：第一级电路，被配置为接收输入信号并反相并存储关于在输入信号中接收的数据位的信息;第二级电路，耦合到第一级电路的输出，以反转和存储关于从第一级电路接收的数据位，以及耦合到第一级电路的输出和第二级电路的输出的误差电路。当第一级电路和第二级电路处于非活动状态时，当存储电路输出匹配时，误差电路产生错误指示。

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