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1. 发明授权

US07220389B2 Biochemical analysis unit and method of producing thereof 失效
标题翻译：生化分析单元及其生产方法
公开(公告)号：US07220389B2
公开(公告)日：2007-05-22
申请号：US10147826
申请日：2002-05-20
申请人： Keiko Neriishi , Yuichi Hosoi , Katsuhiro Kohda , Masahiro Eto , Akifumi Kato , Kenji Nakajima
发明人： Keiko Neriishi , Yuichi Hosoi , Katsuhiro Kohda , Masahiro Eto , Akifumi Kato , Kenji Nakajima
IPC分类号： B01L11/00
CPC分类号： G01N23/04 , B01J2219/00317 , B01J2219/00364 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01L3/02 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/168 , C40B60/14 , G01N21/0303 , G01N21/6428 , G01N21/6452 , G01N21/76 , G01N2201/0642
摘要： The biochemical analysis unit has a base plate and absorptive regions. The absorptive regions are surrounded by the base plate formed of materials which shield a radioactive ray and a light. In the absorptive regions are applied and absorbed specific binding substances to be bound with substances derived from a living organism that are labeled with labeling substances for generating the radioactive ray or the light. The base plate prevents the specific binding substances from penetrating in the other absorptive regions. When an analysis of data of the radioactive ray and the light is carried out, an image of the radioactive ray and the light is generated without noises.
摘要翻译：生化分析装置具有底板和吸收区。吸收区被由屏蔽放射线和光的材料形成的基板包围。在吸收区域中应用和吸收的特定结合物质与被生物体标记的生物体衍生的物质结合，以产生放射线或光。底板防止特定的结合物质渗入另一个吸收区域。当进行放射线和光的数据分析时，产生放射线和光的图像而没有噪声。

2. 发明申请

US20070184483A1 Biochemical analysis unit and method of producing thereof 审中-公开
公开(公告)号：US20070184483A1
公开(公告)日：2007-08-09
申请号：US11783163
申请日：2007-04-06
申请人： Keiko Neriishi , Yuichi Hosoi , Katsuhiro Kohda , Masahiro Eto , Akifumi Kato , Kenji Nakajima
发明人： Keiko Neriishi , Yuichi Hosoi , Katsuhiro Kohda , Masahiro Eto , Akifumi Kato , Kenji Nakajima
IPC分类号： C12Q1/68 , G01N33/53 , C12M3/00
CPC分类号： G01N23/04 , B01J2219/00317 , B01J2219/00364 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01L3/02 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/168 , C40B60/14 , G01N21/0303 , G01N21/6428 , G01N21/6452 , G01N21/76 , G01N2201/0642
摘要： The biochemical analysis unit has a base plate and absorptive regions. The absorptive regions are surrounded by the base plate formed of materials which shield a radioactive ray and a light. In the absorptive regions are applied and absorbed specific binding substances to be bound with substances derived from a living organism that are labeled with labeling substances for generating the radioactive ray or the light. The base plate prevents the specific binding substances from penetrating in the other absorptive regions. When an analysis of data of the radioactive ray and the light is carried out, an image of the radioactive ray and the light is generated without noises.

3. 发明授权

US07368026B2 Biochemical analysis unit and method for producing thereof 失效
标题翻译：生化分析单元及其制造方法
公开(公告)号：US07368026B2
公开(公告)日：2008-05-06
申请号：US10355257
申请日：2003-01-31
申请人： Kenji Nakajima , Akifumi Kato
发明人： Kenji Nakajima , Akifumi Kato
IPC分类号： B32B37/00
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00387 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00677 , B01J2219/00722 , B01L3/5085 , B01L2200/12 , B01L2300/069 , B01L2300/0829 , B01L2300/168 , G01N33/54366 , G01N33/54393 , Y10T156/1002 , Y10T156/1007 , Y10T156/107
摘要： In producing a biochemical analysis unit (1), an adhesive agent (25) is applied to a base. After calcinations, the adhesive agent (25) forms an adhesive layer (25a, 25b) on a wall of each holes (3) formed in the base (2). Thereafter, an excess adhesive agent (25c) remaining on the surface of the base (2) is removed. Then, a sheet of an absorptive material (4) is set to overlap the base (2). A press roller pair (27, 28) presses them to charge the absorptive material (4) in the holes (3). Thus the absorptive material (4) is fixed in the hole (3) of the base (2) through the adhesive layer (25a, 25b).
摘要翻译：在生产生化分析单元（1）中，将粘合剂（25）施加到基底上。在煅烧之后，粘合剂（25）在形成在基体（2）中的每个孔（3）的壁上形成粘合剂层（25a，25b）。此后，除去残留在基体（2）的表面上的多余的粘合剂（25c）。然后，将一张吸收材料（4）设置成与基部（2）重叠。压辊对（27,28）按压它们以对孔（3）中的吸收材料（4）充电。因此，吸收材料（4）通过粘合剂层（25a，25b）固定在基体（2）的孔（3）中。

4. 发明授权

US07262048B2 Biochemical analysis unit 失效
标题翻译：生化分析单位
公开(公告)号：US07262048B2
公开(公告)日：2007-08-28
申请号：US10800676
申请日：2004-03-16
申请人： Kenji Nakajima , Akifumi Kato
发明人： Kenji Nakajima , Akifumi Kato
IPC分类号： C12M1/34
CPC分类号： G01N33/54366 , B01L3/502 , B01L3/5085 , B01L2300/0636 , B01L2300/069 , B01L2300/0861 , B01L2300/0877 , B01L2400/0487
摘要： A biochemical analysis unit comprises a base plate, which has holes, and a porous adsorptive material, which is filled in each of the holes and forms each of adsorptive regions. Each of the adsorptive regions is provided with a layer, which has pores having a comparatively small mean pore diameter, and a layer, which has pores having a comparatively large mean pore diameter. In cases where the layers, which constitute each of the adsorptive regions, are connected with the layers, which constitute an adjacent adsorptive region, at one of surfaces of the base plate, the biochemical analysis unit further comprises a signal absorbing layer for absorbing a signal, which passes through layers located under the base plate and thus propagates from a certain hole toward an adjacent hole.
摘要翻译：生化分析单元包括具有孔的基板和多孔吸附材料，其填充在每个孔中并形成每个吸附区域。每个吸附区域设置有具有平均孔径相对较小的孔的层和具有平均孔径相对较大的孔的层。在构成每个吸附区域的层与构成相邻吸附区域的层在基板的一个表面连接的情况下，生化分析单元还包括用于吸收信号的信号吸收层其通过位于基板下方的层，从而从一定孔向邻近的孔传播。

5. 发明授权

US07713729B2 Biochemical analysis unit 失效
标题翻译：生化分析单位
公开(公告)号：US07713729B2
公开(公告)日：2010-05-11
申请号：US11782786
申请日：2007-07-25
申请人： Kenji Nakajima , Akifumi Kato
发明人： Kenji Nakajima , Akifumi Kato
IPC分类号： C12M1/34
CPC分类号： G01N33/54366 , B01L3/502 , B01L3/5085 , B01L2300/0636 , B01L2300/069 , B01L2300/0861 , B01L2300/0877 , B01L2400/0487
摘要： A biochemical analysis unit comprises a base plate, which has holes, and a porous adsorptive material, which is filled in each of the holes and forms each of adsorptive regions. Each of the adsorptive regions is provided with a layer, which has pores having a comparatively small mean pore diameter, and a layer, which has pores having a comparatively large mean pore diameter. In cases where the layers, which constitute each of the adsorptive regions, are connected with the layers, which constitute an adjacent adsorptive region, at one of surfaces of the base plate, the biochemical analysis unit further comprises a signal absorbing layer for absorbing a signal, which passes through layers located under the base plate and thus propagates from a certain hole toward an adjacent hole.
摘要翻译：生化分析单元包括具有孔的基板和多孔吸附材料，其填充在每个孔中并形成每个吸附区域。每个吸附区域设置有具有平均孔径相对较小的孔的层和具有平均孔径相对较大的孔的层。在构成每个吸附区域的层与构成相邻吸附区域的层在基板的一个表面连接的情况下，生化分析单元还包括用于吸收信号的信号吸收层其通过位于基板下方的层，从而从一定孔向邻近的孔传播。

6. 发明授权

US07531057B2 Method for producing biochemical analysis unit 失效
标题翻译：生化分析单位生产方法
公开(公告)号：US07531057B2
公开(公告)日：2009-05-12
申请号：US10354994
申请日：2003-01-31
申请人： Akifumi Kato , Kenji Nakajima
发明人： Akifumi Kato , Kenji Nakajima
IPC分类号： B32B37/00
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00378 , B01J2219/00387 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00677 , B01J2219/00722 , B29C35/0894 , B29C59/046 , B32B3/12 , G01N21/6428 , Y10T156/107 , Y10T156/1084 , Y10T156/1741
摘要： A continuous substrate and a continuous absorptive sheet are fed to a press station, and pressed continuously or intermittently. Part of the continuous absorptive sheet is charged in plural holes formed in the continuous substrate to form a biochemical analysis sheet. The biochemical analysis sheet is cut into predetermined tips to obtain a biochemical analysis unit.
摘要翻译：将连续的基材和连续的吸收性片材供给到压制台，连续地或间歇地进行压制。将连续吸收性片材的一部分填充在连续基板中形成的多个孔中，形成生化分析片。将生化分析片切成预定的尖端以获得生化分析单元。

7. 发明申请

US20070274859A1 BIOCHEMICAL ANALYSIS UNIT 失效
标题翻译：生物化学分析单位
公开(公告)号：US20070274859A1
公开(公告)日：2007-11-29
申请号：US11782786
申请日：2007-07-25
申请人： Kenji Nakajima , Akifumi Kato
发明人： Kenji Nakajima , Akifumi Kato
IPC分类号： B01J19/00
CPC分类号： G01N33/54366 , B01L3/502 , B01L3/5085 , B01L2300/0636 , B01L2300/069 , B01L2300/0861 , B01L2300/0877 , B01L2400/0487
摘要： A biochemical analysis unit comprises a base plate, which has holes, and a porous adsorptive material, which is filled in each of the holes and forms each of adsorptive regions. Each of the adsorptive regions is provided with a layer, which has pores having a comparatively small mean pore diameter, and a layer, which has pores having a comparatively large mean pore diameter. In cases where the layers, which constitute each of the adsorptive regions, are connected with the layers, which constitute an adjacent adsorptive region, at one of surfaces of the base plate, the biochemical analysis unit further comprises a signal absorbing layer for absorbing a signal, which passes through layers located under the base plate and thus propagates from a certain hole toward an adjacent hole.
摘要翻译：生化分析单元包括具有孔的基板和多孔吸附材料，其填充在每个孔中并形成每个吸附区域。每个吸附区域设置有具有平均孔径相对较小的孔的层和具有平均孔径相对较大的孔的层。在构成每个吸附区域的层与构成相邻吸附区域的层在基板的一个表面连接的情况下，生化分析单元还包括用于吸收信号的信号吸收层其通过位于基板下方的层，从而从一定孔向邻近的孔传播。

8. 发明授权

US4128606A Impact-resistant chemically blended propylene polymer composition and process for preparation thereof 失效
标题翻译：耐冲击化学混合丙烯聚合物组合物及其制备方法
公开(公告)号：US4128606A
公开(公告)日：1978-12-05
申请号：US757026
申请日：1977-01-05
申请人： Kunio Furutachi , Akifumi Kato , Mikio Nakagawa , Masaru Nakano , Shunji Arita , Aikich Yamamoto
发明人： Kunio Furutachi , Akifumi Kato , Mikio Nakagawa , Masaru Nakano , Shunji Arita , Aikich Yamamoto
IPC分类号： C08L23/00 , C08F2/00 , C08F4/00 , C08F4/60 , C08F8/00 , C08F10/00 , C08F210/00 , C08F210/16 , C08F297/08 , C08L7/00 , C08L21/00 , C08L23/16 , C08L101/00
CPC分类号： C08F297/086
摘要： An improved process for preparing an impact-resistant chemically blended propylene polymer or copolymer, which comprises the following three steps:(1) a first step of polymerizing propylene containing 0 to 1 mole% of another olefin in the presence of a catalyst composed of (a) a carrier-supported titanium catalyst component containing at least magnesium, halogen and titanium on the surface of the carrier and (b) an organo aluminum compound to form specific crystalline polypropylene;(2) a second step of copolymerizing propylene and ethylene in the presence of the reaction product of the first step and the same catalyst while maintaining the content of propylene in the gaseous phase of the polymerization zone at 65 to 90 mole% thereby to form specific low-crystalline propylene/ethylene copolymer; and(3) a third step of polymerizing ethlene, or both ethylene and propylene in the presence of the reaction product of the second step and the same catalyst while maintaining the content of propylene in the gaseous phase of the polymerization zone at 0 to 15 mole% thereby to form specific polyethylene or ethylene/propylene copolymer.
摘要翻译：一种制备耐冲击化学混合丙烯聚合物或共聚物的改进方法，其包括以下三个步骤：

9. 发明授权

US08501914B2 Recombinant protein S composition 失效
标题翻译：重组蛋白S组成
公开(公告)号：US08501914B2
公开(公告)日：2013-08-06
申请号：US12540501
申请日：2009-08-13
申请人： Yutaka Kanda , Hiroshi Sato , Tsuyoshi Yamada , Akifumi Kato , Mitsuo Satoh
发明人： Yutaka Kanda , Hiroshi Sato , Tsuyoshi Yamada , Akifumi Kato , Mitsuo Satoh
IPC分类号： A61K38/16 , C12P21/02
CPC分类号： C07K14/745 , A61K38/00 , C12P21/005
摘要： A pharmaceutical agent for treating a disease such as inflammatory diseases, blood coagulation diseases associated with deficiency of Protein S has been required. The present invention provides a Protein S composition comprising recombinant Protein S molecules having complex type N-glycoside-linked sugar chains, wherein the Protein S has a higher binding activity to a receptor for advanced glycation end products (hereinafter referred to as “RAGE”) than native Protein S present in healthy human blood, and also has a higher ratio of sugar chains in which fucose is not bound to the complex type N-glycoside-linked sugar chains bound to Protein S than native Protein S present in healthy human blood.
摘要翻译：需要用于治疗诸如炎性疾病，与蛋白S缺乏相关的血液凝固疾病等疾病的药剂。本发明提供了包含具有复合型N-糖苷连接的糖链的重组蛋白S分子的蛋白S组合物，其中蛋白S与晚期糖基化终产物的受体（以下称为“RAGE”）具有较高的结合活性，比存在于健康人血液中的天然蛋白S高，并且与健康人血液中存在的天然蛋白S相比，岩藻糖与其与蛋白S结合的复合型N-糖苷连接的糖链不结合的糖链的比例更高。

10. 发明申请

US20080054515A1 Production method of polymer film and production apparatus of the same 审中-公开
标题翻译：聚合物膜的制造方法及其制造装置
公开(公告)号：US20080054515A1
公开(公告)日：2008-03-06
申请号：US11896840
申请日：2007-09-06
申请人： Akifumi Kato , Hidekazu Yamazaki , Hitoshi Ikeda
发明人： Akifumi Kato , Hidekazu Yamazaki , Hitoshi Ikeda
IPC分类号： B29C39/20
CPC分类号： B29C41/26 , B29K2001/00 , B29K2001/12
摘要： There is provided a casting drum having an outer peripheral surface provided with an electrical insulating layer. Direct-current high voltage is applied to an electrode bar disposed in an upstream side from a discharge port to discharge toward the casting drum. Bead is attracted to the charged casting drum by electrostatic attraction. Thereby, the adhesion between the bead and the casting drum is increased, and therefore the occurrence of phenomenon of air entrainment can be prevented. A wet film obtained by peeling a casting film from the casting drum is dried. Accordingly, it is possible to produce a film having few defects such as voids and high quality such as excellent smoothness at high speed and stably.
摘要翻译：提供了具有设置有电绝缘层的外周面的流延鼓。直流高电压被施加到从排出口设置在上游侧的电极棒，以朝着流延鼓排出。珠子被静电吸引吸引到充电的流延鼓上。由此，珠与流延鼓之间的粘合力增加，因此可以防止空气夹带现象的发生。干燥通过从流延滚筒剥离流延膜获得的湿膜。因此，可以在高速且稳定地制造诸如空隙和高质量的缺陷如平滑性优异的膜。

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