专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110053942A1 ORALLY DISINTEGRATING TABLETS 审中-公开
标题翻译： ORALLY DISINCAGE TABLETS
公开(公告)号：US20110053942A1
公开(公告)日：2011-03-03
申请号：US12867532
申请日：2009-02-13
申请人： Keiichi Fujiwara , Yasushi Ochiai , Yohei Kimura
发明人： Keiichi Fujiwara , Yasushi Ochiai , Yohei Kimura
IPC分类号： A61K31/5375 , A61K31/519 , A61K31/167 , A61K31/417 , A61K31/423
CPC分类号： A61K31/5375 , A61K9/0056 , A61K9/2018 , A61K9/2054 , A61K9/2059
摘要： The present invention relates to an orally disintegrating tablet containing (1) an active ingredient, (2) mannitol, (3) crystalline cellulose and (4) at least two kinds of particular ingredients selected from the group consisting of low-substituted hydroxypropylcellulose, cornstarch and carmellose, wherein the blending ratio of each ingredient relative to 100 wt % of the disintegrating tablet is (1) 0.01 to 50 wt %, (2) 20 to 86 wt %, (3) 10 to 30 wt %, and (4) 1 to 20 wt % for each particular ingredient and 3 to 60 wt % as the total of the particular ingredients to be blended, and an assembly of (3) crystalline cellulose to be blended has a bulk density of not more than 0.18 g/cm3, and can provide an orally disintegrating tablet having both suitable hardness and rapid disintegrability in oral cavity, which maintains orally disintegrability even under moist conditions, and hardness of not less than a predetermined level necessary for using in an automatic packaging machine.
摘要翻译：本发明涉及一种口腔崩解片，其含有（1）活性成分，（2）甘露醇，（3）结晶纤维素和（4）至少两种选自低取代羟丙基纤维素，玉米淀粉和羧甲基纤维素，其中各成分相对于崩解片100重量％的配合比例为（1）0.01〜50重量％，（2）20〜86重量％，（3）10〜30重量％，（4））对于每种特定成分为1至20重量％，并且将要混合的特定成分的总量为3至60重量％，并且（3）待混合的结晶纤维素的组合体积密度不超过0.18克/ 并且可以提供口腔崩解片，其在口腔中具有合适的硬度和快速崩解性，即使在潮湿条件下也保持口腔崩解性，并且在自动包装机中使用不低于预定水平的硬度。

2. 发明授权

US08153161B2 Medicament-containing particle and a solid preparation containing the particle 失效
标题翻译：含药物颗粒和含有颗粒的固体制剂
公开(公告)号：US08153161B2
公开(公告)日：2012-04-10
申请号：US10582174
申请日：2004-12-07
申请人： Keiichi Fujiwara , Kiyomi Sogo , Shizuo Okamoto , Koichiro Shibamori , Norihito Shimono
发明人： Keiichi Fujiwara , Kiyomi Sogo , Shizuo Okamoto , Koichiro Shibamori , Norihito Shimono
IPC分类号： A61K9/50 , A61K9/20
CPC分类号： A61K9/1652 , A61K9/0056 , A61K9/1623 , A61K9/2077 , A61K31/5375 , A61K47/26 , A61K47/38
摘要： The invention provides a medicament-containing particle wherein an unpleasant taste of the medicament is alleviated, which is obtainable by mixing and granulating the following ingredients: (1) the medicament with an unpleasant taste, (2) methylcellulose and (3) mannitol; and a solid preparation including the particle. The invention can make an unpleasant taste of the medicament alleviated and furthermore when the formulation including the particle is administered, the unpleasant taste can be masked and the formulation has a good dissolvability in gastrointestinal tract.
摘要翻译：本发明提供了一种药物含有颗粒，其中药物的令人不快的味道得到缓解，其可通过混合和造粒以下成分获得：（1）具有不愉快味道的药物，（2）甲基纤维素和（3）甘露醇; 和包含该颗粒的固体制剂。本发明可以使缓解的药物变得令人不愉快的味道，此外，当施用包含颗粒的制剂时，可以掩蔽不愉快的味道，并且制剂在胃肠道中具有良好的溶解性。

3. 发明申请

US20070148230A1 Medicament-containing particle and a solid preparation containing the particle 失效
标题翻译：含药物颗粒和含有颗粒的固体制剂
公开(公告)号：US20070148230A1
公开(公告)日：2007-06-28
申请号：US10582174
申请日：2004-12-07
申请人： Keiichi Fujiwara , Kiyomi Sogo , Shizuo Okamoto , Koichiro Shibamori , Norihito Shimono
发明人： Keiichi Fujiwara , Kiyomi Sogo , Shizuo Okamoto , Koichiro Shibamori , Norihito Shimono
IPC分类号： A61K31/5375 , A61K9/20
CPC分类号： A61K9/1652 , A61K9/0056 , A61K9/1623 , A61K9/2077 , A61K31/5375 , A61K47/26 , A61K47/38
摘要： The invention provides a medicament-containing particle wherein an unpleasant taste of the medicament is alleviated, which is obtainable by mixing and granulating the following ingredients: (1) the medicament with an unpleasant taste, (2) methylcellulose and (3) mannitol; and a solid preparation including the particle. The invention can make an unpleasant taste of the medicament alleviated and furthermore when the formulation including the particle is administered, the unpleasant taste can be masked and the formulation has a good dissolvability in gastrointestinal tract.
摘要翻译：本发明提供了一种药物含有颗粒，其中药物的令人不快的味道得到缓解，其可通过混合和造粒以下成分获得：（1）具有不愉快味道的药物，（2）甲基纤维素和（3）甘露醇; 和包含该颗粒的固体制剂。本发明可以使缓解的药物变得令人不愉快的味道，此外，当施用包含颗粒的制剂时，可以掩蔽不愉快的味道，并且制剂在胃肠道中具有良好的溶解性。

4. 发明授权

US08900602B2 Disintegrating particle composition and orally rapidly disintegrating tablet 有权
标题翻译：崩解颗粒组合物和口服快速崩解片剂
公开(公告)号：US08900602B2
公开(公告)日：2014-12-02
申请号：US13389874
申请日：2010-08-11
申请人： Keiichi Fujiwara , Tadashi Fukami , Haruka Koizumi
发明人： Keiichi Fujiwara , Tadashi Fukami , Haruka Koizumi
IPC分类号： A23L1/48 , A61K47/26 , A61K9/20 , A61K31/5375 , A61K9/00
CPC分类号： A61K9/0056 , A61K9/2018 , A61K31/5375
摘要： Disclosed is an orally rapidly disintegrating tablet which has a good texture and taste in the oral cavity, such a sufficient hardness as not giving any worry of being chipped or dusted during production or transportation and good disintegrating properties in the oral cavity. The orally rapidly disintegrating tablet, which has a good texture and taste, an appropriate hardness, and good disintegrating properties, can be produced by using a composition, which is prepared by dispersing, by spray-drying, an inorganic excipient and starch(es) in complex particles composed of mannitol and xylitol, in an orally rapidly disintegrating tablet.
摘要翻译：公开了一种在口腔中具有良好质地和口感的口腔快速崩解片，足够的硬度，不会在生产或运输过程中担心切屑或粉尘，并且在口腔中具有良好的崩解性能。可以通过使用通过喷雾干燥分散无机赋形剂和淀粉而制备的组合物来制备具有良好的质地和味道，适当的硬度和良好的崩解性的口腔快速崩解片剂，在由甘露糖醇和木糖醇组成的复合颗粒中，在口腔快速崩解片剂中。

5. 发明授权

US08591955B2 Orally rapidly disintegrating tablet that contains two or more types of particles 有权
标题翻译：口服快速崩解包含两种或多种类型颗粒的片剂
公开(公告)号：US08591955B2
公开(公告)日：2013-11-26
申请号：US13389280
申请日：2010-08-11
申请人： Keiichi Fujiwara
发明人： Keiichi Fujiwara
IPC分类号： A61K9/50
CPC分类号： A61K31/5375 , A61K9/0056 , A61K9/2018 , A61K9/2054 , A61K9/5089
摘要： The present invention provides an orally rapidly-disintegrating tablet comprising at least two particles. Regarding medicaments with unpleasant taste, the present invention provides a tablet comprising such medicament having a suitable hardness so that the tablet can be handled without any difficulty in the period from the formulation of the tablet to the administration thereof (in particular, a tablet which can maintain the hardness thereof when it is stored under a humidified condition); a small size; no unpleasant taste; a pleasant feeling in a mouth after administration; and an excellent disintegration character in the oral cavity and an excellent dissolution character in the gastrointestinal tract.
摘要翻译：本发明提供一种包含至少两种颗粒的口服快速崩解片剂。对于具有不愉快味道的药物，本发明提供了包含具有适当硬度的药物的片剂，使得片剂可以在从片剂的制剂到给药期间无任何困难地处理（特别是可以将片剂保持其在加湿条件下储存时的硬度）; 小尺寸没有不愉快的味道; 给药后口感愉快; 在口腔中具有优异的崩解性，并且在胃肠道中具有极好的溶解特性。

6. 发明申请

US20120165413A1 DISINTEGRATING PARTICLE COMPOSITION AND ORALLY RAPIDLY DISINTEGRATING TABLET 有权
标题翻译：消毒颗粒组合物和ORANDY快速消毒片
公开(公告)号：US20120165413A1
公开(公告)日：2012-06-28
申请号：US13389874
申请日：2010-08-11
申请人： Keiichi Fujiwara , Tadashi Fukami , Haruka Koizumi
发明人： Keiichi Fujiwara , Tadashi Fukami , Haruka Koizumi
IPC分类号： A61K47/26 , A23L1/48
CPC分类号： A61K9/0056 , A61K9/2018 , A61K31/5375
摘要： Disclosed is an orally rapidly disintegrating tablet which has a good texture and taste in the oral cavity, such a sufficient hardness as not giving any worry of being chipped or dusted during production or transportation and good disintegrating properties in the oral cavity. The orally rapidly disintegrating tablet, which has a good texture and taste, an appropriate hardness, and good disintegrating properties, can be produced by using a composition, which is prepared by dispersing, by spray-drying, an inorganic excipient and starch(es) in complex particles composed of mannitol and xylitol, in an orally rapidly disintegrating tablet.
摘要翻译：公开了一种在口腔中具有良好质地和口感的口腔快速崩解片，足够的硬度，不会在生产或运输过程中担心切屑或粉尘，并且在口腔中具有良好的崩解性能。可以通过使用通过喷雾干燥分散无机赋形剂和淀粉而制备的组合物来制备具有良好的质地和味道，适当的硬度和良好的崩解性的口腔快速崩解片剂，在由甘露糖醇和木糖醇组成的复合颗粒中，在口腔快速崩解片剂中。

7. 发明申请

US20050069294A1 Monitoring image recording apparatus 审中-公开
标题翻译：监控图像记录装置
公开(公告)号：US20050069294A1
公开(公告)日：2005-03-31
申请号：US10939241
申请日：2004-09-10
申请人： Haruo Tagawa , Yoshihiro Hinode , Keiichi Fujiwara
发明人： Haruo Tagawa , Yoshihiro Hinode , Keiichi Fujiwara
IPC分类号： H04N5/915 , H04N5/77 , H04N7/18 , H04N9/804 , H04N5/91
CPC分类号： H04N21/42661 , G08B13/19645 , G08B13/19667 , G08B13/19693 , H04N5/23241 , H04N5/77 , H04N7/18 , H04N9/8042 , H04N21/2187 , H04N21/4223 , H04N21/4432
摘要： It is an object to provide a monitoring image recording apparatus capable of carrying out multi-screen monitoring through a live image by means of a plurality of cameras even if an auxiliary power switch is turned OFF. There are provided an image data compressing and extending portion 104 for compressing and extending monitoring image data, an HDD 107 for recording the image data thus compressed, and a control portion 130 for controlling the image data compressing and extending portion 104 and the HDD 107, the control portion 130 has an HDD power supply control portion 200 for controlling the supply of a power to the HDD 107.
摘要翻译：本发明的目的是提供一种监视图像记录装置，即使辅助电源开关被关闭，也能通过多个摄像机通过实时图像进行多屏监视。提供了用于压缩和扩展监视图像数据的图像数据压缩和扩展部分104，用于记录如此压缩的图像数据的HDD 107和用于控制图像数据压缩和扩展部分104和HDD 107的控制部分130，控制部分130具有用于控制向HDD 107供电的HDD电源控制部分200。

8. 发明授权

US09446055B2 Disintegrating particle composition and orally rapidly disintegrating tablet 有权
标题翻译：崩解颗粒组合物和口服快速崩解片剂
公开(公告)号：US09446055B2
公开(公告)日：2016-09-20
申请号：US13389880
申请日：2010-08-11
申请人： Keiichi Fujiwara , Tadashi Fukami , Haruka Koizumi
发明人： Keiichi Fujiwara , Tadashi Fukami , Haruka Koizumi
IPC分类号： A61K47/26 , A61K31/167 , A61K9/14 , A61K31/616 , A61K9/00 , A61K9/20
CPC分类号： A61K31/616 , A61K9/0056 , A61K9/2018
摘要： There has been a need for an orally rapidly disintegrating tablet which has a good texture and taste in the oral cavity, such a sufficient hardness as not giving any worry of being chipped or dusted during production or transportation and good disintegrating properties in the oral cavity and can sustain a sufficient hardness even under humid conditions after opening. Disclosed are a disintegrating particle composition which is prepared by dispersing, in the presence of water, mannitol, xylitol, an inorganic excipient, a disintegrating agent and carmellose and drying, and an orally rapidly disintegrating tablet which comprises said disintegrating particle composition, an active substance and a disintegrating agent. The disintegrating tablet has a good texture and taste, an appropriate hardness and good disintegrating properties and can sustain a sufficient hardness under humid conditions.
摘要翻译：需要一种在口腔中具有良好质地和口感的口服快速崩解片剂，足够的硬度，不会在生产或运输过程中担心不会被切碎或撒粉，并且在口腔中具有良好的崩解性能，即使在开放后的潮湿条件下，也能维持足够的硬度。公开了通过在水，甘露糖醇，木糖醇，无机赋形剂，崩解剂和羧甲基纤维素和干燥剂的存在下分散而制备的崩解颗粒组合物，以及包含所述崩解颗粒组合物的口服快速崩解片剂，活性物质和崩解剂。崩解片具有良好的质地和味道，适当的硬度和良好的崩解性能，并能在潮湿条件下维持足够的硬度。

9. 发明申请

US20120156261A1 DISINTEGRATING PARTICLE COMPOSITION AND ORALLY RAPIDLY DISINTEGRATING TABLET 有权
标题翻译：消毒颗粒组合物和ORANDY快速消毒片
公开(公告)号：US20120156261A1
公开(公告)日：2012-06-21
申请号：US13389880
申请日：2010-08-11
申请人： Keiichi Fujiwara , Tadashi Fukami , Haruka Koizumi
发明人： Keiichi Fujiwara , Tadashi Fukami , Haruka Koizumi
IPC分类号： A61K47/26 , A61K31/167 , A61K9/14 , A61K31/616 , A61K47/02 , A61K47/34
CPC分类号： A61K31/616 , A61K9/0056 , A61K9/2018
摘要： There has been a need for an orally rapidly disintegrating tablet which has a good texture and taste in the oral cavity, such a sufficient hardness as not giving any worry of being chipped or dusted during production or transportation and good disintegrating properties in the oral cavity and can sustain a sufficient hardness even under humid conditions after opening. Disclosed are a disintegrating particle composition which is prepared by dispersing, in the presence of water, mannitol, xylitol, an inorganic excipient, a disintegrating agent and carmellose and drying, and an orally rapidly disintegrating tablet which comprises said disintegrating particle composition, an active substance and a disintegrating agent. The disintegrating tablet has a good texture and taste, an appropriate hardness and good disintegrating properties and can sustain a sufficient hardness under humid conditions.
摘要翻译：需要一种在口腔中具有良好的质地和口感的口服快速崩解片剂，足够的硬度，不会在生产或运输过程中担心不会被切碎或撒粉，并且在口腔中具有良好的崩解性能，即使在开放后的潮湿条件下，也能维持足够的硬度。公开了通过在水，甘露醇，木糖醇，无机赋形剂，崩解剂和羧甲基纤维素和干燥剂的存在下分散而制备的崩解颗粒组合物，以及包含所述崩解颗粒组合物的口服快速崩解片剂，活性物质和崩解剂。崩解片具有良好的质地和味道，适当的硬度和良好的崩解性能，并能在潮湿条件下维持足够的硬度。

10. 发明申请

US20120135991A1 ORALLY RAPIDLY DISINTEGRATING TABLET THAT CONTAINS TWO OR MORE TYPES OF PARTICLES 有权
标题翻译：包含两种或多种颗粒的ORALLY快速消毒片
公开(公告)号：US20120135991A1
公开(公告)日：2012-05-31
申请号：US13389280
申请日：2010-08-11
申请人： Keiichi Fujiwara
发明人： Keiichi Fujiwara
IPC分类号： A61K47/38 , A61P1/00 , A61K31/5375
CPC分类号： A61K31/5375 , A61K9/0056 , A61K9/2018 , A61K9/2054 , A61K9/5089
摘要： The present invention provides an orally rapidly-disintegrating tablet comprising at least two particles. Regarding medicaments with unpleasant taste, the present invention provides a tablet comprising such medicament having a suitable hardness so that the tablet can be handled without any difficulty in the period from the formulation of the tablet to the administration thereof (in particular, a tablet which can maintain the hardness thereof when it is stored under a humidified condition); a small size; no unpleasant taste; a pleasant feeling in a mouth after administration; and an excellent disintegration character in the oral cavity and an excellent dissolution character in the gastrointestinal tract.
摘要翻译：本发明提供一种包含至少两种颗粒的口服快速崩解片剂。对于具有不愉快味道的药物，本发明提供了包含具有适当硬度的药物的片剂，使得片剂可以在从片剂的制剂到给药期间无任何困难地处理（特别是可以将片剂保持其在加湿条件下储存时的硬度）; 小尺寸没有不愉快的味道; 给药后口感愉快; 在口腔中具有优异的崩解性，并且在胃肠道中具有极好的溶解特性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式