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1. 发明授权

US5326827A Heat-curable resin composition containing acrylic polymer having alicyclic epoxide functions 失效
标题翻译：含有脂环式环氧官能团的丙烯酸类聚合物的热固性树脂组合物
公开(公告)号：US5326827A
公开(公告)日：1994-07-05
申请号：US139076
申请日：1993-10-21
申请人： Kei Aoki , Shinji Nakano , Nobuaki Tomita
发明人： Kei Aoki , Shinji Nakano , Nobuaki Tomita
IPC分类号： C08K5/36 , C08F8/00 , C08F20/32 , C08G59/32 , C08G59/68 , C08K5/55 , C08K5/59 , C08L33/04 , C08L33/14 , C08L63/00 , C09D133/04 , C09D133/06 , C09D133/14 , C09J133/04 , C09J133/14
CPC分类号： C08F8/00 , C08G59/3209 , C08G59/68 , C09D133/068 , C08L63/00
摘要： A curable resin composition comprising (a) an acrylic polymer having a plurality of alicyclic epoxide functions, and (b) an amount effective to initiate the curing reaction of the acrylic polymer (a) upon heating of a heat-latent cation polymerization initiator. The composition finds its uses in coating compositions, sealants, potting and casting compositions.
摘要翻译：一种可固化树脂组合物，其包含（a）具有多个脂环族环氧官能团的丙烯酸类聚合物，和（b）在热潜阳离子聚合引发剂加热时有效引发丙烯酸类聚合物（a）的固化反应的量。该组合物可用于涂料组合物，密封剂，灌封和浇铸组合物中。

2. 发明授权

US5169896A Polymerizable compound and polymer therefrom 失效
标题翻译：可聚合化合物和聚合物
公开(公告)号：US5169896A
公开(公告)日：1992-12-08
申请号：US861549
申请日：1992-04-01
申请人： Satoshi Urano , Kei Aoki , Nobuaki Tomita , Hirohiko Mori
发明人： Satoshi Urano , Kei Aoki , Nobuaki Tomita , Hirohiko Mori
IPC分类号： C07C233/56 , C08F20/18 , C08L83/04
CPC分类号： C08F20/18 , C07C233/56 , C08L83/04 , C08G77/16
摘要： A curable composition comprises a compound having at least two hydroxyl groups and a homopolymer or a copolymer of a polymerizable compound represented by formula (I):A--X--COCOOR.sub.1 (I)wherein R.sub.1 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or an aryl group; X represents an oxygen atom, a sulfur atom, --COO-- or --NR.sub.5 -- wherein R.sub.5 is a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group; A represents a C.sub.3 -C.sub.18 alkenyl, alkynyl, alkenylaryl or alkenylaralykyl group, or a group represented by: ##STR1## wherein R.sub.2 and R.sub.3, which may be the same or different, independently represent a hydrogen atom or a C.sub.1 -C.sub.5 alkyl groups; Y represents an oxygen atom or --NR.sub.4 -- wherein R.sub.4 represents a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group; n is an integer of 1 to 5;m is an integer of 1 to 10; and 1 is 0 or an integer of 1 to 20;with the proviso that if Y is present, X is not --NR.sub.5 --.
摘要翻译：可固化组合物包含具有至少两个羟基的化合物和由式（I）表示的可聚合化合物的均聚物或共聚物：AX-COCOOR1（I）其中R1表示氢原子，C1-C5烷基或芳基; X表示氧原子，硫原子，-COO-或-NR5-，其中R5是氢原子或C1-C5烷基; A表示C 3 -C 18烯基，炔基，烯基芳基或链烯基烷基，或由下式表示的基团：其中R 2和R 3可以相同或不同，独立地表示氢原子或C 1 -C 5烷基; Y表示氧原子或-NR4-，其中R4表示氢原子或C1-C5烷基; n为1〜5的整数， m为1〜10的整数。 1为0或1〜20的整数，条件是如果存在Y，则X不是-NR 5 - 。

3. 发明授权

US5663262A Compound containing an oxamic acid group, a process for producing the compound, and a resin composition containing the compound 失效
标题翻译：含有羟基酸基团的化合物，该化合物的制备方法和含有该化合物的树脂组合物
公开(公告)号：US5663262A
公开(公告)日：1997-09-02
申请号：US433097
申请日：1989-11-08
申请人： Shinsuke Shirakawa , Kazunori Kanda , Mitsuo Yamada , Kei Aoki , Satoshi Urano , Nobuaki Tomita
发明人： Shinsuke Shirakawa , Kazunori Kanda , Mitsuo Yamada , Kei Aoki , Satoshi Urano , Nobuaki Tomita
IPC分类号： B01F17/00 , B01F17/54 , C07C233/56 , C07C271/12 , C08C19/22 , C08F8/30 , C08F8/44 , C08F12/26 , C08F20/36 , C08F20/60 , C08G18/64 , C08G59/14 , C08G63/91 , C08G69/48 , C08G73/02 , C08G77/388 , C09D5/44 , C09D201/00 , C08F26/00 , C07C69/52 , C08F126/00 , C08F226/00
CPC分类号： C08G69/48 , B01F17/0035 , B01F17/005 , B01F17/0071 , C07C233/56 , C07C271/12 , C08C19/22 , C08F12/26 , C08F20/36 , C08F20/60 , C08F8/30 , C08F8/44 , C08G18/643 , C08G59/1477 , C08G63/91 , C08G73/0206 , C08G77/388 , C09D5/4434
摘要： The present invention relates to compounds containing an oxamic acid group, which show high reactivity and have stability for water and are used as paints, adhesives, and plastic materials etc. in the form of a reaction material or a resin. Since into these compounds an oxamic acid group is introduced in a part of the molecule and the oxamic acid group is an ionic functional group, the compounds show superior solubility and dispersing character in water and also, since the oxamic acid group is a group of a disappearing type with heating, the compounds do not remain, after hardening, in the hardened product. Accordingly, the hardened products obtained from these compounds are superior in water-resistant and anticorrosion properties and in durability.
摘要翻译：本发明涉及具有高反应性并且具有水稳定性并用作反应材料或树脂形式的油漆，粘合剂和塑料材料等的含有羟基酸基团的化合物。由于在这些化合物中，在分子的一部分中引入了一个羟基酸基团，而且该酰胺酸基是一个离子官能团，所以该化合物在水中表现出优异的溶解性和分散性，而且由于羟基酸组是消失型加热，化合物在硬化后不会残留在硬化产品中。因此，由这些化合物得到的硬化物的耐水性，耐腐蚀性和耐久性优异。

4. 发明授权

US5442096A Polymerizable compound and polymer therefrom 失效
标题翻译：可聚合的化合物和聚合物
公开(公告)号：US5442096A
公开(公告)日：1995-08-15
申请号：US84966
申请日：1993-07-02
申请人： Satoshi Urano , Kei Aoki , Nobuaki Tomita , Hirohiko Mori
发明人： Satoshi Urano , Kei Aoki , Nobuaki Tomita , Hirohiko Mori
IPC分类号： C07C233/56 , C08F20/18 , C08L83/04 , C07C69/34
CPC分类号： C08F20/18 , C07C233/56 , C08L83/04 , C08G77/16
摘要： A homopolymer or a copolymer comprises a polymerizable compound represented by formula (I):A--X--COCOOR.sub.1 (I)wherein R.sub.1 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or an aryl group; X represents an oxygen atom, a sulfur atom, --COO-- or --NR.sub.5 -- wherein R.sub.5 is a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group; A represents a C.sub.3 -C.sub.18 alkenyl, alkynyl, alkenylaryl or alkenylaralkyl group, or a group represented by: ##STR1## wherein R.sub.2 and R.sub.3, which may be the same or different, independently represent a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group; Y represents an oxygen atom or --NR.sub.4 -- wherein R.sub.4 represents a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group; n is an integer of 1 to 5; m is an integer of 1 to 10; and 1 is 0 or an integer of 1 to 20;with the proviso that if Y is present, X is not --NR.sub.5 --. Additionally, disclosed are processes of preparing the homopolymer or copolymer as well as the polymerizable compound.
摘要翻译：均聚物或共聚物包含由式（I）表示的可聚合化合物：其中R 1表示氢原子，C 1 -C 5烷基或芳基的A-X-COCOOR 1（I） X表示氧原子，硫原子，-COO-或-NR5-，其中R5是氢原子或C1-C5烷基; A表示C 3 -C 18烯基，炔基，链烯基芳基或链烯基烷基，或由相同或不同表示的基团独立地表示氢原子或C1-C5烷基; Y表示氧原子或-NR4-，其中R4表示氢原子或C1-C5烷基; n为1〜5的整数， m为1〜10的整数。 1为0或1〜20的整数，条件是如果存在Y，则X不是-NR 5 - 。此外，公开了制备均聚物或共聚物以及可聚合化合物的方法。

5. 发明授权

US5117044A Polymerizable compound and polymer therefrom 失效
标题翻译：可聚合化合物和聚合物
公开(公告)号：US5117044A
公开(公告)日：1992-05-26
申请号：US464121
申请日：1990-01-12
申请人： Satoshi Urano , Kei Aoki , Nobuaki Tomita , Hirohiko Mori
发明人： Satoshi Urano , Kei Aoki , Nobuaki Tomita , Hirohiko Mori
IPC分类号： C07C69/36 , C07C69/54 , C07C69/716 , C07C233/18 , C07C233/20 , C07C233/36 , C07C233/47 , C07C233/56 , C07C327/22 , C08F18/02 , C08F20/02 , C08F20/06 , C08F20/08 , C08F20/18 , C08F20/26 , C08F20/28 , C08F26/00 , C08F26/02 , C08F28/00 , C08F28/02 , C08F290/00 , C08F299/00 , C08G63/12 , C08G63/20 , C08G63/668 , C08G63/68 , C08G63/685 , C08G63/688 , C08G81/02 , C08G83/00 , C08L33/04 , C08L83/04 , C08L83/06 , C09D133/04
CPC分类号： C08F20/18 , C07C233/56 , C07C69/36 , C07C69/54 , C08F20/28 , C08L83/04 , C08L83/06 , C08G77/16 , C08G77/70
摘要： The invention provides a polymerizable compound represented by the formula (I):A--X--COCOOR.sub.1wherein A represents a C.sub.1 -C.sub.18 alkenyl, alkynyl, alkenylaryl or alkenylaralkyl group, or a group represented bywherein R.sub.2 and R.sub.3, which are the same or different, represent a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group, Y represents an oxygen atom or --NR.sub.4 --, in which R.sub.4 represents a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group, n is an integer of 1 to 5, m is an integer of 1 to 10 and 1 is 0 or an integer of 1 to 20;R.sub.1 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or an aryl group; andX represents an oxygen atom, a sulfur atom, --COO-- or --NR.sub.5 --, in which R.sub.5 is a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group, provided that if Y is present, X is not --NR.sub.5 --,its production and polymers prepared therefrom.
摘要翻译：本发明提供由式（I）表示的可聚合化合物：AX-COCOOR1其中A表示C1-C18链烯基，炔基，链烯基芳基或链烯基烷基，或其中R2和R3表示的基团相同或不同，表示氢原子或C1-C5烷基，Y表示氧原子或-NR4-，其中R4表示氢原子或C1-C5烷基，n为1〜5的整数，m为整数为1〜10，1为0或1〜20的整数。 R1表示氢原子，C1-C5烷基或芳基; 并且X表示氧原子，硫原子，-COO-或-NR5-，其中R5是氢原子或C1-C5烷基，条件是如果存在Y，则X不是-NR 5 - ，其生产和由其制备的聚合物。

6. 发明申请

US20080025994A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF PANCREATITIS 审中-公开
标题翻译：用于治疗胰腺癌的方法和组合物
公开(公告)号：US20080025994A1
公开(公告)日：2008-01-31
申请号：US11845638
申请日：2007-08-27
申请人： Lance Steward , George Sachs , Kei Aoki
发明人： Lance Steward , George Sachs , Kei Aoki
IPC分类号： A61K39/395 , A61P1/18
CPC分类号： C07K14/33 , A61K47/6415 , C07K2317/53 , C07K2319/00 , C07K2319/33
摘要： Methods and compositions for the treatment of acute pancreatitis in a mammal. Particular compositions comprise a binding element, a translocation element, and a therapeutic element able to prevent accumulation of digestive enzymes within the pancreas.
摘要翻译：用于治疗哺乳动物急性胰腺炎的方法和组合物。特定的组合物包含结合元件，易位元件和能够防止胰脏内的消化酶积累的治疗元件。

7. 发明申请

US20060275325A1 Method for treating allodynia by peripheral administration of a neurotoxin 有权
标题翻译：通过外周施用神经毒素治疗异常性疼痛的方法
公开(公告)号：US20060275325A1
公开(公告)日：2006-12-07
申请号：US11205380
申请日：2005-08-16
申请人： Kei Aoki , Minglei Cui , Stephen Jenkins
发明人： Kei Aoki , Minglei Cui , Stephen Jenkins
IPC分类号： A61K39/08
CPC分类号： A61K38/4893
摘要： Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
摘要翻译：用于治疗非痉挛的方法通过外周给予患者治疗有效量的神经毒素如肉毒杆菌毒素而引起疼痛。

8. 发明申请

US20060257430A1 Methods of modulating intracellular degradation rates of toxins 审中-公开
标题翻译：调节毒素的细胞内降解速率的方法
公开(公告)号：US20060257430A1
公开(公告)日：2006-11-16
申请号：US11259514
申请日：2005-10-25
申请人： Shengwen Li , Kei Aoki
发明人： Shengwen Li , Kei Aoki
IPC分类号： A61K38/48 , A61K39/08
CPC分类号： A61K9/0019 , A61K38/4886
摘要： The present invention provides for methods of modulating the degradation rate of a toxin in a cell, thereby modulating the half-life of the toxin. Particularly, the invention features methods of modulating the degradation rate of a toxin by modulating fusion between a lysosome and an endosome that carries the toxin in the cell.
摘要翻译：本发明提供调节细胞中毒素降解速率的方法，从而调节毒素的半衰期。特别地，本发明的特征在于通过调节在细胞内携带毒素的溶酶体和内体之间的融合来调节毒素的降解速率的方法。

9. 发明申请

US20060211619A1 Multivalent clostridial toxin derivatives and methods of their use 有权
标题翻译：多价梭菌毒素衍生物及其使用方法
公开(公告)号：US20060211619A1
公开(公告)日：2006-09-21
申请号：US11376696
申请日：2006-03-15
申请人： Lance Steward , Fernandez-Salas Ester , Joseph Francis , Shengwin Li , Marcella Gilmore , Kei Aoki
发明人： Lance Steward , Fernandez-Salas Ester , Joseph Francis , Shengwin Li , Marcella Gilmore , Kei Aoki
IPC分类号： A61K38/17 , C07K14/715 , C07K16/28
CPC分类号： C07K14/33 , A61K38/4886 , C07K2319/00 , C07K2319/035 , C07K2319/06
摘要： The present invention is directed to multivalent Clostridial neurotoxin derivatives having more than one binding domain directed to a cell surface feature of a target cell. Such modified neurotoxins are useful as therapeutic compositions to prevent exocytosis and secretion by the target cell. Conditions in which such compositions man be useful include, without limitation, disorders of the sensory or motor nervous system, acute or chronic pain, cancer, pancreatitis, hyperhydrosis, glandular disorders, viral infections, cystic fibrosis and the like. The invention is also directed to methods of using and administering such a composition, and methods of treating a given condition using such a composition.
摘要翻译：本发明涉及具有针对靶细胞的细胞表面特征的多于一个结合结构域的多价梭菌神经毒素衍生物。这种修饰的神经毒素可用作预防目标细胞胞吐和分泌的治疗组合物。这些组合物可用的条件包括但不限于感觉或运动神经系统的疾病，急性或慢性疼痛，癌症，胰腺炎，超氧化，腺体疾病，病毒感染，囊性纤维变性等。本发明还涉及使用和施用这种组合物的方法，以及使用这种组合物治疗给定病症的方法。

10. 发明申请

US20060063222A1 Fluorescence polarization assays for determining clostridial toxin activity 有权
公开(公告)号：US20060063222A1
公开(公告)日：2006-03-23
申请号：US10948097
申请日：2004-09-22
申请人： Dudley Williams , Marcella Gilmore , Lance Steward , Marc Verhagen , Kei Aoki
发明人： Dudley Williams , Marcella Gilmore , Lance Steward , Marc Verhagen , Kei Aoki
IPC分类号： C12Q1/37 , C12N11/16
CPC分类号： G01N33/542 , C12N9/52 , C12Q1/37 , G01N2333/33
摘要： The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease activity, a clostridial toxin substrate which includes a fluorophore; a bulking group; and a clostridial toxin recognition sequence containing a cleavage site that intervenes between the fluorophore and the bulking group; (b) exciting the fluorophore with plane polarized light; and (c) determining fluorescence polarization of the treated substrate relative to a control substrate, where a change in fluorescence polarization of the treated substrate as compared to fluorescence polarization of the control substrate is indicative of the presence or activity of the clostridial toxin.

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