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1. 发明授权

US07348424B2 Polysaccharide containing phosphorylcholine group and process for producing the same 失效
标题翻译：含有磷酸胆碱的多糖组及其制备方法
公开(公告)号：US07348424B2
公开(公告)日：2008-03-25
申请号：US10506771
申请日：2003-04-08
申请人： Kazuyuki Miyazawa , Toshio Yanaki , Francoise M. Winnik
发明人： Kazuyuki Miyazawa , Toshio Yanaki , Francoise M. Winnik
IPC分类号： C07H5/04 , C07H5/06 , C08B37/00
CPC分类号： C08B37/0072 , A61K8/73 , A61K8/731 , A61K8/735 , A61Q19/00 , C08B11/20 , C08B15/06 , C08B37/00 , C08B37/0018 , C08B37/0021 , C08B37/003
摘要： The present invention is a method for manufacturing a phosphorylcholine group-containing polysaccharide wherein the aldehyde derivative-containing compound obtained by the oxidative ring-opening reaction of glycerophosphorylcholine is added to a polysaccharide containing amino groups as well as a new polysaccharide having phosphorylcholine groups obtained from this manufacturing method.The object of the present invention is to provide a phosphorylcholine group-containing polysaccharide that is superior in biocompatibility and moisture retention, and is useful as a polymer material for medical use, as well as a simple method of manufacturing it.The polysaccharide of the present invention is utilized, for example, in artificial organs, biomembranes, coating agents for medical tools, drug delivery, and in cosmetics.
摘要翻译：本发明是一种含有磷酰胆碱基团的多糖的制造方法，其中将通过甘油磷酰胆碱的氧化开环反应得到的含有醛衍生物的化合物加入到含有氨基的多糖中，以及具有磷酸胆碱基团的新型多糖，这种制造方法。本发明的目的是提供一种生物相容性和保湿性优异的含磷酰胆碱基团的多糖，作为医疗用聚合物材料，以及其制造方法简单。本发明的多糖可用于例如人造器官，生物膜，医疗工具用涂剂，药物输送和化妆品中。

2. 发明授权

US08367082B2 Microgel and external compositions containing the same 有权
标题翻译：微凝胶和含有它们的外用组合物
公开(公告)号：US08367082B2
公开(公告)日：2013-02-05
申请号：US12082130
申请日：2008-04-09
申请人： Kazuyuki Miyazawa , Isamu Kaneda , Toshio Yanaki , Tadashi Nakamura , Masatoshi Ochiai , Tomoyuki Kawasoe
发明人： Kazuyuki Miyazawa , Isamu Kaneda , Toshio Yanaki , Tadashi Nakamura , Masatoshi Ochiai , Tomoyuki Kawasoe
IPC分类号： A61K8/02 , A61Q5/00
CPC分类号： A61K8/042 , A61K8/0212 , A61K8/44 , A61K8/65 , A61K8/676 , A61K8/73 , A61K8/733 , A61K8/8147 , A61K8/8152 , A61K8/8158 , A61K8/86 , A61K8/97 , A61K8/982 , A61K9/0014 , A61K47/36 , A61K47/42 , A61K2800/412 , A61Q5/06 , A61Q5/065 , A61Q19/00 , A61Q19/02 , C08L5/00 , C08L5/04 , C08L5/12 , C08L89/06 , C08L2666/02
摘要： The present invention provides a microgel having a mean particle size of 0.1-1,000 μm, the microgel being produced from a gel which is formed by use of a hydrophilic compound capable of forming a gel. An external composition containing the microgel provides an excellent sensation during use; i.e., the composition provides neither sticky sensation during use nor frictional sensation. Furthermore, even when a large amount of a pharmaceutical ingredient, such as a whitening ingredient, or a salt is incorporated into the composition, the viscosity of the composition is not lowered, and the composition exhibits excellent viscosity increasing property. In addition, the composition exhibits long-term stability, without inviting separation of water.
摘要翻译：本发明提供了一种平均粒度为0.1-1,000μm的微凝胶，该微凝胶由凝胶制成，其通过使用能形成凝胶的亲水性化合物形成。含有微凝胶的外用组合物在使用过程中提供极好的感觉; 即，该组合物在使用期间既不提供粘性感，也不提供摩擦感。此外，即使在组合物中加入大量的增白成分或者盐等药物成分，也不会降低组合物的粘度，而且显示出优异的增粘性。此外，该组合物长期稳定，不会引起水分离。

3. 发明授权

US06391288B1 Microcapsule and method of making the same 有权
标题翻译：微胶囊及其制作方法
公开(公告)号：US06391288B1
公开(公告)日：2002-05-21
申请号：US09625504
申请日：2000-07-26
申请人： Kazuyuki Miyazawa , Isamu Kaneda , Toshio Yanaki
发明人： Kazuyuki Miyazawa , Isamu Kaneda , Toshio Yanaki
IPC分类号： A61K742
CPC分类号： A61Q19/00 , A61K8/0208 , A61K8/0212 , A61K8/11 , A61K8/73 , A61K9/5036 , A61K2800/28 , A61K2800/412 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q15/00 , A61Q17/04 , Y10S514/844 , Y10S514/937
摘要： A microcapsule of the present invention is characterized in that it encapsulate oil droplets having average particle size of 0.01 to 3 &mgr;m and its capsulating agent is a hydrophilic polymer gelling agent. The main component of the capsulating agent is preferably a hydrophilic polymer gelling agent which hardens by heating and cooling, and, in particular, agar or carrageenan. In the making method of the present invention, a microcapsule can be made efficiently due to no loss in the inner oil phase, and its particle size can easily be controlled. The microcapsule is excellent in shearing-resistance, store stability. Also, if the fracture strength of the microcapsule is within a specific range, a microcapsule which releasing characteristic of encapsulated oil droplets when applied is immediately-, gradually- or non-releasing can be obtained. Further, when such a hydrophilic microcapsule is coated, the contraction in air, dispersibility to various medium, and elusion of encapsulated components in medium can be also improved.
摘要翻译：本发明的微胶囊的特征在于，其包封平均粒度为0.01〜3μm的油滴，其包封剂为亲水性聚合物胶凝剂。封装剂的主要成分优选为通过加热和冷却而硬化的亲水性聚合物胶凝剂，特别是琼脂或角叉菜胶。在本发明的制造方法中，由于内部油相中没有损失，可以有效地制造微胶囊，并且可以容易地控制其粒径。该微胶囊具有优异的抗剪切性，稳定性。此外，如果微胶囊的断裂强度在特定范围内，则可以获得当施加时封装油滴的特性释放的微胶囊即时，逐渐或不释放。此外，当涂布这样的亲水性微胶囊时，也可以提高空气中的收缩，各种介质的分散性和包封成分在培养基中的脱落。

4. 发明申请

US20050222405A1 Polysaccharide containing phosphorylcholine group and process for producing the same 失效
标题翻译：含有磷酸胆碱的多糖组及其制备方法
公开(公告)号：US20050222405A1
公开(公告)日：2005-10-06
申请号：US10506771
申请日：2003-04-08
申请人： Kazuyuki Miyazawa , Toshio Yanaki , Francoise Winnik
发明人： Kazuyuki Miyazawa , Toshio Yanaki , Francoise Winnik
IPC分类号： A61L27/00 , A61K8/73 , A61Q19/00 , C08B11/20 , C08B15/00 , C08B15/06 , C08B37/00 , C08B37/02 , C08B37/08 , C07H13/06
CPC分类号： C08B37/0072 , A61K8/73 , A61K8/731 , A61K8/735 , A61Q19/00 , C08B11/20 , C08B15/06 , C08B37/00 , C08B37/0018 , C08B37/0021 , C08B37/003
摘要： The present invention is a method for manufacturing a phosphorylcholine group-containing polysaccharide wherein the aldehyde derivative-containing compound obtained by the oxidative ring-opening reaction of glycerophosphorylcholine is added to a polysaccharide containing amino groups as well as a new polysaccharide having phosphorylcholine groups obtained from this manufacturing method. The object of the present invention is to provide a phosphorylcholine group-containing polysaccharide that is superior in biocompatibility and moisture retention, and is useful as a polymer material for medical use, as well as a simple method of manufacturing it. The polysaccharide of the present invention is utilized, for example, in artificial organs, biomembranes, coating agents for medical tools, drug delivery, and in cosmetics.
摘要翻译：本发明是一种含有磷酰胆碱基团的多糖的制造方法，其中将通过甘油磷酰胆碱的氧化开环反应得到的含有醛衍生物的化合物加入到含有氨基的多糖中，以及具有磷酸胆碱基团的新型多糖，这种制造方法。本发明的目的是提供一种生物相容性和保湿性优异的含磷酰胆碱基团的多糖，作为医疗用聚合物材料，以及其制造方法简单。本发明的多糖可用于例如人造器官，生物膜，医疗工具用涂剂，药物输送和化妆品中。

5. 发明授权

US6127431A Protein removed .beta.-1,3 glucan and coupling medium for probe of ultrasonograph containing same 失效
标题翻译：蛋白质除去β-1,3葡聚糖和用于包含其的超声波探针的偶联介质
公开(公告)号：US6127431A
公开(公告)日：2000-10-03
申请号：US115744
申请日：1998-07-15
申请人： Kazuyuki Miyazawa , Toshio Yanaki
发明人： Kazuyuki Miyazawa , Toshio Yanaki
IPC分类号： G01N29/28 , A61B8/00 , C08B37/00 , G10K11/02 , B01J13/00 , C12P19/04
CPC分类号： G10K11/02 , C08B37/0024
摘要： There is provided a .beta.-1,3 glucan obtained by applying ultrasonic treatment in a mixed solution of an organic solvent containing at least dimethyl sulfoxide to remove the contaminant proteins and there is provided a coupling medium for a probe of an ultrasonograph comprised of a gel composed of a .beta.-1,3 glucan, as a main component, from which contaminant proteins have been removed as a coupling medium for a probe of an ultrasonograph superior in physical properties and safety.
摘要翻译：提供了通过在含有至少二甲基亚砜的有机溶剂的混合溶液中进行超声波处理以除去污染物蛋白而获得的β-1,3葡聚糖，并且提供了由凝胶组成的超声波检查仪的探针的偶联介质由作为主要组分的β-1,3葡聚糖组成，从物质特性和安全性优异的超声波检查仪的探针中除去杂质蛋白质。

6. 发明申请

US20090047312A1 Microgel and external compositions containing the same 有权
标题翻译：微凝胶和含有它们的外用组合物
公开(公告)号：US20090047312A1
公开(公告)日：2009-02-19
申请号：US12082130
申请日：2008-04-09
申请人： Kazuyuki Miyazawa , Isamu Kaneda , Toshio Yanaki , Tadashi Nakamura , Masatoshi Ochiai , Tomoyuki Kawasoe
发明人： Kazuyuki Miyazawa , Isamu Kaneda , Toshio Yanaki , Tadashi Nakamura , Masatoshi Ochiai , Tomoyuki Kawasoe
IPC分类号： A61K8/02 , A61Q5/00
CPC分类号： A61K8/042 , A61K8/0212 , A61K8/44 , A61K8/65 , A61K8/676 , A61K8/73 , A61K8/733 , A61K8/8147 , A61K8/8152 , A61K8/8158 , A61K8/86 , A61K8/97 , A61K8/982 , A61K9/0014 , A61K47/36 , A61K47/42 , A61K2800/412 , A61Q5/06 , A61Q5/065 , A61Q19/00 , A61Q19/02 , C08L5/00 , C08L5/04 , C08L5/12 , C08L89/06 , C08L2666/02
摘要： The present invention provides a microgel having a mean particle size of 0.1-1,000 μm, the microgel being produced from a gel which is formed by use of a hydrophilic compound capable of forming a gel. An external composition containing the microgel provides an excellent sensation during use; i.e., the composition provides neither sticky sensation during use nor frictional sensation. Furthermore, even when a large amount of a pharmaceutical ingredient, such as a whitening ingredient, or a salt is incorporated into the composition, the viscosity of the composition is not lowered, and the composition exhibits excellent viscosity increasing property. In addition, the composition exhibits long-term stability, without inviting separation of water.
摘要翻译：本发明提供了一种平均粒径为0.1-1000μm的微凝胶，该微凝胶由凝胶制成，其通过使用能形成凝胶的亲水性化合物形成。含有微凝胶的外用组合物在使用过程中提供极好的感觉; 即，该组合物在使用期间既不提供粘性感，也不提供摩擦感。此外，即使在组合物中加入大量的增白成分或者盐等药物成分，也不会降低组合物的粘度，而且显示出优异的增粘性。此外，该组合物长期稳定，不会引起水分离。

7. 发明授权

US06326011B1 Copolymer containing reactive silyl groups, composition containing the same and method of treatment with the same 有权
标题翻译：含有反应性甲硅烷基的共聚物，含有相同的组成和与之相同的处理方法
公开(公告)号：US06326011B1
公开(公告)日：2001-12-04
申请号：US09230582
申请日：1999-01-28
申请人： Kazuyuki Miyazawa , Toshio Yanaki , Fumiaki Matsuzaki
发明人： Kazuyuki Miyazawa , Toshio Yanaki , Fumiaki Matsuzaki
IPC分类号： A61K600
摘要： A copolymer having silyl groups with at least one reactive functional group bonded thereto. The copolymer comprises a monomer (A) shown by the following Formula (I): wherein R1 is hydrogen atom or methyl; R2 is alkylene group having 1-6 carbon atoms; and R3, R4 and R5 each is a reactive functional group which can cross-link molecules of the copolymer by hydrolyzing. Further, the copolymer preferably comprises, as a constituent monomer, an alkyl (meth)acrylate and a siloxane-containing (meth)acrylate. A coating-forming method comprises hydrolyzing the composition on a material to be treated to cross-link molecules of the copolymer when on the material. A coating of the cross-linked copolymer has resistance to washing. This coating can modify the nature of hair, improve make-up retention, and provide skin-protecting. It can impart water-repellency, resistance to fouling, suitability as a sizing and crease resistance to fibers. Further, it can improve a skin-cleaning effect, applicability, strippability and coating-strength of a peeling-off type cosmetic pack.
摘要翻译：具有与其键合有至少一个反应性官能团的甲硅烷基的共聚物。共聚物包含由下式（I）表示的单体（A）：其中R 1 是氢原子或甲基; R 2 是具有1-6个碳原子的亚烷基; 和R 3 ，R 4 和R 5 各自是可通过水解将共聚物分子交联的反应性官能团。此外，共聚物优选包含（甲基）丙烯酸烷基酯和含硅氧烷的（甲基）丙烯酸酯作为构成单体。涂覆形成方法包括在待处理的材料上水解组合物以在材料上交联共聚物的分子。交联共聚物的涂层具有耐洗涤性。这种涂层可以改变头发的性质，改善补妆保持性，并提供皮肤保护。它可以赋予防水性，耐污垢性，适合性作为纤维的上胶和抗折皱性。此外，它可以改善剥离型化妆品包装的皮肤清洁效果，适用性，剥离性和涂布强度。

8. 发明授权

US08551332B2 Affinity particle and affinity separation method 失效
标题翻译：亲和粒子和亲和力分离法
公开(公告)号：US08551332B2
公开(公告)日：2013-10-08
申请号：US12495936
申请日：2009-07-01
申请人： Katsuyuki Maeno , Kazuyuki Miyazawa , Akira Ishikubo , Kazuhiko Ishihara
发明人： Katsuyuki Maeno , Kazuyuki Miyazawa , Akira Ishikubo , Kazuhiko Ishihara
IPC分类号： B01D15/08
CPC分类号： B01J20/286 , B01D15/3804 , B01J20/28004 , B01J20/3204 , B01J20/3219 , B01J20/3242 , B01J20/3248 , B01J20/3259 , B01J20/3274 , B01J20/3285 , B01J2220/58 , C07F9/091 , G01N33/54393
摘要： The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of inorganic powder.The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing inexpensive inorganic particles and is capable of separating the target substance easily and with high accuracy.
摘要翻译：本发明是亲水性粒子，其特征在于将由下式（1）表示的磷酸胆碱基团共价键合到无机粉末的表面上，还可以通过将具有特定亲和力的配体与共价键合或吸附在无机粉末。本发明的目的是提供使用廉价的无机粒子的亲和粒子的亲和力分离方法，能够容易且高精度地分离目标物质。

9. 发明授权

US08318865B2 Eye lens material and method of manufacturing thereof 失效
标题翻译：眼镜片材料及其制造方法
公开(公告)号：US08318865B2
公开(公告)日：2012-11-27
申请号：US10593682
申请日：2005-05-18
申请人： Yukimitsu Suda , Kazuyuki Miyazawa , Kazuhiko Ishihara
发明人： Yukimitsu Suda , Kazuyuki Miyazawa , Kazuhiko Ishihara
IPC分类号： C08C19/24
CPC分类号： C08J7/12 , A61F2/16 , A61F2002/1699 , A61L27/28 , G02B1/043
摘要： The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded to the surface of an eye lens material having hydroxyl groups wherein the chemical compound represented by the following formula (2) is reacted and covalently bonded through ester-bonding to the eye lens material in an organic solvent.The object of the present invention is to provide an eye lens material that prevents protein adsorption and a method of manufacturing thereof.
摘要翻译：本发明是一种眼镜透镜材料的制造方法，其具有下述通式（1）所示的含磷酰胆碱基的化合物与具有羟基的眼晶状体材料的表面反应并共价键合的方法，其中，由下式（2）表示的化合物通过酯键在有机溶剂中与眼晶体材料反应并共价键合。本发明的目的是提供一种防止蛋白质吸附的眼用透镜材料及其制造方法。

10. 发明授权

US08277834B2 Method for producing protein adsorption-preventing ocular lens material 失效
标题翻译：产生蛋白质吸附防止眼透镜材料的方法
公开(公告)号：US08277834B2
公开(公告)日：2012-10-02
申请号：US10592772
申请日：2005-05-18
申请人： Yukimitsu Suda , Kazuyuki Miyazawa , Kazuhiko Ishihara
发明人： Yukimitsu Suda , Kazuyuki Miyazawa , Kazuhiko Ishihara
IPC分类号： A61K31/80
CPC分类号： C08J7/12 , A61F2/16 , G02B1/043
摘要： The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded onto the surface of an eye lens material wherein a chemical compound having an end amino group is introduced to said eye lens material and then the chemical compound represented by the following formula (2) or (3) is introduced through said chemical compound having an end amino group.The object of the present invention is to provide a method of manufacturing a contact lens that prevents protein adsorption.
摘要翻译：本发明是一种眼透镜材料的制造方法，其具有以下处理：将由下式（1）表示的含磷酰胆碱基的化合物反应并共价键合到眼晶状体材料的表面上，其中具有将末端氨基引入所述眼晶状体材料中，然后通过具有末端氨基的化合物引入由下式（2）或（3）表示的化合物。本发明的目的是提供一种制造防止蛋白质吸附的隐形眼镜的方法。

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