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1. 发明授权

US06780619B2 D-aminoacylase and gene encoding the same 失效
标题翻译： D-氨基酸酰化酶和编码相同的基因
公开(公告)号：US06780619B2
公开(公告)日：2004-08-24
申请号：US09770517
申请日：2001-01-26
申请人： Kazuya Mitsuhashi , Hiroaki Yamamoto , Akinobu Matsuyama , Shinji Tokuyama
发明人： Kazuya Mitsuhashi , Hiroaki Yamamoto , Akinobu Matsuyama , Shinji Tokuyama
IPC分类号： C12P1304
CPC分类号： C12N9/80 , C12P13/04 , C12P13/227 , C12P41/007
摘要： The present invention provides the D-aminoacylase-encoding gene derived from Hypomyces mycophilus, a filamentous fungus, the polypeptide encoded by the gene, and the homologues thereof. The D-aminoacylase of the present invention is capable of producing D-tryptophan from N-acetyl-D-tryptophan. D-tryptophan is useful as a medicinal raw material or the like.
摘要翻译：本发明提供了源自嗜酸菌的D-氨基酸酰化酶编码基因，丝状真菌，由该基因编码的多肽及其同源物。本发明的D-氨基酰化酶能够从N-乙酰基-D-色氨酸产生D-色氨酸。 D-色氨酸可用作药用原料等。

2. 发明授权

US06514742B1 D-aminoacylases, method for producing the same, and method for producing D-amino acids using the same 失效
公开(公告)号：US06514742B1
公开(公告)日：2003-02-04
申请号：US09361901
申请日：1999-07-27
申请人： Kazuya Mitsuhashi , Hiroaki Yamamoto , Akinobu Matsuyama , Shinji Tokuyama
发明人： Kazuya Mitsuhashi , Hiroaki Yamamoto , Akinobu Matsuyama , Shinji Tokuyama
IPC分类号： C12N978
CPC分类号： C12P13/04 , C12N9/80 , C12P41/007
摘要： D-aminoacylase derived from fungi is provided. The fungi capable of producing D-aminoacylase include those belonging to the genus Hypomyces, Fusarium, Auricularia, Pythium, and Menisporopsis. The fungal D-aminoacylase is useful for efficiently producing D-amino acids from N-acetyl-D-amino acids.

3. 发明授权

US06887697B2 D-aminoacylase and gene encoding the same 失效
标题翻译： D-氨基酸酰化酶和编码相同的基因
公开(公告)号：US06887697B2
公开(公告)日：2005-05-03
申请号：US10750026
申请日：2003-12-31
申请人： Kazuya Mitsuhashi , Hiroaki Yamamoto , Akinobu Matsuyama , Shinji Tokuyama
发明人： Kazuya Mitsuhashi , Hiroaki Yamamoto , Akinobu Matsuyama , Shinji Tokuyama
IPC分类号： C12N15/09 , C12N1/21 , C12N9/80 , C12N15/55 , C12P13/04 , C12P13/22 , C12P41/00 , C12Q1/68 , C12R1/19 , C12R1/645 , C12N9/78 , C07H21/04 , C07K1/00 , C12N9/10 , C12N9/14
CPC分类号： C12N9/80 , C12P13/04 , C12P13/227 , C12P41/007
摘要： The present invention provides the D-aminoacylase-encoding gene derived from Hypomyces mycophilus, a filamentous fungus, the polypeptide encoded by the gene, and the homologues thereof. The D-aminoacylase of the present invention is capable of producing D-tryptophan from N-acetyl-D-tryptophan. D-tryptophan is useful as a medicinal raw material or the like.
摘要翻译：本发明提供了源自嗜酸菌的D-氨基酸酰化酶编码基因，丝状真菌，由该基因编码的多肽及其同源物。本发明的D-氨基酰化酶能够从N-乙酰基-D-色氨酸产生D-色氨酸。 D-色氨酸可用作药用原料等。

4. 发明授权

US06905861B2 D-aminoacylases, method for producing the same, and method for producing D-amino acids using the same 失效
标题翻译： D-氨酰基酶，其制备方法，以及使用其制备D-氨基酸的方法
公开(公告)号：US06905861B2
公开(公告)日：2005-06-14
申请号：US10242378
申请日：2002-09-10
申请人： Kazuya Mitsuhashi , Hiroaki Yamamoto , Akinobu Matsuyama , Shinji Tokuyama
发明人： Kazuya Mitsuhashi , Hiroaki Yamamoto , Akinobu Matsuyama , Shinji Tokuyama
IPC分类号： C12N15/09 , C12N9/80 , C12N15/55 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/12 , C12P13/20 , C12P13/22 , C12P41/00 , C12R1/645 , C12R1/77 , C12N9/78
CPC分类号： C12P13/04 , C12N9/80 , C12P41/007
摘要： D-aminoacylase derived from fungi is provided. The fungi capable of producing D-aminoacylase include those belonging to the genus Hypomyces, Fusarium, Auricularia, Pythium, and Menisporopsis. The fungal D-aminoacylase is useful for efficiently producing D-amino acids from N-acetyl-D-amino acids.
摘要翻译：提供了从真菌得到的D-氨基酰化酶。能够产生D-氨基酸酰化酶的真菌包括属于Hypomyces属，Fusarium，Auricularia属，腐霉属和Menisporopsis属的那些真菌。真菌D-氨基酸酰化酶可有效地从N-乙酰基-D-氨基酸产生D-氨基酸。

5. 发明授权

US5916781A Method for producing D-tryptophan 失效
标题翻译： D-色氨酸的生产方法
公开(公告)号：US5916781A
公开(公告)日：1999-06-29
申请号：US5110
申请日：1998-01-09
申请人： Hiroaki Yamamoto , Kazuya Mitsuhashi , Akinobu Matsuyama , Fusao Tomita
发明人： Hiroaki Yamamoto , Kazuya Mitsuhashi , Akinobu Matsuyama , Fusao Tomita
IPC分类号： C12P13/22 , C12P41/00 , C12R1/01 , C12R1/05 , C12R1/15 , C12R1/18 , C12R1/19 , C12R1/22 , C12R1/37 , C12R1/40 , C12R1/425 , C12R1/64 , C12R1/84
CPC分类号： C12P41/001 , C12P13/227
摘要： The method for producing D-tryptophan with high optical purity and high yield is provided, which comprises contacting a mixture of D,L-tryptophan with organisms which produce tryptophanase to degrade L-tryptophan selectively, thereby increasing the content of D-tryptophan in D,L-tryptophan.
摘要翻译：提供了具有高光学纯度和高产率的D-色氨酸的制备方法，其包括使D，L-色氨酸的混合物与产生色氨酸酶的生物体接触以选择性降解L-色氨酸，从而增加D中的D-色氨酸含量，L-色氨酸。

6. 发明授权

US06902915B2 Heat-stable D-aminoacylase 失效
标题翻译：热稳定的D-氨基酸酰基酶
公开(公告)号：US06902915B2
公开(公告)日：2005-06-07
申请号：US10361509
申请日：2003-02-07
申请人： Shinji Tokuyama , Akinobu Matsuyama
发明人： Shinji Tokuyama , Akinobu Matsuyama
IPC分类号： C12N15/09 , C12N1/20 , C12N1/21 , C12N9/80 , C12N15/55 , C12P13/04 , C12P13/06 , C12P13/12 , C12P13/20 , C12P13/22 , C12R1/465 , C12N9/78 , C12P13/08
CPC分类号： C12R1/465 , C12N9/80 , C12P13/04
摘要： The present invention provides a novel D-aminoacylase, as well as method for producing a D-amino acid using the same. In order to achieve the above objective, the present inventors have succeeded in purifying heat-stable D-aminoacylase from microorganisms belonging to the genus Streptomyces by combining various purification methods. Furthermore, the present inventors found that the purified heat-stable D-aminoacylase is useful in industrial production of D-amino acids. By utilizing the heat-stable D-aminoacylase, it is possible to readily and efficiently produce the corresponding D-amino acids from N-acetyl-DL-amino acids (for example, N-acetyl-DL-methionine, N-acetyl-DL-valine, N-acetyl-DL-tryptophan, N-acetyl-DL-phenylalanine, N-acetyl-DL-alanine, N-acetyl-DL-leucine, and so on).
摘要翻译：本发明提供了一种新的D-氨基酸酰基酶，以及使用其制备D-氨基酸的方法。为了实现上述目的，本发明人通过组合各种纯化方法成功地从属于链霉菌属的微生物纯化热稳定的D-氨基酰化酶。此外，本发明人发现纯化的热稳定性D-氨基酸酰基酶可用于工业生产D-氨基酸。通过利用热稳定的D-氨基酸酰化酶，可以容易且有效地从N-乙酰基-DL-氨基酸（例如，N-乙酰基-DL-甲硫氨酸，N-乙酰基-DL- 缬氨酸，N-乙酰基-DL-色氨酸，N-乙酰基-DL-苯丙氨酸，N-乙酰基-DL-丙氨酸，N-乙酰基-DL-亮氨酸等）。

7. 发明授权

US06664083B2 Methods for racemizing N-acylamino acids and producing optically active amino acids 失效
公开(公告)号：US06664083B2
公开(公告)日：2003-12-16
申请号：US09794534
申请日：2001-02-27
申请人： Akinobu Matsuyama , Shinji Tokuyama
发明人： Akinobu Matsuyama , Shinji Tokuyama
IPC分类号： C12P1304
CPC分类号： C12P41/007 , C12P13/04
摘要： A method for racemizing with N-acylamino acid racemase (NAAR) derived from Sebekia benihana and a method for producing optically active amino acids using the racemaization method are provided. The racemase of the present invention can efficiently catalyze the racemization of acylamino acid substrates including N-acylalanine, N-acylaspartic acid, N-acylleucine, and N-acylvaline. Furthermore, this method can be applied to efficient production of optically active amino acids, which are useful, for example, as medicinal raw materials.

8. 发明授权

US06596528B2 Heat-stable D-aminoacylase 失效
公开(公告)号：US06596528B2
公开(公告)日：2003-07-22
申请号：US09921156
申请日：2001-08-02
申请人： Shinji Tokuyama , Akinobu Matsuyama
发明人： Shinji Tokuyama , Akinobu Matsuyama
IPC分类号： C12N980
CPC分类号： C12R1/465 , C12N9/80 , C12P13/04
摘要： The present invention provides a novel D-aminoacylase, as well as method for producing a D-amino acid using the same. In order to achieve the above objective, the present inventors have succeeded in purifying heat-stable D-aminoacylase from microorganisms belonging to the genus Streptomyces by combining various purification methods. Furthermore, the present inventors found that the purified heat-stable D-aminoacylase is useful in industrial production of D-amino acids. By utilizing the heat-stable D-aminoacylase, it is possible to readily and efficiently produce the corresponding D-amino acids from N-acetyl-DL-amino acids (for example, N-acetyl-DL-methionine, N-acetyl-DL-valine, N-acetyl-DL-tryptophan, N-acetyl-DL-phenylalanine, N-acetyl-DL-alanine, N-acetyl-DL-leucine, and so on).

9. 发明授权

US06255092B1 Stereospecific alcohol dehydrogenase isolated from Candida parapsilosis, amino acid and DNA sequences therefor, and method of preparation thereof 失效
标题翻译：从念珠菌分离的立体特异性醇脱氢酶，氨基酸及其DNA序列及其制备方法
公开(公告)号：US06255092B1
公开(公告)日：2001-07-03
申请号：US08855767
申请日：1997-06-11
申请人： Tomoko Kojima , Hiroaki Yamamoto , Naoki Kawada , Akinobu Matsuyama
发明人： Tomoko Kojima , Hiroaki Yamamoto , Naoki Kawada , Akinobu Matsuyama
IPC分类号： C12N904
CPC分类号： C12N9/0006 , C12P7/04 , C12P7/24 , C12P41/002
摘要： The present invention provides a novel secondary alcohol dehydrogenase useful for the synthesis of optically active alcohol and DNA encoding said enzyme. A microorganism belonging to genus Candida was found to produce a novel secondary alcohol dehydrogenase with a high stereochemical specificity. Using said enzyme, optically active alcohols were prepared, and by cloning of DNA encoding said enzyme, the base sequence of said DNA was determined. By providing a novel secondary alcohol dehydrogenase with a high stereochemical specificity and the gene encoding said enzyme, an efficient production of optically active alcohols became possible.
摘要翻译：本发明提供了可用于合成光学活性醇和编码所述酶的DNA的新型仲醇脱氢酶。发现属于念珠菌属的微生物产生具有高立体化学特异性的新型仲醇脱氢酶。使用所述酶制备光学活性醇，通过克隆编码所述酶的DNA，测定所述DNA的碱基序列。通过提供具有高立体化学特异性的新型仲醇脱氢酶和编码所述酶的基因，可以有效地制备光学活性醇。

10. 发明授权

US5763236A Method for producing ketone or aldehyde using an alcohol dehydrogenase of Candida Parapsilosis 失效
标题翻译：使用拟南非假丝酵母属酒精脱氢酶生产酮或醛的方法
公开(公告)号：US5763236A
公开(公告)日：1998-06-09
申请号：US713254
申请日：1996-09-12
申请人： Tomoko Kojima , Hiroaki Yamamoto , Naoki Kawada , Akinobu Matsuyama
发明人： Tomoko Kojima , Hiroaki Yamamoto , Naoki Kawada , Akinobu Matsuyama
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/04 , C12N15/00 , C12N15/53 , C12P7/04 , C12P7/24 , C12P7/26 , C12P41/00 , C12R1/19 , C12R1/72 , C12P7/16
CPC分类号： C12N9/0006 , C12P41/002 , C12P7/04 , C12P7/24
摘要： The present invention provides a novel secondary alcohol dehydrogenase useful for the synthesis of optically active alcohol and DNA encoding said enzyme. A microorganism belonging to genus Candida was found to produce a novel secondary alcohol dehydrogenase with a high stereochemical specificity. Using said enzyme, optically active alcohols were prepared, and by cloning of DNA encoding said enzyme, the base sequence of said DNA was determined. By providing a novel secondary alcohol dehydrogenase with a high stereochemical specificity and the gene encoding said enzyme, an efficient production of optically active alcohols became possible.
摘要翻译：本发明提供了可用于合成光学活性醇和编码所述酶的DNA的新型仲醇脱氢酶。发现属于念珠菌属的微生物产生具有高立体化学特异性的新型仲醇脱氢酶。使用所述酶制备光学活性醇，通过克隆编码所述酶的DNA，测定所述DNA的碱基序列。通过提供具有高立体化学特异性的新型仲醇脱氢酶和编码所述酶的基因，可以有效地制备光学活性醇。

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