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1. 发明授权

US06303350B1 Physiologically active substances TKR2449, process for producing the same, and microorganism 失效
标题翻译：生理活性物质TKR2449，其生产方法和微生物
公开(公告)号：US06303350B1
公开(公告)日：2001-10-16
申请号：US09445543
申请日：2000-03-07
申请人： Kazutoh Takesako , Mitsuhiro Ueno , Naoyuki Awazu , Yoko Uno , Ikunoshin Kato
发明人： Kazutoh Takesako , Mitsuhiro Ueno , Naoyuki Awazu , Yoko Uno , Ikunoshin Kato
IPC分类号： C12P1302
CPC分类号： C07C235/76 , C12P13/02 , Y10S435/911
摘要： The present invention has for its object to provide novel biologically active substances which is of value as a therapeutic agent for fungal infections and immune disorders. This invention is related to a biologically active substance TKR2449 analog(s) which is represented by the following general formula (A); (In the formula, R1, R2 and R3 are the same or differ each other, and each represents hydrogen or an alkyl group of carbon number of 1 to 4. R4 is a linear or branched alkyl or alkenyl group of carbon number of 1 to 8.).
摘要翻译：本发明的目的是提供新的生物活性物质，其作为真菌感染和免疫疾病的治疗剂是有价值的。本发明涉及由以下通式（A）表示的生物活性物质TKR2449类似物：（式中，R 1，R 2和R 3相同或不同，各自表示氢或碳数为1〜4的烷基.R 4为碳原子数为1〜8的直链或支链烷基或烯基。

2. 发明授权

US06337410B2 Antibiotic TKR459, production method, and microorganism 失效
标题翻译：抗生素TKR459，生产方法和微生物
公开(公告)号：US06337410B2
公开(公告)日：2002-01-08
申请号：US09731041
申请日：2000-12-07
申请人： Kazutoh Takesako , Mitsuhiro Ueno , Naoyuki Awazu , Kazuo Shimanaka , Ikunoshin Kato
发明人： Kazutoh Takesako , Mitsuhiro Ueno , Naoyuki Awazu , Kazuo Shimanaka , Ikunoshin Kato
IPC分类号： C07D31500
CPC分类号： C07D313/00 , C12P17/08
摘要： The present invention has its object to provide a noble antifungal substance which is use of as clinical medicine in the therapy of fungal infectious diseases. The present invention is related to an antibiotic TKR459 having the following chemical formula (1) or its pharmacologically acceptable salt.
摘要翻译：本发明的目的是提供一种在真菌感染性疾病的治疗中用作临床药物的贵重抗真菌物质。本发明涉及具有以下化学式（1）或其药理学上可接受的盐的抗生素TKR459。

3. 发明授权

US06333305B1 Antibiotic TKR2999, process for the preparation thereof and microbe 失效
标题翻译：抗生素TKR2999，其制备方法和微生物
公开(公告)号：US06333305B1
公开(公告)日：2001-12-25
申请号：US09582025
申请日：2000-08-02
申请人： Kazutoh Takesako , Naoyuki Awazu , Mitsuhiro Ueno , Yoshimi Onishi , Ikunoshin Kato
发明人： Kazutoh Takesako , Naoyuki Awazu , Mitsuhiro Ueno , Yoshimi Onishi , Ikunoshin Kato
IPC分类号： A01N3718
CPC分类号： C12R1/645 , A61K38/00 , C07K4/06 , C12P21/02
摘要： The antibiotic TKR2999 having the physicochemical properties described below and its pharmacologically acceptable salt: (1) FAB-MS m/z 971 [M+H)]+, (2) the molecular formula: C44H78N10O14, and high-resolution FAB-MS m/z 971.5776 [M+H]+, (3) the ultraviolet absorption spectrum in methanol has an end absorption, (4) the infrared absorption spectrum by KBr method shows the major absorption wave numbers at 3320, 2920, 1680, 1540, 1210, 1140, 840, 800, and 720 cm−1, (5) aspartic acid, threonine, serine, glycine, alanine, &bgr;-alanine, and ornithine are detected by the amino acid analysis using ninhydrin reaction, and (6) the solubility is that it is soluble in methanol, and practically insoluble in hexane, chloroform, and water.
摘要翻译：具有下述物理化学性质的抗生素TKR2999及其药理学上可接受的盐：（1）FAB-MS m / z 971 [M + H]] +，（2）分子式：C44H78N10O14和高分辨率FAB-MS m / z 971.5776 [M + H] +，（3）甲醇中的紫外吸收光谱具有终点吸收，（4）通过KBr方法的红外吸收光谱显示3320,2920,1680,1540,1210的主要吸收波数，1140,840,800和720cm -1，（5）通过使用茚三酮反应的氨基酸分析检测天冬氨酸，苏氨酸，丝氨酸，甘氨酸，丙氨酸，β-丙氨酸和鸟氨酸，和（6）溶解度它是溶于甲醇，几乎不溶于己烷，氯仿和水。

4. 发明授权

US06261826B1 Antibiotic TKR2648 and process for producing the same 失效
标题翻译：抗生素TKR2648及其生产方法
公开(公告)号：US06261826B1
公开(公告)日：2001-07-17
申请号：US09269437
申请日：1999-03-26
申请人： Kazutoh Takesako , Hideharu Saito , Mitsuhiro Ueno , Naoyuki Awazu , Ikunoshin Kato
发明人： Kazutoh Takesako , Hideharu Saito , Mitsuhiro Ueno , Naoyuki Awazu , Ikunoshin Kato
IPC分类号： C12N114
CPC分类号： A61K31/366 , C07D309/32 , C12P17/06
摘要： Antibitic TKR2648 having the following chemical formula (I) or its pharmacologically acceptable salt.
摘要翻译：具有以下化学式（I）的抗生素TKR2648或其药理学上可接受的盐。

5. 发明申请

US20060166924A1 Gene therapeutics 审中-公开
标题翻译：基因治疗
公开(公告)号：US20060166924A1
公开(公告)日：2006-07-27
申请号：US11390345
申请日：2006-03-28
申请人： Ikunoshin Kato , Kiyozo Asada , Mitsuhiro Ueno , Kimikazu Hashino , Hirofumi Yoshioka , Keiji Tanaka
发明人： Ikunoshin Kato , Kiyozo Asada , Mitsuhiro Ueno , Kimikazu Hashino , Hirofumi Yoshioka , Keiji Tanaka
IPC分类号： A61K48/00
CPC分类号： A61K48/00 , C12N15/86 , C12N2710/10043 , C12N2740/13043 , C12N2810/40
摘要： Gene therapeutics to be used in treating diseases showing sensitivity to gene therapy, characterized by containing as the active ingredient an efficacious amount of a functional substance which has a function of having an affinity for a virus containing a gene usable in the gene therapy and another function of having an affinity specific for a target cell with a need for the gene transfer, or an efficacious amount of a functional substance which has an affinity for the above virus and an efficacious amount of another functional substance which has an affinity specific for the above cell.
摘要翻译：用于治疗对基因治疗具有敏感性的疾病的基因疗法，其特征在于含有作为活性成分的有效量的具有对含有可用于基因治疗的基因的病毒具有亲和力的功能物质的功能物质，以及另一功能对具有基因转移需要的靶细胞具有亲和力的特异性，或对上述病毒具有亲和力的有效量的功能性物质和对上述细胞具有亲和力的有效量的另一种功能性物质。

6. 发明授权

US06787359B1 Gene transfer methods 有权
标题翻译：基因转移方法
公开(公告)号：US06787359B1
公开(公告)日：2004-09-07
申请号：US09743354
申请日：2001-01-09
申请人： Mitsuhiro Ueno , Hirofumi Yoshioka , Haruko Konishi , Kimikazu Hashino , Mio Morishita , Hideto Chono , Tsuyoshi Miyamura , Mutsumi Sano , Kiyozo Asada , Kei Fujinaga , Ikunoshin Kato
发明人： Mitsuhiro Ueno , Hirofumi Yoshioka , Haruko Konishi , Kimikazu Hashino , Mio Morishita , Hideto Chono , Tsuyoshi Miyamura , Mutsumi Sano , Kiyozo Asada , Kei Fujinaga , Ikunoshin Kato
IPC分类号： C12N1563
CPC分类号： C12N15/86 , A61K48/00 , C12N2740/13043 , C12N2740/13045 , C12N2810/10 , C12N2810/80 , C12N2810/851 , C12N2810/859
摘要： Improved methods for transferring a gene into target cells by using a retrovirus, wherein the gene transfer efficiency is improved and the target cells are efficiently transformed by binding the retrovirus to a functional substance which is immobilized on as carrier and having an activity of binding to retroviruses followed by washing; using an antibody capable of specifically recognizing cells, laminin or mannose-rich type sugar chain as a substance having an activity of binding to the target cells; pre-treating the target cells so as to inactivate transferrin receptor, or introducing a new functional group into the functional substance.
摘要翻译：通过使用逆转录病毒将基因转移到靶细胞中的改进方法，其中基因转移效率得到改善，并且通过将逆转录病毒结合到固定在载体上并具有结合逆转录病毒活性的功能物质来有效转化靶细胞随后洗涤; 使用能够特异性识别细胞的抗体，层粘连蛋白或富甘糖型糖链作为具有与靶细胞结合的活性的物质; 预处理靶细胞以使转铁蛋白受体失活，或将新的官能团引入功能物质。

7. 发明授权

US06995010B1 Gene transfer method 失效
标题翻译：基因转移法
公开(公告)号：US06995010B1
公开(公告)日：2006-02-07
申请号：US10111708
申请日：2000-10-23
申请人： Takashi Ueno , Hajime Matsumura , Keiji Tanaka , Tomoko Iwasaki , Mitsuhiro Ueno , Kei Fujinaga , Kiyozo Asada , Ikunoshin Kato
发明人： Takashi Ueno , Hajime Matsumura , Keiji Tanaka , Tomoko Iwasaki , Mitsuhiro Ueno , Kei Fujinaga , Kiyozo Asada , Ikunoshin Kato
IPC分类号： C12N5/16 , C12N15/861 , C12N15/864 , A61K48/00
CPC分类号： C12N15/86 , C12N2710/10343 , C12N2800/30
摘要： A method of transferring a foreign gene into cells, characterized by involving: the step of transferring into the cells with the use of an adenovirus vector, a first nucleic acid, which has a sequence provided with adeno-associated virus-origin ITRs in both sides of the target foreign gene to be transferred, and a second nucleic acid, which has an adeno-associated virus-origin rep gene and a promoter for expressing this gene and carries a stuffer sequence inserted thereinto sandwiched in two recombinase recognition sequences and located between the rep gene and the promoter; and the step of expressing the Rep protein under the action of recombinase in the cells obtained in the above step to thereby integrate the target foreign gene into the chromosomal DNA.
摘要翻译：将外源基因转移到细胞中的方法，其特征在于包括：使用腺病毒载体转移到细胞中的步骤，第一核酸，其具有在两侧具有腺相关病毒起源ITR的序列的待转移的目标外源基因的第二核酸和具有腺相关病毒起源rep基因的第二核酸和用于表达该基因的启动子，并携带插入其中的填充序列夹在两个重组酶识别序列中并位于 rep基因和启动子; 以及在上述步骤中获得的细胞中在重组酶的作用下表达Rep蛋白的步骤，从而将靶外源基因整合到染色体DNA中。

8. 发明申请

US20080206873A1 COMPLEX 审中-公开
标题翻译：复杂
公开(公告)号：US20080206873A1
公开(公告)日：2008-08-28
申请号：US11748003
申请日：2007-05-14
申请人： Hideto Chono , Hajime Matsumura , Mitsuhiro Ueno , Ikunoshin Kato
发明人： Hideto Chono , Hajime Matsumura , Mitsuhiro Ueno , Ikunoshin Kato
IPC分类号： C12N15/74 , C12N15/00
CPC分类号： C12N15/907 , A01K2217/05 , A61K48/00 , C07K14/005 , C12N15/86 , C12N15/90 , C12N2740/13022 , C12N2740/13043
摘要： A complex comprising a double-stranded DNA containing a terminal repeated sequence originating in a retrovirus and a DNA having a base sequence which does not occur in this retrovirus and a retrovirus-origin protein component.
摘要翻译：包含含有源自逆转录病毒的末端重复序列的双链DNA和在该逆转录病毒中不发生碱基序列的DNA和逆转录病毒起始蛋白质组分的复合物。

9. 发明申请

US20080080359A1 Optical pickup unit and disk drive unit 审中-公开
标题翻译：光学拾取单元和磁盘驱动单元
公开(公告)号：US20080080359A1
公开(公告)日：2008-04-03
申请号：US11898256
申请日：2007-09-11
申请人： Yuji Tamenori , Mitsuhiro Ueno , Kazuhito Kurita , Tadami Nakamura
发明人： Yuji Tamenori , Mitsuhiro Ueno , Kazuhito Kurita , Tadami Nakamura
IPC分类号： G11B17/30
CPC分类号： G11B17/056
摘要： An optical pickup unit, including: a base chassis; a disk table mounted to the base chassis for chucking an optical disk to be able to freely rotate; an optical pickup that records and/or reproduces an information signal with respect to the optical disk; a guide shaft supported by the base chassis, and guides the optical pickup to move in a diameter direction of the optical disk; and a pickup transfer mechanism including a lead screw supported parallel to the guide shaft and engaged with the optical pickup via a rack member, and a drive motor for rotate-driving the lead screw. In the optical pickup unit, the drive motor is disposed out of a projection area of, with respect to the base chassis, the optical disk chucked to the disk table.
摘要翻译：一种光学拾取单元，包括：基座; 安装到基座的盘台，用于夹紧光盘以能够自由旋转; 记录和/或再现关于光盘的信息信号的光学拾取器; 由所述底架支撑的引导轴，并且引导所述光拾取器沿所述光盘的直径方向移动; 以及拾取器传送机构，其包括平行于所述引导轴支撑并经由齿条构件与所述光学拾取器配合的引导螺杆，以及用于旋转所述丝杠的驱动马达。在光学拾取单元中，驱动马达设置在相对于底架的投影区域中，该光盘被卡在盘台上。

10. 发明授权

US07706839B2 Information processing device, information processing method, and information processing program 有权
标题翻译：信息处理装置，信息处理方法和信息处理程序
公开(公告)号：US07706839B2
公开(公告)日：2010-04-27
申请号：US11271649
申请日：2005-11-10
申请人： Mitsuhiro Ueno
发明人： Mitsuhiro Ueno
IPC分类号： H04B1/38
CPC分类号： H04B1/3816 , H04M1/0214 , H04M1/72522 , H04M2250/14 , H04W8/205 , H04W88/02 , H04W92/08
摘要： An information processing device including a communication device. The information device, an information processing method, and an information processing program use a plurality of SIM cards having different recorded information and enable reading of the information from the SIM cards and writing into the SIM cards, thereby improving the convenience of the SIM cards. The information processing device includes a communication device (48) communicating with an external communication device via a communication line and uses a plurality of SIM cards, SIM card I (361) and SIM card II (362) having different storage information. The information processing device includes an information processing part (CPU 40) for selecting a SIM card according to selection information specifying a SIM card and reading or writing SIM card information between the selected SIM card and the communication device.
摘要翻译：一种包括通信设备的信息处理设备。信息装置，信息处理方法和信息处理程序使用具有不同记录信息的多个SIM卡，并且能够从SIM卡读取信息并写入SIM卡，从而提高SIM卡的便利性。信息处理装置包括通过通信线与外部通信装置通信的通信装置（48），并且使用具有不同存储信息的多个SIM卡SIM卡I（361）和SIM卡II（362）。信息处理装置包括：信息处理部（CPU40），用于根据指定SIM卡的选择信息选择SIM卡，并在所选择的SIM卡和通信装置之间读取或写入SIM卡信息。

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