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1. 发明申请

US20080286785A1 Method to predict or monitor the response of a patient to an erbb receptor drug 审中-公开
标题翻译：预测或监测患者对erbb受体药物反应的方法
公开(公告)号：US20080286785A1
公开(公告)日：2008-11-20
申请号：US12080959
申请日：2008-04-07
申请人： Kazuto Nishio , Hideharu Kimura , Kazuo Kasahara
发明人： Kazuto Nishio , Hideharu Kimura , Kazuo Kasahara
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： The invention provides a method of detecting ErbB receptor mutations comprising the steps of providing a bio-fluid sample from a patient; extracting DNA from said sample; and screening said DNA for the presence of one or more mutations that alter tyrosine kinase activity in the receptor.
摘要翻译：本发明提供了一种检测ErbB受体突变的方法，其包括从患者提供生物流体样品的步骤; 从所述样品中提取DNA; 并筛选出所述DNA存在一种或多种改变受体中酪氨酸激酶活性的突变。

2. 发明申请

US20110300364A1 POLYMER SHEET AND METHOD FOR PRODUCING SAME 有权
标题翻译：聚合物片及其制造方法
公开(公告)号：US20110300364A1
公开(公告)日：2011-12-08
申请号：US13138212
申请日：2010-01-21
申请人： Masamichi Hikosaka , Kiyoka Okada , Kaori Watanabe , Junichiro Washiyama , Hideharu Kimura , Koji Yamada , Takeshi Nakajima , Akihiro Otsubo
发明人： Masamichi Hikosaka , Kiyoka Okada , Kaori Watanabe , Junichiro Washiyama , Hideharu Kimura , Koji Yamada , Takeshi Nakajima , Akihiro Otsubo
IPC分类号： B32B27/32 , B29C43/24
CPC分类号： B29C47/14 , B29C47/0004 , B29C47/0019 , B29C47/0021 , B29C47/8845 , B29C47/8895 , B29K2023/12 , B29K2105/162 , B29K2105/256 , B29K2995/0017 , B29K2995/0026 , B29K2995/0077 , C08J5/18 , C08J2323/12 , Y10T428/254 , Y10T428/31855
摘要： A polymer sheet according to at least one embodiment of the present invention is a polymer sheet whose main component is oriented nanocrystals of a polymer, and which satisfies the following conditions (I), (II), and (III): (I) having a crystallinity of not less than 70%; (II) having a tensile strength at break of not less than 100 MPa and a tensile modulus of not less than 3 GPa; and (III) having an average thickness of not less than 0.15 mm. According to at least one embodiment of the present invention, it is possible to provide a polymer sheet excelling in properties such as mechanical strength, heat tolerance, and transparency, particularly a polymer sheet having excellent properties such as mechanical strength, heat tolerance, and transparency in general-purpose plastics such as polypropylene.
摘要翻译：根据本发明的至少一个实施方式的聚合物片是其主要成分为聚合物的取向纳米晶体的聚合物片材，其满足以下条件（I），（II）和（III）：（I）具有结晶度不小于70％; （II），断裂拉伸强度为100MPa以上，拉伸弹性模量不小于3GPa; 和（III）的平均厚度不小于0.15mm。根据本发明的至少一个实施方案，可以提供具有机械强度，耐热性和透明性等特性优异的聚合物片材，特别是具有优异性能例如机械强度，耐热性和透明性的聚合物片材在通用塑料如聚丙烯中。

3. 发明授权

US5714569A Aliphatic polyester resin and method for producing same 失效
标题翻译：脂肪族聚酯树脂及其制造方法
公开(公告)号：US5714569A
公开(公告)日：1998-02-03
申请号：US696997
申请日：1996-08-21
申请人： Mitsuhiro Imaizumi , Hideharu Kimura , Ryutaro Fujihira , Yasushi Ichikawa , Jun Suzuki , Yoshihiro Moteki , Takashi Fujimaki , Eiichiro Takiyama
发明人： Mitsuhiro Imaizumi , Hideharu Kimura , Ryutaro Fujihira , Yasushi Ichikawa , Jun Suzuki , Yoshihiro Moteki , Takashi Fujimaki , Eiichiro Takiyama
IPC分类号： C08G18/42 , C08G18/80 , C08G63/20 , C08G63/685 , C08G63/91 , C08L101/16 , C08G63/02
CPC分类号： C08G18/4241 , C08G18/4238 , C08G18/8022 , C08G63/20 , C08G63/91 , C08G2230/00
摘要： An aliphatic polyester resin having a .lambda. value representing the magnitude of non-linearity of elongational viscosity of 1.5 to 8.0, said .lambda. value being defined by the following formula (1): .lambda.=.lambda..sub.1 /.lambda..sub.0 ( 1) wherein .lambda..sub.0 denotes the elongational viscosity at the transition point and .lambda..sub.1 denotes the elongational viscosity when strain become twice that of a transition point, said transition point meaning a point between a linear region, i.e., the infinitesimal-deformation region, and a non-linear region, i.e., the large-deformation region. According to the present invention, an aliphatic polyester resin having excellent formability and forming stability as well as good biodegradability is provided.
摘要翻译： PCT No.PCT / JP95 / 02616 Sec。 371日期：1996年8月21日 102（e）日期1996年8月21日PCT提交1995年12月20日PCT公布。出版物WO96 / 日期1996年6月27日具有λ值为拉伸粘度非线性大小的λ值为1.5〜8.0的脂肪族聚酯树脂，所述λ值由下式（1）定义：λ=λ1 /λ0（1 ）其中λ0表示转变点处的伸长粘度，λ1表示当应变变为转变点的两倍时的拉伸粘度，所述转变点表示线性区域即无穷小变形区域和非线性区域，即大变形区域。根据本发明，提供了具有优异的成形性和形成稳定性以及良好生物降解性的脂肪族聚酯树脂。

4. 发明授权

US09138933B2 Process and apparatus for producing crystalline resin film or sheet 有权
标题翻译：用于生产结晶树脂膜或片的方法和装置
公开(公告)号：US09138933B2
公开(公告)日：2015-09-22
申请号：US13146009
申请日：2010-01-22
申请人： Junichiro Washiyama , Hideharu Kimura , Koji Yamada , Takeshi Nakajima , Akihiro Otsubo , Masamichi Hikosaka , Kiyoka Okada , Kaori Watanabe
发明人： Junichiro Washiyama , Hideharu Kimura , Koji Yamada , Takeshi Nakajima , Akihiro Otsubo , Masamichi Hikosaka , Kiyoka Okada , Kaori Watanabe
IPC分类号： B29C47/00 , B29C47/36 , B29C33/58 , B29C43/22 , B29C47/32 , B29C47/92 , C08J5/18 , B29C47/38 , B29C47/34 , B29C47/88 , B29K23/00 , B29K25/00 , B29K27/06 , B29L7/00
CPC分类号： B29C47/364 , B29C33/58 , B29C43/222 , B29C47/0019 , B29C47/0021 , B29C47/004 , B29C47/0057 , B29C47/32 , B29C47/34 , B29C47/367 , B29C47/38 , B29C47/884 , B29C47/8845 , B29C47/888 , B29C47/92 , B29C2947/92019 , B29C2947/92095 , B29C2947/92152 , B29C2947/92209 , B29C2947/9238 , B29C2947/9258 , B29C2947/9259 , B29C2947/926 , B29C2947/92647 , B29C2947/92704 , B29C2947/92885 , B29C2947/92923 , B29K2023/00 , B29K2023/04 , B29K2023/10 , B29K2025/04 , B29K2027/06 , B29K2995/0041 , B29L2007/008 , C08J5/18 , C08J2323/12
摘要： A process and apparatus for manufacturing a crystalline resin film or sheet. This manufacturing apparatus includes: an extruder that melts crystalline resin while supplying it; a gear pump that is provided on the downstream side of the extruder; a die which is provided on the downstream side of the gear pump, and which has a slit-shaped aperture; a cooling apparatus which cools film-shaped or sheet-shaped crystalline resin (A) discharged in a melted state from the die to a temperature which is not less than the crystallization temperature but not more than the melting point; and a pair of pinch rolls that press-roll between them the film-shaped or sheet-shaped crystalline resin (B) which has passed through the cooling apparatus (40), wherein the pair of guide rolls are positioned such that the thickness of the film-shaped or sheet-shaped crystalline resin (B) which has passed through the cooling apparatus is between 1.3 and 8.0 times the thickness of the film or sheet (C, D) after it has been press-rolled.
摘要翻译：用于制造结晶树脂膜或片的方法和装置。该制造装置包括：挤出机，其在供给时熔化结晶性树脂; 设置在挤出机的下游侧的齿轮泵; 模具，其设置在齿轮泵的下游侧，并且具有狭缝形孔; 将从熔融状态排出的膜状或片状结晶性树脂（A）从模具冷却至不低于结晶温度但不高于熔点的温度的冷却装置; 以及一对夹送辊，其在它们之间挤压已经通过冷却装置（40）的膜状或片状结晶树脂（B），其中一对导辊定位成使得已经通过冷却装置的膜状或片状结晶性树脂（B）在被压制后的膜或片（C，D）的厚度的1.3〜8.0倍。

5. 发明授权

US08962115B2 Fire-resistant piping material 有权
标题翻译：防火管道材料
公开(公告)号：US08962115B2
公开(公告)日：2015-02-24
申请号：US12733359
申请日：2007-08-29
申请人： Masashi Okabe , Koji Ichihara , Hideharu Kimura , Toshifumi Sanni
发明人： Masashi Okabe , Koji Ichihara , Hideharu Kimura , Toshifumi Sanni
IPC分类号： F16L11/12 , C08K3/04 , B32B1/08 , B32B27/18 , B32B27/30 , F16L5/04 , F16L55/10 , F16L59/14 , C08L27/06
CPC分类号： C08K3/04 , B32B1/08 , B32B13/12 , B32B21/08 , B32B27/18 , B32B27/30 , B32B27/32 , B32B27/322 , B32B27/40 , B32B2270/00 , B32B2274/00 , B32B2307/3065 , B32B2307/308 , B32B2307/718 , B32B2597/00 , C08L27/06 , F16L5/04 , F16L55/1026 , F16L59/145 , Y10T428/1352 , Y10T428/1359 , Y10T428/1379 , Y10T428/139 , Y10T428/1393
摘要： It is an object to provide a fire-resistant piping material that can be fire-protection measures by itself and is excellent in construction workability. A single-layered fire-resistant piping material according to the present invention is constituted of a fire-resistant resin composition containing heat-expandable graphite in an amount of 1 to 10 parts by weight based on 100 parts by weight of a polyvinyl chloride-based resin. A multilayered fire-resistant piping material according to the present invention includes a tubular fire-resistant expandable layer made of a heat-expandable fire-resistant resin composition and a covering layer covering at least one of the outer surface and the inner surface of the fire-resistant expandable layer, and the fire-resistant expandable layer is formed of a fire-resistant resin composition containing heat-expandable graphite in an amount of 1 to 15 parts by weight based on 100 parts by weight of a polyvinyl chloride-based resin, and the covering layer is formed of a polyvinyl chloride-based resin composition not containing heat-expandable fire-resistant materials.
摘要翻译：本发明的目的是提供一种耐火管道材料，其自身可以是防火措施，并且具有优异的施工作业性。根据本发明的单层耐火管道材料由耐热树脂组合物构成，耐火树脂组合物含有相对于聚氯乙烯系100重量份为1〜10重量份的热膨胀性石墨树脂。根据本发明的多层耐火管道材料包括由热膨胀性耐火树脂组合物制成的管状耐火膨胀层和覆盖火的外表面和内表面中的至少一个的覆盖层耐火可膨胀层，耐火可膨胀层由含有热可膨胀石墨的耐火树脂组合物形成，所述耐火树脂组合物的含量为基于100重量份的聚氯乙烯类树脂为1〜15重量份，覆盖层由不含热膨胀性耐火材料的聚氯乙烯类树脂组合物形成。

6. 发明申请

US20140051823A1 METHOD FOR PRODUCING ALIPHATIC POLYESTER HAVING INCREASED MOLECULAR WEIGHT 有权
标题翻译：生产具有增加的分子量的脂肪族聚酯的方法
公开(公告)号：US20140051823A1
公开(公告)日：2014-02-20
申请号：US14009896
申请日：2012-01-17
申请人： Yasushi Ichikawa , Hideharu Kimura , Akira Ishii
发明人： Yasushi Ichikawa , Hideharu Kimura , Akira Ishii
IPC分类号： C08G63/78
CPC分类号： C08G63/78 , C08G18/4238 , C08G18/73 , C08G63/916 , Y02P20/149
摘要： The problem to be solved by the present invention is to provide a method for continuously and effectively producing an aliphatic polyester having an increased molecular weight which prevents evaporation of diisocyanate at the step of mixing the diisocyanate with the aliphatic polyester prepolymer in a molten state at a temperature not lower than the melting point of the prepolymer and enables uniform mixing of the diisocyanate with the aliphatic polyester prepolymer. In order to solve this problem, the present invention provides a method for producing an aliphatic polyester having an increased molecular weight comprising the steps of: (i) quantitatively injecting a diisocyanate into an aliphatic polyester prepolymer which has a number average molecular weight of 5000 or higher and has terminal hydroxyl groups and in which at least one acid component is a succinic acid compound, in a molten state at a temperature not lower than the melting point thereof, wherein the amount of diisocyanate is equivalent to between one tenth and two times the amount of the hydroxyl groups in the aliphatic polyester prepolymer, (ii) quantitatively and continuously mixing the diisocyanate-containing aliphatic polyester prepolymer obtained at step (i) by a static mixer, discharging same from the static mixer, and then supplying same to a coupling reaction tank, and (iii) reacting the aliphatic polyester prepolymer with the diisocyanate in the coupling reaction tank.
摘要翻译：本发明要解决的问题是提供一种连续有效地制造具有增加的分子量的脂族聚酯的方法，该方法在熔融状态下将二异氰酸酯与脂族聚酯预聚物混合在一起的步骤中防止二异氰酸酯蒸发温度不低于预聚物的熔点，可使二异氰酸酯与脂族聚酯预聚物均匀混合。为了解决这个问题，本发明提供一种生产分子量增加的脂族聚酯的方法，包括以下步骤：（i）将二异氰酸酯定量注入数均分子量为5000的脂族聚酯预聚物或更高且具有末端羟基，并且其中至少一种酸组分是琥珀酸化合物，在不低于其熔点的温度下处于熔融状态，其中二异氰酸酯的量等于十二分之一到二分之一脂肪族聚酯预聚物中的羟基量，（ii）通过静态混合器将步骤（i）中获得的含二异氰酸酯的脂族聚酯预聚物定量连续混合，从静态混合器中排出，然后将其提供给偶联剂反应罐，和（iii）在偶联反应槽中使脂族聚酯预聚物与二异氰酸酯反应。

7. 发明授权

US08852517B2 Method for producing aliphatic polyester having increased molecular weight 有权
标题翻译：具有分子量增加的脂肪族聚酯的制造方法
公开(公告)号：US08852517B2
公开(公告)日：2014-10-07
申请号：US13997364
申请日：2011-04-19
申请人： Yasushi Ichikawa , Hideharu Kimura , Akira Ishii
发明人： Yasushi Ichikawa , Hideharu Kimura , Akira Ishii
IPC分类号： B01J19/20 , C08G18/42 , C08G18/73 , C08G18/08
CPC分类号： C08G18/4238 , B01F7/169 , B01F7/18 , B01F15/028 , C08G18/0895 , C08G18/73 , C08G63/916 , Y02P20/149
摘要： The present invention addresses the problem of providing a method for continuously and effectively producing an aliphatic polyester having an increased molecular weight by preventing evaporation of a diisocyanate when blending the diisocyanate with an aliphatic polyester prepolymer in a molten state at a temperature not lower than the melting point thereof so that the diisocyanate and the aliphatic polyester prepolymer are uniformly blended.In order to solve the above-mentioned problem, the present invention provides a method for producing an aliphatic polyester having an increased molecular weight comprising the steps of (i) quantitatively injecting a diisocyanate into an aliphatic polyester prepolymer which has a number average molecular weight of 5,000 or higher and has terminal hydroxyl groups and in which at least one acid component is a succinic acid compound, in a melting state at a temperature not lower than the melting point thereof wherein the amount of the diisocyanate is equivalent to between one tenth and two times the amount of hydroxyl groups in the aliphatic polyester prepolymer, (ii) quantitatively and continuously introducing the diisocyanate-containing aliphatic polyester prepolymer obtained at the step (i) into a mixing tank, discharging same from the mixing tank under stirring and supplying it to a coupling reaction tank, and (iii) reacting the aliphatic polyester prepolymer with the diisocyanate in the coupling reaction tank.
摘要翻译：本发明的目的在于提供一种连续而有效地制造分子量增加的脂肪族聚酯的方法，该方法通过防止二异氰酸酯与脂肪族聚酯预聚物在不低于熔点点，使得二异氰酸酯和脂肪族聚酯预聚物均匀混合。为了解决上述问题，本发明提供了具有增加的分子量的脂肪族聚酯的制造方法，其特征在于，包括以下步骤：（i）将二异氰酸酯定量注入脂族聚酯预聚物中，所述脂族聚酯预聚物的数均分子量为 5,000以上，具有末端羟基，其中至少一种酸成分为琥珀酸化合物，在不低于其熔点的熔融状态下，二异氰酸酯的量相当于十分之一至二十分之一（ii）将步骤（i）中得到的含二异氰酸酯的脂肪族聚酯预聚物定量连续地引入混合槽中，在搅拌槽中从混合槽中排出，并将其供给到偶联反应槽，和（iii）使脂族聚酯预聚物与二异氰酸酯在t中反应他耦合反应罐。

8. 发明申请

US20100173109A1 FIRE-RESISTANT PIPING MATERIAL 有权
标题翻译：防火管材
公开(公告)号：US20100173109A1
公开(公告)日：2010-07-08
申请号：US12733359
申请日：2007-08-29
申请人： Masashi Okabe , Koji Ichihara , Hideharu Kimura , Toshifumi Sanni
发明人： Masashi Okabe , Koji Ichihara , Hideharu Kimura , Toshifumi Sanni
IPC分类号： B32B1/08 , C08K3/04 , C08K5/09
CPC分类号： C08K3/04 , B32B1/08 , B32B13/12 , B32B21/08 , B32B27/18 , B32B27/30 , B32B27/32 , B32B27/322 , B32B27/40 , B32B2270/00 , B32B2274/00 , B32B2307/3065 , B32B2307/308 , B32B2307/718 , B32B2597/00 , C08L27/06 , F16L5/04 , F16L55/1026 , F16L59/145 , Y10T428/1352 , Y10T428/1359 , Y10T428/1379 , Y10T428/139 , Y10T428/1393
摘要： It is an object to provide a fire-resistant piping material that can be fire-protection measures by itself and is excellent in construction workability. A single-layered fire-resistant piping material according to the present invention is constituted of a fire-resistant resin composition containing heat-expandable graphite in an amount of 1 to 10 parts by weight based on 100 parts by weight of a polyvinyl chloride-based resin. A multilayered fire-resistant piping material according to the present invention includes a tubular fire-resistant expandable layer made of a heat-expandable fire-resistant resin composition and a covering layer covering at least one of the outer surface and the inner surface of the fire-resistant expandable layer, and the fire-resistant expandable layer is formed of a fire-resistant resin composition containing heat-expandable graphite in an amount of 1 to 15 parts by weight based on 100 parts by weight of a polyvinyl chloride-based resin, and the covering layer is formed of a polyvinyl chloride-based resin composition not containing heat-expandable fire-resistant materials.
摘要翻译：本发明的目的是提供一种耐火管道材料，其自身可以是防火措施，并且具有优异的施工作业性。根据本发明的单层耐火管道材料由耐热树脂组合物构成，耐火树脂组合物含有相对于聚氯乙烯系100重量份为1〜10重量份的热膨胀性石墨树脂。根据本发明的多层耐火管道材料包括由热膨胀性耐火树脂组合物制成的管状耐火膨胀层和覆盖火的外表面和内表面中的至少一个的覆盖层耐火可膨胀层，耐火可膨胀层由含有热可膨胀石墨的耐火树脂组合物形成，所述耐火树脂组合物的含量为基于100重量份的聚氯乙烯类树脂为1〜15重量份，覆盖层由不含热膨胀性耐火材料的聚氯乙烯类树脂组合物形成。

9. 发明授权

US5314927A Polyester foamed articles and method for producing the same 失效
标题翻译：聚酯发泡制品及其制备方法
公开(公告)号：US5314927A
公开(公告)日：1994-05-24
申请号：US48412
申请日：1993-04-20
申请人： Haruhiko Kondo , Mitsuhiro Imaizumi , Ryosuke Kamei , Hideharu Kimura , Eiichiro Takiyama
发明人： Haruhiko Kondo , Mitsuhiro Imaizumi , Ryosuke Kamei , Hideharu Kimura , Eiichiro Takiyama
IPC分类号： B32B27/10 , B32B27/36 , C08G18/08 , C08G18/42 , C08G18/48 , C08G63/16 , C08G63/20 , C08G63/91 , C08J5/18 , C08J9/04 , C08J9/06 , C08J9/14 , C08J9/18 , D01D5/42 , D01F6/62 , D01F6/70 , C08G18/00
CPC分类号： C08J9/18 , B32B27/10 , B32B27/36 , C08G18/0895 , C08G18/4236 , C08G18/4238 , C08G18/4241 , C08G18/4283 , C08G18/4286 , C08G18/4854 , C08G63/16 , C08G63/20 , C08G63/916 , C08J5/18 , C08J9/04 , C08J9/06 , C08J9/14 , D01D5/42 , D01F6/625 , D01F6/70 , C08G2101/00 , C08G2101/0008 , C08G2230/00 , C08G2250/00 , C08J2201/03 , C08J2367/00 , C08J2367/02 , C08J2375/06
摘要： A method for producing polyester foamed articles comprising: heating and foaming a resin composition comprising a foaming agent, and an aliphatic polyester having a melt viscosity of 1.0.times.10.sup.3 -1.0.times.10.sup.6 poises at a temperature of 190.degree. C. and a shear rate of 100 sec.sup.-1, and having a melting point of 70.degree.-190.degree. C. Extrusion or forming in a mold using preexpanded beads can be applied. The foamed articles such as insulating boxes and cushioning materials have biodegradability and excellent mechanical properties such as tensile strength and cushioning properties.
摘要翻译：一种生产聚酯发泡制品的方法，包括：在190℃的温度和100秒的剪切速率下加热和发泡包含发泡剂的树脂组合物和熔体粘度为1.0×10 3 -1.0×10 6泊的脂族聚酯 -1，熔点为70°-190℃。可以应用使用预烧珠的模具中的挤出或成型。发泡制品如隔热箱和缓冲材料具有生物降解性和优异的机械性能如拉伸强度和缓冲性能。

10. 发明授权

US08865081B2 Method for producing aliphatic polyester having increased molecular weight 有权
标题翻译：具有分子量增加的脂肪族聚酯的制造方法
公开(公告)号：US08865081B2
公开(公告)日：2014-10-21
申请号：US14009896
申请日：2012-01-17
申请人： Yasushi Ichikawa , Hideharu Kimura , Akira Ishii
发明人： Yasushi Ichikawa , Hideharu Kimura , Akira Ishii
IPC分类号： B01J19/20 , C08G18/42 , C08G63/78 , C08G63/91
CPC分类号： C08G63/78 , C08G18/4238 , C08G18/73 , C08G63/916 , Y02P20/149
摘要： The problem to be solved by the present invention is to provide a method for continuously and effectively producing an aliphatic polyester having an increased molecular weight which prevents evaporation of diisocyanate at the step of mixing the diisocyanate with the aliphatic polyester prepolymer in a molten state at a temperature not lower than the melting point of the prepolymer and enables uniform mixing of the diisocyanate with the aliphatic polyester prepolymer. In order to solve this problem, the present invention provides a method for producing an aliphatic polyester having an increased molecular weight comprising the steps of: (i) quantitatively injecting a diisocyanate into an aliphatic polyester prepolymer which has a number average molecular weight of 5000 or higher and has terminal hydroxyl groups and in which at least one acid component is a succinic acid compound, in a molten state at a temperature not lower than the melting point thereof, wherein the amount of diisocyanate is equivalent to between one tenth and two times the amount of the hydroxyl groups in the aliphatic polyester prepolymer, (ii) quantitatively and continuously mixing the diisocyanate-containing aliphatic polyester prepolymer obtained at step (i) by a static mixer, discharging same from the static mixer, and then supplying same to a coupling reaction tank, and (iii) reacting the aliphatic polyester prepolymer with the diisocyanate in the coupling reaction tank.
摘要翻译：本发明要解决的问题是提供一种连续有效地制造具有增加的分子量的脂族聚酯的方法，该方法在熔融状态下将二异氰酸酯与脂族聚酯预聚物混合在一起的步骤中防止二异氰酸酯蒸发温度不低于预聚物的熔点，可使二异氰酸酯与脂族聚酯预聚物均匀混合。为了解决这个问题，本发明提供一种生产分子量增加的脂族聚酯的方法，包括以下步骤：（i）将二异氰酸酯定量注入数均分子量为5000的脂族聚酯预聚物或更高且具有末端羟基，并且其中至少一种酸组分是琥珀酸化合物，在不低于其熔点的温度下处于熔融状态，其中二异氰酸酯的量等于十二分之一到二分之一脂肪族聚酯预聚物中的羟基量，（ii）通过静态混合器将步骤（i）中获得的含二异氰酸酯的脂族聚酯预聚物定量连续混合，从静态混合器中排出，然后将其提供给偶联剂反应罐，和（iii）在偶联反应槽中使脂族聚酯预聚物与二异氰酸酯反应。

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