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1. 发明授权

US06841183B2 Process for producing aspartame derivatives, process for purifying aspartame derivatives, production intermediates, and process for producing production intermediates 失效
标题翻译：制备阿斯巴甜衍生物的方法，天冬酰苯丙氨酸甲酯衍生物的纯化方法，生产中间体以及生产中间体的生产方法
公开(公告)号：US06841183B2
公开(公告)日：2005-01-11
申请号：US10108426
申请日：2002-03-29
申请人： Kazutaka Nagashima , Shinji Fujita , Yuuichi Aoki , Shigeru Kawahara , Tadashi Takemoto , Eriko Ono
发明人： Kazutaka Nagashima , Shinji Fujita , Yuuichi Aoki , Shigeru Kawahara , Tadashi Takemoto , Eriko Ono
IPC分类号： A23L27/30 , C07D311/20 , C07K5/072 , C07K5/075 , A23L1/236
CPC分类号： C07K5/06113 , A23L27/32 , C07D311/20 , C07K5/0613 , Y02P20/582
摘要： N-[N-[3-(2-hydroxy-substituted phenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester derivatives, which are useful as sweeteners, may be conveniently produced by subjecting a 2-hydroxychroman derivative having various substituents on the benzene ring and aspartame to a reductive alkylation reaction. These compounds may be purified by subjecting such a derivative containing one or more impurities to a crystallization step to crystallize the same. Further, there are provided a process for producing dialkoxychroman derivatives useful as intermediates for the production of such aspartame derivatives in the above process, and novel dialkoxychroman derivatives thus produced, which are excellent as the production intermediate.
摘要翻译：可用作甜味剂的N- [N- [3-（2-羟基取代的苯基）丙基] -L-α-天冬氨酰基] -L-苯丙氨酸1-甲酯衍生物可以方便地通过使2- 在苯环上具有各种取代基的羟基苯并二氢吡喃衍生物和阿斯巴甜进行还原烷基化反应。这些化合物可以通过将含有一种或多种杂质的衍生物进行结晶步骤进行结晶来纯化。此外，提供了用作上述方法中用于生产这种阿斯巴甜衍生物的中间体的二烷氧基苯并二氢吡喃衍生物的方法，以及如此生产的新型二烷氧基苯并二氢吡喃衍生物，其作为制备中间体是优异的。

2. 发明申请

US20050175755A1 Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof 审中-公开
标题翻译：天冬氨酰二肽酯衍生物的生产方法，其生产中间体及其生产方法
公开(公告)号：US20050175755A1
公开(公告)日：2005-08-11
申请号：US11105428
申请日：2005-04-14
申请人： Kazutaka Nagashima , Yuuichi Aoki , Tadashi Takemoto , Nao Funakoshi , Eriko Ono
发明人： Kazutaka Nagashima , Yuuichi Aoki , Tadashi Takemoto , Nao Funakoshi , Eriko Ono
IPC分类号： A23L27/30 , C07K5/072 , C07K5/075 , A23L1/236
CPC分类号： C07K5/06113 , A23L27/32
摘要： The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners, and aldehydes that can be used in the manufacturing processes.
摘要翻译：本发明涉及可用作甜味剂的天冬氨酰二肽酯化合物的制造方法和可用于制造过程中的醛。

3. 发明授权

US06818243B2 Crystals of aspartame derivative 失效
标题翻译：阿斯巴甜衍生物晶体
公开(公告)号：US06818243B2
公开(公告)日：2004-11-16
申请号：US10183652
申请日：2002-06-28
申请人： Kazutaka Nagashima , Yuuichi Aoki , Eriko Ono , Tadashi Takemoto
发明人： Kazutaka Nagashima , Yuuichi Aoki , Eriko Ono , Tadashi Takemoto
IPC分类号： A23L1236
CPC分类号： C07K5/06113 , A23L27/32
摘要： N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester useful as a sweetener with a high potency of sweetness, is provided in the crystalline form having a high stability and a good purity which is favorable as a commercial product.
摘要翻译：在结晶中提供了可用作甜度高的甜味剂的N- [N- [3-（3-羟基-4-甲氧基苯基）丙基] -L-α-天冬氨酰基] -L-苯丙氨酸1-甲基酯形式具有高稳定性和良好的纯度，作为商业产品是有利的。

4. 发明授权

US06794531B2 Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof 有权
公开(公告)号：US06794531B2
公开(公告)日：2004-09-21
申请号：US10117196
申请日：2002-04-08
申请人： Kazutaka Nagashima , Yuuichi Aoki , Tadashi Takemoto , Yusuke Amino , Nao Funakoshi , Eriko Ono
发明人： Kazutaka Nagashima , Yuuichi Aoki , Tadashi Takemoto , Yusuke Amino , Nao Funakoshi , Eriko Ono
IPC分类号： C07C22900
CPC分类号： C07K5/06113 , A23L27/32
摘要： The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners, and aldehydes that can be used in the manufacturing processes.

5. 发明授权

US06538133B1 Process for producing xylitol of high purity 失效
标题翻译：生产高纯度木糖醇的方法
公开(公告)号：US06538133B1
公开(公告)日：2003-03-25
申请号：US09631351
申请日：2000-08-02
申请人： Yuuichi Aoki , Eriko Ono , Kazutaka Nagashima
发明人： Yuuichi Aoki , Eriko Ono , Kazutaka Nagashima
IPC分类号： C07H106
CPC分类号： C13B20/148 , C07C29/76 , C12P7/18 , C07C31/18
摘要： Herein are disclosed a process for producing xylitol of high purity (one-step desalting process) which comprises the steps of (1) removing the solid matter from a culture froth obtained by culturing a xylitol-producing microorganism in an aqueous culture medium, (2) desalting the resulting solid matter-removed culture broth by removing the ionic substances therefrom by means of a cation-exchange resin and an anion-exchange resin, (3) subjecting the resulting desalted solution to the chromatography using a strongly acidic cation-exchange resin to separate the xylitol from the other sugar alcohol(s) and sugar(s), and (4) obtaining the xylitol by separating it at a high purity from the resulting xylitol solution (fraction), and to a similar process (two-step desalting process) but wherein the desalting carried out twice by adding the ion-exclusion step between Steps (1) and (2) of the above-mentioned process, whereby most of the ionic substances are removed, by which processes highly pure xylitol can be obtained from a xylitol solution in a commercially effective way, in the method for producing xylitol by using a xylitol-producing microorganism.
摘要翻译：本文公开了一种生产高纯度（一步脱盐方法）的木糖醇的方法，其包括以下步骤：（1）从通过在水性培养基中培养产生木糖醇的微生物获得的培养泡中除去固体物质，（2 ）通过用阳离子交换树脂和阴离子交换树脂除去其中的离子物质对所得的固体物质去除的培养液进行脱盐，（3）使用强酸性阳离子交换树脂对得到的脱盐溶液进行色谱分离将木糖醇与其它糖醇和糖分离，和（4）通过从所得木糖醇溶液（级分）中以高纯度分离得到木糖醇，并进行类似的方法（两步法）脱盐工艺），但是其中通过在上述方法的步骤（1）和（2）之间加入离子排除步骤进行两次脱盐，由此除去大部分离子物质，通过该过程高纯度木糖醇可以以商业上有效的方式从木糖醇溶液中获得，在通过使用产生木糖醇的微生物生产木糖醇的方法中。

6. 发明申请

US20130191561A1 DATA READING DEVICE, COMMUNICATION DEVICE, DATA READING METHOD AND PROGRAM 审中-公开
标题翻译：数据读取设备，通信设备，数据读取方法和程序
公开(公告)号：US20130191561A1
公开(公告)日：2013-07-25
申请号：US13877703
申请日：2011-10-05
申请人： Yuuichi Aoki
发明人： Yuuichi Aoki
IPC分类号： G06F5/14
CPC分类号： G06F5/14 , H04L13/08 , H04L49/90
摘要： The wireless communication device of the present invention is provided with a received data FIFO for temporarily storing received data, and a data reading section for reading received data from the received data FIFO. The data reading section, when received data to be read is stored in the received data FIFO, reads and outputs the stored received data. Meanwhile, when the received data to be read is not stored in the received data FIFO and a predetermined condition is fulfilled, the data reading section outputs dummy received data. Furthermore, when the received data to be read is not stored in the received data FIFO and the predetermined condition is not fulfilled, the data reading section outputs an error.
摘要翻译：本发明的无线通信装置设置有用于临时存储接收数据的接收数据FIFO，以及用于从接收数据FIFO读取接收数据的数据读取部分。当接收到的要被读取的数据被存储在接收数据FIFO中时，数据读取部分读出并输出存储的接收数据。同时，当接收到的要被读取的数据不存储在接收数据FIFO中并且满足预定条件时，数据读取部输出虚拟接收数据。此外，当接收到的要被读取的数据未被存储在接收数据FIFO中并且不满足预定条件时，数据读取部输出错误。

7. 发明授权

US07867466B2 Thermally conductive, electrically insulating material and production method thereof 有权
标题翻译：导热，电绝缘材料及其制造方法
公开(公告)号：US07867466B2
公开(公告)日：2011-01-11
申请号：US11978503
申请日：2007-10-29
申请人： Yukihisa Takeuchi , Yasumasa Hagiwara , Yuuichi Aoki , Eiichi Torigoe
发明人： Yukihisa Takeuchi , Yasumasa Hagiwara , Yuuichi Aoki , Eiichi Torigoe
IPC分类号： C01B21/072 , B32B9/00 , B32B15/04 , H01L31/062 , B05D3/04 , C30B23/00 , C04B35/00
CPC分类号： C23C26/02 , B32B15/04 , C23C2/26 , C23C8/02 , H01L21/318 , Y10T428/31678
摘要： Means for a thermally conductive and electrically insulating material 1 containing an AlN crystal 150 mainly comprising AlN, and a production method thereof. In production, a molten aluminum layer is formed on an AlN substrate 11 with at least its surface comprising AlN in an atmosphere of a non-oxidizing gas, and the molten aluminum layer is then heated in an atmosphere of N2 gas to form an AlN crystal 150 which mainly comprises an AlN layer 125. The means are also a thermally conductive and electrically insulating material having an AlN crystal and an Al gradient layer, and a production method thereof. In production, a heating step of forming a molten aluminum layer 15 on the AlN layer 125 and heating it in an atmosphere of N2 gas is repeated at least twice or more. At this time, the amount of the N2 gas dissolved in the molten aluminum layer is decreased as the heating step is repeated.
摘要翻译：含有主要包含AlN的AlN晶体150的导热和电绝缘材料1的方法及其制备方法。在制造中，在AlN基板11上形成熔融铝层，至少在AlN的表面包含非氧化性气体的AlN，然后在N 2气氛中加热熔融铝层，形成AlN晶体 150，其主要包括AlN层125.该装置也是具有AlN晶体和Al梯度层的导热和电绝缘材料及其制造方法。在生产中，在AlN层125上形成熔融铝层15并在N 2气氛中加热的加热步骤重复至少两次以上。此时，随着加热步骤重复，溶解在熔融铝层中的N 2气体的量减少。

8. 发明申请

US20100321245A1 MULTIBAND TRANSCEIVER AND POSITIONING SYSTEM USING THE TRANSCEIVER 有权
标题翻译：多功能收发器和使用收发器的定位系统
公开(公告)号：US20100321245A1
公开(公告)日：2010-12-23
申请号：US12526356
申请日：2008-02-14
申请人： Yuuichi Aoki
发明人： Yuuichi Aoki
IPC分类号： G01S13/84 , H04B1/38
CPC分类号： G01S13/84 , G01S13/87 , H04B1/005
摘要： The present invention comprising: a first local oscillator for generating a first frequency; a second local oscillator for generating a second frequency; phase-difference setting means for setting a first phase difference between a transmission signal and an output of the aforementioned first local oscillator; phase-difference detection means for detecting a second phase difference which is the phase difference between a reception signal and an output of the aforementioned second local oscillator, and calculation means for calculating a distance to a communication counterpart from a third phase difference and a fourth phase difference which are notified by the communication counterpart, and from the aforementioned first phase difference and second phase difference, wherein the third phase difference is set to the second frequency by the communication counterpart, and the fourth phase difference is set to the first frequency by the communication counterpart.
摘要翻译：本发明包括：用于产生第一频率的第一本地振荡器; 用于产生第二频率的第二本地振荡器; 相位差设定装置，用于设定发送信号与上述第一本地振荡器的输出之间的第一相位差; 相位差检测装置，用于检测作为接收信号和上述第二本地振荡器的输出之间的相位差的第二相位差;以及计算装置，用于根据第三相位差和第四相位计算到通信对方的距离由通信对方通知的差值，以及上述第一相位差和第二相位差，其中第三相位差被通信对方设置为第二频率，并且第四相位差被设置为第一频率通讯对应

9. 发明授权

US07726024B2 Manufacturing method for a heat exchanger 失效
标题翻译：热交换器的制造方法
公开(公告)号：US07726024B2
公开(公告)日：2010-06-01
申请号：US11637846
申请日：2006-12-12
申请人： Katsuya Ishii , Hirokazu Hashimoto , Yuuichi Aoki , Kazuo Itoh
发明人： Katsuya Ishii , Hirokazu Hashimoto , Yuuichi Aoki , Kazuo Itoh
IPC分类号： B23P15/26
CPC分类号： B23K20/10 , B21D53/085 , B23K20/12 , B23K2101/14 , F28D1/0535 , F28F1/32 , F28F9/16 , F28F9/18 , F28F2275/065 , Y10T29/4935 , Y10T29/49364 , Y10T29/49373 , Y10T29/49377 , Y10T29/4938
摘要： In a heat exchanger, a core portion includes a plurality of plate fins each shaped like a flat plate and a plurality of tubes in which a fluid flows and each of which is inserted into each of the plate fins to be mechanically bonded thereto. Further, an end portion in a longitudinal direction of each of the tubes is bonded to a header plate which constructs a part of a header tank. The manufacturing method for this heat exchanger includes inserting the tube into the plate fins; expanding the tube to attach the plate fins; connect the tube into the header plate; and vibrate the tube with respect to the plate while applying a load to the tube in the direction of the header plate.
摘要翻译：在热交换器中，芯部包括多个板状翅片，每个板状翅片均形成为平板，多个管流体流动，其中每个均插入每个板翅片以机械结合。此外，每个管的纵向方向上的端部被接合到构成集水箱的一部分的集管板。该热交换器的制造方法包括将管插入板翅片; 膨胀管附接板翅; 将管连接到集管板中; 并且相对于板振动管，同时在集管板的方向上向管施加负载。

10. 发明授权

US07232925B2 Process for producing (4E)-5-chloro-2-isopropyl-4-pentenoate and optically active form thereof 有权
标题翻译：制备（4E）-5-氯-2-异丙基-4-戊烯酸酯及其光学活性形式的方法
公开(公告)号：US07232925B2
公开(公告)日：2007-06-19
申请号：US11147255
申请日：2005-06-08
申请人： Nobuaki Mori , Yasushi Matsumura , Yoshitomi Morizawa , Toshihiko Kaminuma , Yuuichi Aoki
发明人： Nobuaki Mori , Yasushi Matsumura , Yoshitomi Morizawa , Toshihiko Kaminuma , Yuuichi Aoki
IPC分类号： C07C69/62
CPC分类号： C07C67/343 , C07B2200/07 , C07B2200/09 , C07C67/32 , C07C67/48 , C07C69/65
摘要： The present invention provides processes for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate and an optical isomer of the (4E)-5-chloro-2-isopropyl-4-pentenoate, namely a process for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate represented by the following formula (4), which comprises reacting a compound represented by the following formula (2) in the presence of an aprotic solvent (II) with a base (II) and then with (1E)-1,3-dichloro-1-propene to give a compound represented by the following formula (3), and dealkoxycarbonylating either ester in the compound represented by the following formula (3), and a process for producing a (S)-(4E)-5-chloro-2-isopropyl-4-pentenoate represented by the following formula (5), which comprises optically resolving a (4E)-5-chloro-2-isopropyl-4-pentenoate represented by the formula (4) obtained by the above-mentioned process (wherein R is a lower alkyl group or an aralkyl group).
摘要翻译：本发明提供了（4E）-5-氯-2-异丙基-4-戊烯酸酯和（4E）-5-氯-2-异丙基-4-戊烯酸酯的旋光异构体的制备方法，即制备由下式（4）表示的（4E）-5-氯-2-异丙基-4-戊烯酸酯，其包括使下式（2）表示的化合物在非质子溶剂（II）的存在下与碱（II），然后与（1E）-1,3-二氯-1-丙烯反应，得到由下式（3）表示的化合物，和由下式（3）表示的化合物中的任一酯脱甲基羰基化，和一种制备由下式（5）表示的（S） - （4E）-5-氯-2-异丙基-4-戊烯酸酯的方法，该方法包括光学拆分（4E）-5-氯-2-异丙基-4-戊烯酸由上述方法（其中R是低级烷基或芳烷基）得到的式（4）表示的4-戊烯酸酯。

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