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1. 发明授权

US06841183B2 Process for producing aspartame derivatives, process for purifying aspartame derivatives, production intermediates, and process for producing production intermediates 失效
标题翻译：制备阿斯巴甜衍生物的方法，天冬酰苯丙氨酸甲酯衍生物的纯化方法，生产中间体以及生产中间体的生产方法
公开(公告)号：US06841183B2
公开(公告)日：2005-01-11
申请号：US10108426
申请日：2002-03-29
申请人： Kazutaka Nagashima , Shinji Fujita , Yuuichi Aoki , Shigeru Kawahara , Tadashi Takemoto , Eriko Ono
发明人： Kazutaka Nagashima , Shinji Fujita , Yuuichi Aoki , Shigeru Kawahara , Tadashi Takemoto , Eriko Ono
IPC分类号： A23L27/30 , C07D311/20 , C07K5/072 , C07K5/075 , A23L1/236
CPC分类号： C07K5/06113 , A23L27/32 , C07D311/20 , C07K5/0613 , Y02P20/582
摘要： N-[N-[3-(2-hydroxy-substituted phenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester derivatives, which are useful as sweeteners, may be conveniently produced by subjecting a 2-hydroxychroman derivative having various substituents on the benzene ring and aspartame to a reductive alkylation reaction. These compounds may be purified by subjecting such a derivative containing one or more impurities to a crystallization step to crystallize the same. Further, there are provided a process for producing dialkoxychroman derivatives useful as intermediates for the production of such aspartame derivatives in the above process, and novel dialkoxychroman derivatives thus produced, which are excellent as the production intermediate.
摘要翻译：可用作甜味剂的N- [N- [3-（2-羟基取代的苯基）丙基] -L-α-天冬氨酰基] -L-苯丙氨酸1-甲酯衍生物可以方便地通过使2- 在苯环上具有各种取代基的羟基苯并二氢吡喃衍生物和阿斯巴甜进行还原烷基化反应。这些化合物可以通过将含有一种或多种杂质的衍生物进行结晶步骤进行结晶来纯化。此外，提供了用作上述方法中用于生产这种阿斯巴甜衍生物的中间体的二烷氧基苯并二氢吡喃衍生物的方法，以及如此生产的新型二烷氧基苯并二氢吡喃衍生物，其作为制备中间体是优异的。

2. 发明申请

US20050175755A1 Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof 审中-公开
标题翻译：天冬氨酰二肽酯衍生物的生产方法，其生产中间体及其生产方法
公开(公告)号：US20050175755A1
公开(公告)日：2005-08-11
申请号：US11105428
申请日：2005-04-14
申请人： Kazutaka Nagashima , Yuuichi Aoki , Tadashi Takemoto , Nao Funakoshi , Eriko Ono
发明人： Kazutaka Nagashima , Yuuichi Aoki , Tadashi Takemoto , Nao Funakoshi , Eriko Ono
IPC分类号： A23L27/30 , C07K5/072 , C07K5/075 , A23L1/236
CPC分类号： C07K5/06113 , A23L27/32
摘要： The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners, and aldehydes that can be used in the manufacturing processes.
摘要翻译：本发明涉及可用作甜味剂的天冬氨酰二肽酯化合物的制造方法和可用于制造过程中的醛。

3. 发明授权

US06818243B2 Crystals of aspartame derivative 失效
标题翻译：阿斯巴甜衍生物晶体
公开(公告)号：US06818243B2
公开(公告)日：2004-11-16
申请号：US10183652
申请日：2002-06-28
申请人： Kazutaka Nagashima , Yuuichi Aoki , Eriko Ono , Tadashi Takemoto
发明人： Kazutaka Nagashima , Yuuichi Aoki , Eriko Ono , Tadashi Takemoto
IPC分类号： A23L1236
CPC分类号： C07K5/06113 , A23L27/32
摘要： N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester useful as a sweetener with a high potency of sweetness, is provided in the crystalline form having a high stability and a good purity which is favorable as a commercial product.
摘要翻译：在结晶中提供了可用作甜度高的甜味剂的N- [N- [3-（3-羟基-4-甲氧基苯基）丙基] -L-α-天冬氨酰基] -L-苯丙氨酸1-甲基酯形式具有高稳定性和良好的纯度，作为商业产品是有利的。

4. 发明授权

US06794531B2 Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof 有权
公开(公告)号：US06794531B2
公开(公告)日：2004-09-21
申请号：US10117196
申请日：2002-04-08
申请人： Kazutaka Nagashima , Yuuichi Aoki , Tadashi Takemoto , Yusuke Amino , Nao Funakoshi , Eriko Ono
发明人： Kazutaka Nagashima , Yuuichi Aoki , Tadashi Takemoto , Yusuke Amino , Nao Funakoshi , Eriko Ono
IPC分类号： C07C22900
CPC分类号： C07K5/06113 , A23L27/32
摘要： The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners, and aldehydes that can be used in the manufacturing processes.

5. 发明授权

US06767572B2 Process for production of aspartame derivative, crystal thereof, novel production intermediate therefor, and process for production of intermediate thereof 有权
公开(公告)号：US06767572B2
公开(公告)日：2004-07-27
申请号：US10117205
申请日：2002-04-08
申请人： Shigeru Kawahara , Kazutaka Nagashima , Kenichi Mori , Tadashi Takemoto , Eriko Ono
发明人： Shigeru Kawahara , Kazutaka Nagashima , Kenichi Mori , Tadashi Takemoto , Eriko Ono
IPC分类号： A23L1236
CPC分类号： C07K5/06113 , A23L27/32 , A23V2002/00 , C07C45/41 , C07C45/79 , C07C47/277 , C07C51/367 , C07C59/64 , C07C65/21 , A23V2250/2482
摘要： The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners.

6. 发明授权

US06538133B1 Process for producing xylitol of high purity 失效
标题翻译：生产高纯度木糖醇的方法
公开(公告)号：US06538133B1
公开(公告)日：2003-03-25
申请号：US09631351
申请日：2000-08-02
申请人： Yuuichi Aoki , Eriko Ono , Kazutaka Nagashima
发明人： Yuuichi Aoki , Eriko Ono , Kazutaka Nagashima
IPC分类号： C07H106
CPC分类号： C13B20/148 , C07C29/76 , C12P7/18 , C07C31/18
摘要： Herein are disclosed a process for producing xylitol of high purity (one-step desalting process) which comprises the steps of (1) removing the solid matter from a culture froth obtained by culturing a xylitol-producing microorganism in an aqueous culture medium, (2) desalting the resulting solid matter-removed culture broth by removing the ionic substances therefrom by means of a cation-exchange resin and an anion-exchange resin, (3) subjecting the resulting desalted solution to the chromatography using a strongly acidic cation-exchange resin to separate the xylitol from the other sugar alcohol(s) and sugar(s), and (4) obtaining the xylitol by separating it at a high purity from the resulting xylitol solution (fraction), and to a similar process (two-step desalting process) but wherein the desalting carried out twice by adding the ion-exclusion step between Steps (1) and (2) of the above-mentioned process, whereby most of the ionic substances are removed, by which processes highly pure xylitol can be obtained from a xylitol solution in a commercially effective way, in the method for producing xylitol by using a xylitol-producing microorganism.
摘要翻译：本文公开了一种生产高纯度（一步脱盐方法）的木糖醇的方法，其包括以下步骤：（1）从通过在水性培养基中培养产生木糖醇的微生物获得的培养泡中除去固体物质，（2 ）通过用阳离子交换树脂和阴离子交换树脂除去其中的离子物质对所得的固体物质去除的培养液进行脱盐，（3）使用强酸性阳离子交换树脂对得到的脱盐溶液进行色谱分离将木糖醇与其它糖醇和糖分离，和（4）通过从所得木糖醇溶液（级分）中以高纯度分离得到木糖醇，并进行类似的方法（两步法）脱盐工艺），但是其中通过在上述方法的步骤（1）和（2）之间加入离子排除步骤进行两次脱盐，由此除去大部分离子物质，通过该过程高纯度木糖醇可以以商业上有效的方式从木糖醇溶液中获得，在通过使用产生木糖醇的微生物生产木糖醇的方法中。

7. 发明申请

US20060014819A1 Crystal of (2R,4R)-monatin potassium salt and sweetener composition containing same 失效
公开(公告)号：US20060014819A1
公开(公告)日：2006-01-19
申请号：US11180622
申请日：2005-07-14
申请人： Ken-ichi Mori , Eriko Ono , Tadashi Takemoto
发明人： Ken-ichi Mori , Eriko Ono , Tadashi Takemoto
IPC分类号： A61K31/405 , C07D209/18
CPC分类号： C07D209/20
摘要： Crystals of (2R,4R)-monatin potassium salt which exhibit an X-ray powder diffraction pattern having characteristic peaks at diffraction angles 2θ of 5.5°, 7.2°, 8.1°, 8.9°, and 16.3°, by powder X-ray diffraction (Cu—Kα radiation), are superior in sweetness, preservation stability, solubility, and color stability.

8. 发明授权

US07553974B2 Crystal of (2R,4R)-monatin potassium salt and sweetener composition containing same 失效
标题翻译：（2R，4R） - 莫拉汀钾盐和含有它的甜味剂组合物的晶体
公开(公告)号：US07553974B2
公开(公告)日：2009-06-30
申请号：US11180622
申请日：2005-07-14
申请人： Ken-ichi Mori , Eriko Ono , Tadashi Takemoto
发明人： Ken-ichi Mori , Eriko Ono , Tadashi Takemoto
IPC分类号： A61K31/405 , C07D209/18
CPC分类号： C07D209/20
摘要： Crystals of (2R,4R)-monatin potassium salt which exhibit an X-ray powder diffraction pattern having characteristic peaks at diffraction angles 2θ of 5.5°, 7.2°, 8.1°, 8.9°, and 16.3°, by powder X-ray diffraction (Cu—Kα radiation), are superior in sweetness, preservation stability, solubility, and color stability.
摘要翻译：通过粉末X射线衍射显示具有在衍射角2θ为5.5°，7.2°，8.1°，8.9°和16.3°的特征峰的X射线粉末衍射图的（2R，4R） - 莫拉汀钾盐的晶体（Cu-Kalpha辐射）在甜度，保存稳定性，溶解性和颜色稳定性方面均优异。

9. 发明授权

US06299675B1 Printing method, image forming process, ink, ink set, recording unit, image forming apparatus and print 有权
标题翻译：打印方法，图像形成处理，墨水，墨水组，记录单元，图像形成装置和打印
公开(公告)号：US06299675B1
公开(公告)日：2001-10-09
申请号：US09317837
申请日：1999-05-25
申请人： Eriko Ono , Yoshihisa Takizawa
发明人： Eriko Ono , Yoshihisa Takizawa
IPC分类号： C09D1102
CPC分类号： C09D11/30 , B41J2/2114
摘要： Disclosed herein is a printing method comprising a step of applying a liquid composition containing a cationic substance and an ink containing an anionic substance respectively on a recording medium so that the liquid composition and the ink are in contact with each other on the recording medium, wherein the ink contains a coloring material at a concentration of not higher than 1% and has a pH of 10.5 or higher. The printing method permits the provision of an image having excellent water fastness, image quality and resistance to bleeding on plain paper and can prevent the occurrence of whitish haze at a highlight part.
摘要翻译：本文公开了一种印刷方法，其包括将包含阳离子物质和含有阴离子物质的油墨的液体组合物分别施加到记录介质上以使液体组合物和油墨在记录介质上彼此接触的步骤，其中油墨含有浓度不高于1％且pH值为10.5以上的着色材料。打印方法允许提供具有优异的耐水性，图像质量和耐普通纸上的渗色性能的图像，并且可以防止在高亮部分发生白色混浊。

10. 发明授权

US07205433B2 Crystal of amino acid ester salt and process for producing the same 失效
标题翻译：氨基酸酯盐的晶体及其制备方法
公开(公告)号：US07205433B2
公开(公告)日：2007-04-17
申请号：US11062879
申请日：2005-02-23
申请人： Toyoto Hijiya , Eriko Ono
发明人： Toyoto Hijiya , Eriko Ono
IPC分类号： C07C229/00
CPC分类号： C07C229/08 , C07C309/04 , C07C309/29 , C07C309/30
摘要： The present invention provides a novel crystal of alanine alkyl ester sulfonate having low hygroscopicity and low corrosiveness, which can be produced industrially economically. The present invention provides crystals of alanine alkyl ester sulfonates represented by formula (1): wherein R1 is a methyl group or an ethyl group, provided that when R1 is a methyl group, R2is an ethylphenyl group or a dimethylphenyl group; and when R1 is an ethyl group, R2 is a methyl group, a phenyl group, a chlorophenyl group, an ethylphenyl group, or a dimethylphenyl group.
摘要翻译：本发明提供了一种具有低吸湿性和低腐蚀性的丙氨酸烷基酯磺酸盐的新型结晶，其可以在工业上经济地得到。本发明提供由式（1）表示的丙氨酸烷基酯磺酸盐晶体：

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