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1. 发明申请

US20100159451A1 Method of detecting interaction between nucleic acid and protein, and apparatus for the same 有权
标题翻译：检测核酸与蛋白质相互作用的方法及其设备
公开(公告)号：US20100159451A1
公开(公告)日：2010-06-24
申请号：US12308370
申请日：2007-06-14
申请人： Kazunori Ikebukuro , Ryo Katayama , Eiji Takahashi , Hiroyuki Takamatsu
发明人： Kazunori Ikebukuro , Ryo Katayama , Eiji Takahashi , Hiroyuki Takamatsu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , G01N21/171 , C12Q2537/101 , C12Q2541/101
摘要： The invention is to easily detect an interaction between nucleic acid and protein with high sensitivity without the need of sample labeling with a fluorescent molecule or sample anchorage onto a metal thin-film. As means for it, the presence or absence of occurrence of the interaction between nucleic acid and protein in a sample (S) is detected in an optical manner. Specifically, the sample (S) is irradiated with excitation rays (Le) and with measuring rays (L2) for measuring a photothermal effect produced in the sample (S) through the irradiation with the excitation rays (Le). A measurement signal for the photothermal effect in the sample (S) by the excitation rays (Le) is produced on the basis of any phase change of the measuring rays (L2). A temporal variation in the measurement signal is used for making a judgment on the presence or absence of any occurrence of interaction between nucleic acid and protein.
摘要翻译：本发明可以容易地以高灵敏度检测核酸和蛋白质之间的相互作用，而不需要用荧光分子或样品锚定物将样品标记在金属薄膜上。作为其手段，以光学方式检测样品（S）中核酸和蛋白质之间的相互作用的存在或不存在。具体地，用激发光线（Le）和用于通过激发光线（Le）的照射测量样品（S）中产生的光热效应的测量光线（L2）来照射样品（S）。基于测量光线（L2）的任何相变，产生通过激发光线（Le）在样品（S）中的光热效应的测量信号。使用测量信号的时间变化来判断核酸和蛋白质之间是否存在任何相互作用的发生。

2. 发明授权

US08367329B2 Method of detecting interaction between nucleic acid and protein, and apparatus for the same 有权
标题翻译：检测核酸与蛋白质相互作用的方法及其设备
公开(公告)号：US08367329B2
公开(公告)日：2013-02-05
申请号：US12308370
申请日：2007-06-14
申请人： Kazunori Ikebukuro , Ryo Katayama , Eiji Takahashi , Hiroyuki Takamatsu
发明人： Kazunori Ikebukuro , Ryo Katayama , Eiji Takahashi , Hiroyuki Takamatsu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , G01N21/171 , C12Q2537/101 , C12Q2541/101
摘要： The invention is to easily detect an interaction between nucleic acid and protein with high sensitivity without the need of sample labeling with a fluorescent molecule or sample anchorage onto a metal thin-film. As means for it, the presence or absence of occurrence of the interaction between nucleic acid and protein in a sample (S) is detected in an optical manner. Specifically, the sample (S) is irradiated with excitation rays (Le) and with measuring rays (L2) for measuring a photothermal effect produced in the sample (S) through the irradiation with the excitation rays (Le). A measurement signal for the photothermal effect in the sample (S) by the excitation rays (Le) is produced on the basis of any phase change of the measuring rays (L2). A temporal variation in the measurement signal is used for making a judgment on the presence or absence of any occurrence of interaction between nucleic acid and protein.
摘要翻译：本发明可以容易地以高灵敏度检测核酸和蛋白质之间的相互作用，而不需要用荧光分子或样品锚定物将样品标记在金属薄膜上。作为其手段，以光学方式检测样品（S）中核酸和蛋白质之间的相互作用的存在或不存在。具体地，用激发光线（Le）和用于通过激发光线（Le）的照射测量样品（S）中产生的光热效应的测量光线（L2）来照射样品（S）。基于测量光线（L2）的任何相变，产生通过激发光线（Le）在样品（S）中的光热效应的测量信号。使用测量信号的时间变化来判断核酸和蛋白质之间是否存在任何相互作用的发生。

3. 发明申请

US20080123099A1 Photothermal conversion measuring instrument 审中-公开
标题翻译：光热转换测量仪器
公开(公告)号：US20080123099A1
公开(公告)日：2008-05-29
申请号：US11902279
申请日：2007-09-20
申请人： Eiji Takahashi , Ryo Katayama , Hiroyuki Takamatsu
发明人： Eiji Takahashi , Ryo Katayama , Hiroyuki Takamatsu
IPC分类号： G01B9/02 , G01N21/00
CPC分类号： G01N21/171 , G01N21/031
摘要： There is provided a photothermal conversion measuring instrument which can measure change in property caused by thermal effect in a sample with high sensitivity and high accuracy by a simple structure. The instrument includes a current control circuit for sequentially switching output light of a plurality of excitation light sources each outputting excitation light having a different wavelength band so that one of the output light is irradiated to the sample, a light detector for interfering measurement light transmitted through the sample with reference light and detecting the intensity of the interference light, and a signal processor for extracting the same cycle components as the switching cycle of the output light switched by the current control circuit from a signal of the interference light intensity obtained from the light detector and for obtaining a difference of signal values corresponding to each of the excitation light based on the extracted signals.
摘要翻译：提供了一种光热转换测量仪器，可以通过简单的结构，以高灵敏度和高精度测量样品中热效应引起的性能变化。该仪器包括电流控制电路，用于顺序地切换多个激发光源的输出光，每个激发光源输出具有不同波长带的激发光，使得输出光中的一个照射到样本，用于干扰测量光的光检测器，具有参考光的样本并检测干涉光的强度;以及信号处理器，用于从由光获得的干涉光强度的信号中提取与由电流控制电路切换的输出光的切换周期相同的周期分量并且用于基于所提取的信号获得与每个激发光对应的信号值的差异。

4. 发明授权

US08023118B2 Analyzer for absorption spectrometry of impurity concentration contained in liquid using exciting light 有权
标题翻译：使用激发光的液体中所含杂质浓度的吸收光谱分析仪
公开(公告)号：US08023118B2
公开(公告)日：2011-09-20
申请号：US12224302
申请日：2007-03-16
申请人： Eiji Takahashi , Ryo Katayama , Masato Kannaka , Hiroyuki Takamatsu
发明人： Eiji Takahashi , Ryo Katayama , Masato Kannaka , Hiroyuki Takamatsu
IPC分类号： G01B9/02 , G01J3/45 , G01N21/00
CPC分类号： G01N21/00 , G01N21/171 , G01N21/45 , G01N21/85 , G01N21/94 , G01N33/18 , G01N2021/1712 , G01N2021/8557 , G01N2030/746
摘要： The concentration of impurities contained in ultrapure water or press water can be efficiently analyzed with high precision. A portion of a liquid to be measured is introduced into an absorption spectrometric portion from a predetermined line. The liquid is irradiated with exciting light from an exciting light irradiation system, and a measurement object region in which a photothermal effect of the impurities in the liquid is produced by the irradiation is irradiated with measuring light from a measuring light irradiation system. A change in phase of the measuring light is detected by a predetermined optical system and a photodetector, and the impurity concentration in the liquid is determined on the basis of the change in phase.
摘要翻译：可以高精度地有效地分析超纯水或压水中所含杂质的浓度。将待测量的液体的一部分从预定线引入吸收光谱测定部分。用激发光照射系统的激发光照射液体，照射测量光照射系统的测量光照射通过照射产生液体中的杂质的光热效应的测量对象区域。通过预定的光学系统和光电检测器检测测量光的相位变化，并且基于相位的变化来确定液体中的杂质浓度。

5. 发明申请

US20090027654A1 Analyzer 有权
标题翻译：分析仪
公开(公告)号：US20090027654A1
公开(公告)日：2009-01-29
申请号：US12224302
申请日：2007-03-16
申请人： Eiji Takahashi , Ryo Katayama , Masato Kannaka , Hiroyuki Takamatsu
发明人： Eiji Takahashi , Ryo Katayama , Masato Kannaka , Hiroyuki Takamatsu
IPC分类号： G01N21/31 , G01N1/20
CPC分类号： G01N21/00 , G01N21/171 , G01N21/45 , G01N21/85 , G01N21/94 , G01N33/18 , G01N2021/1712 , G01N2021/8557 , G01N2030/746
摘要： The concentration of impurities contained in ultrapure water or press water can be efficiently analyzed with high precision.A portion of a liquid to be measured is introduced into an absorption spectrometric portion 2c from a predetermined line. The liquid is irradiated with exciting light Le from an exciting light irradiation system 10, and a measurement objet region AS in which a photothermal effect of the impurities in the liquid is produced by the irradiation is irradiated with measuring light Lm from a measuring light irradiation system 20. A change in phase of the measuring light Lm is detected by a predetermined optical system and a photodetector 36, and the impurity concentration in the liquid is determined on the basis of the change in phase.
摘要翻译：可以高精度地有效地分析超纯水或压水中所含杂质的浓度。将待测量的液体的一部分从预定线引入吸收光谱测量部分2c。用激发光照射系统10的激励光Le照射液体，并且通过照射产生液体中的杂质的光热效应的测量对象区域AS从测量光照射系统通过预定的光学系统和光电检测器36检测测量光Lm的相位变化，并且基于相位的变化来确定液体中的杂质浓度。

6. 发明授权

US07522287B2 Photothermal conversion measurement apparatus, photothermal conversion measurement method, and sample cell 失效
标题翻译：光热转换测量装置，光热转换测量方法和样品池
公开(公告)号：US07522287B2
公开(公告)日：2009-04-21
申请号：US11350954
申请日：2006-02-10
申请人： Eiji Takahashi , Hiroyuki Takamatsu , Masato Kannaka , Naokazu Sakoda , Tsutomu Morimoto
发明人： Eiji Takahashi , Hiroyuki Takamatsu , Masato Kannaka , Naokazu Sakoda , Tsutomu Morimoto
IPC分类号： G01B11/02 , G01N21/00 , G01N1/10
CPC分类号： G01N21/171 , G01N21/031 , G01N2021/1712 , G01N2021/178 , G01N2201/105
摘要： A liquid sample is irradiated with excitation light and measurement light, and a measurement position at which a traveling path of the measurement light passes through an excitation section of the excitation light in the sample is changed while the sample is being irradiated with the excitation light and the measurement light. Then, the phase change of the measurement light is measured for each measurement by optical interferometry on the basis of the measurement light after the measurement light passes through the sample. The measurement position is changed by, for example, scanning the excitation light, moving the sample, moving a lens that collects the excitation light in the sample so as to change the light-collecting position (focal position) in the sample, etc.
摘要翻译：用激发光和测量光照射液体样品，并且在样品被激发光照射的同时改变测量光的行进路径通过样品中的激发光的激发部分的测量位置，以及测量灯。然后，基于测量光通过样品后的测量光，通过光学干涉测量对每次测量测量测量光的相位变化。通过例如扫描激发光，移动样品，移动收集样品中的激发光的透镜来改变测量位置，以便改变样品中的聚光位置（焦点位置）等。

7. 发明申请

US20060181708A1 Photothermal conversion measurement apparatus, photothermal conversion measurement method, and sample cell 失效
公开(公告)号：US20060181708A1
公开(公告)日：2006-08-17
申请号：US11350954
申请日：2006-02-10
申请人： Eiji Takahashi , Hiroyuki Takamatsu , Masato Kannaka , Naokazu Sakoda , Tsutomu Morimoto
发明人： Eiji Takahashi , Hiroyuki Takamatsu , Masato Kannaka , Naokazu Sakoda , Tsutomu Morimoto
IPC分类号： G01N21/59
CPC分类号： G01N21/171 , G01N21/031 , G01N2021/1712 , G01N2021/178 , G01N2201/105
摘要： A liquid sample is irradiated with excitation light and measurement light, and a measurement position at which a traveling path of the measurement light passes through an excitation section of the excitation light in the sample is changed while the sample is being irradiated with the excitation light and the measurement light. Then, the phase change of the measurement light is measured for each measurement by optical interferometry on the basis of the measurement light after the measurement light passes through the sample. The measurement position is changed by, for example, scanning the excitation light, moving the sample, moving a lens that collects the excitation light in the sample so as to change the light-collecting position (focal position) in the sample, etc.

8. 发明授权

US09279762B2 Apparatus and method for measuring semiconductor carrier lifetime 有权
标题翻译：测量半导体载体寿命的装置和方法
公开(公告)号：US09279762B2
公开(公告)日：2016-03-08
申请号：US13500305
申请日：2010-10-01
申请人： Kazushi Hayashi , Hiroyuki Takamatsu , Yoshito Fukumoto , Shingo Sumie
发明人： Kazushi Hayashi , Hiroyuki Takamatsu , Yoshito Fukumoto , Shingo Sumie
IPC分类号： G01N21/31 , G01N21/3563 , H01L21/66
CPC分类号： G01N21/3151 , G01N21/31 , G01N2021/3568 , H01L22/14 , H01L2924/0002 , H01L2924/00
摘要： In a semiconductor carrier lifetime measuring apparatus A1 of the present invention, at least two types of light having mutually different wavelengths are irradiated onto a semiconductor X to be measured, a predetermined measurement wave is irradiated onto the semiconductor X to be measured, a reflected wave of the measurement wave that has been reflected by the semiconductor X to be measured or a transmitted wave of the measurement wave that has transmitted through the semiconductor X to be measured is detected, and the carrier lifetime in the semiconductor X to be measured is obtained based on the detection results so as to minimize the error. Accordingly, the semiconductor carrier lifetime measuring apparatus A1 configured as described above can more accurately measure the carrier lifetime.
摘要翻译：在本发明的半导体载体寿命测量装置A1中，将具有相互不同波长的至少两种类型的光照射到要测量的半导体X上，将预定测量波照射到要测量的半导体X上，反射波检测被测半导体X所反射的测量波，或检测通过半导体X的被测量的测定波的透过波，测定半导体X的载流子寿命，检测结果，以最小化误差。因此，如上所述构成的半导体载体寿命测定装置A1能够更准确地测定载流子寿命。

9. 发明授权

US07268114B2 Protein and process for preparing the same 失效
标题翻译：蛋白质及其制备方法
公开(公告)号：US07268114B2
公开(公告)日：2007-09-11
申请号：US10365231
申请日：2003-02-12
申请人： Fusao Makishima , Hiroyuki Takamatsu , Hideo Miki , Shinji Kawai , Michio Kimura , Tomoaki Matsumoto , Mieko Katsuura , Koichi Enomoto , Yusuke Satoh
发明人： Fusao Makishima , Hiroyuki Takamatsu , Hideo Miki , Shinji Kawai , Michio Kimura , Tomoaki Matsumoto , Mieko Katsuura , Koichi Enomoto , Yusuke Satoh
IPC分类号： A61K38/18 , C07K14/51 , C12N15/12 , C12N1/21 , C12P21/02 , A61F2/30 , A61F2/28
CPC分类号： C07K14/51 , A61K38/00 , Y10S514/801
摘要： A protein having amino acid sequence in SEQ ID NO: 1 of the Sequence Listing derived from human MP52, and a dimer protein thereof. A homodimer protein described above can be obtained by constructing a plasmid containing DNA coding amino acid sequence in SEQ ID NO: 1 of the Sequence Listing with a methionine at the N-terminus, introducing the plasmid into E. coli for transformation, solubilizing inclusion bodies obtained by culturing the transformant, purifying the monomer protein from the solubilized solution, refolding the monomer protein into a dimer protein and purifying the same. The homodimer protein described above is useful as a pharmaceutical composition for treating cartilage and bone diseases.
摘要翻译：衍生自人MP52的序列表的SEQ ID NO：1中具有氨基酸序列的蛋白质及其二聚体蛋白质。可以通过在N末端构建含有序列表的SEQ ID NO：1的DNA编码氨基酸序列的质粒与甲硫氨酸在N末端引入，将质粒导入大肠杆菌进行转化，从而增溶包涵体通过培养转化体获得，从溶解的溶液中纯化单体蛋白质，将单体蛋白重折叠成二聚体蛋白质并进行纯化。上述同型二聚体蛋白质可用作治疗软骨和骨疾病的药物组合物。

10. 发明授权

US5760597A Method of and apparatus for measuring lifetime of carriers in semiconductor sample 失效
标题翻译：测量半导体样品中载流子寿命的方法和装置
公开(公告)号：US5760597A
公开(公告)日：1998-06-02
申请号：US659515
申请日：1996-06-06
申请人： Naoyuki Yoshida , Hiroyuki Takamatsu , Shingo Sumie , Yutaka Kawata , Hidehisa Hashizume , Futoshi Ojima , Yuji Hirao
发明人： Naoyuki Yoshida , Hiroyuki Takamatsu , Shingo Sumie , Yutaka Kawata , Hidehisa Hashizume , Futoshi Ojima , Yuji Hirao
IPC分类号： G01N21/88 , G01N21/00 , G01N21/956 , G01R31/265 , G01R31/28 , H01L21/66 , G01R31/26
CPC分类号： G01R31/2656 , G01R31/2831 , H01L22/14
摘要： In addition to microwave and excitation light, bias light as well is irradiated upon a surface of a semiconductor sample that is passivated using a solution which contains an electrolyte. Irradiation of the bias light increases the quantity of ionic substances that exist in the solution, largely changes a surface potential of the semiconductor sample, and suppresses surface recombination. This makes it possible to measure the lifetime of carriers which exist within the semiconductor sample at a high accuracy, without influenced by surface recombination.
摘要翻译：除了微波和激发光之外，偏光也照射在使用含有电解质的溶液钝化的半导体样品的表面上。偏置光的照射增加溶液中存在的离子物质的量，极大地改变了半导体样品的表面电位，并抑制了表面复合。这使得可以以高精度测量半导体样品内存在的载流子的寿命，而不受表面复合的影响。

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