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1. 发明申请

US20090269328A1 Dry Composition for Oral Ingestion and Gel Composition Prepared Just Before Use for Oral Ingestion 有权
标题翻译：用于口服食入之前准备的口服食入和凝胶组合物的干性成分
公开(公告)号：US20090269328A1
公开(公告)日：2009-10-29
申请号：US11628744
申请日：2005-05-23
申请人： Kazumi ISHII , Saichi Ono , Tadahiko Chiba
发明人： Kazumi ISHII , Saichi Ono , Tadahiko Chiba
IPC分类号： A61K33/44 , A61P1/16
CPC分类号： A23L1/0305 , A23K20/163 , A23K50/40 , A23L29/015 , A23L29/212 , A23L29/25 , A61K8/042 , A61K9/0007 , A61K9/06 , A61K9/14 , A61K9/141 , A61K9/146
摘要： A dry composition for oral ingestion characterized by comprising as an active ingredient a gas-releasing substance which releases gas by soak with water, and further comprising a gel base in an amount sufficient for gel formation; a gel composition for oral ingestion formed by adding water or a liquid diluent to the dry compound when taking; and a mixed feed obtainable by mixing the gel composition with a feed, are disclosed.
摘要翻译：一种口服摄取用干粉组合物，其特征在于，含有通过用水浸泡而释放气体的气体释放物质作为活性成分，并且还含有一定量的凝胶基质，其量足够用于凝胶形成; 用于口服摄取的凝胶组合物，其通过在干燥化合物中加入水或液体稀释剂而形成; 和通过将凝胶组合物与进料混合而获得的混合进料。

2. 发明授权

US09161557B2 Dry composition for oral ingestion and gel composition prepared just before use for oral ingestion 有权
标题翻译：用于口服摄入的干组合物和用于口服摄入前使用的凝胶组合物
公开(公告)号：US09161557B2
公开(公告)日：2015-10-20
申请号：US11628744
申请日：2005-05-23
申请人： Kazumi Ishii , Saichi Ono , Tadahiko Chiba
发明人： Kazumi Ishii , Saichi Ono , Tadahiko Chiba
IPC分类号： A61K9/14 , A61K47/32 , A61K47/36 , A61K47/38 , A61K33/44 , A23L1/03 , A61K8/04 , A23K1/16 , A23K1/18 , A23L1/0522 , A23L1/053 , A61K9/46 , A61K9/06
CPC分类号： A23L1/0305 , A23K20/163 , A23K50/40 , A23L29/015 , A23L29/212 , A23L29/25 , A61K8/042 , A61K9/0007 , A61K9/06 , A61K9/14 , A61K9/141 , A61K9/146
摘要： A dry composition for oral ingestion characterized by comprising as an active ingredient a gas-releasing substance which releases gas by soak with water, and further comprising a gel base in an amount sufficient for gel formation; a gel composition for oral ingestion formed by adding water or a liquid diluent to the dry compound when taking; and a mixed feed obtainable by mixing the gel composition with a feed, are disclosed.
摘要翻译：一种口服摄取用干粉组合物，其特征在于，含有通过用水浸泡而释放气体的气体释放物质作为活性成分，并且还含有一定量的凝胶基质，其量足够用于凝胶形成; 用于口服摄取的凝胶组合物，其通过在干燥化合物中加入水或液体稀释剂而形成; 和通过将凝胶组合物与进料混合而获得的混合进料。

3. 发明申请

US20130344147A1 TABLET-FORMED PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：用于口服给药的片剂形成的药物组合物及其生产方法
公开(公告)号：US20130344147A1
公开(公告)日：2013-12-26
申请号：US14002989
申请日：2012-03-05
申请人： Ayumi Kainose , Yohei Koya , Yoshiki Machi , Saichi Ono , Tadahiko Chiba
发明人： Ayumi Kainose , Yohei Koya , Yoshiki Machi , Saichi Ono , Tadahiko Chiba
IPC分类号： A61K9/20 , A61K33/44
CPC分类号： A61K9/20 , A61K9/205 , A61K9/2095 , A61K33/44
摘要： The object of the present invention is to provide an adsorbent for oral administration, which can: obviate sandy texture of granules-formed adsorbent for oral administration, reduce the volume administered compared to encapsulated adsorbent for oral administration, and be easy to take.The object of the present invention is solved by a tablet-formed pharmaceutical composition consisting of 65% or more by weight of particulate substance as an active ingredient and one or more additives, characterized in that: (a) the particulate substance does not exhibit water solubility and swelling property in water, has a distortion rate of 2% or less when subjected to a pressure of 2 MPa, and has a fracture strength of 5 MPa or more, (b) the tablet-formed pharmaceutical composition comprises one or more particle-formulating additives wherein the amount of the particle-formulating additives is 1% or more by weight in total with respect to the weight of the tablet-formed pharmaceutical composition, and a thin layer of the particle-formulating additive can be formed when 0.5 mL of solution or dispersion liquid of the particle-formulating additive of 1% by weight is dropped on a plane surface of fluorine resin and heat-dried.
摘要翻译：本发明的目的是提供一种用于口服给药的吸附剂，其可以：消除用于口服给药的颗粒形成的吸附剂的沙质质，与口服给药的封装吸附剂相比，减少施用的体积，并且容易服用。本发明的目的是通过由作为活性成分的颗粒物质的65重量％或更多的添加剂和一种或多种添加剂组成的片剂形式的药物组合物来解决，其特征在于：（a）颗粒物质不显示水在水中的溶解性和溶胀性在经受2MPa的压力时具有2％以下的变形率，断裂强度为5MPa以上，（b）片剂形成的药物组合物包含一种或多种颗粒制剂添加剂，相对于片剂形成的药物组合物的重量，配制粉剂的总量为1重量％以上，配方添加剂的薄层可以在0.5mL 的配方添加剂的1重量％的溶液或分散液滴在氟树脂的平面上并进行加热干燥。

4. 发明授权

US5686081A Divided package of adsorbent for internal use 失效
标题翻译：用于内部使用的分开的吸附剂包装
公开(公告)号：US5686081A
公开(公告)日：1997-11-11
申请号：US618336
申请日：1996-03-19
申请人： Saichi Ono , Tadahiko Chiba , Yasuo Uehara
发明人： Saichi Ono , Tadahiko Chiba , Yasuo Uehara
IPC分类号： B65D75/58 , A61K9/00 , A61K33/44 , B65D1/09
CPC分类号： B65D75/5805 , B65D75/5811
摘要： Disclosed herein are a divided package of a medicinal adsorbent for internal use, comprising a divided package bag and an adsorbent for internal use which releases air ranging from 1.3 to 10 ml based on one gram of the adsorbent on heating from 10.degree. C. to 30.degree. C. and is packed therein, and having a volume expansion coefficient ranging from 0 to 0.064 ml/.degree.C..multidot.g (adsorbent for internal use) at a temperature of from 10.degree. to 30.degree. C., and a process for producing the same.
摘要翻译：本文公开了一种用于内部使用的药用吸附剂的分割包装，包括分开的包装袋和用于内部的吸收剂，其在加热至10℃至30℃时基于1g吸附剂释放1.3至10ml的空气在10℃〜30℃的温度下填充体积膨胀系数为0〜0.064ml /℃×（内部吸附剂）的制造方法，相同。

5. 发明授权

US06750249B1 Controlled release oral preparations of esculetin and its derivatives 失效
标题翻译：七叶亭及其衍生物的控释口服制剂
公开(公告)号：US06750249B1
公开(公告)日：2004-06-15
申请号：US09806636
申请日：2001-05-23
申请人： Iwao Yamaguchi , Saichi Ono , Tadahiko Chiba
发明人： Iwao Yamaguchi , Saichi Ono , Tadahiko Chiba
IPC分类号： A61K3135
CPC分类号： A61K9/5042 , A61K9/2054 , A61K9/2866 , A61K9/4866 , A61K31/37
摘要： The present invention relates to an oral preparation of esculetin with controlled release. The oral preparation of esculetin with controlled release of the present invention comprises a gel-forming polymer base, preferably hydroxypropylmethylcellulose. The preparation may be coated with an enteric polymer base such as hydroxypropylmethylcellulose acetate succinate to thereby enhance solubility in the intestines. When orally administered, the preparation can continuously release esculetin. Thus, the administration frequency and dose can be reduced and a therapeutic effect on arthropathy can be established.
摘要翻译：本发明涉及具有控制释放的七叶亭的口服制剂。具有本发明的控制释放的七叶亭的口服制剂包含凝胶形成聚合物基质，优选羟丙基甲基纤维素。该制剂可以用肠溶性聚合物基质如乙酸琥珀酸羟丙基甲基纤维素包衣，从而增强肠内的溶解度。口服给药时，可以连续释放七叶亭。因此，可以降低给药频率和剂量，并且可以建立对关节病的治疗效果。

6. 发明申请

US20060293641A1 Housing body for deglutition of solid molding for oral ingestion, container for the housing body, and deglutition method 审中-公开
标题翻译：用于口腔摄入的固体成型用于脱脂的壳体，用于壳体的容器和脱脂方法
公开(公告)号：US20060293641A1
公开(公告)日：2006-12-28
申请号：US10556592
申请日：2004-05-14
申请人： Fuyuhiko Nishijima , Saichi Ono , Tadahiko Chiba , Yukio Iwase , Yoshiaki Osaka , Koichi Niimura
发明人： Fuyuhiko Nishijima , Saichi Ono , Tadahiko Chiba , Yukio Iwase , Yoshiaki Osaka , Koichi Niimura
IPC分类号： A61M31/00
CPC分类号： A61J7/0038 , A47G21/183
摘要： A housing body (10) for deglutition of a shaped solid (5) for oral ingestion which is stored therein, comprising a generally tubular water-resistant envelope (1); an opening-side end part (A) at one end of the envelope, having an unsealable structure part (2), and capable of forming an opening part (22) by removing the unsealable structure part; a shielding-side end part (B) at the other end of the envelope, having a means for preventing the shaped solid for oral ingestion from release, the means allowing liquid to pass therethrough but not allowing the shaped solid for oral ingestion to pass therethrough; and a storage chamber (6) storing the shaped solid for oral ingestion between the opening-side end part and the shielding-side end part is disclosed. A method for swallowing a shaped solid for oral ingestion, wherein an unsealable structure part installed at an opening-side end part of the housing body is removed; the shielding-side end part of the housing body is immersed into liquid in a vessel while the shaped solid for oral ingestion is stored in the storage chamber in the tubular envelope; and an opening part formed at the opening-side end part is held between the lips so that the shaped solid for oral ingestion is sucked in together with the liquid in the vessel is also disclosed.
摘要翻译：一种用于口腔成形固体（5）脱水的壳体（10），其用于口腔摄取，其存储在其中，包括大致管状的防水外壳（1）; 在封套的一端处的开口侧端部（A），具有可开封结构部分（2），并且能够通过移除开封结构部分形成开口部分（22）; 在封套的另一端处的屏蔽侧端部（B）具有用于防止成形固体口服摄取的装置，允许液体通过但不允许用于口服摄取的成形固体通过的装置 ; 公开了一种在开口侧端部和屏蔽侧端部之间存储用于口腔摄取的成形固体的储存室（6）。一种吞咽用于口服摄取的成形固体的方法，其中移除安装在所述壳体的开口侧端部的开封结构部分; 将壳体的屏蔽侧端部浸入容器中的液体中，同时将用于口腔摄取的成形固体储存在管状外壳中的储存室中; 并且形成在开口侧端部处的开口部分保持在唇缘之间，使得用于口服摄取的成形固体与容器中的液体一起被吸入。

7. 发明授权

US6083535A Effervescent granular preparation for keeping cut flower freshness 失效
标题翻译：用于保持切花新鲜度的泡腾颗粒制剂
公开(公告)号：US6083535A
公开(公告)日：2000-07-04
申请号：US930995
申请日：1997-12-29
申请人： Tadahiko Chiba , Shiro Yamazaki , Toshihide Saishoji
发明人： Tadahiko Chiba , Shiro Yamazaki , Toshihide Saishoji
IPC分类号： A01N3/02 , A01N43/653 , A61K9/14
CPC分类号： A01N3/02 , A01N43/653
摘要： An effervescent granular preparation for keeping cut flower freshness includes an azole-substituted cyclopentanol derivative represented by formula (I) (set forth below) and 2-bromo-2-nitro-1, 3-propanediol as effective components and to a process for producing the same. The effervescent granular preparation is produced by granulation of a mixture containing at least one of glucose, D-mannitol and sucrose as an excipient by incorporating an organic acid such as citric acid or malic acid and a hydrogen carbonate such as sodium hydrogen carbonate. ##STR1## wherein A represents a nitrogen atom or a CH group, R.sup.1 and R.sup.2 represent each independently a hydrogen or a C.sub.1 -C.sub.3 alkyl group, and X represents a hydrogen atom or a halogen atom.
摘要翻译： PCT No.PCT / JP96 / 00445 Sec。 371日期1997年12月29日第 102（e）日期1997年12月29日PCT提交1996年2月27日PCT公布。出版物WO96 / 32012 PCT 日期1996年10月17日用于保持切花新鲜度的泡腾颗粒制剂包括由式（I）表示的唑类取代的环戊醇衍生物（下文）和作为有效成分的2-溴-2-硝基-1,3-丙二醇，涉及其制造方法。通过掺入有机酸如柠檬酸或苹果酸和碳酸氢钠如碳酸氢钠，通过造粒含有葡萄糖，D-甘露糖醇和蔗糖中的至少一种作为赋形剂的混合物来制备泡腾颗粒制剂。其中A表示氮原子或CH基团，R 1和R 2各自独立地表示氢或C 1 -C 3烷基，X表示氢原子或卤素原子。

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