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1. 发明申请

US20110039332A1 HUMAN PLURIPOTENT STEM CELLS INDUCED FROM UNDIFFERENTIATED STEM CELLS DERIVED FROM A HUMAN POSTNATAL TISSUE 审中-公开
标题翻译：从人类后组织衍生的不同的干细胞诱导的人PLUIPOTENT干细胞
公开(公告)号：US20110039332A1
公开(公告)日：2011-02-17
申请号：US12663840
申请日：2007-11-20
申请人： Kazuhiro Sakurada , Hldeki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hldeki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： C12N5/071 , C12N5/0735
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： To establish human pluripotent stem cells having properties close to human ES cells comprising the genome of the patient per se that can circumvent immunological rejection of transplanted cells from cells derived from a postnatal human tissue. It was found that human pluripotent stem cells can be induced by introducing three genes of Oct3/4, Sox2 and KIf 4, or three genes of Oct3/4, Sox2 and KIf 4 plus the c-Myc gene or a histone deacetylase (HDAC) inhibitor to undifferentiated stem cells present in various human postnatal tissues in which each gene of Tert, Nanog, Oct3/4 and Sox2 has not undergone epigenetic inactivation.
摘要翻译：建立具有接近人类ES细胞的人类多能干细胞，其包含患者本身的基因组，其可以规避来自出生后人体组织的细胞的移植细胞的免疫排斥。发现人类多能干细胞可以通过引入Oct3 / 4，Sox2和KIf4的三个基因或Oct3 / 4，Sox2和KIf4的三个基因加上c-Myc基因或组蛋白脱乙酰酶（HDAC）来诱导，抑制剂存在于各种人类出生后组织中的未分化干细胞，其中Tert，Nanog，Oct3 / 4和Sox2的每个基因未经历表观遗传学失活。

2. 发明申请

US20090191159A1 Multipotent/pluripotent cells and methods 有权
标题翻译：多能/多能细胞和方法
公开(公告)号：US20090191159A1
公开(公告)日：2009-07-30
申请号：US12157967
申请日：2008-06-13
申请人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： A61K45/00 , C12N5/08 , C12Q1/68 , G01N33/53 , A61P25/28 , A61P3/10
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.
摘要翻译：本文描述的是多能干细胞，例如人和其他哺乳动物多能干细胞，以及相关方法。

3. 发明申请

US20100120069A1 MULTIPOTENT/PLURIPOTENT CELLS AND METHODS 审中-公开
公开(公告)号：US20100120069A1
公开(公告)日：2010-05-13
申请号：US12564836
申请日：2009-09-22
申请人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： G01N33/53 , C12N5/071 , C12N5/074
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.

4. 发明申请

US20100267135A1 MULTIPOTENT/PLURIPOTENT CELLS AND METHODS 审中-公开
公开(公告)号：US20100267135A1
公开(公告)日：2010-10-21
申请号：US12685569
申请日：2010-01-11
申请人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： C12N5/071
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.

5. 发明申请

US20100105100A1 MULTIPOTENT/PLURIPOTENT CELLS AND METHODS 审中-公开
标题翻译：多重/多核细胞和方法
公开(公告)号：US20100105100A1
公开(公告)日：2010-04-29
申请号：US12580216
申请日：2009-10-15
申请人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： C12Q1/02 , C12N5/0797
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.
摘要翻译：本文描述的是多能干细胞，例如人和其他哺乳动物多能干细胞，以及相关方法。

6. 发明授权

US08211697B2 Induced pluripotent stem cells produced using reprogramming factors and a rho kinase inhibitor or a histone deacetylase inhibitor 有权
标题翻译：使用重编程因子和rho激酶抑制剂或组蛋白脱乙酰酶抑制剂产生的诱导多能干细胞
公开(公告)号：US08211697B2
公开(公告)日：2012-07-03
申请号：US12157967
申请日：2008-06-13
申请人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： C12N5/02 , C12N15/00
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.
摘要翻译：本文描述的是多能干细胞，例如人和其他哺乳动物多能干细胞，以及相关方法。

7. 发明申请

US20090304646A1 Multipotent/Pluripotent Cells and Methods 审中-公开
标题翻译：多能/多能细胞和方法
公开(公告)号：US20090304646A1
公开(公告)日：2009-12-10
申请号：US12465633
申请日：2009-05-13
申请人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： A61K35/12 , C12N5/08 , C12Q1/68
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.
摘要翻译：本文描述的是多能干细胞，例如人和其他哺乳动物多能干细胞，以及相关方法。

8. 发明申请

US20100240090A1 METHODS AND PLATFORMS FOR DRUG DISCOVERY 审中-公开
标题翻译：药物发现的方法和平台
公开(公告)号：US20100240090A1
公开(公告)日：2010-09-23
申请号：US12709379
申请日：2010-02-19
申请人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： C12Q1/02
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： The present invention involves methods for identifying an agent that corrects a phenotype associated with a health condition or a predisposition for a health condition. The invention also involves methods for identifying a diagnostic cellular phenotype, determining the risk of a health condition in a subject, methods for reducing the risk of drug toxicity in a human subject, and methods for identifying a candidate gene that contributes to a human disease. The invention also discloses human induced pluripotent stem cell lines.
摘要翻译：本发明涉及用于鉴定校正与健康状况或健康状况的倾向相关联的表型的药剂的方法。本发明还涉及用于鉴定诊断性细胞表型，确定受试者健康状况风险的方法，降低人类受试者中药物毒性风险的方法，以及用于鉴定对人类疾病有贡献的候选基因的方法。本发明还公开了人诱导的多能干细胞系。

9. 发明授权

US09272642B2 Vehicle seat 有权
标题翻译：车座
公开(公告)号：US09272642B2
公开(公告)日：2016-03-01
申请号：US14477272
申请日：2014-09-04
申请人： Hideki Kobayashi , Tetsuya Ishikawa , Kazuhisa Nishimura
发明人： Hideki Kobayashi , Tetsuya Ishikawa , Kazuhisa Nishimura
IPC分类号： B60N2/30 , B60N2/36 , B60N2/48
CPC分类号： B60N2/3065 , B60N2/3013 , B60N2/3088 , B60N2/36 , B60N2/859 , B60N2/874 , B60N2205/40
摘要： In a vehicle seat (car seat 1) including a first seat portion (seat cushion 10) movable between a use position and a retracted position, and a second seat portion (seat back 20) movable between a use position and a retracted position, an actuator mechanism is configured to cause the second seat portion to start moving toward its retracted position at a time when the first seat portion passes a predetermined intermediate position that is on a way from the use position toward the retracted position. In one embodiment, the actuator mechanism includes a biasing member (torsion spring 13, 23) configured to bias each of the seat cushion 10 and the seat back 20 from the use position toward the retracted position, a lock member (lock arm 42) configured to lock the seat back 20 in the use position, and an unlock device (cable 44, 42A) configured to release the lock member to cause the seat back 20 to start moving toward the retracted position, at a time when the seat cushion 10 passes the predetermined intermediate position that is on the way from a posture in which the seat cushion is ready for use toward a posture in which the seat cushion 10 is tipped up.
摘要翻译：在包括在使用位置和缩回位置之间可移动的第一座椅部分（座垫10）和可在使用位置和缩回位置之间移动的第二座椅部分（座椅靠背20）的车辆座椅（汽车座椅1）中，致动器机构构造成使得第二座椅部分在第一座椅部分经过从使用位置朝向缩回位置的途中经过的预定中间位置时开始向其缩回位置移动。在一个实施例中，致动器机构包括构造成将座垫10和座椅靠背20中的每一个从使用位置朝向缩回位置偏置的偏置构件（扭转弹簧13,23），配置在锁定构件将座椅靠背20锁定在使用位置，以及解锁装置（电缆44,42A），其构造成在座垫10通过时释放锁定构件以使座椅靠背20开始向缩回位置移动在从座垫准备好使用的姿势朝向座垫10倾斜的姿势的途中的预定中间位置。

10. 发明授权

US08651638B2 Inkjet printing apparatus 有权
标题翻译：喷墨打印设备
公开(公告)号：US08651638B2
公开(公告)日：2014-02-18
申请号：US13218626
申请日：2011-08-26
申请人： Tetsuya Ishikawa
发明人： Tetsuya Ishikawa
IPC分类号： B41J2/175
CPC分类号： B41J2/17509 , B41J2/175 , B41J2/17513 , B41J2/1752 , B41J2/17523 , B41J2/17553 , B41J2/17596
摘要： An inkjet printing apparatus comprises an ink tank including an ink accommodating unit, an ink leading-out mechanism for leading out the ink in the ink accommodating unit to an outside, and a housing, and an ink tank holder for removably retaining the ink tank, wherein a space is formed between the ink leading-out mechanism and the housing, and when the ink tank is mounted to the ink tank holder, an ink flow passage is formed by contact of an outer periphery of an ink leading-out needle in the ink tank holder with a sealing member in the ink leading-out mechanism, further comprising restriction means for restricting a position of the ink tank to the ink tank holder such that when removing the ink tank from the ink tank holder, the ink tank stops in a state where a tip end of the ink leading-out needle is in the space.
摘要翻译：一种喷墨打印设备包括一个墨盒，包括墨水容纳单元，用于将墨水容纳单元中的墨水引导到外部的墨水引出机构和外壳以及用于可拆卸地保持墨水盒的墨水盒保持器，其中在所述墨水引出机构和所述壳体之间形成空间，并且当所述墨水罐安装到所述墨水盒保持器时，墨水流动通道通过所述墨水引出针的外周部在墨水引出机构中具有密封构件的墨水盒保持器还包括限制装置，用于将墨水罐的位置限制到墨水盒保持器，使得当从墨水盒保持器移除墨水盒时，墨水罐停止墨水引出针的前端位于空间中的状态。

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