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1. 发明申请

US20100240090A1 METHODS AND PLATFORMS FOR DRUG DISCOVERY 审中-公开
标题翻译：药物发现的方法和平台
公开(公告)号：US20100240090A1
公开(公告)日：2010-09-23
申请号：US12709379
申请日：2010-02-19
申请人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： C12Q1/02
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： The present invention involves methods for identifying an agent that corrects a phenotype associated with a health condition or a predisposition for a health condition. The invention also involves methods for identifying a diagnostic cellular phenotype, determining the risk of a health condition in a subject, methods for reducing the risk of drug toxicity in a human subject, and methods for identifying a candidate gene that contributes to a human disease. The invention also discloses human induced pluripotent stem cell lines.
摘要翻译：本发明涉及用于鉴定校正与健康状况或健康状况的倾向相关联的表型的药剂的方法。本发明还涉及用于鉴定诊断性细胞表型，确定受试者健康状况风险的方法，降低人类受试者中药物毒性风险的方法，以及用于鉴定对人类疾病有贡献的候选基因的方法。本发明还公开了人诱导的多能干细胞系。

2. 发明申请

US20090191159A1 Multipotent/pluripotent cells and methods 有权
标题翻译：多能/多能细胞和方法
公开(公告)号：US20090191159A1
公开(公告)日：2009-07-30
申请号：US12157967
申请日：2008-06-13
申请人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： A61K45/00 , C12N5/08 , C12Q1/68 , G01N33/53 , A61P25/28 , A61P3/10
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.
摘要翻译：本文描述的是多能干细胞，例如人和其他哺乳动物多能干细胞，以及相关方法。

3. 发明申请

US20100267135A1 MULTIPOTENT/PLURIPOTENT CELLS AND METHODS 审中-公开
公开(公告)号：US20100267135A1
公开(公告)日：2010-10-21
申请号：US12685569
申请日：2010-01-11
申请人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： C12N5/071
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.

4. 发明申请

US20100105100A1 MULTIPOTENT/PLURIPOTENT CELLS AND METHODS 审中-公开
标题翻译：多重/多核细胞和方法
公开(公告)号：US20100105100A1
公开(公告)日：2010-04-29
申请号：US12580216
申请日：2009-10-15
申请人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： C12Q1/02 , C12N5/0797
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.
摘要翻译：本文描述的是多能干细胞，例如人和其他哺乳动物多能干细胞，以及相关方法。

5. 发明申请

US20100120069A1 MULTIPOTENT/PLURIPOTENT CELLS AND METHODS 审中-公开
公开(公告)号：US20100120069A1
公开(公告)日：2010-05-13
申请号：US12564836
申请日：2009-09-22
申请人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： G01N33/53 , C12N5/071 , C12N5/074
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.

6. 发明授权

US08211697B2 Induced pluripotent stem cells produced using reprogramming factors and a rho kinase inhibitor or a histone deacetylase inhibitor 有权
标题翻译：使用重编程因子和rho激酶抑制剂或组蛋白脱乙酰酶抑制剂产生的诱导多能干细胞
公开(公告)号：US08211697B2
公开(公告)日：2012-07-03
申请号：US12157967
申请日：2008-06-13
申请人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： C12N5/02 , C12N15/00
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.
摘要翻译：本文描述的是多能干细胞，例如人和其他哺乳动物多能干细胞，以及相关方法。

7. 发明申请

US20090304646A1 Multipotent/Pluripotent Cells and Methods 审中-公开
标题翻译：多能/多能细胞和方法
公开(公告)号：US20090304646A1
公开(公告)日：2009-12-10
申请号：US12465633
申请日：2009-05-13
申请人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hideki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： A61K35/12 , C12N5/08 , C12Q1/68
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.
摘要翻译：本文描述的是多能干细胞，例如人和其他哺乳动物多能干细胞，以及相关方法。

8. 发明申请

US20110039332A1 HUMAN PLURIPOTENT STEM CELLS INDUCED FROM UNDIFFERENTIATED STEM CELLS DERIVED FROM A HUMAN POSTNATAL TISSUE 审中-公开
标题翻译：从人类后组织衍生的不同的干细胞诱导的人PLUIPOTENT干细胞
公开(公告)号：US20110039332A1
公开(公告)日：2011-02-17
申请号：US12663840
申请日：2007-11-20
申请人： Kazuhiro Sakurada , Hldeki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
发明人： Kazuhiro Sakurada , Hldeki Masaki , Tetsuya Ishikawa , Shunichi Takahashi
IPC分类号： C12N5/071 , C12N5/0735
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2799/027
摘要： To establish human pluripotent stem cells having properties close to human ES cells comprising the genome of the patient per se that can circumvent immunological rejection of transplanted cells from cells derived from a postnatal human tissue. It was found that human pluripotent stem cells can be induced by introducing three genes of Oct3/4, Sox2 and KIf 4, or three genes of Oct3/4, Sox2 and KIf 4 plus the c-Myc gene or a histone deacetylase (HDAC) inhibitor to undifferentiated stem cells present in various human postnatal tissues in which each gene of Tert, Nanog, Oct3/4 and Sox2 has not undergone epigenetic inactivation.
摘要翻译：建立具有接近人类ES细胞的人类多能干细胞，其包含患者本身的基因组，其可以规避来自出生后人体组织的细胞的移植细胞的免疫排斥。发现人类多能干细胞可以通过引入Oct3 / 4，Sox2和KIf4的三个基因或Oct3 / 4，Sox2和KIf4的三个基因加上c-Myc基因或组蛋白脱乙酰酶（HDAC）来诱导，抑制剂存在于各种人类出生后组织中的未分化干细胞，其中Tert，Nanog，Oct3 / 4和Sox2的每个基因未经历表观遗传学失活。

9. 发明授权

US07841568B2 Suction cup 失效
标题翻译：吸盘
公开(公告)号：US07841568B2
公开(公告)日：2010-11-30
申请号：US12413191
申请日：2009-03-27
申请人： Shunichi Takahashi , Makoto Kawabata
发明人： Shunichi Takahashi , Makoto Kawabata
IPC分类号： F16B47/00
CPC分类号： F16B47/00
摘要： Herein disclosed a suction cup including: a suction cup body having at least one surface having a gel, the surface being a suction surface; and an elastically deformable spring element provided in or on the suction cup body, having a concave shape so as to make the suction surface have a concave shape, and energizing a central part of the suction surface away from a surface to be sucked in the condition where the suction surface is in suction contact with the surface to be sucked, wherein the spring element is formed from a material having a modulus of elasticity higher than those of natural rubber and synthetic rubbers.
摘要翻译：这里公开了一种吸盘，其包括：吸杯体，其具有至少一个具有凝胶的表面，所述表面是吸力表面; 以及设置在吸盘主体内或上的可弹性变形的弹簧元件，其具有凹形，以使吸引表面具有凹形，并且使抽吸表面的中心部分远离待吸附表面的状态其中吸入表面与待吸附的表面进行吸力接触，其中弹性元件由弹性模量高于天然橡胶和合成橡胶的材料形成。

10. 发明申请

US20110176703A1 SPEAKER DEVICE 审中-公开
标题翻译：扬声器设备
公开(公告)号：US20110176703A1
公开(公告)日：2011-07-21
申请号：US12921715
申请日：2009-07-29
申请人： Minoru Horigome , Hiroyuki Kobayashi , Shunichi Takahashi , Yasuhisa Abe , Yasuhiro Saso , Toshihiro Hikichi , Takuei Nagasawa , Tempei Katsuta
发明人： Minoru Horigome , Hiroyuki Kobayashi , Shunichi Takahashi , Yasuhisa Abe , Yasuhiro Saso , Toshihiro Hikichi , Takuei Nagasawa , Tempei Katsuta
IPC分类号： H04R9/06
CPC分类号： H04R1/2819 , H04R1/2842 , H04R1/2865 , H04R1/30 , H04R9/041 , H04R9/045 , H04R9/047 , H04R2499/11 , H04R2499/13 , H04R2499/15
摘要： A speaker device includes a speaker unit and a cabinet on or in which the speaker unit is mounted. The speaker unit includes a diaphragm, a static part supporting the diaphragm vibratably in a vibration direction, and a driving part provided at the static part to vibrate the diaphragm in response to an audio signal. The driving part includes a magnetic circuit forming a magnetic gap, a voice coil vibrating in a direction different from the vibration direction of the diaphragm upon the inputted audio signal, and a rigid vibration direction converter part configured to convert the vibration direction of the voice coil and transmit the vibration to the diaphragm.
摘要翻译：扬声器装置包括扬声器单元和安装有扬声器单元的机柜。扬声器单元包括隔膜，支撑振动板在振动方向上振动的静止部分，以及设置在静止部分的驱动部分，以响应音频信号振动隔膜。驱动部包括形成磁隙的磁路，在与所输入的音频信号的振动方向不同的振动方向上振动的音圈;以及刚性振动方向转换部，其将音圈的振动方向并将振动传递到隔膜。

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