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1. 发明授权

US5284091A Plate roll and an adhesive sheet therefor 失效
标题翻译：平板辊及其粘合片
公开(公告)号：US5284091A
公开(公告)日：1994-02-08
申请号：US884270
申请日：1992-05-08
申请人： Kazuhiro Kon , Koichi Hirota , Masao Kogure , Takanori Saito
发明人： Kazuhiro Kon , Koichi Hirota , Masao Kogure , Takanori Saito
IPC分类号： B41F27/12 , B41F13/10 , H01L21/68
CPC分类号： B41F27/1275 , B41N6/02 , Y10S428/913 , Y10T428/1462 , Y10T428/28 , Y10T428/2809 , Y10T428/283 , Y10T428/2848 , Y10T428/2857 , Y10T428/2883 , Y10T428/2891 , Y10T428/31678 , Y10T428/31692 , Y10T428/31699
摘要： A plate roll attached by an adhesive sheet to a printing plate made of a resin. The attached printing plate is easily detached. The adhesive sheet and remaining adhesive are easily removed after printing is finished and the efficiency of the operation of printing is enhanced. The adhesive sheet includes a photocurable adhesive, which loses adhesive ability by curing by irradiation of electromagnetic waves or an electron beam or a water swelling adhesive, which loses adhesive ability by swelling by water. Adhesive sheets for the plate roll comprise supporting sheets, removable sheets and a photocurable adhesive, which loses adhesive ability by curing by irradiation of electromagnetic waves or an electron beam or a water swelling adhesive, which loses adhesive ability by swelling by water.
摘要翻译：由粘合片附着到由树脂制成的印版上的平板辊。附着的印版容易分离。粘合片和剩余的粘合剂在印刷完成后容易地除去，并且印刷操作的效率提高。粘合片包括可光固化的粘合剂，其通过电磁波的照射或电子束或水溶性粘合剂的固化而失去粘合性，其通过水膨胀而失去粘合能力。用于板卷的粘合片包括支撑片，可移除片和可光固化的粘合剂，其通过电磁波的照射或电子束或水溶性粘合剂固化而失去粘合性，其通过水膨胀而失去粘合能力。

2. 发明授权

US5589192A Gel pharmaceutical formulation for local anesthesia 失效
标题翻译：凝胶药物制剂局部麻醉
公开(公告)号：US5589192A
公开(公告)日：1996-12-31
申请号：US353322
申请日：1994-12-05
申请人： Hideaki Okabe , Eiji Suzuki , Masao Kogure , Takanori Saito
发明人： Hideaki Okabe , Eiji Suzuki , Masao Kogure , Takanori Saito
IPC分类号： A61K9/70 , A61K31/165 , A61K31/167 , A61K31/245 , A61K45/00 , A61K47/32 , A61P23/02 , A61P25/02 , A61L15/00
CPC分类号： A61K9/7061 , A61K31/245 , Y10S514/816 , Y10S514/818 , Y10S514/944 , Y10S514/946
摘要： An article of manufacture in the form of a gel pharmaceutical formulation for local anesthesia is prepared by a process comprising: coating a supporting substrate, which preferably is porous, e.g., a non-woven fabric, and has an impervious backing sheet, with a matrix of a copolymer of alkyl (meth)acrylates and (meth)acrylic acid and a local anesthetic whereby the matrix penetrates the substrate, crosslinking the copolymer in the matrix to form a polymer/drug matrix, and coating the surface of the matrix with an aqueous fluid, thereby converting the matrix into a gel and preferably covering the gel matrix with an impervious protective sheet. The product has excellent percutaneous absorption, provides local anesthesia easily just by attaching the formulation to the skin, enables elimination of various kinds of pain, such as the pain at the time of hypodermic injection, can be removed easily from the skin, and causes no soiling of fingers, hands or cloths.
摘要翻译：用于局部麻醉的凝胶药物制剂形式的制品是通过以下方法制备的，该方法包括：将优选为多孔的支撑基底（例如无纺织物）涂覆并具有不透水的背衬片，的（甲基）丙烯酸烷基酯和（甲基）丙烯酸烷基酯和局部麻醉剂的共聚物，由此基质渗透底物，使基质中的共聚物交联以形成聚合物/药物基质，并用水性从而将基质转化成凝胶，并且优选用不透水的保护片覆盖凝胶基质。该产品具有优异的经皮吸收，通过将配方附着到皮肤上即可轻松提供局部麻醉，能够消除各种疼痛，如皮下注射时的疼痛，可以容易地从皮肤上清除，不会导致弄脏手指，手或布。

3. 发明授权

US09324591B2 Heat treatment apparatus and heat treatment method 有权
标题翻译：热处理设备及热处理方法
公开(公告)号：US09324591B2
公开(公告)日：2016-04-26
申请号：US13438234
申请日：2012-04-03
申请人： Koji Yoshii , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
发明人： Koji Yoshii , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
IPC分类号： F27D21/00 , H01L21/67
CPC分类号： H01L21/67109 , H01L21/67248
摘要： A heat treatment apparatus including: a processing container for processing wafers held in a boat; heaters for heating the processing container; and a control section for controlling the heaters. Heater temperature sensors are provided between the heaters and the processing container, in-container temperature sensors are provided in the processing container, and movable temperature sensors are provided in the boat. The temperature sensors are connected to a temperature estimation section. The temperature estimation section selects two of the three types of temperature sensors, e.g. the movable temperature sensors and the in-container temperature sensors, and determines the temperature of a wafer according to the following formula: T=T1×(1−α)+T2×α, α>1, where T1 and T2 represent detection temperatures of the selected temperature sensors, and α represents a mixing ratio.
摘要翻译：一种热处理设备，包括：处理容器，用于处理保存在船上的晶片; 用于加热处理容器的加热器; 以及用于控制加热器的控制部。加热器温度传感器设置在加热器和处理容器之间，容器内温度传感器设置在处理容器中，并且可移动的温度传感器设置在船上。温度传感器连接到温度估计部。温度估计部分选择三种类型的温度传感器中的两种，例如，可移动温度传感器和容器内温度传感器，并根据以下公式确定晶片的温度：T = T1×（1-α）+ T2×α，α> 1，其中T1和T2表示检测温度的选定温度传感器，α表示混合比。

4. 发明授权

US09273128B2 Pharmaceutical composition for treatment and/or prophylaxis of cancer 有权
标题翻译：用于治疗和/或预防癌症的药物组合物
公开(公告)号：US09273128B2
公开(公告)日：2016-03-01
申请号：US14236793
申请日：2012-08-03
申请人： Fumiyoshi Okano , Shinichi Kobayashi , Yoshitaka Minamida , Takanori Saito
发明人： Fumiyoshi Okano , Shinichi Kobayashi , Yoshitaka Minamida , Takanori Saito
IPC分类号： C07K16/30 , A61K39/395 , C07K16/18 , A61K45/06 , C07K16/28
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/732
摘要： This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer comprising the same as an active ingredient.
摘要翻译：本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。更具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列或具有80％以上序列同一性的氨基酸序列组成的部分CAPRIN-1多肽具有免疫学反应性的抗体或其片段和用于治疗和/或预防癌症的药物组合物，其包含其作为活性成分。

5. 发明授权

US09180188B2 Pharmaceutical composition for treatment and/or prophylaxis of cancer 有权
标题翻译：用于治疗和/或预防癌症的药物组合物
公开(公告)号：US09180188B2
公开(公告)日：2015-11-10
申请号：US14236795
申请日：2012-08-03
申请人： Shinichi Kobayashi , Fumiyoshi Okano , Yoshitaka Minamida , Takanori Saito
发明人： Shinichi Kobayashi , Fumiyoshi Okano , Yoshitaka Minamida , Takanori Saito
IPC分类号： C07K16/30 , A61K39/395 , A61K45/06 , C07K16/28 , A61K39/00
CPC分类号： A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/732 , A61K2300/00
摘要： It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising amino acid sequences of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising this antibody or fragment as an active ingredient.
摘要翻译：旨在鉴定在癌细胞表面上特异性表达的癌抗原蛋白，并提供靶向抗原蛋白的抗体和使用抗体作为癌症的治疗和/或预防剂。本发明提供了与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体包含包含SEQ ID NO：5,6和7的氨基酸序列的重链可变区和轻链可变区包含SEQ ID NO：9,10和11的氨基酸序列，和包含该抗体或片段作为活性成分的用于治疗和/或预防癌症的药物组合物。

6. 发明申请

US20140178373A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PROPHYLAXIS OF CANCER 有权
公开(公告)号：US20140178373A1
公开(公告)日：2014-06-26
申请号：US14236665
申请日：2012-08-03
申请人： Shinichi Kobayashi , Fumiyoshi Okano , Takanori Saito
发明人： Shinichi Kobayashi , Fumiyoshi Okano , Takanori Saito
IPC分类号： C07K16/30 , A61K45/06 , A61K39/395
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6861 , A61K47/6865 , A61K47/6869 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/732
摘要： An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.

7. 发明申请

US20120258415A1 HEAT TREATMENT APPARATUS AND HEAT TREATMENT METHOD 有权
标题翻译：热处理设备和热处理方法
公开(公告)号：US20120258415A1
公开(公告)日：2012-10-11
申请号：US13438234
申请日：2012-04-03
申请人： Koji YOSHII , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
发明人： Koji YOSHII , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
IPC分类号： F27D21/00 , F27D3/00
CPC分类号： H01L21/67109 , H01L21/67248
摘要： A heat treatment apparatus including: a processing container for processing wafers held in a boat; heaters for heating the processing container; and a control section for controlling the heaters. Heater temperature sensors are provided between the heaters and the processing container, in-container temperature sensors are provided in the processing container, and movable temperature sensors are provided in the boat. The temperature sensors are connected to a temperature estimation section. The temperature estimation section selects two of the three types of temperature sensors, e.g. the movable temperature sensors and the in-container temperature sensors, and determines the temperature of a wafer according to the following formula: T=T1×(1−α)+T2×α, α>1, where T1 and T2 represent detection temperatures of the selected temperature sensors, and α represents a mixing ratio.
摘要翻译：一种热处理设备，包括：处理容器，用于处理保存在船上的晶片; 用于加热处理容器的加热器; 以及用于控制加热器的控制部。加热器温度传感器设置在加热器和处理容器之间，容器内温度传感器设置在处理容器中，并且可移动的温度传感器设置在船上。温度传感器连接到温度估计部。温度估计部分选择三种类型的温度传感器中的两种，例如，可移动温度传感器和容器内温度传感器，并根据以下公式确定晶片的温度：T = T1×（1-α）+ T2×α，α> 1，其中T1和T2表示检测温度的选定温度传感器，α表示混合比。

8. 发明申请

US20110256144A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT AND PREVENTION OF CANCERS 有权
标题翻译：用于治疗和预防癌症的药物组合物
公开(公告)号：US20110256144A1
公开(公告)日：2011-10-20
申请号：US13057709
申请日：2009-08-05
申请人： Fumiyoshi Okano , Takayoshi Ido , Takanori Saito , Shinichi Kobayashi
发明人： Fumiyoshi Okano , Takayoshi Ido , Takanori Saito , Shinichi Kobayashi
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02 , C07K16/18
CPC分类号： C07K16/3015 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K16/3053 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734
摘要： The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.
摘要翻译：本发明涉及用于治疗和/或预防癌症的药物组合物，其包含与包含7个或更多个连续氨基酸的CAPRIN-1蛋白或其片段具有免疫学反应性的抗体或其片段作为活性成分酸。

9. 发明申请

US20100224614A1 Heat Treatment Apparatus, Heater, and Method for Manufacturing the Heater 有权
标题翻译：热处理装置，加热器及加热器制造方法
公开(公告)号：US20100224614A1
公开(公告)日：2010-09-09
申请号：US12223162
申请日：2007-02-07
申请人： Makoto Kobayashi , Kenichi Yamaga , Takanori Saito
发明人： Makoto Kobayashi , Kenichi Yamaga , Takanori Saito
IPC分类号： F27D11/00 , H05B3/02
CPC分类号： H01L21/67109 , H01L21/425 , Y10T29/49083
摘要： The present invention provides a heat treatment apparatus having a high degree of freedom of an outlet design and capable of adjusting the rate of a reduction in the temperature of each part of a heater without using an adjustment valve. The heat treatment apparatus having a simple flow path structure can be constructed with simplified sealing and a reduced cost.The heat treatment apparatus 1 includes a process chamber 2, a tubular heater 3, a heat exhaust system 25 and a cooling section 26. The process chamber 2 accommodates objects W to be placed in multiple stages and to be treated. A predetermined heat treatment is performed in the process chamber. The heater 3 surrounds an outer circumference of the process chamber 2 and heats the objects W to be treated. The heat exhaust system 25 is adapted to exhaust an atmosphere present in a space 24 existing between the heater 3 and the process chamber 2. The cooling section 26 is adapted to blow a cooling fluid into the space 24 to cool the atmosphere. The heater 3 includes a tubular heat insulator 17, a heat generating resistor 18 and an outer shell 20. The heat generating resistor 18 is provided on an inner circumference of the heat insulator 17. The outer shell 20 is provided on an outer circumference of the heat insulator 17. The cooling section 26 includes at least one annular flow path 28 and an outlet 29. The annular flow path 28 is arranged between the heat insulator 17 and the outer shell 20. The outlet 29 is provided in the heat insulator 17. The outlet 29 is arranged to ensure that the cooling fluid is blown out of the outlet 29 toward a vertical central axis of the heat insulator 17 or in a direction oblique to the direction toward vertical central axis of the heat insulator 17.
摘要翻译：本发明提供一种热处理装置，其具有出口设计的高自由度，并且能够调节加热器的每个部件的温度降低的速率而不使用调节阀。具有简单的流路结构的热处理装置可以以简单的密封和降低的成本构成。热处理设备1包括处理室2，管状加热器3，散热系统25和冷却部分26.处理室2容纳待放置的多个物体W并进行处理。在处理室中进行预定的热处理。加热器3围绕处理室2的外周并加热被处理物体W. 散热系统25适于排出存在于加热器3和处理室2之间的空间24中的气氛。冷却部分26适于将冷却流体吹入空间24以冷却大气。加热器3包括管状隔热件17，发热电阻18和外壳20.发热电阻18设置在隔热材料17的内周上。外壳20设置在绝热体17的外周。绝热体17.冷却部分26包括至少一个环形流动路径28和出口29.环形流路28设置在绝热体17和外壳20之间。出口29设置在绝热体17中。出口29布置成确保冷却流体从出口29朝向隔热件17的垂直中心轴线或者沿着与隔热件17的垂直中心轴方向倾斜的方向吹出。

10. 发明授权

US06885814B2 Carbon wire heating object sealing heater and fluid heating apparatus using the same heater 失效
公开(公告)号：US06885814B2
公开(公告)日：2005-04-26
申请号：US10395395
申请日：2003-03-25
申请人： Takanori Saito , Hiroshi Mori , Akira Otsu , Norihiko Saito , Hiroyuki Honma , Eiichi Toya , Tomio Konn , Tomohiro Nagata , Ken Nakao , Kazutoshi Miura , Harunari Hasegawa , George Hoshi , Katsutoshi Ishi , Sunao Seko
发明人： Takanori Saito , Hiroshi Mori , Akira Otsu , Norihiko Saito , Hiroyuki Honma , Eiichi Toya , Tomio Konn , Tomohiro Nagata , Ken Nakao , Kazutoshi Miura , Harunari Hasegawa , George Hoshi , Katsutoshi Ishi , Sunao Seko
IPC分类号： H01L23/34 , H05B3/14 , H05B3/00
CPC分类号： H05B3/145 , H01L2924/0002 , H01L2924/00
摘要： A carbon wire heating element sealing heater is provided. Therein, a carbon wire heating element using carbon fibers is sealed in a quartz glass member, wherein absorption water quantity of the carbon wire heating element is 2×10−3 g/cm3 or less.

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