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1. 发明授权

US5811293A Processes for producing optically active 2-amino-1-phenylethanol derivatives by reduction of the corresponding ketone 失效
标题翻译：通过还原相应的酮制备光学活性2-氨基-1-苯基乙醇衍生物的方法
公开(公告)号：US5811293A
公开(公告)日：1998-09-22
申请号：US738864
申请日：1996-10-28
申请人： Kazuaki Furukawa , Takayuki Abe , Hidekazu Akamatsu , Akinobu Matsuyama , Michio Ito , Noritsugu Yamasaki , Katsuya Miki , Kiyoshi Ikura , Takeshi Ishiguro
发明人： Kazuaki Furukawa , Takayuki Abe , Hidekazu Akamatsu , Akinobu Matsuyama , Michio Ito , Noritsugu Yamasaki , Katsuya Miki , Kiyoshi Ikura , Takeshi Ishiguro
IPC分类号： C07C213/00 , C07C213/04 , C07C213/08 , C07C213/10 , C07C215/08 , C07C231/18 , C12P7/22 , C12P13/00 , C12P41/00
CPC分类号： C12P7/22 , C07C213/00 , C07C213/04 , C07C213/08 , C07C213/10 , C07C231/18 , C12P13/001 , C12P13/008 , C12P41/00 , C12P41/001 , C12P41/002 , Y10S435/822 , Y10S435/911
摘要： An (R)-2-amino-1-phenylethanol derivative shown by the general formula (IIa) ##STR1## wherein R.sup.1 and R.sup.5 represent a hydrogen atom, etc.; R.sup.2, R.sup.3 and R.sup.4 independently represent a halogen atom, etc., or a salt thereof, can readily be produced (1) by permitting a microorganism belonging to the genus Rhodosporidium, the genus Comamonas or the like to act on a mixture of corresponding (R)-form and (S)-form to asymmetrically utilize, or (2) by permitting a microorganism belonging to the genus Lodderomyces, the genus Pilimelia or the like to act on a corresponding aminoketone derivative to asymmetrically reduce. An (R,R)-1-phenyl-2-�(2-phenyl-1-alkylethyl) amino!ethanol derivative having a high optical purity can easily be obtained from the compound of the formula (IIa) or a salt thereof. Said derivative is useful as an intermediate for producing an anti-obesity agent and so on.
摘要翻译：由通式（IIa）表示的（R）-2-氨基-1-苯基乙醇衍生物（IIa）其中R1和R5表示氢原子等; R2，R3和R4独立地表示卤素原子等，或其盐可以容易地制备（1）通过使属于Rhodosporidium属，Comamonas属等的微生物作用于相应的（或者（2）通过允许属于罗德氏菌属的属微生物，类风云属等的微生物作用于相应的氨基酮衍生物以不对称地还原。具有高光学纯度的（R，R）-1-苯基-2 - [（2-苯基-1-烷基乙基）氨基]乙醇衍生物可以容易地从式（IIa）化合物或其盐获得。所述衍生物可用作生产抗肥胖剂等的中间体。

2. 发明授权

US5629200A Production of optically active 2-amino-1-phenylethanol derivatives by asymetrical assimilation 失效
标题翻译：通过非对称同化生产光学活性2-氨基-1-苯基乙醇衍生物
公开(公告)号：US5629200A
公开(公告)日：1997-05-13
申请号：US343952
申请日：1994-11-17
申请人： Kazuaki Furukawa , Takayuki Abe , Hidekazu Akamatsu , Akinobu Matsuyama , Michio Ito , Noritsugu Yamasaki , Katsuya Miki , Kiyoshi Ikura , Takeshi Ishiguro
发明人： Kazuaki Furukawa , Takayuki Abe , Hidekazu Akamatsu , Akinobu Matsuyama , Michio Ito , Noritsugu Yamasaki , Katsuya Miki , Kiyoshi Ikura , Takeshi Ishiguro
IPC分类号： C07C213/00 , C07C213/04 , C07C213/08 , C07C213/10 , C07C215/08 , C07C231/18 , C12P7/22 , C12P13/00 , C12P41/00
CPC分类号： C12P7/22 , C07C213/00 , C07C213/04 , C07C213/08 , C07C213/10 , C07C231/18 , C12P13/001 , C12P13/008 , C12P41/00 , C12P41/001 , C12P41/002 , Y10S435/822 , Y10S435/911
摘要： An (R)-2-amino-1-phenylethanol derivative shown by the general formula (IIa) ##STR1## wherein R.sup.1 and R.sup.5 represent a hydrogen atom, etc.; R.sup.2, R.sup.3 and R.sup.4 independently represent a halogen atom, etc., or a salt thereof, can readily be produced (1) by permitting a microorganism to act on a mixture of corresponding (R)-form and (S)-form to asymmetrically utilize, or (2) by permitting a microorganism to act on a corresponding aminoketone derivative to asymmetrically reduce. An (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl) amino]ethanol derivative having a high optical purity can easily be obtained from the compound of the formula (IIa) or a salt thereof. Said derivative is useful as an intermediate for producing an anti-obesity agent.
摘要翻译：由通式（IIa）表示的（R）-2-氨基-1-苯基乙醇衍生物（IIa）其中R1和R5表示氢原子等; R2，R3和R4独立地表示卤素原子等，或其盐可容易地制备（1）通过允许微生物作用于相应的（R）形式和（S）形式的混合物到不对称的利用或（2）通过允许微生物作用于相应的氨基酮衍生物以不对称地还原。具有高光学纯度的（R，R）-1-苯基-2 - [（2-苯基-1-烷基乙基）氨基]乙醇衍生物可以容易地从式（IIa）化合物或其盐获得。所述衍生物可用作制备抗肥胖剂的中间体。

3. 发明授权

US6114582A Processes for producing optically active 2-amino-1-phenylethanol derivatives 失效
标题翻译：光学活性2-氨基-1-苯基乙醇衍生物的制备方法
公开(公告)号：US6114582A
公开(公告)日：2000-09-05
申请号：US095733
申请日：1998-06-11
申请人： Kazuaki Furukawa , Takayuki Abe , Hidekazu Akamatsu
发明人： Kazuaki Furukawa , Takayuki Abe , Hidekazu Akamatsu
IPC分类号： C07C213/00 , C07C213/04 , C07C213/08 , C07C213/10 , C07C215/08 , C07C231/18 , C12P7/22 , C12P13/00 , C12P41/00
CPC分类号： C12P7/22 , C07C213/00 , C07C213/04 , C07C213/08 , C07C213/10 , C07C231/18 , C12P13/001 , C12P13/008 , C12P41/00 , C12P41/001 , C12P41/002 , Y10S435/822 , Y10S435/911
摘要： An (R)-2-amino-1-phenylethanol derivative shown by the general formula (IIa) ##STR1## wherein R.sup.1 and R.sup.5 represent a hydrogen atom, etc.; R.sup.2, R.sup.3 and R.sup.4 independently represent a halogen atom, etc., or a salt thereof, can readily be produced (1) by permitting a Microorganism belonging to the genus Rhodosporidium, the genus Comamonas or the like to act on a mixture of corresponding (R)-form and (S)-form to asymmetrically utilize, or (2) by permitting a microorganism belonging to the genus Lodderomyces, the genus Pilimelia or the like to act on a corresponding aminoketone derivative to asymmetrically reduce. An (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl) amino]ethanol derivative having a high optical purity can easily be obtained from the compound of the formula (IIa) or a salt thereof. Said derivative is useful as an intermediate for producing an anti-obesity agent and so on.
摘要翻译：由通式（IIa）表示的（R）-2-氨基-1-苯基乙醇衍生物，其中R 1和R 5表示氢原子等; R2，R3和R4独立地表示卤素原子等，或其盐可容易地制备（1）通过使属于Rhodosporidium属，Comamonas属等的微生物作用于相应的（或者（2）通过允许属于罗德氏菌属的属微生物，类风云属等的微生物作用于相应的氨基酮衍生物以不对称地还原。具有高光学纯度的（R，R）-1-苯基-2 - [（2-苯基-1-烷基乙基）氨基]乙醇衍生物可以容易地从式（IIa）化合物或其盐获得。所述衍生物可用作生产抗肥胖剂等的中间体。

4. 发明授权

US5929398A Muffler device 失效
标题翻译：消声器装置
公开(公告)号：US5929398A
公开(公告)日：1999-07-27
申请号：US31676
申请日：1998-02-27
申请人： Hideo Amino , Kazuaki Furukawa
发明人： Hideo Amino , Kazuaki Furukawa
IPC分类号： F01N1/08
CPC分类号： F01N1/089 , F01N2490/04
摘要： A small-sized muffler having porous partition walls includes a first expansion chamber, a second expansion chamber, a third expansion chamber and a fourth expansion chamber. A first porous partition wall is longitudinally arranged within the third expansion chamber so as to define a fifth expansion chamber. Similarly, a second porous partition wall is longitudinally arranged within the first expansion chamber so as to define the sixth expansion chamber. The first porous partition wall and the second porous partition wall are provided with small holes over their entire surface. The first porous partition wall and the second porous partition wall are each formed as a convexly curved surface curved toward the center of the muffler around the first feeding pipe and the second feeding pipe, respectively.
摘要翻译：具有多孔分隔壁的小型消声器包括第一膨胀室，第二膨胀室，第三膨胀室和第四膨胀室。纵向地布置在第三膨胀室内的第一多孔分隔壁以限定第五膨胀室。类似地，第二多孔分隔壁纵向设置在第一膨胀室内，以限定第六膨胀室。第一多孔分隔壁和第二多孔分隔壁在其整个表面上设置有小孔。第一多孔分隔壁和第二多孔分隔壁分别形成为围绕第一供给管和第二进料管朝向消声器的中心弯曲的凸曲面。

5. 发明授权

US08573555B2 Support structure of operation panel for machine tool 有权
标题翻译：机床操作面板支撑结构
公开(公告)号：US08573555B2
公开(公告)日：2013-11-05
申请号：US13635211
申请日：2010-10-06
申请人： Akira Yai , Kazuaki Furukawa , Taku Yamazaki
发明人： Akira Yai , Kazuaki Furukawa , Taku Yamazaki
IPC分类号： F16M13/00
CPC分类号： B23Q1/0009 , B23Q1/0045
摘要： The present invention provides capability to instantaneously adjust a height of an operation panel to an optimal height in accordance with a height of an operator with extremely easy operation and slight operating force. The operation panel is attached to a housing side wall of a machine tool in a vertically movable manner, supporting a load of the operation panel by the housing through a gas spring with a hydraulic lock. The operation panel is set to be capable of being vertically adjusted in position by disposing a handling unit which releases the hydraulic lock of the gas spring at the vicinity of the lower side of the operation panel.
摘要翻译：本发明提供了能够根据操作者的高度将操作面板的高度瞬时地调整到最佳高度的能力，操作者具有极其简单的操作和微小的操作力。操作面板以可垂直移动的方式附接到机床的壳体侧壁，通过具有液压锁的气弹簧通过壳体支撑操作面板的负载。操作面板被设置为能够通过设置在操作面板的下侧附近释放气弹簧的液压锁定的操作单元来垂直调整位置。

6. 发明授权

US08222016B2 Recombinant C-terminal α-amidating enzyme derivative 有权
标题翻译：重组C-末端α-酰胺酶衍生物
公开(公告)号：US08222016B2
公开(公告)日：2012-07-17
申请号：US12666032
申请日：2008-06-27
申请人： Takeshi Okumura , Kazuaki Furukawa , Masayuki Yabuta
发明人： Takeshi Okumura , Kazuaki Furukawa , Masayuki Yabuta
IPC分类号： C12N9/02
CPC分类号： C12N9/0071 , C12P21/02
摘要： Disclosed are: a recombinant C-terminal α-amidated enzyme derivative which lacks the formation of at least one disulfide bond among five disulfide bonds occurring in a C-terminal α-amidated enzyme derived from Xenopus laevis; DNA encoding the derivative; an expression vector carrying the DNA; a bacterium Escherichia coli transformed with the expression vector; and a method for producing the derivative by using the bacterium Escherichia coli.
摘要翻译：公开了一种重组C末端α-酰胺化酶衍生物，其在来源于非洲爪蟾的C末端α-酰胺化酶中发生的五个二硫键中缺少至少一个二硫键; 编码衍生物的DNA; 携带DNA的表达载体; 用表达载体转化的细菌大肠杆菌; 以及使用该细菌大肠杆菌生产该衍生物的方法。

7. 发明申请

US20060008869A1 Process for production of biopterin compound 失效
标题翻译：生物蝶呤化合物的生产工艺
公开(公告)号：US20060008869A1
公开(公告)日：2006-01-12
申请号：US11194564
申请日：2005-08-02
申请人： Masayuki Yabuta , Kazuaki Furukawa , Nobue Miyamoto , Katsuhiko Yamamoto , Kazuhiro Ohsuye
发明人： Masayuki Yabuta , Kazuaki Furukawa , Nobue Miyamoto , Katsuhiko Yamamoto , Kazuhiro Ohsuye
IPC分类号： C12P25/00 , C07D475/02
CPC分类号： C12N15/52 , C12N9/00 , C12P17/182
摘要： The present invention provides a transformed cell which is transformed by at least one gene of enzymes participating in biosynthesis of tetrahydrobiopterin and a process for the production of a biopterin compound using the same. In accordance with the present invention, the biopterin compound can be produced in large quantities in an industrial advantageous manner from less expensive materials.
摘要翻译：本发明提供了通过参与四氢生物喋呤的生物合成的酶的至少一个基因转化的转化细胞和使用其生产生物蝶呤化合物的方法。根据本发明，生物蝶呤化合物可以以较便宜的材料以工业上有利的方式大量生产。

8. 发明申请

US20130003276A1 SUPPORT STRUCTURE OF OPERATION PANEL FOR MACHINE TOOL 有权
标题翻译：机床操作面板支撑结构
公开(公告)号：US20130003276A1
公开(公告)日：2013-01-03
申请号：US13635211
申请日：2010-10-06
申请人： Akira Yai , Kazuaki Furukawa , Taku Yamazaki
发明人： Akira Yai , Kazuaki Furukawa , Taku Yamazaki
IPC分类号： H05K7/00
CPC分类号： B23Q1/0009 , B23Q1/0045
摘要： The present invention provides capability to instantaneously adjust a height of an operation panel to an optimal height in accordance with a height of an operator with extremely easy operation and slight operating force. The operation panel is attached to a housing side wall of a machine tool in a vertically movable manner, supporting a load of the operation panel by the housing through a gas spring with a hydraulic lock. The operation panel is set to be capable of being vertically adjusted in position by disposing a handling unit which releases the hydraulic lock of the gas spring at the vicinity of the lower side of the operation panel.
摘要翻译：本发明提供了能够根据操作者的高度将操作面板的高度瞬时地调整到最佳高度的能力，操作者具有极其简单的操作和微小的操作力。操作面板以可垂直移动的方式附接到机床的壳体侧壁，通过具有液压锁的气弹簧通过壳体支撑操作面板的负载。操作面板被设置为能够通过设置在操作面板的下侧附近释放气弹簧的液压锁定的操作单元来垂直调整位置。

9. 发明申请

US20100261249A1 RECOMBINANT C-TERMINAL ALPHA-AMIDATING ENZYME DERIVATIVE 有权
标题翻译：重组C末端氨基酸酶衍生物
公开(公告)号：US20100261249A1
公开(公告)日：2010-10-14
申请号：US12666032
申请日：2008-06-27
申请人： Takeshi Okumura , Kazuaki Furukawa , Masayuki Yabuta
发明人： Takeshi Okumura , Kazuaki Furukawa , Masayuki Yabuta
IPC分类号： C12N9/02 , C07H21/04 , C12N15/63 , C12N1/21
CPC分类号： C12N9/0071 , C12P21/02
摘要： Disclosed are: a recombinant C-terminal α-amidated enzyme derivative which lacks the formation of at least one disulfide bond among five disulfide bonds occurring in a C-terminal α-amidated enzyme derived from Xenopus laevis; DNA encoding the derivative; an expression vector carrying the DNA; a bacterium Escherichia coli transformed with the expression vector; and a method for producing the derivative by using the bacterium Escherichia coli.
摘要翻译：公开了一种重组C末端α-酰胺化酶衍生物，其在来源于非洲爪蟾的C末端α-酰胺化酶中发生的五个二硫键中缺少至少一个二硫键; 编码衍生物的DNA; 携带DNA的表达载体; 用表达载体转化的细菌大肠杆菌; 以及使用该细菌大肠杆菌生产该衍生物的方法。

10. 发明授权

US07807421B2 Process for production of biopterin compound 失效
标题翻译：生物蝶呤化合物的生产工艺
公开(公告)号：US07807421B2
公开(公告)日：2010-10-05
申请号：US11194564
申请日：2005-08-02
申请人： Masayuki Yabuta , Kazuaki Furukawa , Nobue Miyamoto , Katsuhiko Yamamoto , Kazuhiro Ohsuye
发明人： Masayuki Yabuta , Kazuaki Furukawa , Nobue Miyamoto , Katsuhiko Yamamoto , Kazuhiro Ohsuye
IPC分类号： C12P17/16 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/00 , C12N9/04 , C12N9/88 , C12N9/78 , C12P21/00 , C12Q1/34 , C07K14/00 , C07H21/00
CPC分类号： C12N15/52 , C12N9/00 , C12P17/182
摘要： The present invention provides a transformed cell which is transformed by at least one gene of enzymes participating in biosynthesis of tetrahydrobiopterin and a process for the production of a biopterin compound using the same. In accordance with the present invention, the biopterin compound can be produced in large quantities in an industrial advantageous manner from less expensive materials.
摘要翻译：本发明提供了通过参与四氢生物喋呤的生物合成的酶的至少一个基因转化的转化细胞和使用其生产生物蝶呤化合物的方法。根据本发明，生物蝶呤化合物可以以较便宜的材料以工业上有利的方式大量生产。

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