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1. 发明申请

US20070141028A1 Cancer gene therapeutic drug 审中-公开
标题翻译：癌症基因治疗药
公开(公告)号：US20070141028A1
公开(公告)日：2007-06-21
申请号：US10575894
申请日：2004-10-15
申请人： Katsuyuki Hamada , Akinobu Goto , Toshiro Shirakawa
发明人： Katsuyuki Hamada , Akinobu Goto , Toshiro Shirakawa
IPC分类号： A61K48/00 , C12N15/86 , A61K31/409 , A61K31/555
CPC分类号： C12N7/00 , A61K31/409 , A61K35/761 , A61K38/193 , A61K48/0058 , A61K2039/5256 , A61K2039/57 , C07K14/475 , C12N15/85 , C12N15/86 , C12N2710/10332 , C12N2710/10343 , C12N2830/008 , C12N2830/85 , A61K2300/00
摘要： A cancer gene therapeutic drug of the present invention includes a carrier cell to be infected with an oncolytic virus, so as to make the oncolytic virus act on a tumor cell within a living body, wherein the carrier cell is selected from A549 cell, 293 cell, SW626 cell and HT-3 cell, showing a potent antitumor effect. Because of use of such cell line having high antitumor effect both in vitro and in vivo as the carrier cell, the cancer gene therapeutic drug provides more potent antitumor effect in comparison to those of conventional carrier cells.
摘要翻译：本发明的癌症基因治疗药物包括用溶瘤病毒感染的载体细胞，使得溶瘤病毒作用于活体内的肿瘤细胞，其中载体细胞选自A549细胞，293细胞，SW626细胞和HT-3细胞，显示出有效的抗肿瘤作用。由于在体外和体内作为载体细胞使用具有高抗肿瘤作用的细胞系，与常规载体细胞相比，癌症基因治疗药物提供更有效的抗肿瘤效果。

2. 发明申请

US20070134202A1 Cancer gene therapeutic drug 审中-公开
标题翻译：癌症基因治疗药
公开(公告)号：US20070134202A1
公开(公告)日：2007-06-14
申请号：US10576047
申请日：2003-10-15
申请人： Katsuyuki Hamada , Akinobu Goto , Toshiro Shirakawa
发明人： Katsuyuki Hamada , Akinobu Goto , Toshiro Shirakawa
IPC分类号： A61K48/00 , C12N15/86
CPC分类号： C12N7/00 , A61K31/409 , A61K35/761 , A61K38/193 , A61K48/0058 , A61K2039/5256 , A61K2039/57 , C07K14/475 , C12N15/85 , C12N15/86 , C12N2710/10332 , C12N2710/10343 , C12N2830/008 , C12N2830/85 , A61K2300/00
摘要： A cancer gene therapeutic drug of the present invention comprises a combination of: a virus for immunological treatment to be administered for inducing a CTL reaction within a living body to administration of a carrier cell; and a carrier cell to be infected with an oncolytic virus before the administration so as to make the oncolytic virus act on a tumor cell within the living body. For example, A549 cell can be used as the carrier cell. Non-proliferative adenovirus inactivated by UV irradiation can be used as the virus for immunological treatment, and a proliferative adenovirus having a tumor-specific promoter can be used as the oncolytic virus, for example.
摘要翻译：本发明的癌症基因治疗药物包含以下组合：用于在活体内诱导CTL反应而施用的用于免疫治疗的病毒，用于施用载体细胞; 以及在施用前被感染有溶瘤病毒的载体细胞，以使得溶瘤病毒作用于活体内的肿瘤细胞。例如，可以使用A549细胞作为载体细胞。通过UV辐射灭活的非增殖性腺病毒可以用作免疫治疗的病毒，例如可以使用具有肿瘤特异性启动子的增殖性腺病毒作为溶瘤病毒。

3. 发明申请

US20050176138A1 Apparatus for cell culture 失效
标题翻译：细胞培养装置
公开(公告)号：US20050176138A1
公开(公告)日：2005-08-11
申请号：US11048559
申请日：2005-02-01
申请人： Takahiro Nishimoto , Yoshiaki Hamada , Seiichi Sakuramoto , Keiichi Yokouchi , Akinobu Goto , Toshiro Shirakawa
发明人： Takahiro Nishimoto , Yoshiaki Hamada , Seiichi Sakuramoto , Keiichi Yokouchi , Akinobu Goto , Toshiro Shirakawa
IPC分类号： C12M1/00 , C12M1/02 , C12M3/00
CPC分类号： C12M47/02 , C12M23/50 , C12M33/06 , C12M37/00 , C12M41/48
摘要： An object of the present invention is to provide an apparatus for cell culture exhibiting favorable property to occupy little space and economical efficiency, capable of reducing the working labor, faulty manipulation and the like, and of promoting the prevention of contamination, which is suitable for small scale cell culture at an experimental level on research, in particular. The present invention is an apparatus for cell culture wherein at least a medium replacement process and a passage culture process can be executed, and characterized by including an aspirator unit for drawing a liquid, a chemical liquid supply unit for supplying a medium, a liquid for detachment, a washing liquid and the like, a pipetting unit for quantitatively aspirating and discharging the liquid, a centrifugal unit for separating cells from the cell suspension in a centrifuge tube, and a handling unit for moving a culture vessel and the centrifuge tube to each unit; and all units being constructed such that they can be stored in a clean bench. Further, according to the present invention, the apparatus may include a clean bench having a sterile operation space, and the aforementioned units may be stored within the sterile operation space in a removable manner.
摘要翻译：本发明的目的是提供一种细胞培养装置，其具有良好的性能，占用空间少，经济效益好，能够减少劳动力，操作不良等，促进防止污染，适用于特别是在实验水平的小规模细胞培养研究。本发明是一种用于细胞培养的装置，其中至少可以执行培养基更换过程和通道培养过程，其特征在于包括用于抽取液体的抽吸单元，用于供给培养基的药液供应单元，用于洗涤液等，用于定量抽吸和排出液体的移液单元，用于在离心管中从细胞悬浮液中分离细胞的离心单元和用于将培养容器和离心管移动到每个的操作单元单元; 并且所有单元被构造成使得它们可以被存储在干净的工作台中。此外，根据本发明，该装置可以包括具有无菌操作空间的清洁台，并且上述单元可以以可移除的方式存储在无菌操作空间内。

4. 发明授权

US07419819B2 Apparatus for cell culture 失效
标题翻译：细胞培养装置
公开(公告)号：US07419819B2
公开(公告)日：2008-09-02
申请号：US11048559
申请日：2005-02-01
申请人： Takahiro Nishimoto , Yoshiaki Hamada , Seiichi Sakuramoto , Keiichi Yokouchi , Akinobu Goto , Toshiro Shirakawa
发明人： Takahiro Nishimoto , Yoshiaki Hamada , Seiichi Sakuramoto , Keiichi Yokouchi , Akinobu Goto , Toshiro Shirakawa
IPC分类号： C12M1/36 , C12M1/38 , C12M3/00
CPC分类号： C12M47/02 , C12M23/50 , C12M33/06 , C12M37/00 , C12M41/48
摘要： Apparatus for cell culture occupying little space, providing economical efficiency, reducing working labor, faulty manipulation, and promoting the prevention of contamination, which is suitable for small scale cell culture . The apparatus permits the execution of at least a medium replacement process and a passage culture process, and includes an aspirator unit for drawing a liquid, a chemical liquid supply unit for supplying a medium, a liquid for detachment, a washing liquid, a pipetting unit for quantitatively aspirating and discharging the liquid, a centrifugal unit for separating cells from the cell suspension in a centrifuge tube, and a handling unit for moving a culture vessel and the centrifuge tube to each unit. All units being constructed for storage in a clean bench. The apparatus may include a clean bench having a sterile operation space, and the aforementioned units may be removably stored within the sterile operation space.
摘要翻译：细胞培养装置空间小，提供经济效益，减少工作劳动，错误操作，促进防止污染，适用于小规模细胞培养。该装置允许至少执行介质置换处理和通道培养处理，并且包括用于抽取液体的抽吸单元，用于供给介质的药液供应单元，用于分离的液体，洗涤液，移液单元用于定量抽吸和排出液体;离心机，用于将细胞从离心管中的细胞悬浮液中分离;以及处理单元，用于将培养容器和离心管移动到每个单元。所有单位正在建造中，用于存放在干净的工作台上。该设备可以包括具有无菌操作空间的清洁台，并且上述单元可以可移除地存储在无菌操作空间内。

5. 发明授权

US4994647A Covered electrode for use in arc welding of Cr-Mo type low alloy steels 失效
标题翻译：用于Cr-Mo型低合金钢电弧焊的覆盖电极
公开(公告)号：US4994647A
公开(公告)日：1991-02-19
申请号：US480974
申请日：1990-02-16
申请人： Osamu Tanaka , Shogo Natsume , Akinobu Goto
发明人： Osamu Tanaka , Shogo Natsume , Akinobu Goto
IPC分类号： B23K35/30
CPC分类号： B23K35/308
摘要： Described herein is a covered electrode for use in arc welding of Cr-Mo type low alloy steel, the covered electrode having a composition determined in consideration of the yield of each additive element as well as the relationship between the contents of certain key component elements, and permitting to form a weld metal with excellent high temperature strength and toughness along with appropriate room temperature strength.

6. 发明授权

US06940042B2 Flux-cored wire for gas-shielded arc welding 失效
标题翻译：用于气体保护电弧焊的焊芯焊丝
公开(公告)号：US06940042B2
公开(公告)日：2005-09-06
申请号：US10620386
申请日：2003-07-17
申请人： Noriyuki Hara , Akinobu Goto , Hitoshi Hatano , Ken Yamashita
发明人： Noriyuki Hara , Akinobu Goto , Hitoshi Hatano , Ken Yamashita
IPC分类号： B23K35/00 , B23K35/30 , B23K35/36 , B23K35/368 , B23K35/02
CPC分类号： B23K35/3608 , B23K35/3053 , B23K35/368
摘要： A flux-cored wire for gas-shielded arc welding comprises a steel sheath, and a flux filled in the steel sheath. The flux-cored wire has a C content of 0.20% by mass or below, a Si content in the range of 0.06 to 1.10% by mass, a Mn content in the range of 0.55 to 1.60% by mass, a Cr content of 2.60% by mass or below, a Mo content in the range of 0.30 to 1.50% by mass, a Mg content in the range of 0.20 to 1.50% by mass, a N content in the range of 0.005 to 0.035% by mass and a B content in the range of 0.001 to 0.020% by mass on the basis of the total mass of the flux-cored wire. The flux has a TiO2 content in the range of 4.2 to 8.2% by mass and a fluorine compound content in terms of F content in the range of 0.025 to 0.55% by mass on the basis of the total mass of the flux-cored wire, and the flux-cored wire has an Al content of 0.50% by mass or below, a Nb content of 0.015% by mass or below, and a V content of 0.015% by mass or below on the basis of the total mass of the flux-cored wire. The flux-cored wire forms a weld metal that is resistant to ferrite band maintains proper tensile strength and excellent toughness even if the weld metal is processed at high temperatures for a long time for PWHT. The flux-cored wire has satisfactory usability
摘要翻译：用于气体保护电弧焊的药芯焊丝包括钢护套和填充在钢护套中的焊剂。药芯焊丝的C含量为0.20质量％以下，Si含量为0.06〜1.10质量％，Mn含量为0.55〜1.60质量％，Cr含量为2.60 质量％以下，Mo含量为0.30〜1.50质量％，Mg含量为0.20〜1.50质量％，N含量为0.005〜0.035质量％，B为含量在基于药芯焊丝的总质量的0.001〜0.020质量％的范围内。助熔剂的TiO 2含量在4.2〜8.2质量％的范围内，氟化合物含量以F含量为基准计，为0.025〜0.55质量％药芯焊丝的质量和药芯焊丝的Al含量为0.50质量％以下，Nb含量为0.015质量％以下，V含量为0.015质量％以下药芯焊丝总质量的基础。药芯焊丝形成耐铁氧体带的焊接金属，即使焊接金属在高温下长时间处理PWHT也能保持合适的拉伸强度和优异的韧性。药芯焊丝具有令人满意的可用性

7. 发明授权

US06479796B2 Flux-cored wire for gas-shielded arc welding of heat resisting steel 有权
标题翻译：耐热钢气焊保护焊丝芯焊丝
公开(公告)号：US06479796B2
公开(公告)日：2002-11-12
申请号：US09824016
申请日：2001-04-03
申请人： Akinobu Goto , Ken Yamashita
发明人： Akinobu Goto , Ken Yamashita
IPC分类号： B23K3502
CPC分类号： B23K35/0266 , B23K35/3053 , B23K35/308 , B23K35/3608 , B23K35/368
摘要： A flux-cored wire for gas-shielded arc welding of heat-resisting steel in the form of a steel tube filled with a flux, which is characterized in that the content of slag-forming agent is 6.10-9.90 mass % (based on the total mass of the wire), said steel tube and said flux all together contain less than 0.20 mass % C., 0.06-1.40 mass % Si, 0.55-1.60 mass % Mn, 0.004-0.090 mass % Cu, 0.004-0.090 mass % Ni, less than 2.60 mass % Cr, and 0.3-1.20 mass % Mo (based on the total mass of the wire), and said flux contains 4.2-8.2 mass % TiO2, 0.025-0.25 mass % of metal fluoride (in terms of fluorine), and 0.20-1.50 mass % Mg. The flux-cored wire has both good welding maneuverability and ability to give weld metal with good mechanical properties, such as strength and toughness.
摘要翻译：一种填充有焊剂的钢管形式的耐热钢气体保护电弧焊药芯焊丝，其特征在于，成渣剂的含量为6.10-9.90质量％（基于所述钢管和所述焊剂一起含有小于0.20质量％的C，0.06-1.40质量％的Si，0.55-1.60质量％的Mn，0.004-0.090质量％的Cu，0.004-0.090质量％ Ni，小于2.60质量％的Cr和0.3〜20质量％的Mo（以线的总质量计），所述助熔剂含有4.2〜8.2质量％的TiO 2，0.025〜0.25质量％的金属氟化物（以氟）和0.20-1.50质量％的Mg。药芯焊丝具有良好的焊接机动性和赋予焊接金属具有良好机械性能如强度和韧性的能力。

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