专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5631257A Benzoxazole derivatives 失效
标题翻译：苯并恶唑衍生物
公开(公告)号：US5631257A
公开(公告)日：1997-05-20
申请号：US487697
申请日：1995-06-07
申请人： Katsuyoshi Iwamatsu , Yasuo Sato , Masaaki Izumi , Fukio Konno , Seiji Shibahara , Shigeharu Inoye , Koichi Shudo , Kazuko Amano
发明人： Katsuyoshi Iwamatsu , Yasuo Sato , Masaaki Izumi , Fukio Konno , Seiji Shibahara , Shigeharu Inoye , Koichi Shudo , Kazuko Amano
IPC分类号： A61K31/42 , A61K31/423 , A61K31/495 , A61K31/496 , A61K31/55 , A61P1/00 , A61P1/08 , A61P1/14 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/22 , A61P43/00 , C07D263/58 , C07D263/60 , C07D487/10 , C07D401/00 , C07D419/00
CPC分类号： C07D263/58 , C07D263/60 , C07D487/10
摘要： A benzoxazole derivative of the formula (1) or (2) which has an alicyclic diamine group at the 2-position: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X.sup.-, m and n are defined herein. The compound shows excellent 5-HT.sub.3 receptor antagonism and is useful as an antiemetic agent, a peristalsis controlling agent, an analgesic agent, an antianxiety agent and a schizophrenia treating agent.
摘要翻译：（2）中具有脂环族二胺基团的式（1）或（2）的苯并恶唑衍生物：其中R1，R2，R3，R4，R5，R6， X，m和n在本文中定义。该化合物显示优异的5-HT 3受体拮抗作用，可用作止吐剂，蠕动控制剂，止痛剂，抗焦虑剂和精神分裂症治疗剂。

2. 发明授权

US06867226B2 Serotonin 5-HT3 receptor partial activator 失效
标题翻译： 5-羟色胺5-HT3受体部分激活剂
公开(公告)号：US06867226B2
公开(公告)日：2005-03-15
申请号：US10219496
申请日：2002-08-16
申请人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
发明人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
IPC分类号： A61K31/42 , A61K31/423 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/55 , A61K31/5513 , A61P1/00 , A61P1/08 , A61P1/12 , A61P1/14 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/26 , A61P43/00 , C07D263/30 , C07D263/58 , C07D263/60 , C07D413/04 , A61K31/50
CPC分类号： C07D263/58 , A61K31/496 , C07D263/30 , C07D413/04
摘要： This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not cause constipation as a side effect.Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT3 receptor antagonism and serotonin 5-HT3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT3 receptor partial activators. In the above formula, R1 to R4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R1 and R2 may be linked together to form a ring structure, namely benzene ring; R5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.
摘要翻译：本发明提供除5-羟色胺5-HT 3受体拮抗作用之外还具有5-羟色胺5-HT 3受体激活作用的5-羟色胺5-HT 3受体部分活化剂，并且不引起便秘作为副作用。特别地，基于以下发现：以下式（2）化合物为代表的新合成苯并恶唑衍生物具有强烈的5-羟色胺5-HT 3受体拮抗作用和5-羟色胺5-HT 3受体激活作用，本发明提供了这些苯并恶唑衍生物作为5-羟色胺5-HT 3受体部分活化剂。式中，R 1〜R 4可以相同或不同，表示氢原子，卤素原子，取代或未取代的低级烷基，取代或未取代的低级烯基或取代或未取代的氨基，或二 R1和R2的基团可以连接在一起形成环结构，即苯环; R5表示氢原子，取代或未取代的低级烷基或取代或未取代的低级烯基; m为1〜4的整数。

3. 发明授权

US06333328B1 Serotonin 5-HT3 receptor partial activator 失效
标题翻译： 5-羟色胺5-HT3受体部分激活剂
公开(公告)号：US06333328B1
公开(公告)日：2001-12-25
申请号：US09686759
申请日：2000-10-12
申请人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
发明人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
IPC分类号： A61K31495
CPC分类号： C07D263/58 , A61K31/496 , C07D263/30 , C07D413/04
摘要： This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT3 receptor antagonism and serotonin 5-HT3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT3 receptor partial activators. In the above formula, R1 to R4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R1 and R2 may be linked together to form a ring structure, namely benzene ring; R5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.
摘要翻译：本发明提供除5-羟色胺5-HT 3受体拮抗作用之外还具有5-羟色胺5-HT 3受体激活作用的5-羟色胺5-HT 3受体部分活化剂，并且不引起便秘作为副作用。特别地，基于以下发现：以下式（2）化合物为代表的新合成苯并恶唑衍生物具有强烈的5-羟色胺5-HT 3受体拮抗作用和5-羟色胺5-HT 3受体激活作用，本发明提供了这些苯并恶唑衍生物作为5-羟色胺5-HT 3受体部分激活因子。式中，R 1〜R 4可以相同或不同，表示氢原子，卤素原子，取代或未取代的低级烷基，取代或未取代的低级烯基或取代或未取代的氨基，或二 R1和R2的基团可以连接在一起形成环结构，即苯环; R5表示氢原子，取代或未取代的低级烷基或取代或未取代的低级烯基; m为1〜4的整数。

4. 发明授权

US6037342A Serotonin 5-HT.sub.3 receptor partial activator 失效
公开(公告)号：US6037342A
公开(公告)日：2000-03-14
申请号：US852747
申请日：1997-05-06
申请人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
发明人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
IPC分类号： A61K31/42 , A61K31/423 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/55 , A61K31/5513 , A61P1/00 , A61P1/08 , A61P1/12 , A61P1/14 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/26 , A61P43/00 , C07D263/30 , C07D263/58 , C07D263/60 , C07D413/04 , A61N43/62 , C07D243/08 , C07D403/00
CPC分类号： C07D263/58 , A61K31/496 , C07D263/30 , C07D413/04
摘要： This invention provides a serotonin 5-HT.sub.3 receptor partial activator which has a serotonin 5-HT.sub.3 receptor activating action, in addition to its serotonin 5-HT.sub.3 receptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT.sub.3 receptor antagonism and serotonin 5-HT.sub.3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT.sub.3 receptor partial activators. ##STR1## In the above formula, R.sub.1 to R.sub.4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R.sub.1 and R.sub.2 may be linked together to form a ring structure, namely benzene ring; R.sub.5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.

5. 发明授权

US06552057B2 Serotonin 5-HT3 receptor partial activator 失效
标题翻译： 5-羟色胺5-HT3受体部分激活剂
公开(公告)号：US06552057B2
公开(公告)日：2003-04-22
申请号：US09796805
申请日：2001-03-02
申请人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
发明人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
IPC分类号： A61K3142
CPC分类号： C07D263/58 , A61K31/496 , C07D263/30 , C07D413/04
摘要： This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT3 receptor antagonism and serotonin 5-HT3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT3 receptor partial activators. In the above formula, R1 to R4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R1 and R2 may be linked together to form a ring structure, namely benzene ring; R5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.
摘要翻译：本发明提供除5-羟色胺5-HT 3受体拮抗作用之外还具有5-羟色胺5-HT 3受体激活作用的5-羟色胺5-HT 3受体部分活化剂，并且不引起便秘作为副作用。特别地，基于以下发现：以下式（2）化合物为代表的新合成苯并恶唑衍生物具有强烈的5-羟色胺5-HT 3受体拮抗作用和5-羟色胺5-HT 3受体激活作用，本发明提供了这些苯并恶唑衍生物作为5-羟色胺5-HT 3受体部分激活因子。式中，R 1〜R 4可以相同或不同，表示氢原子，卤素原子，取代或未取代的低级烷基，取代或未取代的低级烯基或取代或未取代的氨基，或二 R1和R2的基团可以连接在一起形成环结构，即苯环; R5表示氢原子，取代或未取代的低级烷基或取代或未取代的低级烯基; m为1〜4的整数。

6. 发明授权

US06297246B1 Serotonin 5-HT3, receptor partial activator 失效
标题翻译： 5-羟色胺5-HT3，受体部分活化剂
公开(公告)号：US06297246B1
公开(公告)日：2001-10-02
申请号：US09298952
申请日：1999-04-26
申请人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
发明人： Yasuo Sato , Megumi Yamada , Kazuko Kobayashi , Katsuyoshi Iwamatsu , Fukio Konno , Koichi Shudo
IPC分类号： A61K31496
CPC分类号： C07D263/58 , A61K31/496 , C07D263/30 , C07D413/04
摘要： This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT3 receptor antagonism and serotonin 5-HT3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT3 receptor partial activators. In the above formula, R1 to R4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R1 and R2 may be linked together to form a ring structure, namely benzene ring; R5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.
摘要翻译：本发明提供除5-羟色胺5-HT 3受体拮抗作用之外还具有5-羟色胺5-HT 3受体激活作用的5-羟色胺5-HT 3受体部分活化剂，并且不引起便秘作为副作用。特别地，基于以下结构式（2）所示的新合成的苯并恶唑衍生物具有强的5-羟色胺5-HT 3受体拮抗作用和5-羟色胺5-HT 3受体活化作用，本发明提供了这些苯并恶唑衍生物作为血清素5-HT3 在上式中，R 1〜R 4可以相同或不同，表示氢原子，卤素原子，取代或未取代的低级烷基，取代或未取代的低级烯基或取代的或未取代的氨基，或两个R 1和R 2可以连接在一起形成环结构，即苯环; R5表示氢原子，取代或未取代的低级烷基或取代或未取代的低级烯基; m为1〜4的整数。

7. 发明授权

US08785625B2 Compound having heterocyclic ring 失效
标题翻译：具有杂环的化合物
公开(公告)号：US08785625B2
公开(公告)日：2014-07-22
申请号：US13372848
申请日：2012-02-14
申请人： Hideyuki Suzuki , Shoji Hizatate , Iwao Utsunomiya , Koichi Shudo
发明人： Hideyuki Suzuki , Shoji Hizatate , Iwao Utsunomiya , Koichi Shudo
IPC分类号： C07D255/02 , C07D273/06
CPC分类号： C07D273/06 , C07D255/02 , C07D413/10 , C07D413/14 , C07D417/14 , C07D471/14 , Y02P20/55
摘要： The invention provides a novel oxazolidinone derivative represented by the formula (I): wherein Ring A, X1, Ring B and R1 are as described in the description, and an antibacterial agent containing the same.
摘要翻译：本发明提供由式（I）表示的新型恶唑烷酮衍生物：其中环A，X1，环B和R1如说明书所述，以及含有该恶唑烷酮衍生物的抗菌剂。

8. 发明授权

US08431613B2 Memory fixation accelerator 有权
标题翻译：记忆固定加速器
公开(公告)号：US08431613B2
公开(公告)日：2013-04-30
申请号：US13459959
申请日：2012-04-30
申请人： Koichi Shudo , Hiroyuki Kagechika
发明人： Koichi Shudo , Hiroyuki Kagechika
IPC分类号： A01N37/00 , A01N55/00 , A61K31/185 , A61K31/695
CPC分类号： A61K31/192 , A61K31/695
摘要： A medicament for promoting memory consolidation, which comprises, as an active ingredient, a non-natural retinoid, preferably a retinoid having a basic skeleton comprising an aromatic ring bound with an aromatic carboxylic acid or tropolone by means of a bridging group, more preferably 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or 4-[(3,5-bis-trimethylsilylphenyl)-carboxamido]benzoic acid.
摘要翻译：一种用于促进记忆巩固的药物，其包含作为活性成分的非天然类视黄醇，优选具有基本骨架的类视黄醇，所述基本骨架包含通过桥连基团与芳族羧酸或托洛替林结合的芳环，更优选4 - [（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸或4 - [（3,5-双三甲基甲硅烷基苯基） - 甲酰胺基]苯甲酸。

9. 发明授权

US08148362B2 Compound having heterocyclic ring 失效
标题翻译：具有杂环的化合物
公开(公告)号：US08148362B2
公开(公告)日：2012-04-03
申请号：US12225819
申请日：2007-03-30
申请人： Hideyuki Suzuki , Shoji Hizatate , Iwao Utsunomiya , Koichi Shudo
发明人： Hideyuki Suzuki , Shoji Hizatate , Iwao Utsunomiya , Koichi Shudo
IPC分类号： A61K31/00 , C07D255/00
CPC分类号： C07D273/06 , C07D255/02 , C07D413/10 , C07D413/14 , C07D417/14 , C07D471/14 , Y02P20/55
摘要： The invention provides a novel oxazolidinone derivative represented by the formula (I): wherein Ring A is optionally substituted or fused and represents (A-1) at least 7-membered monocyclic hetero ring containing at least three N atoms; (A-2) at least 6-membered monocyclic hetero ring containing at least two N atoms and at least one O atom; or (A-3) at least 7-membered monocyclic hetero ring containing at least two N atoms and at least one S atom; X1 is a single bond, —O—, —S—, —NR2—, —CO—, —CS—, —CONR3—, —NR4CO—, —SO2NR5—, and —NR6SO2— (wherein R2-R6 are independently hydrogen or lower alkyl), or lower alkylene or lower alkenylene in which one of the preceding groups may intervene; Ring B is optionally substituted carbocycle or optionally substituted heterocycle; R1 is hydrogen, or an organic residue which is able to bind to the 5-position of oxazolidinone ring in oxazolidinone antimicrobial agent, and an antibacterial agent containing the same.
摘要翻译：本发明提供由式（I）表示的新型恶唑烷酮衍生物：其中环A任选被取代或稠合并且代表（A-1）含有至少三个N原子的至少七元单环杂环; （A-2）至少含有至少两个N原子和至少一个O原子的6元单环杂环; 或（A-3）至少含有至少两个N原子和至少一个S原子的7元单环杂环; X 1是单键，-O - ， - S - ， - NR 2 - ， - CO - ， - C - ， - CONR 3 - ， - NR 4 CO-，-SO 2 NR 5 - 和-NR 6 SO 2 - 或低级烷基）或其中一个前述基团可以介入的低级亚烷基或低级亚烯基; 环B是任选取代的碳环或任选取代的杂环; R1是氢，或能够与恶唑烷酮抗微生物剂中的恶唑烷酮环的5位结合的有机残基，以及含有该残基的抗菌剂。

10. 发明授权

US08143260B2 Tricyclic amine compound 失效
标题翻译：三环胺化合物
公开(公告)号：US08143260B2
公开(公告)日：2012-03-27
申请号：US12673221
申请日：2008-08-14
申请人： Yohei Amano , Masayuki Noguchi , Koichi Shudo
发明人： Yohei Amano , Masayuki Noguchi , Koichi Shudo
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04
CPC分类号： C07C229/60 , C07C2601/02 , C07C2603/28 , C07C2603/34 , C07D239/42
摘要： A compound represented by the following general formula (I): [wherein R1 represents hydrogen atom or a C1-6 alkyl group, A and B represent —(CH2)2—, —(CH2)3— or —(CH2)4—, X represents —N(R2)— (R2 represents hydrogen atom or a C1-6 alkyl group), —CO—, —C(═N—R3)— (R3 represents hydrogen atom or a C1-6 alkyl group), or —C(═C(R4)(R5))— (R4 and R5 independently represent hydrogen atom or a C1-6 alkyl group), and Ar represents an aryldiyl group or a heteroaryldiyl group], which has an action of controlling physiological activities of retinoids and useful as an active ingredient of a medicament.
摘要翻译：由下列通式（I）表示的化合物：[其中R1表示氢原子或C1-6烷基，A和B表示 - （CH2）2-， - （CH2）3-或 - （CH2）4- ，X表示-N（R 2） - （R 2表示氢原子或C 1-6烷基），-CO-，-C（= N-R 3） - （R 3表示氢原子或C 1-6烷基）或-C（= C（R4）（R5）） - （R4和R5独立地表示氢原子或C1-6烷基），Ar表示芳基二基或杂芳基二基]，其具有控制生理类维生素A的活性并且可用作药物的活性成分。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式