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1. 发明授权

US4676635A Optical fiber characteristic measuring method and apparatus 失效
标题翻译：光纤特性测量方法及装置
公开(公告)号：US4676635A
公开(公告)日：1987-06-30
申请号：US705837
申请日：1985-02-26
申请人： Katsuji Sakamoto , Akio Ohta , Yuichi Toda , Shuzo Suzuki , Takashi Ide
发明人： Katsuji Sakamoto , Akio Ohta , Yuichi Toda , Shuzo Suzuki , Takashi Ide
IPC分类号： G01M11/00 , G01M11/02 , G02B6/00 , G01N21/84 , G01N21/88
CPC分类号： G01M11/33 , G01M11/31
摘要： An optical fiber characteristic measuring method and apparatus are disclosed whereby measurements of a plurality of different parameters of an optical fiber can be carried out automatically and successively with a minimum of operator time required. A stage is provided which is movable along a straight line, and a setting station is arranged in the direction of movement of the stage. A plurality of measurement stations are provided having first holders for holding fibers provided on the side of the measuring devices and arranged along a straight line extending parallel to the direction of movement of the stage with a predetermined distance therebetween. The stage is provided with a plurality of second holders for holding the optical fibers to be measured, with the second holders being arranged along a straight line extending parallel to the direction of arrangement of the first holders with the same distance as the predetermined distance therebetween.
摘要翻译：公开了一种光纤特性测量方法和装置，其中可以以最少的操作者时间自动且连续地执行光纤的多个不同参数的测量。提供能够沿着直线移动的台架，并且设置台沿台架的移动方向布置。多个测量站具有第一保持器，用于保持设置在测量装置一侧的纤维，并沿平行于平台的移动方向延伸的直线布置，其间具有预定距离。该台设置有多个用于保持被测量的光纤的第二保持器，其中第二保持器沿与第一保持器的布置方向平行延伸的直线以与它们之间的预定距离相同的距离布置。

2. 发明申请

US20130324461A1 METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING OBESITY 审中-公开
标题翻译：用于预防或治疗肥胖的方法和组合物
公开(公告)号：US20130324461A1
公开(公告)日：2013-12-05
申请号：US13819229
申请日：2011-08-26
申请人： Michail V. Sitkovsky , Akio Ohta
发明人： Michail V. Sitkovsky , Akio Ohta
IPC分类号： A61K31/7076 , A23L1/29 , A61K31/337 , A61K31/00 , A61K45/06 , A61K38/22
CPC分类号： A61K31/7076 , A23L33/40 , A61K31/00 , A61K31/337 , A61K31/365 , A61K31/52 , A61K38/2264 , A61K45/06 , A61K2300/00
摘要： The invention includes methods of treating, preventing, or limiting obesity or weight gain, or reducing or suppressing appetite, by the administration of A2A adenosine receptor pathway agonists. The A2AR pathway agonists may be administered in conjunction with a therapeutic agent having a side effect of weight gain, in order to prevent or limit that weight gain. In some instances, the A2AR pathway agonist is administered as a sleeping pill, and in other instances the A2AR pathway agonist is administered in a non-drowsy formulation.
摘要翻译：本发明包括通过施用A2A腺苷受体途径激动剂来治疗，预防或限制肥胖或体重增加或减少或抑制食欲的方法。 A2AR通路激动剂可以与具有体重增加的副作用的治疗剂联合施用，以便防止或限制体重增加。在一些情况下，A2AR途径激动剂作为睡眠药剂施用，而在另一些情况下，A2AR途径激动剂以非瞌睡制剂施用。

3. 发明授权

US07293375B2 Crawler frame for construction machine 有权
标题翻译：建筑机械履带架
公开(公告)号：US07293375B2
公开(公告)日：2007-11-13
申请号：US10789160
申请日：2004-02-27
申请人： Akira Fukushima , Akio Ohta , Kohei Urase , Takaharu Nishimura
发明人： Akira Fukushima , Akio Ohta , Kohei Urase , Takaharu Nishimura
IPC分类号： E02F3/58
CPC分类号： E02F9/0825 , E02F9/02
摘要： In a crawler frame in which legs in a center frame are formed from cast steel, a simple structure is achieved by reducing the number of components. To this end, the crawler frame, which has a center frame composed of a central frame section for supporting a swing bearing and legs located on the right and left sides of the central frame section; and track frames disposed on the sides of the distal ends of the legs, respectively, of the center frame, is designed such that each of the legs is bifurcated into front and rear leg sections and the front and rear leg sections are respectively formed from cast steel.
摘要翻译：在中心框架的脚由铸钢形成的履带架中，通过减少部件的数量来实现简单的结构。为此，履带架具有由支撑摆动轴承的中央框架部分和位于中心框架部分的右侧和左侧的支腿构成的中心框架; 并且分别设置在中心框架的腿部的远端侧面的轨道框架，使得每个腿部分叉成前腿部分段和后腿部分段，并且前后腿部分段由铸件钢。

4. 发明授权

US08586366B2 Gel for radiation dosimeter and radiation dosimeter which uses the same 失效
标题翻译：用于辐射剂量计的凝胶和使用其的辐射剂量计
公开(公告)号：US08586366B2
公开(公告)日：2013-11-19
申请号：US13160645
申请日：2011-06-15
申请人： Akihiro Hiroki , Naotsugu Nagasawa , Masao Tamada , Takuji Kojima , Yuichi Sato , Akio Ohta , Hisamichi Yamabayashi , Takayoshi Yamamoto
发明人： Akihiro Hiroki , Naotsugu Nagasawa , Masao Tamada , Takuji Kojima , Yuichi Sato , Akio Ohta , Hisamichi Yamabayashi , Takayoshi Yamamoto
IPC分类号： G01N23/00
CPC分类号： G01T1/04
摘要： Gel for radiation dosimeter including a gel part (A) and a gel part (B) that become cloudy when exposed to a fixed dose or more, wherein said gel part (A) exposed to more than a specified dose above the fixed dose maintains a cloudy state regardless of the decrease in external temperature; and said gel part (B) exposed to less than the specified dose above the fixed dose changes gradually from a cloudy state into a transparent state according to the decrease in external temperature.
摘要翻译：包含凝胶部分（A）和凝胶部分（B）的凝胶，其在暴露于固定剂量或更多剂量时变得混浊，其中暴露于高于固定剂量的规定剂量的所述凝胶部分（A）维持a 不管外界温度下降，多云状态; 并且暴露于低于固定剂量以上的规定剂量的凝胶部分（B）根据外部温度的降低逐渐从浑浊状态变为透明状态。

5. 发明授权

US08883500B2 Method of preparing adenosine-resistant anti-tumor T lymphocytes for adoptive immunotherapy 有权
标题翻译：用于过继性免疫治疗的抗腺癌抗肿瘤T淋巴细胞的制备方法
公开(公告)号：US08883500B2
公开(公告)日：2014-11-11
申请号：US13133121
申请日：2009-12-07
申请人： Michail V. Sitkovsky , Akio Ohta
发明人： Michail V. Sitkovsky , Akio Ohta
IPC分类号： C12N5/0783 , A61K39/00 , A61K35/12
CPC分类号： A61K39/0011 , A61K2035/124 , A61K2039/5158 , C12N5/0636 , C12N2501/01
摘要： In the past, adoptive immunotherapy often failed because the transferred immune cells were inactive in vivo. This disclosure provides a method of producing immune cells that are highly active in vivo. The immune cells may be expanded in vitro in the presence of an adenosine receptor agonist or an antisense nucleic acid that downregulates expression of an adenosine receptor, for example. The immune cells may be tumor-infiltrating lymphocytes (TIL), cytotoxic T lymphocytes (CTL), natural killer (NK) cells, or lymphokine-activated killer (LAK) cells, for example. The methods described herein may be used to treat a number of diseases including cancer, infectious diseases, and immunodeficiencies.
摘要翻译：过去，过继免疫疗法经常失败，因为转移的免疫细胞在体内无活性。本公开提供了在体内高度活性的产生免疫细胞的方法。例如，在腺苷受体激动剂或下调腺苷受体表达的反义核酸的存在下，体外可以扩增免疫细胞。例如，免疫细胞可以是肿瘤浸润淋巴细胞（TIL），细胞毒性T淋巴细胞（CTL），天然杀伤（NK）细胞或淋巴因子激活的杀伤细胞（LAK）细胞。本文描述的方法可用于治疗许多疾病，包括癌症，感染性疾病和免疫缺陷。

6. 发明授权

US08716301B2 Methods for using extracellular adenosine inhibitors and adenosine receptor inhibitors to enhance immune response and inflammation 有权
标题翻译：使用细胞外腺苷抑制剂和腺苷受体抑制剂增强免疫反应和炎症的方法
公开(公告)号：US08716301B2
公开(公告)日：2014-05-06
申请号：US13310264
申请日：2011-12-02
申请人： Michail V. Sitkovsky , Akio Ohta
发明人： Michail V. Sitkovsky , Akio Ohta
IPC分类号： A61K31/522 , A61K31/53
CPC分类号： A61K39/39 , A61K31/00 , A61K31/365 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/53 , A61K31/7088 , A61K35/17 , A61K39/0011 , A61K39/39558 , A61K45/06 , A61K2039/55561 , G01N33/5041 , G01N33/5055 , G01N2333/705
摘要： A method is provided herein to increase an immune response to an antigen. The method includes administering an agent that inhibits extracellular adenosine or inhibits adenosine receptors. Also disclosed are methods to increase the efficacy of a vaccine and to increase an immune response to a tumor antigen or immune cell-mediated tumor destruction.
摘要翻译：本文提供了增加对抗原的免疫应答的方法。该方法包括施用抑制细胞外腺苷或抑制腺苷受体的药剂。还公开了增加疫苗功效并增加对肿瘤抗原或免疫细胞介导的肿瘤破坏的免疫应答的方法。

7. 发明申请

US20100178299A1 METHODS AND COMPOSITIONS FOR IMPROVING IMMUNE RESPONSES 审中-公开
标题翻译：改善免疫应答的方法和组合物
公开(公告)号：US20100178299A1
公开(公告)日：2010-07-15
申请号：US12527181
申请日：2008-02-13
申请人： Michail V. Sitkovsky , Akio Ohta , Dmitriy Lukashev
发明人： Michail V. Sitkovsky , Akio Ohta , Dmitriy Lukashev
IPC分类号： A61K39/00 , A61P35/00 , C12Q1/02
CPC分类号： A61K39/0011 , A61K2039/555 , A61K2039/55511 , A61K2300/00
摘要： The present invention relates to compositions and methods for enhancing an immune response, for example to a vaccine, by combining the administration of oxygen (O2 gas), an adenosine pathway antagonist and/or an HIF-1α antagonist, and/or inhibitors of enzymes that produce or generate adenosine with the administration of the vaccine to the patient.The present invention also relates to methods of inducing or enhancing immune responses, methods of treating subjects having a tumor, methods of ablating or killing tumor cells and methods of disrupting the blood supply to a tumor, comprising administering oxygen alone or in combination with therapeutic agents that prevent inhibition of anti-tumor T cells. Tumor defense-resistant immune cells, anti-viral immune cells, and methods of their production are also disclosed.
摘要翻译：本发明涉及通过组合施用氧（O 2气体），腺苷途径拮抗剂和/或HIF-1α拮抗剂和/或酶抑制剂来增强免疫应答，例如增加免疫应答的组合物和方法其向患者施用疫苗产生或产生腺苷。本发明还涉及诱导或增强免疫应答的方法，治疗患有肿瘤的受试者的方法，消融或杀死肿瘤细胞的方法以及扰乱对肿瘤的供血的方法，包括单独或与治疗剂组合施用氧可以防止抗肿瘤T细胞的抑制。还公开了抗肿瘤免疫细胞，抗病毒免疫细胞及其生产方法。

8. 发明申请

US20120093856A1 METHODS FOR USING EXTRACELLULAR ADENOSINE INHIBITORS AND ADENOSINE RECEPTOR INHIBITORS TO ENHANCE IMMUNE RESPONSE AND INFLAMMATION 有权
标题翻译：使用细胞内腺苷抑制剂和腺苷受体抑制剂以增强免疫应答和炎症的方法
公开(公告)号：US20120093856A1
公开(公告)日：2012-04-19
申请号：US13310264
申请日：2011-12-02
申请人： Michail V. Sitkovsky , Akio Ohta
发明人： Michail V. Sitkovsky , Akio Ohta
IPC分类号： A61K39/12 , A61K39/02 , A61K39/39 , A61P31/12 , A61P31/04 , A61K39/00 , A61P37/04
CPC分类号： A61K39/39 , A61K31/00 , A61K31/365 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/53 , A61K31/7088 , A61K35/17 , A61K39/0011 , A61K39/39558 , A61K45/06 , A61K2039/55561 , G01N33/5041 , G01N33/5055 , G01N2333/705
摘要： A method is provided herein to increase an immune response to an antigen. The method includes administering an agent that inhibits extracellular adenosine or inhibits adenosine receptors. Also disclosed are methods to increase the efficacy of a vaccine and to increase an immune response to a tumor antigen or immune cell-mediated tumor destruction.
摘要翻译：本文提供了增加对抗原的免疫应答的方法。该方法包括施用抑制细胞外腺苷或抑制腺苷受体的药剂。还公开了增加疫苗功效并增加对肿瘤抗原或免疫细胞介导的肿瘤破坏的免疫应答的方法。

9. 发明申请

US20110312097A1 GEL FOR RADIATION DOSIMETER AND RADIATION DOSIMETER WHICH USES THE SAME 失效
标题翻译：用于辐射剂量计和使用其的辐射剂量计的凝胶
公开(公告)号：US20110312097A1
公开(公告)日：2011-12-22
申请号：US13160645
申请日：2011-06-15
申请人： Akihiro HIROKI , Naotsugu Nagasawa , Masao Tamada , Takuji Kojima , Yuichi Sato , Akio Ohta , Hisamichi Yamabayashi , Takayoshi Yamamoto
发明人： Akihiro HIROKI , Naotsugu Nagasawa , Masao Tamada , Takuji Kojima , Yuichi Sato , Akio Ohta , Hisamichi Yamabayashi , Takayoshi Yamamoto
IPC分类号： G01N23/02
CPC分类号： G01T1/04
摘要： Gel for radiation dosimeter including a gel part (A) and a gel part (B) that become cloudy when exposed to a fixed dose or more, wherein said gel part (A) exposed to more than a specified dose above the fixed dose maintains a cloudy state regardless of the decrease in external temperature; and said gel part (B) exposed to less than the specified dose above the fixed dose changes gradually from a cloudy state into a transparent state according to the decrease in external temperature.
摘要翻译：包含凝胶部分（A）和凝胶部分（B）的凝胶，其在暴露于固定剂量或更多剂量时变得混浊，其中暴露于高于固定剂量的规定剂量的所述凝胶部分（A）维持a 不管外界温度下降，多云状态; 并且暴露于低于固定剂量以上的规定剂量的凝胶部分（B）根据外部温度的降低逐渐从浑浊状态变为透明状态。

10. 发明申请

US20080045109A1 Process for Producing Nonwoven Fabric and Nonwoven Fabric 审中-公开
标题翻译：生产无纺布和无纺布的方法
公开(公告)号：US20080045109A1
公开(公告)日：2008-02-21
申请号：US10599400
申请日：2005-03-29
申请人： Toshiyuki Ogata , Shin Kasai , Hirofumi Yashiro , Akio Ohta
发明人： Toshiyuki Ogata , Shin Kasai , Hirofumi Yashiro , Akio Ohta
IPC分类号： D04H3/04 , D01F8/00 , D04H3/14 , D02G3/36
CPC分类号： D04H3/14 , D01F8/00 , D04H3/04 , Y10T442/637 , Y10T442/641
摘要： The nonwoven fabric production process of the invention comprises a laminating step in which composite yarn, obtained by bundling a plurality of resin single filaments each having a core-sheath structure with a filamentous core resin surrounded by a sheath resin with a melting point of at least 20° C. lower than the core resin and fusing the sheath resin together, is laminated in at least the three directions of warp direction, slant direction and reverse slant direction, and a bonding step of heating the laminated filament bundles at a temperature lower than the melting point of the core resin and higher than the melting point of the sheath resin for bonding. According to the invention, it is possible to provide a nonwoven fabric production process and nonwoven fabrics with excellent plasticity and shape following property, as well as adjustable strength for adaptation to different purposes and required properties.
摘要翻译：本发明的非织造布生产方法包括层压步骤，其中复合纱线通过将具有芯鞘结构的多根树脂单丝与由护套树脂包围的丝状核心树脂以至少熔点至少在经纱方向，倾斜方向和反向倾斜方向的三个方向上层压在芯树脂20℃以下并将鞘树脂熔合在一起的粘合工序，以及在低于芯树脂的熔点高于用于粘合的护套树脂的熔点。根据本发明，可以提供具有优异的可塑性和形状的无纺布生产方法和非织造织物，并且具有可调节的强度以适应不同的目的和所需的性能。

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