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1. 发明授权

US4226847A Latex polymer sensitized with steroid-serum albumin conjugate, preparation and test therewith 失效
标题翻译：用类固醇 - 血清白蛋白缀合物敏化的胶乳聚合物，制备和测试
公开(公告)号：US4226847A
公开(公告)日：1980-10-07
申请号：US917254
申请日：1978-06-20
申请人： Katsuhiro Ogasa , Morio Kuboyama , Minoru Saito , Tsutomu Kudo , Yoshitsugu Harada , Akio Kawashiri , Eiji Takahashi
发明人： Katsuhiro Ogasa , Morio Kuboyama , Minoru Saito , Tsutomu Kudo , Yoshitsugu Harada , Akio Kawashiri , Eiji Takahashi
IPC分类号： G01N33/53 , A61B10/00 , G01N33/15 , G01N33/531 , G01N33/543 , A61K39/00 , A61K31/74 , G01N31/00 , G01N33/16
CPC分类号： G01N33/54313 , Y10S436/817 , Y10S530/815
摘要： Latex reagents for quantitative assay of a variety of steroid hormones or metabolites thereof which are contained in body fluid or excreted fluid of human beings comprise latex particles which are immunologically sensitized with a conjugate selected from a variety of steroid-serum albumin conjugates in which the steroid to be detected is bonded to serum albumin in a very small ratio ranging from 0.5 to 7 molecules per 1 molecule of the serum albumin used.Sensitization of latex particles with such a conjugate is performed using a limited amount dependent on the bonding ratio of steroid molecules per molecule of serum albumin in the conjugate and the particle size of the latex used.The latex reagents show very high sensitivity amounting to 0.2-0.04 nmole steroid equivalent/ml.
摘要翻译：用于定量测定体液或人体排泄液中各种类固醇激素或其代谢物的胶乳试剂包含用选自多种类固醇 - 血清白蛋白缀合物的缀合物进行免疫敏化的胶乳颗粒，其中类固醇要被检测的是以每1分子所用血清白蛋白0.5至7个分子的非常小的比例与血清白蛋白结合。使用这样的缀合物对胶乳颗粒进行敏化，其取决于缀合物中每分子血清白蛋白的类固醇分子的键合比例和所使用的胶乳的粒径。乳胶试剂显示非常高的灵敏度，达到0.2-0.04nmol类固醇当量/ ml。

2. 发明授权

US4275056A HGI-Glycoprotein capable of stimulating proliferation and differentiation of human granulocyte, process for preparing same and leukopenia curative containing same 失效
标题翻译： HGI-能够刺激人粒细胞增殖和分化的糖蛋白，其制备方法和含有其的白细胞减少症
公开(公告)号：US4275056A
公开(公告)日：1981-06-23
申请号：US22594
申请日：1979-03-19
申请人： Fumimaro Takaku , Katsuhiro Ogasa , Morio Kuboyama , Minoru Saito , Nobuya Yanai , Masayuki Nishida
发明人： Fumimaro Takaku , Katsuhiro Ogasa , Morio Kuboyama , Minoru Saito , Nobuya Yanai , Masayuki Nishida
IPC分类号： C07K1/22 , A61K35/22 , A61K38/00 , A61K38/16 , A61P7/00 , A61P35/02 , A61P37/00 , A61P43/00 , C07G99/00 , C07K14/00 , C07K14/52 , G01N33/50 , C07G7/00
CPC分类号： C07K14/52 , A61K35/22 , A61K38/00 , Y10S530/834
摘要： A colony-stimulating factor having definite physical and chemical properties and a function of stimulating activity on human bone marrow cells to proliferate and differentiate, thereby forming granulocyte colonies, is obtained from human urine by concentrating the urine with respect to proteins contained therein by adsorption chromatography with silica gel, salting out with ammonium sulfate and other means, then removing impurities by adsorption on cation exchanger, and further purifying by ion exchanging chromatography on anion exchanger, gel filtrating chromatography with highly crosslinked gels, affinitive chromatography with sugar affinitire adsorbents and electrophoresis.
摘要翻译：具有确定的物理和化学性质以及刺激人骨髓细胞活性增殖和分化，从而形成粒细胞集落的功能的集落刺激因子通过浓缩尿液相对于其中所含蛋白质的吸附色谱从人尿中获得用硅胶盐析，用硫酸铵等手段进行盐析，然后通过阳离子交换器吸附除去杂质，并进一步通过阴离子交换层析离子交换色谱，高度交联凝胶的凝胶过滤层析，糖亲和吸附剂亲和色谱和电泳进行纯化。

3. 发明授权

US4100022A Process for preparing a curing agent for myelogenic leukemia 失效
标题翻译：制备骨髓性白血病固化剂的方法
公开(公告)号：US4100022A
公开(公告)日：1978-07-11
申请号：US727653
申请日：1976-09-29
申请人： Katsuhiro Ogasa , Morio Kuboyama , Minoru Saito , Kazuhiro Nagata
发明人： Katsuhiro Ogasa , Morio Kuboyama , Minoru Saito , Kazuhiro Nagata
IPC分类号： A61K38/00 , A61K35/50 , A61P35/02 , C12K9/00
CPC分类号： A61K35/50
摘要： A process for preparing a therapeutic agent characterized by preculturing human amnion cells isolated from human amnion by trypsinization or human amnion cells obtained by subculturing the isolated cells in a medium containing calf or bovine fetal serum at least one time for 1 to 5 days to form a monolayer, removing the medium, adding a medium containing 0.5 to 20 mg of human serum albumin per 1 ml of medium thereto and culturing it for 3 to 6 days, dialyzing the culture liquid against diluted buffer or water, and filtering the dialyzed culture liquid through a bacterial filter thereby obtaining a germ free liquid agent.
摘要翻译：一种治疗剂的制备方法，其特征在于，通过胰蛋白酶消化法分离人羊膜中的人羊膜细胞，或通过将分离的细胞在含有小牛或牛胎儿血清的培养基中传代培养获得的人羊膜细胞，至少一次进行1至5天，形成单层，除去培养基，每1ml培养基中加入含有0.5〜20mg人血清白蛋白的培养基，培养3〜6天，将培养液用稀释的缓冲液或水透析，并将透析的培养液通过细菌过滤器，从而获得无菌液体剂。

4. 发明授权

US4342828A Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells 失效
标题翻译：能够刺激人造粒干细胞分化和增殖的物质生产方法
公开(公告)号：US4342828A
公开(公告)日：1982-08-03
申请号：US169107
申请日：1980-07-15
申请人： Fumimaro Takaku , Katsuhiro Ogasa , Morio Kuboyama , Nobuya Yanai , Muneo Yamada , Yoshiteru Watanabe
发明人： Fumimaro Takaku , Katsuhiro Ogasa , Morio Kuboyama , Nobuya Yanai , Muneo Yamada , Yoshiteru Watanabe
IPC分类号： A61K38/00 , C07K14/535 , C12N1/38 , C12N5/00 , C12P19/26
CPC分类号： C12N1/38 , C07K14/535 , A61K38/00
摘要： A colony stimulating factor effective in treating human granulocytopenia is produced by cultivating monocytes and macrophages isolated from the human peripheral blood in a synthetic medium for tissue culture containing a glycoprotein isolated from human urine and capable of stimulating the formation of human granulocytes or mouse macrophages and granulocytes.
摘要翻译：有效治疗人粒细胞减少症的集落刺激因子是通过在含有从人尿中分离出来的糖蛋白的组织培养物的合成培养基中培养从人外周血中分离的单核细胞和巨噬细胞产生的，并且能够刺激人粒细胞或小鼠巨噬细胞和粒细胞的形成。

5. 发明授权

US4230697A Virus-inactivated HGI-glycoprotein capable of stimulating proliferation and differentiation of human granulocyte, process for preparing same and leukopenia curative containing same 失效
标题翻译：能够刺激人粒细胞增殖和分化的病毒灭活的HGI-糖蛋白，其制备方法和含有其的白细胞减少症
公开(公告)号：US4230697A
公开(公告)日：1980-10-28
申请号：US37515
申请日：1979-05-09
申请人： Masayuki Nishida , Satoshi Funakoshi , Katsuhiro Ogasa , Morio Kuboyama , Nobuya Yanai , Muneo Yamada
发明人： Masayuki Nishida , Satoshi Funakoshi , Katsuhiro Ogasa , Morio Kuboyama , Nobuya Yanai , Muneo Yamada
IPC分类号： A61K35/22 , A61K38/00 , C07K14/52 , A61K37/00 , C07C103/52
CPC分类号： A61K35/22 , C07K14/52 , A61K38/00 , Y10S530/83 , Y10S530/834 , Y10S530/851
摘要： A colony-stimulating factor having definite physical and chemical properties and a function of stimulating activity on human bone marrow cells to proliferate and differentiate, thereby forming granulocyte colonies, is obtained from human urine by concentrating the urine with respect to proteins contained therein by adsorption chromatography with silica gel, salting out with ammonium sulfate and other means, then removing impurities by adsorption on cation exchanger, and further purifying by ion exchanging chromatography on anion exchanger, gel filtrating chromatography with highly crosslinked gels, affinity chromatography with sugar affinitive adsorbents and electrophoresis. This substance is stable in the presence of a stabilizer such as albumin or urinary proteins, against heat-treatment of virus-inactivation and can be used as a leukopenia curative which is precluded from fear of virus-infection.
摘要翻译：具有确定的物理和化学性质以及刺激人骨髓细胞活性增殖和分化，从而形成粒细胞集落的功能的集落刺激因子通过浓缩尿液相对于其中所含蛋白质的吸附色谱从人尿中获得用硅胶盐析，用硫酸铵等方法盐析，然后通过阳离子交换器上的吸附除去杂质，进一步通过阴离子交换柱上的离子交换色谱，高度交联凝胶的凝胶过滤色谱，糖亲和性吸附剂的亲和层析和电泳进行纯化。这种物质在稳定剂如白蛋白或尿蛋白存在下是稳定的，用于病毒灭活的热处理，并且可以用作免于病毒感染的白细胞减少症治疗剂。

6. 发明授权

US4303678A Method of manufacturing a packaged soybean curd 失效
标题翻译：包装大豆凝乳的制造方法
公开(公告)号：US4303678A
公开(公告)日：1981-12-01
申请号：US174439
申请日：1980-08-01
申请人： Katsuhiro Ogasa , Morio Kuboyama , Kunisuke Kuwahara , Ryo Kato , Hiroshi Shimada
发明人： Katsuhiro Ogasa , Morio Kuboyama , Kunisuke Kuwahara , Ryo Kato , Hiroshi Shimada
IPC分类号： A23C20/02 , A23L11/00 , A23L1/20 , A23J3/00
CPC分类号： A23C20/025 , A23L11/09
摘要： A method of manufacturing a packaged soybean curd with a long shelf life without the inclusion of any artificial additives such as coagulating agents, germicides and the like; wherein soybean juice is subjected to lactic acid fermentation until its pH is reached to a value equal to or less than a value which is determined from the percentage of the solids content (5-16 wt. %) of soybean juice and then is subjected to heating (60.degree.-95.degree. C., 10-100 minutes) to adjust the curd tension to above 20 g.
摘要翻译：一种制造长寿命的包装大豆凝乳的方法，而不包括任何人造添加剂如凝结剂，杀菌剂等; 其中大豆汁进行乳酸发酵，直到其pH达到等于或小于由大豆汁的固体含量（5-16重量％）的百分比确定的值，然后进行加热（60°-95℃，10-100分钟），将凝乳张力调节至20g以上。

7. 发明授权

US4038992A Granular composition for tobacco filter 失效
标题翻译：烟草滤芯颗粒组成
公开(公告)号：US4038992A
公开(公告)日：1977-08-02
申请号：US617582
申请日：1975-09-29
申请人： Katsuhiro Ogasa , Joji Ono , Tsutomu Kudo , Kazuyoshi Doi , Katsuichi Noguchi , Kazuo Maeda
发明人： Katsuhiro Ogasa , Joji Ono , Tsutomu Kudo , Kazuyoshi Doi , Katsuichi Noguchi , Kazuo Maeda
IPC分类号： A24D3/06 , A24B15/02 , A24B15/033
CPC分类号： A24D3/06
摘要： A granular composition having a grain size of 10 to 50 mesh and a bulk density of 0.5 to 0.7 g/cm.sup.3 suitable for use in a tobacco filter or a tobacco pipe and having the ability to selectively remove carcinogenic and deleterious components from tobacco smoke comprises granules which are composed of bovine milk whey protein power and/or egg white protein powder, and one or more excipients selected from the group consisting of powdered cellulose, wheat flour, starch, rice flour, sugar, glucose, lactose, talc, alumina, zeolite or silica gel; or composite granules which are a blend of said granules and charcoal granules.
摘要翻译：适用于烟草过滤嘴或烟草管并具有从烟草烟雾中选择性除去致癌和有害成分的能力的颗粒大小为10至50目，体积密度为0.5至0.7g / cm 3的颗粒组合物包含颗粒由牛奶乳清蛋白粉和/或蛋白蛋白粉组成的一种或多种赋形剂，以及选自粉状纤维素，小麦粉，淀粉，米粉，糖，葡萄糖，乳糖，滑石，氧化铝，沸石或硅胶; 或作为所述颗粒和木炭颗粒的混合物的复合颗粒。

8. 发明授权

US4000326A Method of manufacturing an aseptic soya bean curd 失效
标题翻译：生产无菌豆腐的方法
公开(公告)号：US4000326A
公开(公告)日：1976-12-28
申请号：US600789
申请日：1975-07-31
申请人： Katsuto Okada , Katsuhiro Ogasa , Kunisuke Kuwahara
发明人： Katsuto Okada , Katsuhiro Ogasa , Kunisuke Kuwahara
IPC分类号： A23C20/02 , A23L3/10 , A23L3/00
CPC分类号： A23L3/10 , A23C20/025
摘要： Packaged aseptic soya bean curd containing no bactericidal agents is manufactured by a method which comprises continuously sterilizing a soya bean juice by maintaining it at a temperature of 128.degree. to 150.degree. C for 1 to 6 seconds and cooling to room temperature; homogeneously mixing said sterilized soya bean juice with a sterilized coagulating agent-containing solution in an aseptic atmosphere continuously or in a pipeline; continuously filling the resulting liquid mixture into a container in an aseptic atmosphere and sealing it; and dipping said sealed container into a water tank heated to 70.degree. to 95.degree. C for 20 to 60 minutes in order to coagulate the mixture.
摘要翻译：不含杀菌剂的无菌豆腐包装制造方法包括：将大豆汁在128℃〜150℃的温度下连续灭菌1〜6秒，冷却至室温，在无菌气氛中连续地或在管道中均匀混合所述灭菌的大豆汁与含灭菌凝固剂的溶液; 将所得液体混合物在无菌气氛中连续填充到容器中并密封; 并将所述密封容器浸入加热至70℃至95℃的水箱中20至60分钟以使混合物凝结。

9. 发明授权

US4057655A Process for preparing a lactulose-containing powder for feed 失效
标题翻译：用于制备含有乳果糖的粉末用于饲料的方法
公开(公告)号：US4057655A
公开(公告)日：1977-11-08
申请号：US702680
申请日：1976-07-06
申请人： Katsuto Okada , Katsuhiro Ogasa , Mamoru Tomita
发明人： Katsuto Okada , Katsuhiro Ogasa , Mamoru Tomita
IPC分类号： C13K13/00 , A23K1/08
CPC分类号： C13K13/005 , Y10S426/807
摘要： A process for preparing a free-flowing lactulose-containing powder from a solution containing lactose, by adding calcium hydroxide to the solution to adjust the pH of said solution to from 9.4 to 11.2; heating the resulting solution so that the pH is reduced to from 7.5 to 9.0; the homogenizing, concentrating and drying.
摘要翻译：通过向溶液中加入氢氧化钙以将所述溶液的pH调节至9.4至11.2，由含有乳糖的溶液制备含自由流动含乳果糖的粉末的方法; 加热所得溶液使pH降至7.5至9.0; 均质，浓缩和干燥。

10. 发明授权

US3968267A Continuous process for preparing a whipped-cream topping dessert 失效
标题翻译：连续制作鞭打奶油顶级甜点的过程
公开(公告)号：US3968267A
公开(公告)日：1976-07-06
申请号：US586804
申请日：1975-06-13
申请人： Katsuhiro Ogasa , Shigeo Okonogi , Hiroya Yuguchi , Yoshinobu Hayashi , Yusuke Miyazaki
发明人： Katsuhiro Ogasa , Shigeo Okonogi , Hiroya Yuguchi , Yoshinobu Hayashi , Yusuke Miyazaki
IPC分类号： A23L9/10 , A23L9/20 , A23G3/00
CPC分类号： A23L9/22 , A23L9/12
摘要： A whipped-cream topping dessert is prepared by a process comprising the steps of: (a) formulating an aqueous mixture containing 10 to 30 percent by weight of fat, 3 to 6 percent by weight of milk protein, 12 to 22 percent by weight of saccharide, 0.3 to 0.8 percent by weight of emulsifier, 0.05 to 0.15 percent by weight of thickening agent and 0.3 to 0.6 percent by weight of gelling agent; (b) homogenizing said mixture; (c) pasteurizing and cooling the mixture to room temperature; (d) thereafter adding an aqueous solution of a calcium salt to said mixture so that the amount of calcium ion in said mixture is 10 to 35 mg. per 1 gram of the milk protein; (e) whipping and heating the resultant mixture at a temperature of 25.degree. to 30.degree.C to prepare a flowable whipped-cream; (f) topping said whipped-cream onto a lower layer dessert base maintained at a temperature of 50.degree. to 70.degree.C which has previously been placed into a container; and (g) solidifying both layers by cooling.
摘要翻译：通过包括以下步骤的方法制备鞭打奶油顶部甜点：（a）配制含有10〜30重量％脂肪，3〜6重量％乳蛋白质，12〜22重量％糖，0.3〜0.8重量％的乳化剂，0.05〜0.15重量％的增稠剂和0.3〜0.6重量％的胶凝剂; （b）均化所述混合物; （c）将混合物巴氏灭菌并冷却至室温; （d）然后向所述混合物中加入钙盐水溶液，使得所述混合物中的钙离子的量为10〜35mg。每1克乳蛋白; （e）在25-30℃的温度下搅拌和加热所得混合物以制备可流动的搅打奶油; （f）将所述搅打奶油顶部保持在预先放入容器中的温度为50℃至70℃的下层甜点基料上; 和（g）通过冷却固化两层。

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