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    • 8. 发明授权
    • Lactoferrin tablets
    • 乳铁蛋白片
    • US06319895B1
    • 2001-11-20
    • US09341316
    • 1999-09-02
    • Mamoru TomitaRyo KatoYuzo AsanoKenji NishiYuriko IiyamaTsutomu Kudo
    • Mamoru TomitaRyo KatoYuzo AsanoKenji NishiYuriko IiyamaTsutomu Kudo
    • A61K3840
    • A61K9/2018A61K35/741A61K38/40Y10S435/822Y10S435/853Y10S435/885A61K2300/00
    • Lactoferrin tablets comprising as the active ingredients lactoferrin and lactulose and having a horizontal hardness of at least 4 kg and a vertical hardness of at least 3 kg; and lactoferrin tablets comprising as the active ingredients a microbial cell powder of at least one microorganism selected from among lactic acid bacteria, lactoferrin and lactulose and having a horizontal hardness of at least 4 kg and a vertical hardness of at least 3 kg. These tablets can be produced by using the conventional tableting apparatuses and yet have high hardness. Thus, they do not adhere to the inner wall of the oral cavity and have a favorable taste. Since no excessive tableting pressure is needed in the production process, moreover, these tablets can contain much viable cells of lactic acid bacteria, though they are in the form of rigid tablet.
    • 乳铁蛋白片剂包含作为活性成分的乳铁蛋白和乳果糖,并且具有至少4kg的水平硬度和至少3kg的垂直硬度; 以及乳铁蛋白片,其包含至少一种选自乳酸菌,乳铁蛋白和乳果糖中的微生物的微生物细胞粉末作为活性成分,并且具有至少4kg的水平硬度和至少3kg的垂直硬度。 这些片剂可以通过使用常规的压片装置制造,但是具有高的硬度。 因此,它们不粘附到口腔的内壁并具有良好的味道。 由于在生产过程中不需要过量的压片压力,所以这些片剂可以含有很多活细胞的乳酸菌,尽管它们是刚性片剂的形式。