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1. 发明授权

US5753186A Reaction tube with a penetrable membrane to minimize contamination 失效
标题翻译：具有可穿透膜的反应管，以最大限度地减少污染
公开(公告)号：US5753186A
公开(公告)日：1998-05-19
申请号：US435014
申请日：1995-05-04
申请人： Kathleen A. Hanley , A. David Hofferbert , Helen H. Lee , Curtis J. Pepe , Timothy J. Perko , Thomas F. Zurek
发明人： Kathleen A. Hanley , A. David Hofferbert , Helen H. Lee , Curtis J. Pepe , Timothy J. Perko , Thomas F. Zurek
IPC分类号： G01N33/566 , B01L3/00 , B01L3/14 , B01L7/00 , B01L99/00 , C12M1/00 , C12N15/09 , C12Q1/68 , B01L11/00
CPC分类号： B01L3/50825 , B01L7/52
摘要： A disposable reaction vessel for performing nucleic acid amplification assay. The disposable reaction vessel has a penetrable cap that can be penetrated by an automated pipettor to aspirate a portion of an amplified reaction product. The disposable reaction vessel contains the reagents necessary to perform a nucleic acid amplification assay. A patient specimen is added to the unit dose reagents in the disposable reaction vessel and the penetrable cap is closed. The disposable reaction vessel containing the reaction mixture and the specimen undergoes amplification, typically by placing it in a thermal cycler. After amplification the intact disposable reaction vessel is transferred to an automated analyzer where an automated pipettor penetrates the closure membrane and aspirates a portion of the amplified sample for further processing, without removal of the reaction vessel cap. This avoids the generation of potentially contaminating aerosols or droplets.
摘要翻译：用于进行核酸扩增测定的一次性反应容器。一次性反应容器具有可穿透的帽，其可被自动移液器穿透以吸收一部分经扩增的反应产物。一次性反应容器含有执行核酸扩增测定所必需的试剂。将患者标本加入到一次性反应容器中的单位剂量试剂中，并将可穿透的盖封闭。含有反应混合物和样品的一次性反应容器通常通过将其放置在热循环仪中进行扩增。扩增后，将完整的一次性反应容器转移至自动分析器，其中自动移液器渗透封闭膜并抽吸一部分扩增的样品用于进一步处理，而不需要移除反应容器盖。这避免了潜在的污染气溶胶或液滴的产生。

2. 发明授权

US5604101A Method of minimizing contamination in amplification reactions using a reaction tube with a penetrable membrane 失效
标题翻译：使用具有可穿透膜的反应管来最小化扩增反应中的污染的方法
公开(公告)号：US5604101A
公开(公告)日：1997-02-18
申请号：US559932
申请日：1995-11-17
申请人： Kathleen A. Hanley , A. David Hofferbert , Helen H. Lee , Curtis J. Pepe , Thomas F. Zurek
发明人： Kathleen A. Hanley , A. David Hofferbert , Helen H. Lee , Curtis J. Pepe , Thomas F. Zurek
IPC分类号： G01N33/566 , B01L3/00 , B01L3/14 , B01L7/00 , B01L99/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C12P19/34
CPC分类号： B01L3/50825 , B01L7/52
摘要： A disposable reaction vessel for performing nucleic acid amplification assay. The disposable reaction vessel has a penetrable cap that can be penetrated by an automated pipettor to aspirate a portion of an amplified reaction product. The disposable reaction vessel contains the reagents necessary to perform a nucleic acid amplification assay. A patient specimen is added to the unit dose reagents in the disposable reaction vessel and the penetrable cap is closed. The disposable reaction vessel containing the reaction mixture and the specimen undergoes amplification, typically by placing it in a thermal cycler. After amplification the intact disposable reaction vessel is transferred to an automated analyzer where an automated pipettor penetrates the closure membrane and aspirates a portion of the amplified sample for further processing, without removal of the reaction vessel cap. This avoids the generation of potentially contaminating aerosols or droplets.
摘要翻译：用于进行核酸扩增测定的一次性反应容器。一次性反应容器具有可穿透的帽，其可被自动移液器穿透以吸收一部分经扩增的反应产物。一次性反应容器含有执行核酸扩增测定所必需的试剂。将患者标本加入到一次性反应容器中的单位剂量试剂中，并将可穿透的盖封闭。含有反应混合物和样品的一次性反应容器通常通过将其放置在热循环仪中进行扩增。扩增后，将完整的一次性反应容器转移至自动分析器，其中自动移液器渗透封闭膜并抽吸一部分扩增的样品用于进一步处理，而不需要移除反应容器盖。这避免了潜在的污染气溶胶或液滴的产生。

3. 发明授权

US5576218A Method for thermal cycling nucleic acid assays 失效
标题翻译：热循环核酸测定方法
公开(公告)号：US5576218A
公开(公告)日：1996-11-19
申请号：US422688
申请日：1995-04-14
申请人： Thomas F. Zurek , Kathleen A. Hanley , Curtis J. Pepe
发明人： Thomas F. Zurek , Kathleen A. Hanley , Curtis J. Pepe
IPC分类号： C12N15/09 , B01L7/00 , C12M1/00 , C12Q1/68 , G05D23/13 , G01N1/00 , G01N25/00
CPC分类号： B01L7/52 , G05D23/138 , Y10T436/115831 , Y10T436/117497 , Y10T436/118339 , Y10T436/12 , Y10T436/25
摘要： The method for thermal cycling of nucleic acid assays includes a blended fluid stream produced from a plurality of constant velocity, constant volume, constant temperature fluid streams wherein to provide a variable temperature, constant velocity, constant volume fluid stream which is introduced into a sample chamber for heating and cooling samples contained therein. By diverting and altering the ratio of the constant temperature fluid streams relative to one another, the blended fluid stream is rapidly variable in temperature, providing for almost instantaneous temperature change within the environment defined by the sample chamber.
摘要翻译：核酸测定的热循环的方法包括由多个等速，恒定体积的恒温流体流产生的混合流体流，其中提供可变温度恒定速度的恒定体积流体流，其被引入样品室用于加热和冷却其中所含的样品。通过转移和改变恒温流体流相对于彼此的比例，混合的流体流在温度上快速变化，从而在由样品室限定的环境内提供几乎瞬时的温度变化。

4. 发明授权

US5089424A Method and apparatus for heterogeneous chemiluminescence assay 失效
标题翻译：用于异种化学发光测定的方法和装置
公开(公告)号：US5089424A
公开(公告)日：1992-02-18
申请号：US425643
申请日：1989-10-23
申请人： Omar S. Khalil , Thomas F. Zurek , Kevin R. Genger , Curtis J. Pepe , Yi-Her Jou , Stephen M. Cotter
发明人： Omar S. Khalil , Thomas F. Zurek , Kevin R. Genger , Curtis J. Pepe , Yi-Her Jou , Stephen M. Cotter
IPC分类号： G01N21/76 , G01N33/52 , G01N33/543 , G01N33/576
CPC分类号： G01N33/54346 , G01N33/521 , G01N33/525 , G01N33/54366 , G01N33/54386 , G01N33/5764
摘要： Apparatus and method for performing a chemiluminescence assay involving the immobilization of a chemiluminescent reaction complex to a solid, porous element. The solid, porous element is preferably treated to provide an immobilizing interaction with the chemiluminescent reaction complex wherein the chemiluminescent reaction complex is thereby immobilized to the solid, porous element. The activating and reading of the chemiluminescent reaction are separately performed by evenly distributing a concentrated chemiluminescent activating solution to form a puddle on the surface of the porous element to which the chemiluminescent reaction complex is immobilized.
摘要翻译：用于进行化学发光测定的装置和方法，涉及将化学发光反应复合物固定在固体多孔元件上。优选处理固体多孔元件以提供与化学发光反应复合物的固定相互作用，其中化学发光反应复合物由此固定在固体多孔元件上。化学发光反应的激活和读取分别通过均匀分布浓缩的化学发光活化溶液在化学发光反应复合物固定的多孔元件的表面上形成一个水坑。

5. 发明申请

US20100161677A1 SIMPLE AGGREGATE MODE FOR TRANSACTIONAL DATA 有权
标题翻译：用于交易数据的简单聚合模式
公开(公告)号：US20100161677A1
公开(公告)日：2010-06-24
申请号：US12339788
申请日：2008-12-19
申请人： Thomas F. Zurek , Klaus Nagel , Stefan Unnebrink
发明人： Thomas F. Zurek , Klaus Nagel , Stefan Unnebrink
IPC分类号： G06F17/30
CPC分类号： G06Q10/10 , G06F17/30489 , G06Q10/06
摘要： This disclosure provides various software and systems for efficiently maintaining aggregates. In one aspect, a system performing a computer implemented method identifies a first change to transactional data in a business application and automatically adds an aggregate record to an aggregate data structure based on the first change. The system then identifies a second change to the transactional data in the business application, the second change comprising an update to key figures associated with the first change. The system can prohibit an update to the aggregate record in the aggregate data structure based on the second change and automatically adds a second aggregate record to the aggregate data structure based on the second change to the transactional data, where the second aggregate record comprises the update to the key figures.
摘要翻译：本公开提供了用于有效维护聚合的各种软件和系统。在一个方面，执行计算机实现的方法的系统识别业务应用中的事务数据的第一变化，并且基于第一变化自动将聚合记录添加到聚合数据结构。系统然后识别业务应用程序中的事务数据的第二个更改，第二个更改包括与第一个更改关联的关键数据的更新。该系统可以基于第二次更改来禁止对聚合数据结构中的聚合记录的更新，并且基于对事务数据的第二次更改自动将第二聚合记录添加到聚合数据结构，其中第二聚合记录包括更新关键人物。

6. 发明授权

US07620642B2 Mapping data structures 有权
标题翻译：映射数据结构
公开(公告)号：US07620642B2
公开(公告)日：2009-11-17
申请号：US11302855
申请日：2005-12-13
申请人： Thomas F. Zurek , Stefan Dipper , Stefan Unnebrink , Klaus Nagel , Erich R. Marschall , Franz X. Faerber , Guenter Radestock , Christian M. Bartholomae
发明人： Thomas F. Zurek , Stefan Dipper , Stefan Unnebrink , Klaus Nagel , Erich R. Marschall , Franz X. Faerber , Guenter Radestock , Christian M. Bartholomae
IPC分类号： G06F17/00
CPC分类号： G06F17/30592 , Y10S707/99943
摘要： A first data storage schema in which a characteristic in a first dimension table is mapped by a first table and a second table can be received and a second data storage schema can be received. The first table maps the characteristic to a first object that include attributes to which time information is irrelevant to data processing activities and the second maps the characteristic to a second object that includes attributes to which time information is relevant to data processing activities. The second data storage schema includes a fact table including at least some facts drawn from the first data storage schema and a second dimension table that includes at least some characteristics drawn from at least one of the first object and the second object.
摘要翻译：第一数据存储模式，其中第一维度表中的特征被第一表和第二表映射，并且可以接收第二数据存储模式。第一表将特征映射到第一对象，其包括时间信息与数据处理活动无关的属性，第二表将特征映射到包括时间信息与数据处理活动相关的属性的第二对象。第二数据存储模式包括包括从第一数据存储模式中提取的至少一些事实的事实表以及包括从第一对象和第二对象中的至少一个绘制的至少一些特征的第二维度表。

7. 发明授权

US5198368A Methods for performing a solid-phase immunoassay 失效
标题翻译：进行固相免疫测定的方法
公开(公告)号：US5198368A
公开(公告)日：1993-03-30
申请号：US643596
申请日：1991-01-18
申请人： Omar S. Khalil , Charles F. Hanna , Thomas F. Zurek
发明人： Omar S. Khalil , Charles F. Hanna , Thomas F. Zurek
IPC分类号： B01L3/00 , G01N33/543
CPC分类号： B01L3/5023 , G01N33/54313 , G01N33/54366 , B01L2200/027 , B01L2300/0809 , B01L2400/0406 , Y10S435/81 , Y10S436/805 , Y10S436/807 , Y10S436/809 , Y10S436/81 , Y10T436/255 , Y10T436/2575
摘要： A method for performing a microparticle diagnostic assay in a device having a shallow sample well for receiving a sample and reagents for forming a reaction mixture, a read well positioned adjacent to said sample well and separated from said sample well by a wall which is constructed and arranged such that when wash fluid is injected into said sample well, sample and reaction mixtures are washed from said shallow sample well, over the wall and into said read well. The steps of the method comprise forming microparticle analyte complexes in said shallow sample well; washing said microparticle analyte complexes from said shallow sample well over the wall and into said read well where a fibrous matrix retains and immobilizes said microparticle analyte complexes; adding to said read well an indicator substance capable of forming an assay signal when said microparticle analyte complexes are present; and detecting said assay signal produced by said indicator substance.
摘要翻译：一种用于在具有用于接收样品的浅样品井和用于形成反应混合物的试剂的装置中进行微粒诊断测定的方法，与所述样品阱相邻定位并与所述样品阱分离的读取井通过构建和排列成使得当将洗涤液注入所述样品孔中时，将样品和反应混合物从所述浅样品井，壁上和所述读取孔中洗涤。该方法的步骤包括在所述浅样品阱中形成微粒分析物复合物; 从所述浅样品中将所述微粒分析物复合物在所述壁上清洗并进入所述读取孔，其中纤维基质保留并固定所述微粒分析物复合物; 当所述微粒分析物复合物存在时，向所述读取孔中加入能够形成测定信号的指示物质; 以及检测由所述指示物质产生的所述测定信号。

8. 外观设计

USD332834S Disposable immunoassay reaction tray 失效
公开(公告)号：USD332834S
公开(公告)日：1993-01-26
申请号：US570565
申请日：1990-08-21
申请人： Charles F. Hanna , Thomas F. Zurek , Omar S. Khalil
设计人： Charles F. Hanna , Thomas F. Zurek , Omar S. Khalil

9. 发明授权

US5006309A Immunoassay device with liquid transfer between wells by washing 失效
标题翻译：免疫测定装置，通过洗涤在井间进行液体转移
公开(公告)号：US5006309A
公开(公告)日：1991-04-09
申请号：US184726
申请日：1988-04-22
申请人： Omar S. Khalil , Charles F. Hanna , Thomas F. Zurek , Denise A. Grigalauski
发明人： Omar S. Khalil , Charles F. Hanna , Thomas F. Zurek , Denise A. Grigalauski
IPC分类号： B01L3/00 , G01N33/543
CPC分类号： G01N33/54366 , B01L3/5023 , B01L2200/027 , B01L2300/0809 , B01L2400/0406 , B01L2400/049 , Y10T436/255 , Y10T436/2575
摘要： A disposable device suitable for performing automated solid-state diagnostic assays which employs microparticles to complex an analyte and where the microparticle complex becomes retained and immobilized on a fibrous matrix such that the presence of analyte on the microparticles can be detected by an optical device. A device is disclosed having a shallow sample well for receiving a sample and reagents for forming a reaction mixture, a read well having (a) an entrance port and wash receiving structure for receiving a quantity of sample and assay reagents, (b) a fibrous matrix for retaining and immobilizing microparticle/analyte complexes for detection, the fibrous matrix positioned below the wash receiving structure, and having an average spatial separation of fibers greater than the average diameter of the microparticles and (c) a structure below the fibrous matrix for assisting the flow of sample and assay reagents through the fibrous matrix, such as an absorbent material or vacuum below the fibrous matrix and a passage means communicating between the shallow sample well and the read well where the sample and reaction mixtures can be transferred and washed from the shallow sample well into the read well without being contacted by any apparatus.
摘要翻译：一种适用于执行自动化固态诊断测定的一次性装置，其使用微粒来复合分析物，并且其中微粒复合物保留并固定在纤维基质上，使得微粒上的分析物的存在可以通过光学装置检测。公开了一种装置，其具有用于接收样品的浅样品阱和用于形成反应混合物的试剂，读数井具有（a）用于接收一定量的样品和测定试剂的入口和洗涤接收结构，（b）纤维用于保持和固定用于检测的微粒/分析物复合物的基质，所述纤维基质位于洗涤接收结构下方，并且具有大于微粒平均直径的纤维的平均空间分离，和（c）纤维基质下面的结构用于辅助通过纤维基质（例如吸收材料或纤维基质下方的真空）的样品和测定试剂的流动以及在浅样品阱和读数井之间连通的通道装置，其中样品和反应混合物可以从浅样品很好地进入读取井，而不被任何装置接触。

10. 发明授权

US08655923B2 Simple aggregate mode for transactional data 有权
标题翻译：交易数据的简单聚合模式
公开(公告)号：US08655923B2
公开(公告)日：2014-02-18
申请号：US12339788
申请日：2008-12-19
申请人： Thomas F. Zurek , Klaus Nagel , Stefan Unnebrink
发明人： Thomas F. Zurek , Klaus Nagel , Stefan Unnebrink
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06Q10/10 , G06F17/30489 , G06Q10/06
摘要： This disclosure provides various software and systems for efficiently maintaining aggregates. In one aspect, a system performing a computer implemented method identifies a first change to transactional data in a business application and automatically adds an aggregate record to an aggregate data structure based on the first change. The system then identifies a second change to the transactional data in the business application, the second change comprising an update to key figures associated with the first change. The system can prohibit an update to the aggregate record in the aggregate data structure based on the second change and automatically adds a second aggregate record to the aggregate data structure based on the second change to the transactional data, where the second aggregate record comprises the update to the key figures.
摘要翻译：本公开提供了用于有效维护聚合的各种软件和系统。在一个方面，执行计算机实现的方法的系统识别业务应用中的事务数据的第一变化，并且基于第一变化自动将聚合记录添加到聚合数据结构。系统然后识别业务应用程序中的事务数据的第二个更改，第二个更改包括与第一个更改关联的关键数据的更新。该系统可以基于第二次更改来禁止对聚合数据结构中的聚合记录的更新，并且基于对事务数据的第二次更改自动将第二聚合记录添加到聚合数据结构，其中第二聚合记录包括更新关键人物。

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