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1. 发明专利

JP2011084537A Agent for protecting/improving liver function 有权
标题翻译：用于保护/改善肝脏功能的药剂
公开(公告)号：JP2011084537A
公开(公告)日：2011-04-28
申请号：JP2009240520
申请日：2009-10-19
申请人： Ichiei:Kk , Kansai Univ , National Institute Of Biomedical Innovation , 学校法人関西大学 , 有限会社一栄 , 独立行政法人医薬基盤研究所
发明人： KAWAHARA HIDEHISA , NAGAOKA YASUO , TAKEMORI HIROSHI , KOIDE YOSHIE
IPC分类号： A61K36/07 , A23L1/30 , A61P1/16
摘要： PROBLEM TO BE SOLVED: To provide an agent for protecting/improving liver function capable of preventing or treating liver function disorders by daily ingesting as a pharmaceutical agent, health food and the like, in relation to an agent for protecting/improving liver function, more concretely, the agent for protecting/improving liver function used as the pharmaceutical, health food and the like having protecting or improving action.
SOLUTION: The agent for protecting/improving the liver function contains Flammulina velutipes habituated at a temperature of 0-10°C.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种用于保护/改善肝功能的药剂，其能够通过每日摄取作为药剂，保健食品等来预防或治疗肝功能障碍，涉及用于保护/改善肝脏的药物更具体地说，作为具有保护或改善作用的药物，保健食品等的用于保护/改善肝功能的药剂。
解决方案：用于保护/改善肝功能的药物含有在0-10℃的温度下习惯的Flammulina velutipes。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2013103926A PPARδ ACTIVATOR AND PRODUCTION METHOD THEREOF 审中-公开
标题翻译： PPARδ激活剂及其生产方法
公开(公告)号：JP2013103926A
公开(公告)日：2013-05-30
申请号：JP2011250865
申请日：2011-11-16
申请人： Kansai Univ , 学校法人関西大学 , National Institute Of Biomedical Innovation , 独立行政法人医薬基盤研究所 , Ichiei:Kk , 有限会社一栄
发明人： KAWAHARA HIDEHISA , NAGAOKA YASUO , TAKEMORI HIROSHI , KOIDE YOSHIE
IPC分类号： A61K36/07 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/00 , A61P29/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide PPAR (peroxisome proliferator-activated receptor) δ activator which activates PPARδ, is expectable of effects such as: antiobesity effect, visceral fat accumulation prevention, prevention and amelioration of insulin resistance, improvement of stamina by increase of red muscle, anti-inflammation effect, dermatitis remedy or the like; and a method for producing the activator.SOLUTION: This PPARδ activator contains an extract of fruit body of Flammulina velutipes acclimatized at a temperature of 0-10°C. The production method of the PPARδ activator comprises an acclimatizing step of acclimatizing a fruit body of Flammulina velutipes at a temperature of 0-10°C, and a step of extracting from the acclimatized fruit body of Flammulina velutipes by a low polar organic solvent.
摘要翻译：要解决的问题：为了提供激活PPARδ的PPAR（过氧化物酶体增殖物激活受体）δ活化剂，可预期的效果如：抗肥胖作用，预防内脏脂肪累积，预防和改善胰岛素抵抗，改善耐力增加红色肌肉，抗炎作用，皮炎治疗等; 和活化剂的制造方法。解决方案：该PPARδ活化剂含有在0-10℃的温度下适应的Flammulina velutipes的果实体的提取物。 PPARδ活化剂的制造方法包括在0〜10℃的温度下适应气候调理的水果体的驯化步骤，以及通过低极性有机溶剂从Flammulina velutipes的驯化果实提取的步骤。版权所有（C）2013，JPO＆INPIT

3. 发明专利

JP2012006895A Melanin production promoter 有权
标题翻译： MELANIN生产促销
公开(公告)号：JP2012006895A
公开(公告)日：2012-01-12
申请号：JP2010146931
申请日：2010-06-28
申请人： Kansai Univ , 学校法人関西大学
发明人： NAGAOKA YASUO , KUMAGAI AYAKO , HORIIE NANAO , TAKEMORI HIROSHI , HORIBE IPPEI , OBATA KATSUYOSHI
IPC分类号： A61K31/352 , A61K8/49 , A61P17/00 , A61Q5/00 , A61Q19/04 , C07D311/30
摘要： PROBLEM TO BE SOLVED: To provide a melanin production promoter having a compound having excellent melanin production promotion effect as an effective component; a gray hair preventive or ameliorative agent having the melanin production promoter as an effective component; and a tanning promoter which is useful as a therapeutic agent for white spot lesion, or as a cosmetic capable of acquiring a sunburn effect without depending on exposure to sunlight (daylight) or the like.SOLUTION: At least one kind of compound selected from a compound group shown by formula (1) is used as an effective component. To put it concretely, following compound are illustrated, namely, Platol, Acacetin, Kaempheride, Fisetin, 4'-O-Methylfisetin, 4'-O-Ethylfisetin, Diosmetin, 3,3',7-O-Acetyl-4'-O-Methylfisetin, 3',5,7-O-Acetyl-Diosmetin, Isoginkgetin and Sciadopitysin.
摘要翻译：解决问题：提供具有优异的黑色素生产促进效果的化合物作为有效成分的黑色素生成促进剂; 具有黑色素生成促进剂作为有效成分的灰发防治剂或改善剂; 以及可用作白斑病变治疗剂的鞣制促进剂，或作为不依赖于阳光（日光）等而获得晒斑效果的化妆品。解决方案：使用选自式（1）所示的化合物基团中的至少一种化合物作为有效成分。具体来说，说明了以下化合物，即Platol，Acacetin，Kaempheride，Fisetin，4'-O-甲基非西汀，4'-O-乙基非丝氨酸，二硫代甜菜碱，3,3'，7-O-乙酰基-4'- O-甲基非丝氨肽，3'，5,7-O-乙酰基二硫代吗啉，异链球蛋白和Sciadopitysin。版权所有（C）2012，JPO＆INPIT

4. 发明专利

JP2012006853A Melanin formation inhibiting agent, cosmetic agent, skin preparation for external use, quasi-drug, and anticancer drug 审中-公开
标题翻译：墨西哥形成抑制剂，化妆品，外用皮肤制剂，药物滥用和抗药性药物
公开(公告)号：JP2012006853A
公开(公告)日：2012-01-12
申请号：JP2010142601
申请日：2010-06-23
申请人： Kansai Univ , Momotani Juntendo:Kk , National Institute Of Biomedical Innovation , 学校法人関西大学 , 株式会社桃谷順天館 , 独立行政法人医薬基盤研究所
发明人： KAWAHARA HIDEHISA , TAKEMORI HIROSHI , NAGAOKA YASUO
IPC分类号： A61K8/37 , A61K31/215 , A61P17/00 , A61P35/00 , A61P43/00 , A61Q17/04 , A61Q19/02
摘要： PROBLEM TO BE SOLVED: To provide a melanin formation inhibiting agent for preventing the melanin formation, and to provide a cosmetic agent, a skin preparation for external use, a quasi-drug and an anticancer drug.SOLUTION: The melanin formation inhibiting agent contains baeomycesic acid. In particular, the melanin formation inhibiting agent includes the content of 50-200 μg/ml of baeomycesic acid, that can be applied to the cosmetic agent, the skin preparation for external use, quasi-drug and the anticancer agent.

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