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1. 发明授权

US4410546A Antiallergic compositions 失效
标题翻译：抗过敏组合物
公开(公告)号：US4410546A
公开(公告)日：1983-10-18
申请号：US260580
申请日：1981-05-05
申请人： Kanji Noda , Akira Nakagawa , Munehiko Hirano , Kenji Yamagata , Yoichi Nakashima , Terumi Hachiya , Hiroyuki Ide , Akihide Koda
发明人： Kanji Noda , Akira Nakagawa , Munehiko Hirano , Kenji Yamagata , Yoichi Nakashima , Terumi Hachiya , Hiroyuki Ide , Akihide Koda
IPC分类号： A61K31/19
CPC分类号： A61K31/19
摘要： An antiallergic composition comprising, as the effective ingredient, a compound represented by the following general formula ##STR1## wherein R is n-butyl group or n-pentyl group, the compound being preferably supported by a carrier such as sugar, starch, gum arabic or calcium stearate.
摘要翻译：一种抗过敏组合物，其包含作为有效成分的由以下通式表示的化合物，其中R是正丁基或正戊基，该化合物优选由载体例如糖，淀粉，阿拉伯树胶或硬脂酸钙。

2. 发明授权

US4228304A Novel cyclohexanecarboxylic acid and its derivatives 失效
标题翻译：新型环己烷羧酸及其衍生物
公开(公告)号：US4228304A
公开(公告)日：1980-10-14
申请号：US895485
申请日：1978-04-11
申请人： Kanji Noda , Akira Nakagawa , Kenji Yamagata , Terumi Hachiya , Hiroyuki Ide , Akihide Koda
发明人： Kanji Noda , Akira Nakagawa , Kenji Yamagata , Terumi Hachiya , Hiroyuki Ide , Akihide Koda
IPC分类号： C07C69/75 , A23G4/00 , A23G4/06 , A23G4/12 , A61K31/16 , A61K31/19 , A61K31/215 , A61P1/04 , A61P1/16 , A61P7/02 , A61P31/04 , A61P37/08 , C07C51/00 , C07C51/08 , C07C61/08 , C07C61/22 , C07C67/00 , C07C67/14 , C07C231/00 , C07C233/63 , C07C313/00 , C07C103/50
CPC分类号： A23G4/06 , A23G4/064 , A23G4/126 , C07C61/08
摘要： The present invention relates to novel cyclohexanecarboxylic acid and its derivatives represented by the general formula: ##STR1## (wherein R.sup.1 is selected from the group consisting of hydrogen or methyl; R.sup.2 is selected from the group consisting of hydroxyl, lower alkoxy with 1-6 carbons or amino acid rest. In case R.sup.1 is hydrogen, however, R.sup.2 means amino acid rest, which of all the compounds of the present invention are entirely novel ones which have never been in any printed publications, possessing a high degree of pharmacological activities such as anti-allergic, anti-inflammatory, anti-ulcerative, antibacterial, anti-thrombotic and liver-function-improving activities, and therefore, these compounds are useful as medicines, and besides, these compounds are surface-active and, therefore, useful as additives for toothpaste and shampoo, as surface active agents for detergents, dispersing agents, emulsifying agents and cosmetics, as anticarious agents, and also in industrial fields the aforesaid compounds are useful as detergents for keeping textiles soft, as additives for lubricating oil, as anti-rust agents, additives for plastics and also as metal-capturing agent, ion-floating agents and emulsifying agents for other industrial purposes).
摘要翻译：本发明涉及由以下通式表示的新型环己烷羧酸及其衍生物：其中R1选自氢或甲基; R2选自羟基，低级烷氧基与1-6 碳或氨基酸残基，然而，在R1为氢的情况下，R2表示氨基酸残基，本发明的所有化合物中的全部是全新的，从未出现在任何印刷出版物中，具有高度的药理活性，作为抗过敏，抗炎，抗溃疡，抗菌，抗血栓形成和肝功能改善的活性，因此这些化合物可用作药物，此外，这些化合物是表面活性的，因此有用作为牙膏和洗发剂的添加剂，作为洗涤剂，分散剂，乳化剂和化妆品的表面活性剂作为反义剂，以及在工业领域中所含的化合物可用作保持纺织品柔软的清洁剂，作为润滑油的添加剂，作为防锈剂，塑料添加剂以及用作金属捕获剂，用于其它工业目的的离子漂浮剂和乳化剂）。

3. 发明授权

US4395405A Alkyl-ketohexopyranoside derivatives and method of use 失效
标题翻译：烷基酮酮衍生物及其使用方法
公开(公告)号：US4395405A
公开(公告)日：1983-07-26
申请号：US150129
申请日：1980-05-15
申请人： Kanji Noda , Akira Nakagawa , Yasushi Haraguchi , Koichiro Ueda , Munehiko Hirano , Itsuo Nishioka , Akira Yagi , Akihide Koda , Hiroyuki Ide
发明人： Kanji Noda , Akira Nakagawa , Yasushi Haraguchi , Koichiro Ueda , Munehiko Hirano , Itsuo Nishioka , Akira Yagi , Akihide Koda , Hiroyuki Ide
IPC分类号： C07H3/02 , A61K31/70 , A61K31/7004 , A61K31/7028 , A61P35/00 , A61P37/08 , C07H15/04
CPC分类号： C07H15/04
摘要： An alkyl-ketohexopyranoside derivative having pharmacological actions such as antiallergic actions, represented by the following general formula ##STR1## wherein R is an alkyl group having at least 3 carbon atoms, the derivatives excluding the D-fructose derivative wherein R is n-propyl group.
摘要翻译：具有抗过敏作用的药物作用的烷基酮基六吡喃糖苷衍生物，其由以下通式表示，其中R是具有至少3个碳原子的烷基，除了D-果糖衍生物之外的衍生物，其中R是正丙基。

4. 发明授权

US4443626A 2,3-Dihydro-indene derivatives 失效
标题翻译： 2,3-二氢 - 茚衍生物
公开(公告)号：US4443626A
公开(公告)日：1984-04-17
申请号：US385673
申请日：1982-06-07
申请人： Kanji Noda , Akira Nakagawa , Kenji Yamagata , Yoichi Nakashima , Masayoshi Tsuji , Tetsuo Aoki , Hiroyuki Ide
发明人： Kanji Noda , Akira Nakagawa , Kenji Yamagata , Yoichi Nakashima , Masayoshi Tsuji , Tetsuo Aoki , Hiroyuki Ide
IPC分类号： C07C59/82 , C07C59/88 , C07C59/90 , C07C205/56 , C07C79/46 , C07C59/86
CPC分类号： C07C59/82 , C07C205/56 , C07C59/88 , C07C59/90
摘要： Novel 2,3-dihydro-indene derivatives having remarkable anti-inflammatory effects and represented by the following formula ##STR1## wherein R.sup.1 and R.sup.2 are each a hydrogen atom, halogen atom, nitro group, lower alkyl group or lower alkyloxy group with the proviso that R.sup.1 and R.sup.2 do not take a hydrogen atom at the same time, and n is an integer of 2-4.
摘要翻译：新颖的2,3-二氢 - 茚衍生物具有显着的抗炎作用，由下式表示：其中R1和R2各自为氢原子，卤原子，硝基，低级烷基或低级烷氧基，条件是 R1和R2不同时取氢原子，n为2-4的整数。

5. 发明授权

US4016166A 1-Nitrophenylquinazoline-2,4(1H,3H)-diones 失效
标题翻译： 1-硝基苯基喹唑啉-2,4（1H，3H） - 二酮
公开(公告)号：US4016166A
公开(公告)日：1977-04-05
申请号：US531097
申请日：1974-12-09
申请人： Kanji Noda , Akira Nakagawa , Terumi Hachiya , Hiroyuki Ide
发明人： Kanji Noda , Akira Nakagawa , Terumi Hachiya , Hiroyuki Ide
IPC分类号： A61K31/505 , C07D239/95 , C07D239/96
摘要： The compounds of the present invention can be represented by the following formula: ##STR1## wherein R is selected from the group consisting of hydrogen, lower alkyl, unsaturated lower alkyl, substituted lower alkyl and aralkyl; X is selected from the group consisting of O and S, possessing a high degree of pharmacological activities such as anti-inflammatory, analgetic, and central nervous system depressive activities, and certain of them are useful as new anti-inflammatory agents, analgesics and central nervous system depressants.
摘要翻译：本发明的化合物可以由下式表示：其中R选自氢，低级烷基，不饱和低级烷基，取代的低级烷基和芳烷基; X选自O和S，具有高度的药理活性，如抗炎，止痛和中枢神经系统抑制活性，其中某些可用作新的抗炎药，镇痛药和中枢神经系统抑制剂。

6. 发明授权

US4165428A Indoleacetic acid ester derivatives 失效
标题翻译：吲哚乙酸酯衍生物
公开(公告)号：US4165428A
公开(公告)日：1979-08-21
申请号：US804280
申请日：1977-06-07
申请人： Kanji Noda , Akira Nakagawa , Satoru Miyata , Yoichi Nakashima , Hiroyuki Ide
发明人： Kanji Noda , Akira Nakagawa , Satoru Miyata , Yoichi Nakashima , Hiroyuki Ide
IPC分类号： A61K31/403 , A61K31/404 , A61K31/405 , A61K31/44 , A61K31/4427 , A61P25/04 , A61P29/00 , C07D209/28 , C07D401/12 , C07D213/79
CPC分类号： C07D209/28
摘要： The present invention relates to the indoleacetic acid ester derivatives of the following general formula: ##STR1## WHEREIN N REPRESENTS AN INTEGER FROM ONE TO 3; R is selected from the group consisting of hydroxyl, halogen, trihalomethyl, alkoxy, acyloxy, substituted phenyl, pyridyl and substituted pyridyl. These compounds possess a high degree of pharmacological activities such as analgetic, anti-inflammatory and anti-pyretic activities as well as low side effects on the gastrointestinal tracts when given orally and topically, and therefore they may be useful as analgesics, anti-inflammatories and anti-pyretics for internal and external use.
摘要翻译：本发明涉及以下通式的吲哚乙酸酯衍生物：其中N代表从1到3的整数; R选自羟基，卤素，三卤甲基，烷氧基，酰氧基，取代的苯基，吡啶基和取代的吡啶基。这些化合物在口服和局部给药时具有高度的药理活性，例如止痛，抗炎和抗热解活性以及对胃肠道的副作用，因此它们可用作镇痛药，抗炎药和用于内部和外部使用的防火剂。

7. 发明授权

US4335251A Phenyl-i-propionic acid esters and pharmaceutical use thereof 失效
标题翻译：苯基-1-丙酸酯及其药物用途
公开(公告)号：US4335251A
公开(公告)日：1982-06-15
申请号：US175498
申请日：1980-08-05
申请人： Kanji Noda , Akira Nakagawa , Yuji Ishikura , Hiroyuki Ide
发明人： Kanji Noda , Akira Nakagawa , Yuji Ishikura , Hiroyuki Ide
IPC分类号： C07D213/30 , C07D213/61 , C07D295/088 , C07D307/12
CPC分类号： C07D213/30 , C07D213/61 , C07D295/088 , C07D307/12
摘要： The present invention relates to the phenyl-propionic acid ester derivative of the following formula: ##STR1## The compound obtained by the present invention possesses a high degree of analgetic, antipyretic and anti-inflammatory activity and causes little side effects on the gastro-intestinal tracts, when administered orally and topically, and it may be useful as an oral and topical analgesic, antipyretic and anti-inflammatory agent.
摘要翻译：本发明涉及下式的苯基 - 丙酸酯衍生物：本发明得到的化合物具有高度的止痛，解热和抗炎活性，对胃肠道几乎没有副作用当口服和局部给药时，它可用作口服和局部止痛剂，解热和抗炎剂。

8. 发明授权

US4400520A Novel process for preparing isoindoline derivatives 失效
标题翻译：异二氢吲哚衍生物的新方法
公开(公告)号：US4400520A
公开(公告)日：1983-08-23
申请号：US299432
申请日：1981-09-04
申请人： Kanji Noda , Akira Nakagawa , Toshiharu Motomura , Hiroyuki Ide
发明人： Kanji Noda , Akira Nakagawa , Toshiharu Motomura , Hiroyuki Ide
IPC分类号： C07D209/46
CPC分类号： C07D209/46
摘要： A process for the preparation of an isoindoline derivative of the following general formula (II): ##STR1## wherein R.sup.2 is a hydrogen atom or lower alkyl group and X is a carboxyl group, carboalkoxy group, amide group or cyano group, which comprisescycling a benzylidene derivative of the following general formula (I) ##STR2## wherein R.sup.1 is a hydrogen atom or lower alkyl group, and R.sup.2 and X are as defined above, in the presence of a reducing agent such as sodium boron hydride. In one embodiment, the benzylidene derivative may be substituted by a reaction mixture containing the same, the reaction mixture being prepared by reacting o-phthalaldehydic acid or its ester with an aniline derivative.
摘要翻译：制备下列通式（II）的异二氢吲哚衍生物的方法：其中R2是氢原子或低级烷基，X是羧基，烷氧羰基，酰胺基或氰基，其包括在还原剂例如钠的存在下，使下列通式（I）的亚苄基衍生物（其中R1是氢原子或低级烷基，R2和X如上所定义）硼氢化物。在一个实施方案中，亚苄基衍生物可以被含有该亚苄基衍生物的反应混合物取代，反应混合物通过邻邻邻苯二甲醛或其酯与苯胺衍生物反应来制备。

9. 发明授权

US3984415A 1-Nitrophenylpyrido [2,3-d] pyrimidine-2,4(1H,3H)-diones 失效
标题翻译： 1-硝基苯基吡啶{8,23-d {9 {0嘧啶-2,4（1H，3H） - 二酮
公开(公告)号：US3984415A
公开(公告)日：1976-10-05
申请号：US531096
申请日：1974-12-09
申请人： Kanji Noda , Akira Nakagawa , Toshiharu Motomura , Hiroyuki Ide
发明人： Kanji Noda , Akira Nakagawa , Toshiharu Motomura , Hiroyuki Ide
IPC分类号： C07D471/04 , A61K31/495 , A61K31/505 , A61P25/00 , A61P25/04 , A61P29/00 , C07D221/00 , C07D239/00 , C07D487/04
CPC分类号： Y10S514/87 , Y10S514/916
摘要： The compounds of the present invention can be represented by the following formula: ##SPC1##Wherein R is selected from the group consisting of hydrogen, lower alkyl, substituted lower alkyl, unsaturated lower alkyl, substituted unsaturated lower alkyl and aralkyl; X is selected from the group consisting of O and S.The compounds of the present invention possess a high degree of pharmacological activities such as anti-inflammatory, anti-ulcerative, analgetic, antipyretic, antihistaminic and central nervous system depressive activities, and certain of them are useful as new anti-inflammatory agents, analgesics and central nervous system depressants.
摘要翻译：本发明的化合物可以由下式表示：

10. 发明授权

US4393076A Anti-inflammatory and analgesic gel composition 失效
标题翻译：抗炎止痛凝胶组成
公开(公告)号：US4393076A
公开(公告)日：1983-07-12
申请号：US348887
申请日：1982-02-16
申请人： Kanji Noda , Akira Nakagawa , Tetsuya Yamagata , Hiroyuki Ide
发明人： Kanji Noda , Akira Nakagawa , Tetsuya Yamagata , Hiroyuki Ide
IPC分类号： A61K9/00 , A61K31/19 , A61K47/32
CPC分类号： A61K47/32 , A61K31/19 , A61K9/0014
摘要： An anti-inflammatory analgesic gel composition comprising (1) ketoprofen and/or flurbiprofen as the effective ingredient, as well as (2) a glycol, lower alcohol, water and/or a mixture of a lower alcohol with water, (3) a gel-forming agent and, if desired, (4) a solubilizing agent and/or non-ionic surface-active agent as the ingredients of a gel base for the gel composition.
摘要翻译：一种抗炎止痛凝胶组合物，其包含（1）酮洛芬和/或氟比洛芬作为有效成分，以及（2）二醇，低级醇，水和/或低级醇与水的混合物，（3）凝胶形成剂，如果需要，（4）增溶剂和/或非离子表面活性剂作为凝胶组合物的凝胶基质的成分。

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