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1. 发明授权

US5266484A Streptomyces spectabilis strains employed for producing streptovaricin C 失效
标题翻译：用于产生链脲霉素C的链霉菌属菌株
公开(公告)号：US5266484A
公开(公告)日：1993-11-30
申请号：US872518
申请日：1992-04-23
申请人： Kaname Inoue , Motohide Yamazaki , Kanji Murofushi , Richard W. Armentrout
发明人： Kaname Inoue , Motohide Yamazaki , Kanji Murofushi , Richard W. Armentrout
IPC分类号： C12P17/18 , C12R1/465 , C12P17/08
CPC分类号： C12R1/465 , C12P17/18 , Y10S435/803 , Y10S435/886
摘要： Disclosed is a method for selecting a mutant strain belonging to the genus Streptomyces which is a hyper-producer of Streptovaricin C superior to those know heretofore. This is accomplished by first subjecting a natural strain of Streptomyces spectabilis to conditions so as to isolate organisms which are streptovaricin resistant. The streptovaricin resistant organisms thus isolated are then subjected to mutagenesis and then cultured. The colonies which are asporogenous are individually cultured in fermentation batches such that the strains take the form of pellets of varying sizes and colors. From the batch having the most heterogeneous mixture of pellets, the smallest pellet or the pellet(s) having the deepest color (usually deep red or crimson) is isolated. We have discovered that the strain of this pellet has a high likelihood of being a hyperproducer of streptovaricin. The strain of this pellet may then be subjected to fermentation conditions to produce streptovaricin. The nutrient broth containing fumaric acid or water-soluble salts thereof, and adsorbent polymer beads and the streptovaricin produced are recovered in the usual manner. In another embodiment, the fermentation may be carried out in a nutrient broth wherein fumaric acid or its water-soluble salts are deliberately excluded to achieve even higher productivity.
摘要翻译：公开了一种选择属于链霉菌属（Streptomyces）属的突变菌株的方法，其是链节链球菌C的超级生产者，其比迄今所知道的更高。这是通过首先对天然链霉菌链霉菌进行条件来分离的，以分离链霉素抗性的生物体。然后将如此分离的链脲霉素抗性生物体进行诱变，然后进行培养。在发酵批次中单独培养异源菌落，使得菌株呈不同大小和颜色的颗粒的形式。从具有最不均匀的颗粒混合物的批料中，分离出具有最深颜色（通常深红色或深红色）的最小颗粒或颗粒。我们已经发现，这种颗粒的菌株很可能成为链球菌素的超生产菌。然后可以将该颗粒的菌株进行发酵条件以产生链脲霉素。以通常的方式回收含有富马酸或其水溶性盐的营养液，以及生成的吸附性聚合物珠粒和链球菌素。在另一个实施方案中，发酵可以在营养肉汤中进行，其中富马酸或其水溶性盐被有意排除以达到更高的生产率。

2. 发明授权

US5208153A Process for producing streptovaricin C 失效
标题翻译：生产STREPTOVARICIN C的方法
公开(公告)号：US5208153A
公开(公告)日：1993-05-04
申请号：US776989
申请日：1991-10-16
申请人： Kaname Inoue , Motohide Yamazaki , Kanji Murofushi , Richard W. Armentrout
发明人： Kaname Inoue , Motohide Yamazaki , Kanji Murofushi , Richard W. Armentrout
IPC分类号： C12N1/20 , C12P17/18 , C12R1/465
CPC分类号： C12R1/465 , C12P17/18 , Y10S435/886
摘要： Disclosed is a method for selecting a mutant strain belonging to the genus Streptomyces which is a hyper-producer of Streptovaricin C superior to those know heretofore. This is accomplished by first subjecting a natural strain of Streptomyces spectabilis to conditions so as to isolate organisms which are streptovaricin resistant. The streptovaricin resistant organisms thus isolated are then subjected to mutagenesis and then cultured. The colonies which are asporogenous are individually cultured in fermentation batches such that the strains take the form of pellets of varying sizes and colors. From the batch having the most heterogeneous mixture of pellets, the smallest pellet or the pellet(s) having the deepest color (usually deep red or crimson) is isolated. We have discovered that the strain of this pellet has a high likelihood of being a hyperproducer of streptovaricin. The strain of this pellet may then be subjected to fermentation conditions to produce streptovaricin. The nutrient broth containing fumaric acid or water-soluble salts thereof, and adsorbent polymer beads and the streptovaricin produced are recovered in the usual manner. In another embodiment, the fermentation may be carried out in a nutrient broth wherein fumaric acid or its water-soluble salts are deliberately excluded to achieve even higher productivity.

3. 发明授权

US5210033A Process for preparing and selecting hyperproducing microorganism strains used for the process for producing streptovaricin C 失效
标题翻译：制备和选择用于生产链脲霉素C的方法的超生产微生物菌株的方法
公开(公告)号：US5210033A
公开(公告)日：1993-05-11
申请号：US872519
申请日：1992-04-23
申请人： Kaname Inoue , Motohide Yamazaki , Kanji Murofushi , Richard W. Armentrout
发明人： Kaname Inoue , Motohide Yamazaki , Kanji Murofushi , Richard W. Armentrout
IPC分类号： C12P17/18
CPC分类号： C12R1/465 , C12P17/18 , Y10S435/803 , Y10S435/886
摘要： Disclosed is a method for selecting a mutant strain belonging to the genus Streptomyces which is a hyper-producer of Streptovaricin C superior to those know heretofore. This is accomplished by first subjecting a natural strain of Streptomyces spectabilis to conditions so as to isolate organisms which are streptovaricin resistant. The streptovaricin resistant organisms thus isolated are then subjected to mutagenesis and then cultured. The colonies which are asporogenous are individually cultured in fermentation batches such that the strains take the form of pellets of varying sizes and colors. From the batch having the most heterogeneous mixture of pellets, the smallest pellet or the pellet(s) having the deepest color (usually deep red or crimson) is isolated. We have discovered that the strain of this pellet has a high likelihood of being a hyperproducer of streptovaricin. The strain of this pellet may then be subjected to fermentation conditions to produce streptovaricin. The nutrient broth containing fumaric acid or water-soluble salts thereof, and adsorbent polymer beads and the streptovaricin produced are recovered in the usual manner. In another embodiment, the fermentation may be carried out in a nutrient broth wherein fumaric acid or its water-soluble salts are deliberately excluded to achieve even higher productivity.
摘要翻译：公开了一种选择属于链霉菌属（Streptomyces）属的突变菌株的方法，其是链节链球菌C的超级生产者，其比迄今所知道的更高。这是通过首先对天然链霉菌链霉菌进行条件来分离的，以分离链霉素抗性的生物体。然后将如此分离的链脲霉素抗性生物体进行诱变，然后进行培养。在发酵批次中单独培养异源菌落，使得菌株呈不同大小和颜色的颗粒的形式。从具有最不均匀的颗粒混合物的批料中，分离出具有最深颜色（通常深红色或深红色）的最小颗粒或颗粒。我们已经发现，这种颗粒的菌株很可能成为链球菌素的超生产菌。然后可以将该颗粒的菌株进行发酵条件以产生链脲霉素。以通常的方式回收含有富马酸或其水溶性盐的营养液，以及生成的吸附性聚合物珠粒和链球菌素。在另一个实施方案中，发酵可以在营养肉汤中进行，其中富马酸或其水溶性盐被有意排除以达到更高的生产率。

4. 发明授权

US5190866A Process for producing antibiotic streptovaricin 失效
标题翻译：生产抗生素链脲霉素的方法
公开(公告)号：US5190866A
公开(公告)日：1993-03-02
申请号：US826371
申请日：1992-01-27
申请人： Kaname Inoue , Motohide Yamazaki , Richard W. Armentrout
发明人： Kaname Inoue , Motohide Yamazaki , Richard W. Armentrout
IPC分类号： C12N1/02 , C12P1/00 , C12P17/18
CPC分类号： C12P17/18 , C12N1/02 , C12P1/00 , Y10S435/803 , Y10S435/886
摘要： A method for separation and recovery of polymeric beads from an antibiotic fermentation broth comprising suspending a mixture of the beads and any inherent mold from the fermentation in an aqueous solution having a specific gravity which is effective to cause the beads to form a discrete layer at or on the surface of the solution, separate and apart from the mold. The separate layer of the beads may then be easily removed from the liquid by a conventional physical methods.
摘要翻译：一种用于从抗生素发酵液中分离和回收聚合物珠的方法，其包括将珠粒和任何固有的霉菌的混合物从发酵中悬浮在具有比重的水溶液中，该水溶液有效地使珠粒在或在溶液的表面上，与模具分离并分开。然后可以通过常规的物理方法将珠的单独层容易地从液体中除去。

5. 发明授权

US5177018A Microorganism employed for producing streptovaricin 失效
标题翻译：用于生产链脲霉素的微生物
公开(公告)号：US5177018A
公开(公告)日：1993-01-05
申请号：US766412
申请日：1991-09-26
申请人： Kaname Inoue , Motohide Yamazaki , Richard W. Armentrout
发明人： Kaname Inoue , Motohide Yamazaki , Richard W. Armentrout
IPC分类号： C12P17/18
CPC分类号： C12R1/465 , C12P17/18 , Y10S435/886
摘要： A method for selecting hyper-producing strains of streptovaricin C by culturing streptomyces spectabilis and separating the asporogenous colonies. The asporogenous colonies are then separately cultured and tested for streptovaricin productivity. Those colonies having the highest productivity may then be easily selected.
摘要翻译：通过培养链霉菌（Streptomyces spectabilis）和分离异种菌落来选择链霉菌素C的高产菌株的方法。然后分开培养异种菌落并测试链脲霉素的生产力。可以容易地选择具有最高生产率的那些菌落。

6. 发明授权

US5114846A Process for producing streptovaricin 失效
标题翻译：生产STREPTOVARICIN的方法
公开(公告)号：US5114846A
公开(公告)日：1992-05-19
申请号：US601876
申请日：1990-10-23
申请人： Kaname Inoue , Motohide Yamazaki , Richard W. Armentrout
发明人： Kaname Inoue , Motohide Yamazaki , Richard W. Armentrout
IPC分类号： C12N1/20 , C12P17/18 , C12R1/465
CPC分类号： C12R1/465 , C12P17/18 , Y10S435/886
摘要： A method for selecting hyper-producing strains of streptovaricin C by culturing streptomyces spectabilis and separating the asporogenous colonies. The asporogenous colonies are then separately cultured and tested for streptovaricin productivity. Those colonies having the highest productivity may then be easily selected.

7. 发明授权

US5258291A Process for producing antibiotics 失效
标题翻译：生产抗生素的方法
公开(公告)号：US5258291A
公开(公告)日：1993-11-02
申请号：US17495
申请日：1993-02-12
申请人： Kaname Inoue , Motohide Yamazaki , Richard W. Armentrout
发明人： Kaname Inoue , Motohide Yamazaki , Richard W. Armentrout
IPC分类号： C12N1/02 , C12P1/00 , C12P17/18 , C12N1/36 , C12P17/08 , C12R1/465
CPC分类号： C12P1/00 , C12N1/02 , C12P17/18 , Y10S435/803 , Y10S435/886
摘要： A method for separation and recovery of polymeric beads from an antibiotic fermentation broth comprising suspending a mixture of the beads and any inherent mold from the fermentation in an aqueous solution having a specific gravity which is effective to cause the beads to form a discrete layer at or on the surface of the solution, separate and apart from the mold. The separate layer of the beads may then be easily removed from the liquid by a conventional physical methods.
摘要翻译：一种用于从抗生素发酵液中分离和回收聚合物珠的方法，其包括将珠粒和任何固有的霉菌的混合物从发酵中悬浮在具有比重的水溶液中，该水溶液有效地使珠粒在或在溶液的表面上，与模具分离并分开。然后可以通过常规的物理方法将珠的单独层容易地从液体中除去。

8. 发明授权

US5156961A Process for producing antibiotics 失效
标题翻译：生产抗生素的方法
公开(公告)号：US5156961A
公开(公告)日：1992-10-20
申请号：US601877
申请日：1990-10-23
申请人： Kaname Inoue , Motohide Yamazaki , Richard W. Armentrout
发明人： Kaname Inoue , Motohide Yamazaki , Richard W. Armentrout
IPC分类号： C12P17/16 , C12N1/02 , C12P1/00 , C12P17/18 , C12R1/465
CPC分类号： C12P1/00 , C12N1/02 , C12P17/18 , Y10S435/803
摘要： A method for separation and recovery of polymeric beads from an antibiotic fermentation broth comprising suspending a mixture of the beads and any inherent mold from the fermentation in an aqueous solution having a specific gravity which is effective to cause the beads to form a discrete layer at or on the surface of the solution, separate and apart from the mold. The separate layer of the beads may then be easily removed from the liquid by a conventional physical methods.

9. 发明授权

US5137825A Process for producing streptovaricin 失效
标题翻译：生产链脲霉素的方法
公开(公告)号：US5137825A
公开(公告)日：1992-08-11
申请号：US766411
申请日：1991-09-26
申请人： Kaname Inoue , Motohide Yamazaki , Richard W. Armentrout
发明人： Kaname Inoue , Motohide Yamazaki , Richard W. Armentrout
IPC分类号： C12P17/18
CPC分类号： C12R1/465 , C12P17/18 , Y10S435/886
摘要： A method for selecting hyper-producing strains of streptovaricin C by culturing Streptomyces spectabilis and separating the asporogenous colonies. The asporogenous colonies are then separately cultured and tested for streptovaricin productivity. Those colonies having the highest productivity may then be easily selected.
摘要翻译：通过培养链霉菌（Streptomyces spectabilis）并分离异种菌落来选择链霉菌素C的高产菌株的方法。然后分开培养异种菌落并测试链脲霉素的生产力。可以容易地选择具有最高生产率的那些菌落。

10. 发明授权

US06605461B2 Production of exopolysaccharides unattached to the surface of bacterial cells 失效
公开(公告)号：US06605461B2
公开(公告)日：2003-08-12
申请号：US09905829
申请日：2001-07-13
申请人： Motohide Yamazaki , Marcia Mikolajczak , Thomas J. Pollock , Richard W. Armentrout
发明人： Motohide Yamazaki , Marcia Mikolajczak , Thomas J. Pollock , Richard W. Armentrout
IPC分类号： C12N120
CPC分类号： C12R1/01 , C08B37/00 , C08B37/006 , C12P19/04
摘要： The present invention is directed to a Sphingomonas bacteria and a method of producing exopolysaccharides by culturing a Shingomonas bacteria in a fermentation broth for a time and temperature effective for providing a sphingan exopolysaccharide in a slime form.

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