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1. 发明授权

US07838258B2 Meter strip and method for lateral flow assay devices 有权
标题翻译：用于侧流测定装置的仪表条和方法
公开(公告)号：US07838258B2
公开(公告)日：2010-11-23
申请号：US12570713
申请日：2009-09-30
申请人： Kaiyuan Yang , Shawn R. Feaster , Ning Wei , Rosann M. Kaylor , Chibueze O. Chidebelu-Eze
发明人： Kaiyuan Yang , Shawn R. Feaster , Ning Wei , Rosann M. Kaylor , Chibueze O. Chidebelu-Eze
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/54366 , B01L3/5023 , B01L2200/027 , B01L2300/0681 , B01L2300/0825 , B01L2300/0867 , B01L2400/0406 , B01L2400/0683 , G01N33/558 , Y10S436/825 , Y10T436/107497 , Y10T436/108331
摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. The kit includes a housing, and a membrane disposed within the housing having a detection region and a collection region. A blood sample meter is provided having a first end for absorption of a blood sample, a filtering section adjacent to the first end that filters red blood cell components from the blood sample, and a storage section adjacent to the filtering section that receives plasma or serum from the filtering section. An opening in the housing is sized for insertion of the sample meter into the housing such that the storage section of the sample meter is disposed in fluid communication with the collection region of the membrane. The plasma or serum is transferred from the storage section of the sample meter to the collection region of the membrane for subsequent migration to the detection region.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。套件包括壳体和设置在壳体内的膜，其具有检测区域和收集区域。提供血样计，其具有用于吸收血液样本的第一端，与第一端相邻的过滤部分，其从血液样品中过滤红细胞成分，以及与过滤部相邻的存储部，其接收血浆或血清从过滤部分。壳体中的开口的尺寸适于将样品计量器插入壳体中，使得样品计量器的存储部分设置成与膜的收集区域流体连通。将血浆或血清从样品计量器的储存部分转移到膜的收集区域，以便随后迁移到检测区域。

2. 发明申请

US20100015658A1 Meter Strip and Method for Lateral Flow Assay Devices 有权
标题翻译：流量测定装置的流量计和方法
公开(公告)号：US20100015658A1
公开(公告)日：2010-01-21
申请号：US12570713
申请日：2009-09-30
申请人： Kaiyuan Yang , Shawn R. Feaster , Ning Wei , Rosann M. Kaylor , Chibueze O. Chidebelu-Eze
发明人： Kaiyuan Yang , Shawn R. Feaster , Ning Wei , Rosann M. Kaylor , Chibueze O. Chidebelu-Eze
IPC分类号： C12Q1/02
CPC分类号： G01N33/54366 , B01L3/5023 , B01L2200/027 , B01L2300/0681 , B01L2300/0825 , B01L2300/0867 , B01L2400/0406 , B01L2400/0683 , G01N33/558 , Y10S436/825 , Y10T436/107497 , Y10T436/108331
摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. The kit includes a housing, and a membrane disposed within the housing having a detection region and a collection region. A blood sample meter is provided having a first end for absorption of a blood sample, a filtering section adjacent to the first end that filters red blood cell components from the blood sample, and a storage section adjacent to the filtering section that receives plasma or serum from the filtering section. An opening in the housing is sized for insertion of the sample meter into the housing such that the storage section of the sample meter is disposed in fluid communication with the collection region of the membrane. The plasma or serum is transferred from the storage section of the sample meter to the collection region of the membrane for subsequent migration to the detection region.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。套件包括壳体和设置在壳体内的膜，其具有检测区域和收集区域。提供血样计，其具有用于吸收血液样本的第一端，与第一端相邻的过滤部分，其从血液样品中过滤红细胞成分，以及与过滤部相邻的存储部，其接收血浆或血清从过滤部分。壳体中的开口的尺寸适于将样品计量器插入壳体中，使得样品计量器的存储部分设置成与膜的收集区域流体连通。将血浆或血清从样品计量器的储存部分转移到膜的收集区域，以便随后迁移到检测区域。

3. 发明授权

US07618810B2 Metering strip and method for lateral flow assay devices 有权
标题翻译：测量条和侧流测定装置的方法
公开(公告)号：US07618810B2
公开(公告)日：2009-11-17
申请号：US11300650
申请日：2005-12-14
申请人： Kaiyuan Yang , Shawn R. Feaster , Ning Wei , Rosann M. Kaylor , Chibueze O. Chidebelu-Eze
发明人： Kaiyuan Yang , Shawn R. Feaster , Ning Wei , Rosann M. Kaylor , Chibueze O. Chidebelu-Eze
IPC分类号： G01N21/00 , G01N15/06 , G01N33/53 , G01N31/00 , G01N33/543 , B01L3/00 , B01L3/02 , B01L11/00 , C12Q1/00 , C12M1/36 , C12M1/34 , C12M3/00
CPC分类号： G01N33/54366 , B01L3/5023 , B01L2200/027 , B01L2300/0681 , B01L2300/0825 , B01L2300/0867 , B01L2400/0406 , B01L2400/0683 , G01N33/558 , Y10S436/825 , Y10T436/107497 , Y10T436/108331
摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. The kit includes a housing, and a membrane disposed within the housing having a detection region and a collection region. A blood sample meter is provided having a first end for absorption of a blood sample, a filtering section adjacent to the first end that filters red blood cell components from the blood sample, and a storage section adjacent to the filtering section that receives plasma or serum from the filtering section. An opening in the housing is sized for insertion of the sample meter into the housing such that the storage section of the sample meter is disposed in fluid communication with the collection region of the membrane. The plasma or serum is transferred from the storage section of the sample meter to the collection region of the membrane for subsequent migration to the detection region.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。套件包括壳体和设置在壳体内的膜，其具有检测区域和收集区域。提供血样计，其具有用于吸收血液样本的第一端，与第一端相邻的过滤部分，其从血液样品中过滤红细胞成分，以及与过滤部相邻的存储部，其接收血浆或血清从过滤部分。壳体中的开口的尺寸适于将样品计量器插入壳体中，使得样品计量器的存储部分设置成与膜的收集区域流体连通。将血浆或血清从样品计量器的储存部分转移到膜的收集区域，以便随后迁移到检测区域。

4. 发明授权

US08377379B2 Lateral flow assay device 有权
标题翻译：侧流测定装置
公开(公告)号：US08377379B2
公开(公告)日：2013-02-19
申请号：US11640435
申请日：2006-12-15
申请人： Shawn R. Feaster , Kaiyuan Yang , Ning Wei , Chibueze O. Chidebelu-Eze , James M. Takeuchi , Rosann M. Kaylor , Enrico L. DiGiammarino , Jeffrey E. Fish
发明人： Shawn R. Feaster , Kaiyuan Yang , Ning Wei , Chibueze O. Chidebelu-Eze , James M. Takeuchi , Rosann M. Kaylor , Enrico L. DiGiammarino , Jeffrey E. Fish
IPC分类号： G01N30/96
CPC分类号： B01L3/5023 , A61B5/150022 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150717 , A61B5/150824 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15186 , A61B5/1519 , A61B5/157 , B01L2200/0605 , B01L2200/16 , B01L2300/0672 , B01L2300/0867 , B01L2400/0683 , G01N33/491
摘要： A lateral flow assay device includes a housing, and a test strip disposed within the housing having a membrane with a detection region and a collection region. A sample meter includes a first end for absorption of a test sample, and a storage section that receives and stores at least a component of the test sample. An opening in the housing is sized for insertion of the sample meter into the housing such that the storage section of the sample meter is disposed adjacent the collection region of the membrane. The test sample component is transferable from the storage section to the collection region for subsequent migration to the detection region. An activatable isolation mechanism is provided within the housing and is disposed so as to isolate portions of the sample meter storage section upon activation thereof such that a defined length of the storage section is presented to the collection region of the membrane.
摘要翻译：侧流测定装置包括壳体和设置在壳体内的测试条，其具有带有检测区域和收集区域的膜。样品计量器包括用于吸收测试样品的第一端和接收并存储至少测试样品的组分的存储部分。壳体中的开口的尺寸用于将样品计量器插入到壳体中，使得样品计量器的存储部分邻近膜的收集区域设置。测试样本组件可从存储部分转移到收集区域，以便随后迁移到检测区域。在壳体内提供可激活的隔离机构，并且被设置成在启动时分离样品计量存储部分的部分，使得存储部分的限定长度被呈现给膜的收集区域。

5. 发明申请

US20080145272A1 Lateral flow assay device 有权
标题翻译：侧流测定装置
公开(公告)号：US20080145272A1
公开(公告)日：2008-06-19
申请号：US11640435
申请日：2006-12-15
申请人： Shawn R. Feaster , Kaiyuan Yang , Ning Wei , Chibueze O. Chidebelu-Eze , James M. Takeuchi , Rosann M. Kaylor , Enrico L. DiGiammarino , Jeffrey E. Fish
发明人： Shawn R. Feaster , Kaiyuan Yang , Ning Wei , Chibueze O. Chidebelu-Eze , James M. Takeuchi , Rosann M. Kaylor , Enrico L. DiGiammarino , Jeffrey E. Fish
IPC分类号： B01L11/00 , G01N33/00
CPC分类号： B01L3/5023 , A61B5/150022 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150717 , A61B5/150824 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15186 , A61B5/1519 , A61B5/157 , B01L2200/0605 , B01L2200/16 , B01L2300/0672 , B01L2300/0867 , B01L2400/0683 , G01N33/491
摘要： A lateral flow assay device includes a housing, and a test strip disposed within the housing having a membrane with a detection region and a collection region. A sample meter includes a first end for absorption of a test sample, and a storage section that receives and stores at least a component of the test sample. An opening in the housing is sized for insertion of the sample meter into the housing such that the storage section of the sample meter is disposed adjacent the collection region of the membrane. The test sample component is transferable from the storagesection to the collection region for subsequent migration to the detection region. An activatable isolation mechanism is provided within the housing and is disposed so as to isolate portions of the sample meter storage section upon activation thereof such that a defined length of the storage section is presented to the collection region of the membrane.
摘要翻译：侧流测定装置包括壳体和设置在壳体内的测试条，其具有带有检测区域和收集区域的膜。样品计量器包括用于吸收测试样品的第一端和接收并存储至少测试样品的组分的存储部分。壳体中的开口的尺寸用于将样品计量器插入到壳体中，使得样品计量器的存储部分邻近膜的收集区域设置。测试样品组分可以从储存区转移到收集区域，以便随后迁移到检测区域。在壳体内提供可激活的隔离机构，并且被设置成在启动时分离样品计量存储部分的部分，使得存储部分的限定长度被呈现给膜的收集区域。

6. 发明授权

US07775991B2 Device for sampling blood 有权
标题翻译：血液取样装置
公开(公告)号：US07775991B2
公开(公告)日：2010-08-17
申请号：US11217091
申请日：2005-08-31
申请人： Shawn R. Feaster , Rosann M. Kaylor , David S. Cohen , Udo Leuschner , Michael Strehl
发明人： Shawn R. Feaster , Rosann M. Kaylor , David S. Cohen , Udo Leuschner , Michael Strehl
IPC分类号： A61B5/00 , A61B17/14 , A61B17/32 , B65D81/00
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/150022 , A61B5/150358 , A61B5/150412 , A61B5/150519 , A61B5/150541 , A61B5/150618 , A61B5/150717 , A61B5/15111 , A61B5/15117 , A61B5/15142
摘要： A blood sampling device includes a lancet having a skin piercing member disposed at an end thereof. The lancet is slidable within and releasably engaged with an elongated lancet guide that remains stationary with use of the device. A shell is axially movable relative to the lancet guide between a rest position and an actuate position, with the lancet being spring loaded within the lancet guide by movement of the shell from the rest position to the actuate position.
摘要翻译：采血装置包括具有设置在其端部的皮肤穿刺构件的刺血针。刺血针可以在使用该装置保持静止的细长刺血针引导件内并可释放地接合。外壳可在静止位置和致动位置之间相对于柳叶刀导向器轴向移动，借助于壳体从静止位置移动到致动位置，柳叶刀通过弹簧加载在刺血针引导件内。

7. 发明授权

US06573040B2 Patterned binding of functionalized microspheres for optical diffraction-based biosensors 有权
$Patterned binding of functionalized microspheres for optical diffraction-based biosensors$
标题翻译：用于光学衍射的生物传感器的官能化微球的图案化结合
公开(公告)号：US06573040B2
公开(公告)日：2003-06-03
申请号：US09733204
申请日：2000-12-08
申请人： Dennis S. Everhart , Rosann M. Kaylor , Kevin McGrath
发明人： Dennis S. Everhart , Rosann M. Kaylor , Kevin McGrath
IPC分类号： G01N33567
CPC分类号： G01N33/54346 , B01J2219/00382 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , C40B60/14 , G01N21/4788 , G01N33/54373 , G01N33/553
摘要： The present invention provides an inexpensive and sensitive system and method for detecting analytes present in a medium. The system comprises a diffraction enhancing element, such as functionalized microspheres, which are modified such that they are capable of binding with a target analyte. Additionally, the system comprises a polymer film, which may include a metal coating, upon which is printed a specific, predetermined pattern of a analyte-specific receptors. Upon attachment of a target analyte to select areas of the polymer film, either directly or with the diffraction enhancing element, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.
摘要翻译：本发明提供了用于检测介质中存在的分析物的廉价且敏感的系统和方法。该系统包括衍射增强元件，例如功能化微球，其被修饰使得它们能够与靶分析物结合。此外，该系统包括聚合物膜，其可以包括金属涂层，在其上印刷特定的预定图案的分析物特异性受体。当将目标分析物直接或与衍射增强元件连接到聚合物膜的选择区域时，透射和/或反射光的衍射通过物理尺寸和限定的精确放置分析物而发生。产生可以用眼睛或可选地用感测装置容易地看到的衍射图像。

8. 发明授权

US07091049B2 Enhanced diffraction-based biosensor devices 有权
$Enhanced diffraction-based biosensor devices$
标题翻译：增强的基于衍射的生物传感器装置
公开(公告)号：US07091049B2
公开(公告)日：2006-08-15
申请号：US10180219
申请日：2002-06-26
申请人： Rameshbabu Boga , Chibueze Obinna Chidebelu-Eze , Rosann M. Kaylor , Xuedong Song
发明人： Rameshbabu Boga , Chibueze Obinna Chidebelu-Eze , Rosann M. Kaylor , Xuedong Song
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , C12Q1/6825 , Y10S435/808 , Y10S436/805 , Y10S436/815 , Y10S436/816 , Y10S436/817 , C12Q2563/107
摘要： An enhanced diffraction based biosensor system and method are provided for detecting an analyte of interest in a test medium. The system incorporates at least one additional detection tag substance with the analyte of interest, the tag emitting a measurable parameter that is different from optical diffraction characteristics of the analyte. The biosensor may be a “fluoroptical” system wherein the detection tag is a fluorescence emitting substance, including fluorescent-labeled diffraction enhancing elements. The enhanced diffraction biosensor system may determine the presence of analytes in biological fluids both qualitatively and quantitatively.
摘要翻译：提供了一种增强衍射的生物传感器系统和方法，用于检测测试介质中感兴趣的分析物。该系统将至少一种额外的检测标签物质与感兴趣的分析物结合，该标签发射不同于分析物的光学衍射特性的可测量参数。生物传感器可以是“荧光光谱”系统，其中检测标签是荧光发射物质，包括荧光标记的衍射增强元件。增强的衍射生物传感器系统可以定性和定量地确定生物流体中分析物的存在。

9. 发明授权

US5603830A Caffeine adsorbent liquid filter with integrated adsorbent 失效
标题翻译：咖啡因吸附剂液体过滤器与集成吸附剂
公开(公告)号：US5603830A
公开(公告)日：1997-02-18
申请号：US448801
申请日：1995-05-24
申请人： Dennis S. Everhart , Rosann M. Kaylor , Kenneth R. Smith
发明人： Dennis S. Everhart , Rosann M. Kaylor , Kenneth R. Smith
IPC分类号： A23F3/38 , A23F5/22 , B01J20/28 , B01D39/00
CPC分类号： B01J20/28028 , A23F3/385 , A23F5/223 , B01J20/28033
摘要： An adsorbent filter for removing caffeine from liquids. The filter is composed of a matrix of fibrous material; and adsorbent particulate material integrated within the matrix of fibrous material, so that passage of a liquid having a caffeine concentration ranging from about 20 to about 100 mg per 100 mL of liquid through the matrix for a contact time of less than about 2 minutes results in at least a 40 percent reduction in the caffeine concentration of the liquid. The matrix of fibrous material may be selected from woven fabrics, knit fabrics and nonwoven fabrics. The adsorbent material may be clay minerals such as, for example, smectite clay minerals. Examples of smectite clay minerals include, bentonite clays and montmorillonite clays. Generally speaking, the filter can be adapted to provide at least a 40 percent reduction in the caffeine concentration for about 1 cup to about 40 cups of a liquid.
摘要翻译：用于从液体中去除咖啡因的吸附剂过滤器。过滤器由纤维材料基体组成; 以及整合在纤维材料基质内的吸附剂颗粒材料，使得咖啡因浓度范围为每100mL液体约20至约100mg的液体通过基质，接触时间小于约2分钟，导致咖啡因浓度至少降低40％。纤维材料的基质可以选自机织织物，针织织物和非织造织物。吸附剂材料可以是粘土矿物，例如蒙脱石粘土矿物。蒙皂石粘土矿物的实例包括膨润土和蒙脱石粘土。一般来说，过滤器可以适合于提供约1杯至约40杯液体的咖啡因浓度的至少40％的降低。

10. 发明授权

US5538629A Process and article for disinfecting water 失效
标题翻译：消毒水的工艺和制品
公开(公告)号：US5538629A
公开(公告)日：1996-07-23
申请号：US368833
申请日：1994-12-15
申请人： Carol A. Blaney , Kristi L. Kiick-Fischer , Rosann M. Kaylor
发明人： Carol A. Blaney , Kristi L. Kiick-Fischer , Rosann M. Kaylor
IPC分类号： A61L2/18 , A61L2/28 , C02F1/28 , C02F1/50 , C02F1/62 , C02F1/68 , C02F1/76
CPC分类号： C02F1/766 , A61L2/18 , A61L2/28 , C02F1/281 , C02F1/283 , C02F1/50 , C02F1/68 , C02F2303/185 , Y10S210/911 , Y10S210/912 , Y10S210/914
摘要： Disclosed is a process for disinfecting water which provides a visual indication after the disinfection is complete. First, the water to be disinfected is generally simultaneously intermixed with at least three items. The items are: (1) a disinfectant which is adapted to render harmless substantially all pathogens present in the water upon the disinfectant being intermixed with the water for a time period T.sub.k ; (2) a colorant; and (3) a material which can remove substantially all of the disinfectant and colorant from the water over a time period t.sub.r, where T.sub.r is greater than T.sub.k. Secondly, the water, disinfectant, colorant and the removing material are allowed to remain intermixed for a time period of T.sub.r or greater. At the end of the time period T.sub.r, substantially all pathogens in the water will be rendered harmless, substantially all of the disinfectant will be removed from the water and substantially all of the colorant will be removed from the water. As a result of the removal of the colorant, the water will become uncolored which will give the consumer a visual indication after the disinfection process is complete and the water is safe to drink. Articles for use in carrying out the process are also disclosed.
摘要翻译：公开了一种消毒水的方法，其在消毒完成后提供视觉指示。首先，要消毒的水通常同时混合至少三个物品。这些项目是：（1）消毒剂，其适于使消毒剂中存在的基本上所有病原体与水混合一段时间Tk; （2）着色剂; 和（3）在Tr大于Tk的时间段tr内可以从水中大量除去基本上所有的消毒剂和着色剂的材料。其次，允许水，消毒剂，着色剂和去除材料保持混合Tr或更长时间。在时间段Tr结束时，水中的基本上所有的病原体将变得无害，基本上所有的消毒剂将从水中除去，并且基本上所有的着色剂将从水中除去。由于着色剂的去除，水将变得无色，这将在消毒过程完成并且水安全饮用后给消费者一个视觉指示。还披露了用于执行该过程的物品。

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