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1. 发明申请

WO2016163727A9 RADIOACTIVE PROBE FOR DETECTING HYDROGEN SULFIDE 审中-公开
标题翻译：放射性探头检测硫化氢
公开(公告)号：WO2016163727A9
公开(公告)日：2017-05-11
申请号：PCT/KR2016003559
申请日：2016-04-06
申请人： KYUNGPOOK NAT UNIV INDUSTRY-ACADEMIC COOP FOUND
发明人： YOO JEONG SOO , SWARBHANU SARKAR , NIKUNJ BHATTT , NISARG SONI , HA YEONG SU , LEE WOONG HEE
IPC分类号： A61K49/04 , A61B9/00 , A61K49/10
CPC分类号： A61B9/00 , A61K49/04 , A61K49/10
摘要： The present invention relates to a radioactive probe for detecting in vivo hydrogen sulfide and, more specifically, to a probe for detecting hydrogen sulfide comprising a complex compound into which a radioactive isotope Cu is introduced. According to the embodiments of the present invention, as a result of observing, in real-time, animal models in which a large amount of hydrogen sulfide involved in various diseases is generated, through optical and nuclear medicine imaging, the probe for detecting hydrogen sulfide according to the present invention can selectively provide images of a site in which hydrogen sulfide has abnormally increased in a cell or a tissue, by selectively combining to hydrogen sulfide, whereby the probe can detect a disease in an unexpected site without affecting the anatomical properties of body parts. In addition, the probe for detecting hydrogen sulfide quickly reacts with hydrogen sulfide, whereby the probe can resolve the existing problem of required wait time for testing after an imaging agent is injected. As such, the probe can be effectively used as a disease detection means such as an imaging composition, an imaging method, etc.
摘要翻译：用于检测体内硫化氢的放射性探针技术领域本发明涉及一种用于检测体内硫化氢的放射性探针，更具体地，涉及一种用于检测硫化氢的探针，其包含放入放射性同位素Cu的配合物。根据本发明的实施方式，通过光学和核医学成像，实时观察其中产生涉及各种疾病的大量硫化氢的动物模型，结果发现用于检测硫化氢的探针根据本发明，通过与硫化氢选择性结合，能够选择性地提供硫化氢在细胞或组织中异常增加的部位的图像，由此探针能够检测出现意外的部位的疾病，而不会影响细胞或组织的解剖学特性身体部位。另外，用于检测硫化氢的探测器迅速与硫化氢反应，由此探针可以解决在注入显像剂后测试所需的等待时间的问题。如此，探针可以有效地用作诸如成像组合物，成像方法等的疾病检测手段。

2. 发明申请

WO2016163727A3 RADIOACTIVE PROBE FOR DETECTING HYDROGEN SULFIDE 审中-公开
标题翻译：用于检测氢硫化物的放射性探针
公开(公告)号：WO2016163727A3
公开(公告)日：2017-03-23
申请号：PCT/KR2016003559
申请日：2016-04-06
申请人： KYUNGPOOK NAT UNIV INDUSTRY-ACADEMIC COOP FOUND
发明人： YOO JEONG SOO , SWARBHANU SARKAR , NIKUNJ BHATTT , NISARG SONI , HA YEONG SU , LEE WOONG HEE
IPC分类号： A61K49/04 , A61B9/00 , A61K49/10
CPC分类号： A61B9/00 , A61K49/04 , A61K49/10
摘要： The present invention relates to a radioactive probe for detecting in vivo hydrogen sulfide and, more specifically, to a probe for detecting hydrogen sulfide comprising a complex compound into which a radioactive isotope Cu is introduced. According to the embodiments of the present invention, as a result of observing, in real-time, animal models in which a large amount of hydrogen sulfide involved in various diseases is generated, through optical and nuclear medicine imaging, the probe for detecting hydrogen sulfide according to the present invention can selectively provide images of a site in which hydrogen sulfide has abnormally increased in a cell or a tissue, by selectively combining to hydrogen sulfide, whereby the probe can detect a disease in an unexpected site without affecting the anatomical properties of body parts. In addition, the probe for detecting hydrogen sulfide quickly reacts with hydrogen sulfide, whereby the probe can resolve the existing problem of required wait time for testing after an imaging agent is injected. As such, the probe can be effectively used as a disease detection means such as an imaging composition, an imaging method, etc.
摘要翻译：本发明涉及用于检测体内硫化氢的放射性探针，更具体地，涉及用于检测硫化氢的探针，其包括引入放射性同位素Cu的络合物。根据本发明的实施方案，通过光学和核医学成像实时观察其中产生涉及各种疾病的大量硫化氢的动物模型的结果，用于检测硫化氢的探针根据本发明，可以选择性地提供硫化氢在细胞或组织中异常增加的部位的图像，通过选择性地组合到硫化氢中，由此探针可以在不期望的位置检测疾病而不影响解剖学特性身体部位。此外，用于检测硫化氢的探针与硫化氢快速反应，由此在注入成像剂之后，探针可以解决所需的等待时间的问题。因此，探针可以有效地用作疾病检测手段，例如成像组合物，成像方法等。

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