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    • 3. 发明申请
    • RADIOACTIVE PROBE FOR DETECTING HYDROGEN SULFIDE
    • 放射性探头检测硫化氢
    • WO2016163727A9
    • 2017-05-11
    • PCT/KR2016003559
    • 2016-04-06
    • KYUNGPOOK NAT UNIV INDUSTRY-ACADEMIC COOP FOUND
    • YOO JEONG SOOSWARBHANU SARKARNIKUNJ BHATTTNISARG SONIHA YEONG SULEE WOONG HEE
    • A61K49/04A61B9/00A61K49/10
    • A61B9/00A61K49/04A61K49/10
    • The present invention relates to a radioactive probe for detecting in vivo hydrogen sulfide and, more specifically, to a probe for detecting hydrogen sulfide comprising a complex compound into which a radioactive isotope Cu is introduced. According to the embodiments of the present invention, as a result of observing, in real-time, animal models in which a large amount of hydrogen sulfide involved in various diseases is generated, through optical and nuclear medicine imaging, the probe for detecting hydrogen sulfide according to the present invention can selectively provide images of a site in which hydrogen sulfide has abnormally increased in a cell or a tissue, by selectively combining to hydrogen sulfide, whereby the probe can detect a disease in an unexpected site without affecting the anatomical properties of body parts. In addition, the probe for detecting hydrogen sulfide quickly reacts with hydrogen sulfide, whereby the probe can resolve the existing problem of required wait time for testing after an imaging agent is injected. As such, the probe can be effectively used as a disease detection means such as an imaging composition, an imaging method, etc.
    • 用于检测体内硫化氢的放射性探针技术领域本发明涉及一种用于检测体内硫化氢的放射性探针,更具体地,涉及一种用于检测硫化氢的探针,其包含放入放射性同位素Cu的配合物。 根据本发明的实施方式,通过光学和核医学成像,实时观察其中产生涉及各种疾病的大量硫化氢的动物模型,结果发现用于检测硫化氢的探针 根据本发明,通过与硫化氢选择性结合,能够选择性地提供硫化氢在细胞或组织中异常增加的部位的图像,由此探针能够检测出现意外的部位的疾病,而不会影响细胞或组织的解剖学特性 身体部位。 另外,用于检测硫化氢的探测器迅速与硫化氢反应,由此探针可以解决在注入显像剂后测试所需的等待时间的问题。 如此,探针可以有效地用作诸如成像组合物,成像方法等的疾病检测手段。
    • 4. 发明申请
    • RADIOACTIVE PROBE FOR DETECTING HYDROGEN SULFIDE
    • 用于检测氢硫化物的放射性探针
    • WO2016163727A3
    • 2017-03-23
    • PCT/KR2016003559
    • 2016-04-06
    • KYUNGPOOK NAT UNIV INDUSTRY-ACADEMIC COOP FOUND
    • YOO JEONG SOOSWARBHANU SARKARNIKUNJ BHATTTNISARG SONIHA YEONG SULEE WOONG HEE
    • A61K49/04A61B9/00A61K49/10
    • A61B9/00A61K49/04A61K49/10
    • The present invention relates to a radioactive probe for detecting in vivo hydrogen sulfide and, more specifically, to a probe for detecting hydrogen sulfide comprising a complex compound into which a radioactive isotope Cu is introduced. According to the embodiments of the present invention, as a result of observing, in real-time, animal models in which a large amount of hydrogen sulfide involved in various diseases is generated, through optical and nuclear medicine imaging, the probe for detecting hydrogen sulfide according to the present invention can selectively provide images of a site in which hydrogen sulfide has abnormally increased in a cell or a tissue, by selectively combining to hydrogen sulfide, whereby the probe can detect a disease in an unexpected site without affecting the anatomical properties of body parts. In addition, the probe for detecting hydrogen sulfide quickly reacts with hydrogen sulfide, whereby the probe can resolve the existing problem of required wait time for testing after an imaging agent is injected. As such, the probe can be effectively used as a disease detection means such as an imaging composition, an imaging method, etc.
    • 本发明涉及用于检测体内硫化氢的放射性探针,更具体地,涉及用于检测硫化氢的探针,其包括引入放射性同位素Cu的络合物。 根据本发明的实施方案,通过光学和核医学成像实时观察其中产生涉及各种疾病的大量硫化氢的动物模型的结果,用于检测硫化氢的探针 根据本发明,可以选择性地提供硫化氢在细胞或组织中异常增加的部位的图像,通过选择性地组合到硫化氢中,由此探针可以在不期望的位置检测疾病而不影响解剖学特性 身体部位。 此外,用于检测硫化氢的探针与硫化氢快速反应,由此在注入成像剂之后,探针可以解决所需的等待时间的问题。 因此,探针可以有效地用作疾病检测手段,例如成像组合物,成像方法等。
    • 9. 发明公开
    • OPTICAL ELEMENT HAVING POLARIZATION DEPENDENCE ON INCIDENT LIGHT, FOR VARYING FOCUSED LIGHT PATTERN
    • 优质元素麻省理工学院梵蒂冈薰衣草维生素维生素EINES FOKUSSIERTEN LICHTMUSTERS
    • EP3006987A4
    • 2017-01-25
    • EP13885904
    • 2013-10-18
    • KYUNGPOOK NAT UNIV INDUSTRY-ACADEMIC COOP FOUND
    • KIM HAK-RIN
    • G02B26/00G02B3/00G02B5/00G02B5/30G02B27/28
    • G02B5/3016G02B3/005G02B3/0068G02B27/285
    • Provided is an optical device with variable focused beam pattern depending on polarization of an incident beam. The optical device with variable focused beam pattern includes a first lens structure which is configured by arranging first lenticular lenses which are formed with liquid crystals or liquid crystal polymers having a first extraordinary refractive index axis direction and of which longitudinal axes are aligned with a first alignment direction, and a second lens structure which is laminated on a beam emitting surface of the first lens structure and configured by arranging second lenticular lenses which are formed with liquid crystals or liquid crystal polymers having a second extraordinary refractive index axis direction and of which longitudinal axes are aligned with a second alignment direction, wherein a beam pattern of output light output from the second lens structure is determined according to a polarization direction of the incident beam incident on the first lens structure, the first and second extraordinary refractive index axis directions of the first and second lens structures, and the first and second alignment directions of the first and second lens structures.
    • 提供了根据入射光束的偏振的具有可变聚焦光束图案的光学装置。 具有可变聚焦束图案的光学装置包括第一透镜结构,其通过布置形成有液晶的第一双凸透镜或具有第一非常折射率轴方向的液晶聚合物构成,并且其纵轴与第一对准 方向和第二透镜结构,其被层压在第一透镜结构的光束发射表面上并且通过布置形成有液晶的第二双凸透镜或具有第二非常折射率轴方向的液晶聚合物构成,并且纵向轴线 与第二对准方向对准,其中根据入射在第一透镜结构上的入射光束的偏振方向确定从第二透镜结构输出的输出光的光束图案,第一和第二非常折射率轴方向 第一和第二透镜结构 s以及第一和第二透镜结构的第一和第二对准方向。