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1. 发明申请

WO02078633A8 AGENT FOR THE TREATMENT OF BLADDER IRRITATIVE SYMPTOMS ACCOMPANIED BY BENIGN PROSTATIC HYPERPLASIA 审中-公开
标题翻译：用于治疗伴有良性前列腺增生症的膀胱刺激症状的药剂
公开(公告)号：WO02078633A8
公开(公告)日：2002-12-05
申请号：PCT/US0209575
申请日：2002-03-29
申请人： KYOWA HAKKO KOGYO KK , UNIV PITTSBURGH , YAMAGATA TSUYOSHI , ATSUKI KAORO , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , YOSHIMURA NAOKI , SCULPTOREANU ADRIAN , KARASAWA AKIRA
发明人： YAMAGATA TSUYOSHI , ATSUKI KAORO , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , YOSHIMURA NAOKI , SCULPTOREANU ADRIAN , KARASAWA AKIRA
IPC分类号： C07D495/04 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/55 , A61K45/00 , A61P13/08 , A61K
CPC分类号： A61K31/55 , A61K31/38 , A61K31/44
摘要： The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising measuring a slowly-inactivating A-type K channel opening activity as an index.
摘要翻译：本发明提供用于治疗伴有良性前列腺增生的膀胱刺激症状的药剂，其包含作为活性成分的具有缓慢失活的A型K +通道开放活性的化合物或其药学上可接受的盐，以及用于治疗伴有良性前列腺增生的膀胱刺激症状的药剂的方法，包括测量缓慢失活的A型K +通道开放活性作为指标。

2. 发明申请

WO02078633A3 AGENT FOR THE TREATMENT OF BLADDER IRRITATIVE SYMPTOMS ACCOMPANIED BY BENIGN PROSTATIC HYPERPLASIA 审中-公开
标题翻译：用于治疗由BENIGN PROSTATIC HYPERPLASIA辅助的刀片激动症状的代理
公开(公告)号：WO02078633A3
公开(公告)日：2003-07-24
申请号：PCT/US0209575
申请日：2002-03-29
申请人： KYOWA HAKKO KOGYO KK , UNIV PITTSBURGH , YAMAGATA TSUYOSHI , ATSUKI KAORO , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , YOSHIMURA NAOKI , SCULPTOREANU ADRIAN , KARASAWA AKIRA
发明人： YAMAGATA TSUYOSHI , ATSUKI KAORO , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , YOSHIMURA NAOKI , SCULPTOREANU ADRIAN , KARASAWA AKIRA
IPC分类号： C07D495/04 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/55 , A61K45/00 , A61P13/08
CPC分类号： A61K31/55 , A61K31/38 , A61K31/44
摘要： The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising measuring a slowly-inactivating A-type K channel opening activity as an index.
摘要翻译：本发明提供一种用于治疗伴有良性前列腺增生的膀胱刺激症状的药剂，其包含作为活性成分的具有缓慢失活的A型K +通道开放活性的化合物或其药学上可接受的盐，以及用于治疗伴有良性前列腺增生的膀胱刺激症状的药物的筛选方法，包括测量缓慢失活的A型K +通道开放活性作为指标。

3. 发明申请

WO02078523A3 AGENT FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
标题翻译：用于治疗过敏性叶片的药剂
公开(公告)号：WO02078523A3
公开(公告)日：2003-07-24
申请号：PCT/US0209577
申请日：2002-03-29
申请人： KYOWA HAKKO KOGYO KK , UNIV PITTSBURGH , YAMAGATA TSUYOSHI , ATSUKI KAORU , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , SCULPOREANU ADRIAN , KARASAWA AKIRA , YOSHIMURA NAOKI
发明人： YAMAGATA TSUYOSHI , ATSUKI KAORU , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , SCULPOREANU ADRIAN , KARASAWA AKIRA , YOSHIMURA NAOKI
IPC分类号： A61K45/00 , A61K31/381 , A61P13/10 , C07D495/04 , A61K31/38
CPC分类号： C07D495/04
摘要： The present invention provides an agent for the treatment of overactive bladder, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of overactive bladder, comprising measuring a slowly-inactivating A-type K channel opening activity as an index.
摘要翻译：本发明提供了治疗膀胱活动过度的药剂，其包含作为活性成分的具有缓慢失活的A型K +通道开放活性的化合物或其药学上可接受的盐，以及筛选剂的方法用于治疗膀胱过度活动，包括测量缓慢失活的A型K +通道开放活性作为指标。

4. 发明公开

EP1372630A4 AGENT FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
标题翻译：手段治疗气泡亢进
公开(公告)号：EP1372630A4
公开(公告)日：2005-03-23
申请号：EP02728597
申请日：2002-03-29
申请人： KYOWA HAKKO KOGYO KK , UNIV PITTSBURGH
发明人： YAMAGATA TSUYOSHI , ATSUKI KAORU , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , SCULPOREANU ADRIAN , KARASAWA AKIRA , YOSHIMURA NAOKI
IPC分类号： A61K45/00 , A61K31/381 , A61P13/10 , C07D495/04 , A61K31/18
CPC分类号： C07D495/04

5. 发明公开

EP1372639A4 AGENT FOR THE TREATMENT OF BLADDER IRRITATIVE SYMPTOMS ACCOMPANIED BY BENIGN PROSTATIC HYPERPLASIA 审中-公开
标题翻译：手段魅力随着气泡症状随附良性前列腺增生症治疗
公开(公告)号：EP1372639A4
公开(公告)日：2006-03-15
申请号：EP02757832
申请日：2002-03-29
申请人： KYOWA HAKKO KOGYO KK , UNIV PITTSBURGH
发明人： YAMAGATA TSUYOSHI , ATSUKI KAORU , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , YOSHIMURA NAOKI , SCULPTOREANU ADRIAN , KARASAWA AKIRA
IPC分类号： A61K31/38 , C07D495/04 , A61K31/381 , A61K31/44 , A61K31/55 , A61K45/00 , A61P13/00 , A61P13/08
CPC分类号： A61K31/55 , A61K31/38 , A61K31/44

6. 发明专利

CA2442452A1 AGENT FOR THE TREATMENT OF BLADDER IRRITATIVE SYMPTOMS ACCOMPANIED BY BENIGN PROSTATIC HYPERPLASIA 未知
公开(公告)号：CA2442452A1
公开(公告)日：2002-10-10
申请号：CA2442452
申请日：2002-03-29
申请人： KYOWA HAKKO KOGYO KK , UNIV PITTSBURGH
发明人： SCULPTOREANU ADRIAN , YOSHIMURA NAOKI , OHNO TETSUJI , SHIRAKURA SHIRO , KARASAWA AKIRA , DEGROAT WILLIAM C , ATSUKI KAORO , YAMAGATA TSUYOSHI
IPC分类号： C07D495/04 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/55 , A61K45/00 , A61P13/08 , A61P13/10 , C12Q1/00 , C12Q1/02
摘要： The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K+ channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising measuring a slowly- inactivating A-type K+ channel opening activity as an index.

7. 发明专利

CA2442437A1 AGENT FOR THE TREATMENT OF OVERACTIVE BLADDER 未知
公开(公告)号：CA2442437A1
公开(公告)日：2002-10-10
申请号：CA2442437
申请日：2002-03-29
申请人： KYOWA HAKKO KOGYO KK , UNIV PITTSBURGH
发明人： SCULPOREANU ADRIAN , DEGROAT WILLIAM C , YOSHIMURA NAOKI , KARASAWA AKIRA , SHIRAKURA SHIRO , ATSUKI KAORU , OHNO TETSUJI , YAMAGATA TSUYOSHI
IPC分类号： A61K45/00 , A61K31/381 , A61P13/10 , C07D495/04 , A61K31/38 , C12Q1/00 , C12Q1/02
摘要： The present invention provides an agent for the treatment of overactive bladder, comprising, as an active ingredient, a compound having a slowly- inactivating A-type K+ channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of overactive bladder, comprising measuring a slowly-inactivating A-type K+ channel opening activity as an index.

8. 发明公开

EP0798288A4 TRICICLIC COMPOUNDS 失效
标题翻译： TRICYCLISCHE VERBINDUNGEN
公开(公告)号：EP0798288A4
公开(公告)日：1999-06-16
申请号：EP96935342
申请日：1996-10-16
申请人： KYOWA HAKKO KOGYO KK
发明人： YOSHIDA MAKOTO , SASAKI SHIN-ICHI , AONO SHIGERU , FUJIWARA SHIGEKI , TAKAI HARUKI , YAMAGATA TSUYOSHI , NAGASAHIMA KEN , KARASAWA AKIRA
IPC分类号： C07C235/16 , C07D221/16 , C07D307/93 , C07D313/12 , C07D333/80 , C07D337/12 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , A61K31/35 , A61K31/38 , A61K31/435 , C07D221/06 , C07D333/78
CPC分类号： C07D491/04 , C07C235/16 , C07C2603/16 , C07C2603/18 , C07C2603/32 , C07D221/16 , C07D307/93 , C07D313/12 , C07D333/80 , C07D337/12 , C07D493/04 , C07D495/04
摘要： Triciclic compounds represented by general formula (I) which are useful as a remedy for urinary incontinence, wherein R1 represents hydrogen, etc.; and -X1-X2-X3- represents -CR?2=CR3-CR4=CR5¿- (wherein R?2, R3, R4 and R5¿ represent each hydrogen, etc.); and Y represents -CH¿2?O- etc.
摘要翻译：本发明涉及可用作尿失禁治疗剂的通式（I）表示的三环化合物：其中R 1表示氢等; -X 1 -X 2 -X 3 - 表示-CR 2 = CR 3 -CR 4 = CR 5 - （其中R 2，R 3， R 4和R 5代表氢等）等; Y表示-CH 2 O-等。

9. 发明公开

EP0979821A4 TRICYCLIC COMPOUNDS 失效
标题翻译： TRIZYKLISCHE VERBINDUNGEN
公开(公告)号：EP0979821A4
公开(公告)日：2002-04-24
申请号：EP98914022
申请日：1998-04-15
申请人： KYOWA HAKKO KOGYO KK
发明人： YOSHIDA MAKOTO , SEISHI TAKASHI , AONO SHIGERU , TAKAI HARUKI , SUZUKI KOJI , YAMAGATA TSUYOSHI , ATSUKI KAORU , KARASAWA AKIRA , KUMAZAWA TOSHIAKI
IPC分类号： C07D313/12 , C07D337/12 , C07D495/04 , A61K31/335 , A61K31/38 , A61K31/435 , C07D333/06 , C07D333/12
CPC分类号： C07D495/04 , C07D313/12 , C07D337/12
摘要： Tricyclic compounds of general formula (I) and pharmacologically acceptable salts thereof, which are useful for the treatment of pollakiuria and enuresis, wherein R1 is hydrogen, substituted or unsubstituted lower alkyl or the like; X?1-X2-X3 is CR5= CR6-CR7=CR8¿ (wherein R?5, R6, R7 and R8¿ are each independently hydrogen, substituted or unsubstituted lower alkyl, hydroxyl, substituted or unsubstituted lower alkoxy or the like), N(O)¿m?=CR?5-CR6-CR7¿ (wherein R?5, R6 and R7¿ are each the same as defined above; and m is 0 to 1), S-CR7=CR8 (wherein R?7 and R8¿ are each the same as defined above) or the like; R2 is hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, a substituted or unsubstituted N-substituted heterocyclic group or a group of general formula (a); (wherein n is 0 or 1; R?3 and R4¿ are each independently hydrogen, substituted or unsubstituted lower alkyl, trifluoromethyl or the like, or alternatively R?3 and R4¿ may be united to form cyclic alkyl; and Q is hydroxyl, halogeno or the like); and Y is -CH¿2?SO2-, -SCH2-, -SOCH2-, -SO2CH2- or the like.
摘要翻译：通式（I）的三环化合物及其药理学上可接受的盐，其可用于治疗尿频和遗尿，其中R 1为氢，取代或未取代的低级烷基等; X 1 -X 2 -X 3是CR 5 = CR 6 -CR 7 = CR 8（其中R 5，R 6，R 7和R 8各自独立地为氢，取代或未取代的低级烷基，羟基，取代或未取代的低级烷氧基等）（式中，R 5，R 6和R 7各自与上述定义相同，m为0〜1），S-CR 7 = CR 8（式中， R 7和R 8各自与上述定义相同）等; R2是氢，取代或未取代的低级烷基，取代或未取代的低级烷氧基，取代或未取代的N-取代杂环基或通式（a）的基团; （其中n是0或1; R 3和R 4各自独立地是氢，取代或未取代的低级烷基，三氟甲基等，或者R 3和R 4可以结合形成环状烷基; Q是羟基，卤代或诸如此类）; Y是-CH 2 SO 2 - ， - SCH 2 - ， - SOCH 2 - ，-SO 2 CH 2 - 等。

10. 发明专利

CA2286723C TRICYCLIC COMPOUNDS 未知
公开(公告)号：CA2286723C
公开(公告)日：2007-01-30
申请号：CA2286723
申请日：1998-04-15
申请人： KYOWA HAKKO KOGYO KK
发明人： SUZUKI KOJI , SEISHI TAKASHI , TAKAI HARUKI , AONO SHIGERU , ATSUKI KAORU , YOSHIDA MAKOTO , YAMAGATA TSUYOSHI , KUMAZAWA TOSHIAKI , KARASAWA AKIRA
IPC分类号： C07D495/04 , A61K31/335 , A61K31/38 , A61K31/435 , C07D313/12 , C07D333/06 , C07D333/12 , C07D337/12
摘要： The present invention provides tricyclic compounds which are useful for the treatment of pollakiuria and urinary incontinence and which are represented by general formula (I) (wherein R1 represents hydrogen, substituted or unsubstituted lower alkyl, etc. ; X1-X2-X3 represents CR5=CR6-CR7=CR8 (wherein R5, R6, R7 and R8, which may be the same or different, each represents hydrogen, substituted or unsubstituted lower alkyl, hydroxy, substituted or unsubstituted lower alkoxy, etc.), N(O) m=CR5-CR6=CR7 (wherein R5, R6 and R7 have the same significances as defined above, and m represents 0 or 1), S-CR7=CR8 (wherein R7 and R8 have the same significances as defined above), etc.; and when R2 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, a substituted or unsubstituted N-substituted heterocyclic group, (wherein n is 0 or 1; R3 and R4, which may be the same or different, each represents hydrogen, substituted or unsubstituted lower alkyl, trifluoromethyl, etc., or R3 and R4 may be combined together to form cyclic alkyl; and Q represents hydroxy, halogen, etc.), etc., Y represents -CH2SO2-, -SCH2-, -SOCH2-, -SO2CH2-, etc.) and pharmaceutically acceptable salts thereof.

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