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1. 发明申请

WO02078523A3 AGENT FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
标题翻译：用于治疗过敏性叶片的药剂
公开(公告)号：WO02078523A3
公开(公告)日：2003-07-24
申请号：PCT/US0209577
申请日：2002-03-29
申请人： KYOWA HAKKO KOGYO KK , UNIV PITTSBURGH , YAMAGATA TSUYOSHI , ATSUKI KAORU , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , SCULPOREANU ADRIAN , KARASAWA AKIRA , YOSHIMURA NAOKI
发明人： YAMAGATA TSUYOSHI , ATSUKI KAORU , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , SCULPOREANU ADRIAN , KARASAWA AKIRA , YOSHIMURA NAOKI
IPC分类号： A61K45/00 , A61K31/381 , A61P13/10 , C07D495/04 , A61K31/38
CPC分类号： C07D495/04
摘要： The present invention provides an agent for the treatment of overactive bladder, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of overactive bladder, comprising measuring a slowly-inactivating A-type K channel opening activity as an index.
摘要翻译：本发明提供了治疗膀胱活动过度的药剂，其包含作为活性成分的具有缓慢失活的A型K +通道开放活性的化合物或其药学上可接受的盐，以及筛选剂的方法用于治疗膀胱过度活动，包括测量缓慢失活的A型K +通道开放活性作为指标。

2. 发明申请

WO02078633A3 AGENT FOR THE TREATMENT OF BLADDER IRRITATIVE SYMPTOMS ACCOMPANIED BY BENIGN PROSTATIC HYPERPLASIA 审中-公开
标题翻译：用于治疗由BENIGN PROSTATIC HYPERPLASIA辅助的刀片激动症状的代理
公开(公告)号：WO02078633A3
公开(公告)日：2003-07-24
申请号：PCT/US0209575
申请日：2002-03-29
申请人： KYOWA HAKKO KOGYO KK , UNIV PITTSBURGH , YAMAGATA TSUYOSHI , ATSUKI KAORO , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , YOSHIMURA NAOKI , SCULPTOREANU ADRIAN , KARASAWA AKIRA
发明人： YAMAGATA TSUYOSHI , ATSUKI KAORO , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , YOSHIMURA NAOKI , SCULPTOREANU ADRIAN , KARASAWA AKIRA
IPC分类号： C07D495/04 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/55 , A61K45/00 , A61P13/08
CPC分类号： A61K31/55 , A61K31/38 , A61K31/44
摘要： The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising measuring a slowly-inactivating A-type K channel opening activity as an index.
摘要翻译：本发明提供一种用于治疗伴有良性前列腺增生的膀胱刺激症状的药剂，其包含作为活性成分的具有缓慢失活的A型K +通道开放活性的化合物或其药学上可接受的盐，以及用于治疗伴有良性前列腺增生的膀胱刺激症状的药物的筛选方法，包括测量缓慢失活的A型K +通道开放活性作为指标。

3. 发明申请

WO02078633A8 AGENT FOR THE TREATMENT OF BLADDER IRRITATIVE SYMPTOMS ACCOMPANIED BY BENIGN PROSTATIC HYPERPLASIA 审中-公开
标题翻译：用于治疗伴有良性前列腺增生症的膀胱刺激症状的药剂
公开(公告)号：WO02078633A8
公开(公告)日：2002-12-05
申请号：PCT/US0209575
申请日：2002-03-29
申请人： KYOWA HAKKO KOGYO KK , UNIV PITTSBURGH , YAMAGATA TSUYOSHI , ATSUKI KAORO , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , YOSHIMURA NAOKI , SCULPTOREANU ADRIAN , KARASAWA AKIRA
发明人： YAMAGATA TSUYOSHI , ATSUKI KAORO , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , YOSHIMURA NAOKI , SCULPTOREANU ADRIAN , KARASAWA AKIRA
IPC分类号： C07D495/04 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/55 , A61K45/00 , A61P13/08 , A61K
CPC分类号： A61K31/55 , A61K31/38 , A61K31/44
摘要： The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising measuring a slowly-inactivating A-type K channel opening activity as an index.
摘要翻译：本发明提供用于治疗伴有良性前列腺增生的膀胱刺激症状的药剂，其包含作为活性成分的具有缓慢失活的A型K +通道开放活性的化合物或其药学上可接受的盐，以及用于治疗伴有良性前列腺增生的膀胱刺激症状的药剂的方法，包括测量缓慢失活的A型K +通道开放活性作为指标。

4. 发明公开

EP1372630A4 AGENT FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
标题翻译：手段治疗气泡亢进
公开(公告)号：EP1372630A4
公开(公告)日：2005-03-23
申请号：EP02728597
申请日：2002-03-29
申请人： KYOWA HAKKO KOGYO KK , UNIV PITTSBURGH
发明人： YAMAGATA TSUYOSHI , ATSUKI KAORU , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , SCULPOREANU ADRIAN , KARASAWA AKIRA , YOSHIMURA NAOKI
IPC分类号： A61K45/00 , A61K31/381 , A61P13/10 , C07D495/04 , A61K31/18
CPC分类号： C07D495/04

5. 发明公开

EP1372639A4 AGENT FOR THE TREATMENT OF BLADDER IRRITATIVE SYMPTOMS ACCOMPANIED BY BENIGN PROSTATIC HYPERPLASIA 审中-公开
标题翻译：手段魅力随着气泡症状随附良性前列腺增生症治疗
公开(公告)号：EP1372639A4
公开(公告)日：2006-03-15
申请号：EP02757832
申请日：2002-03-29
申请人： KYOWA HAKKO KOGYO KK , UNIV PITTSBURGH
发明人： YAMAGATA TSUYOSHI , ATSUKI KAORU , OHNO TETSUJI , SHIRAKURA SHIRO , DEGROAT WILLIAM C , YOSHIMURA NAOKI , SCULPTOREANU ADRIAN , KARASAWA AKIRA
IPC分类号： A61K31/38 , C07D495/04 , A61K31/381 , A61K31/44 , A61K31/55 , A61K45/00 , A61P13/00 , A61P13/08
CPC分类号： A61K31/55 , A61K31/38 , A61K31/44

6. 发明专利

CA2442452A1 AGENT FOR THE TREATMENT OF BLADDER IRRITATIVE SYMPTOMS ACCOMPANIED BY BENIGN PROSTATIC HYPERPLASIA 未知
公开(公告)号：CA2442452A1
公开(公告)日：2002-10-10
申请号：CA2442452
申请日：2002-03-29
申请人： KYOWA HAKKO KOGYO KK , UNIV PITTSBURGH
发明人： SCULPTOREANU ADRIAN , YOSHIMURA NAOKI , OHNO TETSUJI , SHIRAKURA SHIRO , KARASAWA AKIRA , DEGROAT WILLIAM C , ATSUKI KAORO , YAMAGATA TSUYOSHI
IPC分类号： C07D495/04 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/55 , A61K45/00 , A61P13/08 , A61P13/10 , C12Q1/00 , C12Q1/02
摘要： The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K+ channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising measuring a slowly- inactivating A-type K+ channel opening activity as an index.

7. 发明专利

CA2442437A1 AGENT FOR THE TREATMENT OF OVERACTIVE BLADDER 未知
公开(公告)号：CA2442437A1
公开(公告)日：2002-10-10
申请号：CA2442437
申请日：2002-03-29
申请人： KYOWA HAKKO KOGYO KK , UNIV PITTSBURGH
发明人： SCULPOREANU ADRIAN , DEGROAT WILLIAM C , YOSHIMURA NAOKI , KARASAWA AKIRA , SHIRAKURA SHIRO , ATSUKI KAORU , OHNO TETSUJI , YAMAGATA TSUYOSHI
IPC分类号： A61K45/00 , A61K31/381 , A61P13/10 , C07D495/04 , A61K31/38 , C12Q1/00 , C12Q1/02
摘要： The present invention provides an agent for the treatment of overactive bladder, comprising, as an active ingredient, a compound having a slowly- inactivating A-type K+ channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of overactive bladder, comprising measuring a slowly-inactivating A-type K+ channel opening activity as an index.

8. 发明申请

WO03015698A2 APPLICATION OF LIPID VEHICLES AND USE FOR DRUG DELIVERY 审中-公开
标题翻译：脂质车辆的应用和用途在药物交付
公开(公告)号：WO03015698A2
公开(公告)日：2003-02-27
申请号：PCT/US0225860
申请日：2002-08-13
申请人： UNIV PITTSBURGH , CHANCELLOR MICHAEL B , FRASER MATTHEW O , CHUANG YAO-CHI , DE GROAT WILLIAM C , HUANG LEAF , YOSHIMURA NAOKI
发明人： CHANCELLOR MICHAEL B , FRASER MATTHEW O , CHUANG YAO-CHI , DE GROAT WILLIAM C , HUANG LEAF , YOSHIMURA NAOKI
IPC分类号： A61K9/00 , A61K9/127 , A61K36/81 , A61P29/00 , A61P31/00 , A61P35/00 , A61K
CPC分类号： A61K9/127 , A61K9/0034
摘要： The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g., antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction. Further related are methods of using these vehicles alone or in conjunction with antibodies, e.g., uroplakin antibodies, to improve duration of liposome attachment, and provide a long-term intravesical drug delivery platform. The present invention specifically relates to antibody-coated liposomes that are useful for targeting specific receptors for drug, peptide, polypeptide, or nucleic acid delivery. In one particular aspect, the present invention relates to liposomes coated with antibodies against nerve growth factor (NGF) receptor and containing NGF antisense nucleic acids, which are used as a treatment for neurogenic bladder dysfunction.
摘要翻译：本发明涉及用于施用基于脂质的载体以治疗各种病症（包括膀胱炎症，感染，功能障碍和癌症）的组合物和方法。在各个方面，本发明的组合物和方法可用于将药物例如抗生素，疼痛治疗和抗癌剂延长递送至膀胱，泌尿生殖道，胃肠系统，肺系统和其他器官或身体系统。具体而言，本发明涉及类脂样化合物如树脂毒素，辣椒素或细菌毒素以及毒素如肉毒杆菌毒素的基于脂质体的递送，用于治疗膀胱疾病，包括疼痛，炎症，失禁和排泄障碍。进一步相关的是单独使用这些载体或与抗体（例如尿激酶原抗体）结合使用这些载体以提高脂质体附着的持续时间并提供长期膀胱内药物递送平台的方法。本发明特别涉及用于靶向药物，肽，多肽或核酸递送的特定受体的抗体包被的脂质体。在一个特定的方面，本发明涉及用针对神经生长因子（NGF）受体的抗体包被并且含有NGF反义核酸的脂质体，其用作神经原性膀胱功能障碍的治疗。

9. 发明专利

AU2002323151A1 Application of lipid vehicles and use for drug delivery 未知
公开(公告)号：AU2002323151A1
公开(公告)日：2003-03-03
申请号：AU2002323151
申请日：2002-08-13
申请人： UNIV PITTSBURGH
发明人： CHUANG YAO-CHI , GROAT WILLIAM C DE , CHANCELLOR MICHAEL B , YOSHIMURA NAOKI , HUANG LEAF , FRASER MATTHEW O
IPC分类号： A61K9/00 , A61K9/127 , A61K36/81 , A61P29/00 , A61P31/00 , A61P35/00 , A61K9/12 , A61K9/107
摘要： The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g., antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction. Further related are methods of using these vehicles alone or in conjunction with antibodies, e.g., uroplakin antibodies, to improve duration of liposome attachment, and provide a long-term intravesical drug delivery platform. The present invention specifically relates to antibody-coated liposomes that are useful for targeting specific receptors for drug, peptide, polypeptide, or nucleic acid delivery. In one particular aspect, the present invention relates to liposomes coated with antibodies against nerve growth factor (NGF) receptor and containing NGF antisense nucleic acids, which are used as a treatment for neurogenic bladder dysfunction.

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