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1. 发明申请

WO9907872A9 PROCESS FOR THE PREPARATION OF HMG-CoA REDUCTASE INHIBITORS 审中-公开
标题翻译：制备HMG-CoA还原酶抑制剂的方法
公开(公告)号：WO9907872A9
公开(公告)日：2003-06-26
申请号：PCT/JP9803396
申请日：1998-07-30
申请人： KYOWA HAKKO KOGYO KK , TAKANO YUTAKA , HASEGAWA MASARU , MORI HIDEO , ANDO KATSUHIKO , OCHIAI KEIKO , MOTOYAMA HIROAKI , OZAKI AKIO
发明人： TAKANO YUTAKA , HASEGAWA MASARU , MORI HIDEO , ANDO KATSUHIKO , OCHIAI KEIKO , MOTOYAMA HIROAKI , OZAKI AKIO
IPC分类号： C12P7/62 , C12P17/06 , C12N1/20
CPC分类号： C12R1/07 , C12P7/62 , C12P17/06
摘要： A process for the preparation of compounds represented by general formula (II-a) (wherein R is hydrogen, optionally substituted alkyl or alkali metal; and R is optionally substituted alkyl or aryl) or lactones (II-b) derived therefrom through ring closure, which comprises treating a compound resulting from a bacillus and represented by general formula (I-a) (wherein R and R are each as described above) or a lactone (I-b) derived therefrom through ring closure with an enzyme source having the activity of forming the compounds (II-a) or (II-b) from the compounds (I-a) or (I-b) in a reaction fluid to form the compound (II-a) or (II-b) in the reaction fluid, and recovering the compound (II-a) or (II-b) from the reaction fluid.
摘要翻译：制备由通式（II-a）表示的化合物（其中R 1为氢，任选取代的烷基或碱金属; R 2为任选取代的烷基或芳基）或内酯（II-b）的方法），其包括处理由芽孢杆菌产生并由通式（Ia）表示的化合物（其中R 1和R 2各自如上所述）或由其衍生的内酯（Ib）通过具有在反应流体中从化合物（Ia）或（Ib）形成化合物（II-a）或（II-b）的活性的酶源的闭环以形成化合物（II-a）或（II -b），并从反应液中回收化合物（II-a）或（II-b）。

2. 发明公开

EP1072683A4 PROCESS FOR PRODUCING ISOPRENOID COMPOUNDS BY USING MICROORGANISMS AND METHOD FOR DETECTING COMPOUNDS HAVING ANTIBACTERIAL OR HERBICIDAL ACTIVITY 有权
标题翻译：过程对于检测具有抗菌活性或除草关系产生类异戊二烯的微生物和方法
公开(公告)号：EP1072683A4
公开(公告)日：2004-10-06
申请号：EP99913662
申请日：1999-04-14
申请人： KYOWA HAKKO KOGYO KK
发明人： MIYAKE KOICHIRO , HASHIMOTO SHINICHI , MOTOYAMA HIROAKI , OZAKI AKIO , SETO HARUO , KUZUYAMA TOMOHISA , TAKAHASHI SHUNJI
IPC分类号： C12N9/10 , C12N15/52 , C12P23/00 , C12Q1/18 , A01N57/18 , C12N9/00 , C12Q1/25 , C12Q1/48
CPC分类号： C12N9/1085 , A01N63/02 , C12N9/0006 , C12N9/1022 , C12N15/52 , C12P7/66 , C12P23/00 , C12Q1/18 , C12Y202/01007 , G01N2430/20
摘要： A process for producing proteins or isoprenoid compounds by using at least one DNA involving a DNA encoding the above proteins which have an activity of elevating the efficiency of synthesizing isoprenoid compounds useful in drugs for the treatment of heart diseases or osteoporosis, hemostasis, prevention of cancer, immunopotentiation, etc., health foods, antifouling coatings, etc.; and a method for detecting compounds having antibacterial activity and herbicidal activity characterized by detecting the above DNAs, the above proteins or substances capable of inhibiting enzymatic reactions on the non-mevalonate pathway.
摘要翻译：本发明提供一种用于生产通过使用DNA做DNA编码类异戊二烯化合物或蛋白质包含一个或多个具有活性的有效药物用于心脏疾病，骨质疏松症，体内稳态，预防类异戊二烯化合物的生物合成，以提高效率的编码蛋白质的DNA的癌症和免疫增强，保健食品和防污涂料产品对藤壶; 的DNA; 的蛋白; 和用于与抗生素筛选的物质和除草包括筛选一对非甲羟戊酸途径的物质抑制酶反应活性的方法。

3. 发明专利

AT389026T 未知
公开(公告)号：AT389026T
公开(公告)日：2008-03-15
申请号：AT98935282
申请日：1998-07-30
申请人： KYOWA HAKKO KOGYO KK
发明人： TAKANO YUTAKA , HASEGAWA MASARU , MORI HIDEO , ANDO KATSUHIKO , OCHIAI KEIKO , MOTOYAMA HIROAKI , OZAKI AKIO
IPC分类号： C12P7/62 , C12N1/20 , C12P17/06
摘要： Disclosed is a process for producing a compound represented by general formula (II-a): (wherein R represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R represents a substituted or unsubstituted alkyl or aryl group) Ähereinafter referred to as Compound (II-a)Ü or the lactone form of Compound (II-a) Ähereinafter referred to as Compound (II-b)Ü which comprises subjecting a compound represented by general formula (I-a): (wherein R represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R represents a substituted or unsubstituted alkyl or aryl group) Ähereinafter referred to as Compound (I-a)Ü or the lactone form of Compound (I-a) Ähereinafter referred to as Compound (I-b)Ü to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.

4. 发明专利

DK0826773T3 未知
公开(公告)号：DK0826773T3
公开(公告)日：2005-04-25
申请号：DK97115289
申请日：1997-09-03
申请人： KYOWA HAKKO KOGYO KK
发明人： OZAKI AKIO , SHIBASAKI TAKESHI , MORI HIDEO , MARUYAMA AKIHIKO , MOTOYAMA HIROAKI
IPC分类号： C12N15/09 , C07H21/04 , C12N1/21 , C12N9/02 , C12N15/22 , C12N15/52 , C12N15/53 , C12P13/24 , C12R1/19
摘要： Provided is an industrially applicable process for producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Dactylosporangium, Amycolatopsis or Streptomyces and which catalyzes the hydroxylation of L-proline into trans-4-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced trans-4-hydroxy-L-proline is collected from the aqueous medium. Also provided is a novel transformant containing a gene, coding for L-proline-4-hydroxylase and having a reinforced L-proline biosynthesis activity. In addition, provided is a process for producing L-proline-4-hydroxylase using the transformant which contains the gene and has a reinforced proline biosynthesis activity.

5. 发明专利

CA2299634A1 PROCESS FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITORS 未知
公开(公告)号：CA2299634A1
公开(公告)日：1999-02-18
申请号：CA2299634
申请日：1998-07-30
申请人： KYOWA HAKKO KOGYO KK
发明人： MOTOYAMA HIROAKI , OCHIAI KEIKO , OZAKI AKIO , TAKANO YUTAKA , HASEGAWA MASARU , MORI HIDEO , ANDO KATSUHIKO
IPC分类号： C12P7/62 , C12P17/06 , C12N1/20
摘要： A process for the preparation of compounds represented by general formula (II a) (wherein R1 is hydrogen, optionally substituted alkyl or alkali metal; and R2 is optionally substituted alkyl or aryl) or lactones (II-b) derived therefrom through ring closure, which comprises treating a compound resulting from a bacillus and represented by general formula (I-a) (wherein R1 and R2 are each as described above) or a lactone (I-b) derived therefrom through ring closure with an enzyme source having the activity of forming the compounds (II a) or (II-b) from the compounds (I-a) or (I-b) in a reaction fluid to form the compound (II-a) or (II-b) in the reaction fluid, and recovering the compound (II-a) or (II-b) from the reaction fluid.

6. 发明专利

AT144792T 未知
公开(公告)号：AT144792T
公开(公告)日：1996-11-15
申请号：AT91112960
申请日：1991-08-01
申请人： KYOWA HAKKO KOGYO KK
发明人： ANAZAWA HIDEHARU , MOTOYAMA HIROAKI , TESHIBA SADAO
IPC分类号： C12P13/04 , C12P13/08 , C12R1/01
摘要： Disclosed is a process for producing amino acids such as L-threonine and L-lysine, which comprises culturing, in a medium containing methanol as a major carbon source, a microorganism which belongs to the genus Methylobacillus and which has an ability to produce the amino acid(s) and resistance to at least one member selected from the group consisting of L-threonine, L-lysine and an amino acid analogue, said microorganism being obtained by mutation of a parent strain which belongs to the genus Methylobacillus and which has an enhanced sensitivity to at least one of an antibiotic and an amino acid analogue; allowing the amino acid(s) to accumulate in the culture; and recovering the amino acid(s) therefrom.

7. 发明专利

HU209842B PROCESS FOR PRODUCING OF L-LYSINE AND L-THREONINE AMINO ACID 未知
公开(公告)号：HU209842B
公开(公告)日：1994-11-28
申请号：HU256691
申请日：1991-08-01
申请人： KYOWA HAKKO KOGYO KK
发明人： MOTOYAMA HIROAKI , TESHIBA SADAO , ANAZAWA HIDEHARU
IPC分类号： C12P13/04 , C12P13/08 , C12R1/01
摘要： Disclosed is a process for producing amino acids such as L-threonine and L-lysine, which comprises culturing, in a medium containing methanol as a major carbon source, a microorganism which belongs to the genus Methylobacillus and which has an ability to produce the amino acid(s) and resistance to at least one member selected from the group consisting of L-threonine, L-lysine and an amino acid analogue, said microorganism being obtained by mutation of a parent strain which belongs to the genus Methylobacillus and which has an enhanced sensitivity to at least one of an antibiotic and an amino acid analogue; allowing the amino acid(s) to accumulate in the culture; and recovering the amino acid(s) therefrom.

8. 发明专利

DE69839248D1 未知
公开(公告)号：DE69839248D1
公开(公告)日：2008-04-24
申请号：DE69839248
申请日：1998-07-30
申请人： KYOWA HAKKO KOGYO KK
发明人： TAKANO YUTAKA , HASEGAWA MASARU , MORI HIDEO , ANDO KATSUHIKO , OCHIAI KEIKO , MOTOYAMA HIROAKI , OZAKI AKIO
IPC分类号： C12P7/62 , C12N1/20 , C12P17/06
摘要： Disclosed is a process for producing a compound represented by general formula (II-a): (wherein R represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R represents a substituted or unsubstituted alkyl or aryl group) Ähereinafter referred to as Compound (II-a)Ü or the lactone form of Compound (II-a) Ähereinafter referred to as Compound (II-b)Ü which comprises subjecting a compound represented by general formula (I-a): (wherein R represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R represents a substituted or unsubstituted alkyl or aryl group) Ähereinafter referred to as Compound (I-a)Ü or the lactone form of Compound (I-a) Ähereinafter referred to as Compound (I-b)Ü to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.

9. 发明专利

DE69732327D1 未知
公开(公告)号：DE69732327D1
公开(公告)日：2005-03-03
申请号：DE69732327
申请日：1997-09-03
申请人： KYOWA HAKKO KOGYO KK
发明人： OZAKI AKIO , SHIBASAKI TAKESHI , MORI HIDEO , MARUYAMA AKIHIKO , MOTOYAMA HIROAKI
IPC分类号： C12N15/09 , C07H21/04 , C12N1/21 , C12N9/02 , C12N15/22 , C12N15/52 , C12N15/53 , C12P13/24 , C12R1/19
摘要： Provided is an industrially applicable process for producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Dactylosporangium, Amycolatopsis or Streptomyces and which catalyzes the hydroxylation of L-proline into trans-4-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced trans-4-hydroxy-L-proline is collected from the aqueous medium. Also provided is a novel transformant containing a gene, coding for L-proline-4-hydroxylase and having a reinforced L-proline biosynthesis activity. In addition, provided is a process for producing L-proline-4-hydroxylase using the transformant which contains the gene and has a reinforced proline biosynthesis activity.

10. 发明专利

HU912566D0 PROCESS FOR PRODUCING AMINO ACID 未知
公开(公告)号：HU912566D0
公开(公告)日：1992-01-28
申请号：HU256691
申请日：1991-08-01
申请人： KYOWA HAKKO KOGYO KK
发明人： ANAZAWA HIDEHARU , MOTOYAMA HIROAKI , TESHIBA SADAO
IPC分类号： C12P13/04 , C12P13/08 , C12R1/01
摘要： Disclosed is a process for producing amino acids such as L-threonine and L-lysine, which comprises culturing, in a medium containing methanol as a major carbon source, a microorganism which belongs to the genus Methylobacillus and which has an ability to produce the amino acid(s) and resistance to at least one member selected from the group consisting of L-threonine, L-lysine and an amino acid analogue, said microorganism being obtained by mutation of a parent strain which belongs to the genus Methylobacillus and which has an enhanced sensitivity to at least one of an antibiotic and an amino acid analogue; allowing the amino acid(s) to accumulate in the culture; and recovering the amino acid(s) therefrom.

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