专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1595869A1 PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：嘧啶衍生物
公开(公告)号：EP1595869A1
公开(公告)日：2005-11-16
申请号：EP04713192.5
申请日：2004-02-20
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： OHSHIMA, Etsuo , MIYAMA, Motoki , YANAGAWA, Koji , ARATAKE, Seiji , MIKI, Ichiro , KOBAYASHI, Katsuya , SATO, Takashi , KAWABE, Ari , TAGAYA, Miho
IPC分类号： C07D239/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , A61K31/506 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00
CPC分类号： C07D401/04
摘要： The present invention provides a pyrimidine derivative represented by Formula (I)
[wherein Ar represents substituted or unsubstituted aryl, etc., R 1 represents -NR 2 R 3 (wherein R 2 represents a hydrogen atom or substituted or unsubstituted lower alkyl and R 3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, etc.), etc. A represents a single bond, Formula (III)
(wherein m 1 represents an integer of 0 to 2, n 1 represents an integer of 0 to 4, a 1 represents a number ranging from 0 to a substitutable number, R 5 represents substituted or unsubstituted lower alkyl, etc. and each R 5 may be the same or different when a 1 is 2 or more), etc. and Q represents -NR 6 R 7 (wherein R 6 and R 7 may be the same or different and each represents a hydrogen atom, a substituted or unsubstituted heteroalicyclic group, etc.), a substituted or unsubstituted heteroalicyclic group, substituted or unsubstituted piperidin-4-ylamino, etc.], or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof which have anti-inflammatory activities, modulating activities on TARC and/or MDC functions and the like, and are useful for treating and/or preventing diseases which is related to T cells such as allergic diseases, autoimmune diseases, transplant rejection, etc.
摘要翻译：本发明提供由式（I）表示的嘧啶衍生物[其中Ar表示取代或未取代的芳基等，R 1表示-NR 2 R 3（其中R 2表示氢原子或取代或未取代的低级烷基，并且R 3表示取代或未取代的低级烷基，取代或未取代的芳烷基等）等.A表示单键，式（III）（式中，m1表示0〜2的整数，n1表示0〜4的整数，a1表示0〜可取代的数，R5表示取代或未取代的低级烷基等，并且当a1为2或更大时，每个R5可以相同或不同），并且Q表示-NR6R7（其中R6和R7可以相同或不同，并且各自表示氢原子，取代或未取代的杂脂环基等），取代或未取代的杂脂环基，取代或未取代的哌啶-4-基氨基等]或它们的季铵盐，或其具有抗炎活性，调节对TARC和/或MDC功能等的活性，并且可用于治疗和/或预防与T细胞有关的疾病，例如变应性疾病，自身免疫疾病，移植排斥等等

2. 发明授权

EP0771794B1 OXYGEN-CONTAINING HETEROCYCLIC COMPOUNDS 失效
标题翻译：含氧杂环化合物
公开(公告)号：EP0771794B1
公开(公告)日：2006-05-03
申请号：EP96915194.3
申请日：1996-05-20
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： KAWAKITA, Takashi , OHSHIMA, Etsuo , YANAGAWA, Koji , IIDA, Kyoichiro , KOIKE, Rie , ICHIMURA, Michio , MANABE, Haruhiko , OHMORI, Kenji , SUZUKI, Fumio , NAKASATO, Yoshisuke
IPC分类号： C07D307/80 , C07D307/94 , C07D405/06 , C07D405/10 , C07D405/12 , A61K31/44 , A61K31/34
CPC分类号： C07D307/79 , C07D307/94 , C07D405/06 , C07D405/12 , C07D405/14
摘要： Oxygen-containing heterocyclic compounds represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R?1 and R2¿ are the same or different and each represents hydrogen, lower alkyl, cyano or -(CH¿2?)n-E-CO-F (wherein E represents a bond, O or NH; F represents OR?6 or NR7R8¿; and n is an integer of from 0 to 4), or R?1 and R2¿ together with the adjacent carbon atom may form a saturated carbocyclic ring, or R2 together with R?11 or R13¿, as will be described hereinbelow, may form a single bond; R3 represents hydrogen, phenyl or halogeno; R4 represents hydroxy, lower alkoxy, etc.; A represents -C(R9)(R10)- or O; B represents O, NR?11, -C(R12)(R13¿)- or -C(R?14)(R15)-C(R16)(R17¿)-; D represents (1) -C(R18)(R19)-X- [where X represents -C(R21)(R22)-, S or NR23], (2) -C(R19a)=Y- [wherein Y represents -C(R24)-Z-, {wherein Z represents CONH, CONHCH¿2? or a bond}, or N] or (3) a bond; and R?5¿ represents aryl, heteroaryl, cycloalkyl, pyridine-N-oxide, cyano or lower alkoxycarbonyl.

3. 发明授权

EP1110961B1 OXYGENIC HETEROCYCLIC COMPOUNDS 有权
标题翻译：含氧杂环化合物
公开(公告)号：EP1110961B1
公开(公告)日：2004-07-14
申请号：EP99968667.8
申请日：1999-09-03
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： OHSHIMA, Etsuo , YANAGAWA, Koji , MANABE, Haruhiko , MIKI, Ichiro , MASUDA, Yoshiaki
IPC分类号： C07D317/64 , C07D319/16 , C07D321/00 , C07D405/04 , C07D407/04 , A61K31/36 , A61K31/335
CPC分类号： C07D405/04 , C07D317/46 , C07D319/20 , C07D407/04 , C07D407/08
摘要： Oxygenic heterocyclic compounds represented by formula (I) or pharmacologically acceptable salts thereof: wherein m is an integer of 0 to 4; R?1, R2, R3, and R4¿ are the same or different and each represents hydrogen, optionally substituted lower alkyl, etc.; R5 represents optionally substituted lower alkoxy, etc.; R6 represents hydrogen, etc.; and Y represents, e.g., formula (II) (wherein R9 represents cyano, etc.; R10 represents hydrogen, etc.; R11 represents carboxy, etc.; and R12 represents hydrogen, etc.).

4. 发明公开

EP0771794A1 OXYGEN-CONTAINING HETEROCYCLIC COMPOUNDS 失效
标题翻译： SAUERSTOFF ENTHALTENDE HETEROCYCLISCHE VERBINDUNGEN
公开(公告)号：EP0771794A1
公开(公告)日：1997-05-07
申请号：EP96915194.3
申请日：1996-05-20
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： KAWAKITA, Takashi , OHSHIMA, Etsuo , YANAGAWA, Koji , IIDA, Kyoichiro , KOIKE, Rie , ICHIMURA, Michio , MANABE, Haruhiko , OHMORI, Kenji , SUZUKI, Fumio , NAKASATO, Yoshisuke
IPC分类号： C07D307/80 , C07D307/94 , C07D405/06 , C07D405/10 , C07D405/12
CPC分类号： C07D307/79 , C07D307/94 , C07D405/06 , C07D405/12 , C07D405/14
摘要： An oxygen-containing heterocyclic compound represented by following Formula (I):
wherein R 1 and R 2 independently represent hydrogen, lower alkyl, cyano, -(CH 2 ) n -E-CO-F (wherein E represents a bond, O, or NH; F represents OR 6 or NR 7 R 8 ; and n represents an integer of 0 to 4), or the like; R 1 and R 2 are combined to represent a saturated carbon ring together with a carbon atom adjacent thereto; or R 2 , and R 11 or R 13 described below are combined to form a single bond; R 3 represents hydrogen, phenyl, or halogen; R 4 represents hydroxy, lower alkoxy, or the like; A represents -C(R 9 )(R 10 )- or O; B represents O, NR 11 , -C(R 12 )(R 13 )-, or -C(R 14 )(R 15 )-C(R 16 )(R 17 )-; D represents (i) -C(R 18 )(R 19 )-X- (wherein X represents -C(R 21 )(R 22 )-, S, or NR 23 ), (ii) -C(R 19a )=Y- [Y represents -C(R 24 )-Z- (wherein Z represents CONH, CONHCH 2 , or a bond), or N], or (iii) a bond; and R 5 represents aryl, an aromatic heterocyclic group, cycloalkyl, pyridine-N-oxide, cyano, or lower alkoxycarbonyl; or a pharmaceutically acceptable salt thereof.
摘要翻译：由下式（I）表示的含氧杂环化合物：其中R 1和R 2独立地表示氢，低级烷基，氰基， - （CH 2）nE-CO-F（其中E表示键，O或NH; F表示OR 6或NR 7 R 8; n表示0〜4的整数）等; R 1和R 2相互结合形成饱和碳环，与其相邻的碳原子一起表示; 或R 2，以及下述R 11或R 13组合形成单键; R 3表示氢，苯基或卤素; R 4表示羟基，低级烷氧基等; A表示-C（R 9）（R 10） - 或O; B表示O，NR 11，-C（R 12）（R 13） - 或-C（R 14）（R 15）-C（R 16）（R 16） <17>） - ; D表示（i）-C（R 18）（R 19）-X-（其中X表示-C（R 21）（R 22） - ，S或NR 23），（ii）-C（R 19）= Y -YY表示-C（R 24） - Z-（其中Z表示CONH，CONHCH 2或键）或N，或（iii）键 ; R 5表示芳基，芳香族杂环基，环烷基，吡啶-N-氧化物，氰基或低级烷氧基羰基; 或其药学上可接受的盐。

5. 发明公开

EP1264829A1 OXYGEN-CONTAINING HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译： SAUERSTOFF-ENTHALTENDE HETEROZYKLEN
公开(公告)号：EP1264829A1
公开(公告)日：2002-12-11
申请号：EP01908240.3
申请日：2001-03-02
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： OHSHIMA, Etsuo , YANAGAWA, Koji , MANABE, Haruhiko , MIKI, Ichiro , MASUDA, Yoshiaki
IPC分类号： C07D319/18 , C07D401/04 , C07D405/04 , C07D407/08 , A61K31/357 , A61K31/453 , A61P43/00 , A61P11/06 , A61P37/08 , A61P17/00 , A61P27/16 , A61P13/12 , A61P11/00 , A61P29/00 , A61P19/02 , A61P25/00 , A61P17/06
CPC分类号： C07D405/08 , A61K31/357 , A61K31/453 , C07D319/18 , C07D407/04
摘要： The present invention relates to oxygen-containing heterocyclic compounds represented by the following formula (I):
wherein m indicates an integer of 0 to 4;
R 1 , R 2 , R 3 and R 4 are the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, etc.; R 5 represents hydroxy or substituted or unsubstituted lower alkoxy; R 6 represents a hydrogen atom or halogen; and Y represents the following formula (i) or formula (ii):
or
or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及由下式（I）表示的含氧杂环化合物：其中m表示0至4的整数; R 1，R 2，R 3和R 4相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的环烷基等; R 5表示羟基或取代或未取代的低级烷氧基; R 6表示氢原子或卤素; 和Y代表下式（i）或式（ⅱ）：其中CHEM或其化学式可接受的盐。

6. 发明公开

EP1110961A1 OXYGENIC HETEROCYCLIC COMPOUNDS 有权
标题翻译：氧杂环化合物
公开(公告)号：EP1110961A1
公开(公告)日：2001-06-27
申请号：EP99968667.8
申请日：1999-09-03
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： OHSHIMA, Etsuo , YANAGAWA, Koji , MANABE, Haruhiko , MIKI, Ichiro , MASUDA, Yoshiaki
IPC分类号： C07D317/64 , C07D319/16 , C07D321/00 , C07D405/04 , C07D407/04 , A61K31/36 , A61K31/335
CPC分类号： C07D405/04 , C07D317/46 , C07D319/20 , C07D407/04 , C07D407/08
摘要： The present invention relates to oxygen-containing heterocyclic compounds represented by the following formula (I):
wherein m represents an integer of 0 to 4; R 1 , R 2 , R 3 and R 4 independently represent a hydrogen atom, substituted or unsubstituted lower alkyl, etc.; R 5 represents substituted or unsubstituted lower alkoxy etc.; R 6 represents a hydrogen atom etc.; and Y represents the following formula (II):
wherein R 9 represents cyano etc., R 10 represents a hydrogen atom etc., R 11 represents carboxy etc., and R 12 represents a hydrogen atom etc.; and the like; or
pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及由下式（I）表示的含氧杂环化合物：其中m表示0至4的整数; R1，R2，R3和R4独立地表示氢原子，取代或未取代的低级烷基等; R5代表取代或未取代的低级烷氧基等; R6代表氢原子等。 Y代表下式（Ⅱ）：其中R9代表氰基等，R10代表氢原子等，R11代表羧基等，R12代表氢原子等。等等; 或其药学上可接受的盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式