专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1595869A1 PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：嘧啶衍生物
公开(公告)号：EP1595869A1
公开(公告)日：2005-11-16
申请号：EP04713192.5
申请日：2004-02-20
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： OHSHIMA, Etsuo , MIYAMA, Motoki , YANAGAWA, Koji , ARATAKE, Seiji , MIKI, Ichiro , KOBAYASHI, Katsuya , SATO, Takashi , KAWABE, Ari , TAGAYA, Miho
IPC分类号： C07D239/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , A61K31/506 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00
CPC分类号： C07D401/04
摘要： The present invention provides a pyrimidine derivative represented by Formula (I)
[wherein Ar represents substituted or unsubstituted aryl, etc., R 1 represents -NR 2 R 3 (wherein R 2 represents a hydrogen atom or substituted or unsubstituted lower alkyl and R 3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, etc.), etc. A represents a single bond, Formula (III)
(wherein m 1 represents an integer of 0 to 2, n 1 represents an integer of 0 to 4, a 1 represents a number ranging from 0 to a substitutable number, R 5 represents substituted or unsubstituted lower alkyl, etc. and each R 5 may be the same or different when a 1 is 2 or more), etc. and Q represents -NR 6 R 7 (wherein R 6 and R 7 may be the same or different and each represents a hydrogen atom, a substituted or unsubstituted heteroalicyclic group, etc.), a substituted or unsubstituted heteroalicyclic group, substituted or unsubstituted piperidin-4-ylamino, etc.], or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof which have anti-inflammatory activities, modulating activities on TARC and/or MDC functions and the like, and are useful for treating and/or preventing diseases which is related to T cells such as allergic diseases, autoimmune diseases, transplant rejection, etc.
摘要翻译：本发明提供由式（I）表示的嘧啶衍生物[其中Ar表示取代或未取代的芳基等，R 1表示-NR 2 R 3（其中R 2表示氢原子或取代或未取代的低级烷基，并且R 3表示取代或未取代的低级烷基，取代或未取代的芳烷基等）等.A表示单键，式（III）（式中，m1表示0〜2的整数，n1表示0〜4的整数，a1表示0〜可取代的数，R5表示取代或未取代的低级烷基等，并且当a1为2或更大时，每个R5可以相同或不同），并且Q表示-NR6R7（其中R6和R7可以相同或不同，并且各自表示氢原子，取代或未取代的杂脂环基等），取代或未取代的杂脂环基，取代或未取代的哌啶-4-基氨基等]或它们的季铵盐，或其具有抗炎活性，调节对TARC和/或MDC功能等的活性，并且可用于治疗和/或预防与T细胞有关的疾病，例如变应性疾病，自身免疫疾病，移植排斥等等

2. 发明公开

EP1552842A1 BICYCLIC PYRIMIDINE DERIVATIVES 审中-公开
标题翻译： BIZYKLISCHE PYRIMIDIN-DERIVATE
公开(公告)号：EP1552842A1
公开(公告)日：2005-07-13
申请号：EP03733302.8
申请日：2003-06-06
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： ARAI, Hitoshi Kyowa Hakko Kogyo Co., Ltd. , MATSUMURA, Tsutomu Kyowa Hakko Kogyo Co., Ltd. , ISHIDA, Hiroshi Kyowa Hakko Kogyo Co., Ltd. , YAMAURA, Yosuke Kyowa Hakko Kogyo Co., Ltd. , ARATAKE, Seiji Kyowa Hakko Kogyo Co., Ltd. , OHSHIMA, Etsuo Kyowa Hakko Kogyo Co., Ltd. , YANAGAWA, Koji Kyowa Hakko Kogyo Co., Ltd. , MIYAMA, Motoki Kyowa Hakko Kogyo Co., Ltd. , SUZUKI, Koji Hakko Kogyo Co., Ltd , KAWABE, Ari Kyowa Hakko Kogyo Co., Ltd. , NAKANISHI, Satoshi Kyowa Hakko Kogyo Co., Ltd. , KOBAYASHI, Katsuya , SATO, Takashi Kyowa Hakko Kogyo Co., Ltd. , MIKI, Ichiro Kyowa Hakko Kogyo Co., Ltd. , UENO, Kimihisa Kyowa Hakko Kogyo Co., Ltd. , FUJII, Shinya Kyowa Hakko Kogyo Co., Ltd. , IWASE, Miho Kyowa Hakko Kogyo Co., Ltd.
IPC分类号： A61K35/00
CPC分类号： C07D263/58 , C07D471/04 , C07D487/04
摘要： [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m + n is 4 or less; R 1 represents NR 4 R 5 (wherein R 4 and R 5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R 2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, -C(=O)-, -SO 2 -, -OC(=O)- or the like; and R 3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like]
Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided. These have anti-inflammatory activities or modulation activities on the functions of TARC and/or MDC and are useful for treating and/or preventing a disease which is related to T cells, such as an allergic disease, an autoimmune disease or transplant rejection.
摘要翻译：其中m和n可以相同或不同，各自表示1〜3的整数，其中m + n为4以下; R 1表示NR 4 R 5（其中R 4和R 5可以相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的芳烷基等）; R 2表示上述式（II），式（IV）等; A表示单键，-C（= O） - ，-SO 2 - ， - OC（= O） - 等; 和R 3表示取代或未取代的低级烷基，取代或未取代的环烷基，取代或未取代的芳烷基等。上式（I）表示的双环嘧啶衍生物或其季铵盐或其药学上可接受的盐或其类似物。它们具有对TARC和/或MDC的功能的抗炎活性或调节活性，并且可用于治疗和/或预防与T细胞相关的疾病，例如过敏性疾病，自身免疫疾病或移植排斥反应。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式