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1. 发明专利

AU2003236028A1 METHOD OF JUDGING LEUKEMIA, PRE-LEUKEMIA OR ALEUKEMIC MALIGNANT BLOOD DISEASE AND DIAGNOSTIC THEREFOR 未知
公开(公告)号：AU2003236028A1
公开(公告)日：2003-10-20
申请号：AU2003236028
申请日：2003-04-09
申请人： KYOWA HAKKO KOGYO CO LTD , KYOWA MEDEX CO LTD , UNIV TOKAI
发明人： ITO CHIE , SATO HIDENAO , FURUYA AKIKO , SHITARA KENYA , SUGIMOTO SEIJI , KOHNO HIROAKI , ANDO KIYOSHI , HOTTA TOMOMITSU
IPC分类号： C07K16/22 , G01N33/574 , G01N33/53 , C12N5/16
摘要： The present invention relates to a method for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases, a method of discriminating leukemia from pre-leukemia or aleukemic malignant blood diseases, a method of discriminating aplastic anemia from myelodysplastic syndrome, a method of diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells, and a method of diagnosing the graft versus host disease, each of said methods comprising quantifying stem cell growth factor (SCGF). The present invention also makes it possible to provide an agent for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases and an agent for diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells or an agent for diagnosing graft versus host disease (GVHD), each containing as an active ingredient an antibody reacting with stem cell growth factor (SCGF).

2. 发明公开

EP1496360A4 METHOD OF JUDGING LEUKEMIA, PRE-LEUKEMIA OR ALEUKEMIC MALIGNANT BLOOD DISEASE AND DIAGNOSTIC THEREFOR 审中-公开
标题翻译：程序评估的白血病，前白血病或非白血性恶性血液病和诊断THEREFOR
公开(公告)号：EP1496360A4
公开(公告)日：2007-06-27
申请号：EP03745988
申请日：2003-04-09
申请人： UNIV TOKAI , KYOWA HAKKO KOGYO KK , KYOWA MEDEX CO LTD
发明人： ANDO KIYOSHI , HOTTA TOMOMITSU , ITO CHIE , SATO HIDENAO , FURUYA AKIKO , SHITARA KENYA , SUGIMOTO SEIJI , KOHNO HIROAKI
IPC分类号： C07K16/22 , G01N33/574 , G01N33/53 , C12N5/16
CPC分类号： C07K16/22 , G01N33/57426 , G01N2333/475
摘要： A method of judging leukemia, pre-leukemia or an aleukemic malignant blood disease characterized by comprising quantifying stem cell growth factor (SCGF); a method of discriminating leukemia from pre-leukemia or an aleukemic malignant blood disease; a method of discriminating aplastic anemia from myelodysplastic syndrome; a method of judging delayed take in hematopoietic stem cells after transplantation of the hematopoietic stem cells; and a method of judging graft versus host disease. It is also possible to provide a diagnostic for leukemia, pre-leukemia or an aleukemic malignant blood disease and a diagnostic for delayed take in hematopoietic stem cells after transplantation of the hematopoietic stem cells or graft versus host disease (GVHD) each containing as the active ingredient an antibody reacting with stem cell growth factor (SCGF).

3. 发明专利

CA2481710A1 METHOD OF JUDGING LEUKEMIA, PRE-LEUKEMIA OR ALEUKEMIC MALIGNANT BLOOD DISEASE AND DIAGNOSTIC THEREFOR 未知
公开(公告)号：CA2481710A1
公开(公告)日：2003-10-16
申请号：CA2481710
申请日：2003-04-09
申请人： UNIV TOKAI , KYOWA HAKKO KOGYO KK , KYOWA MEDEX CO LTD
发明人： HOTTA TOMOMITSU , ITO CHIE , ANDO KIYOSHI , SATO HIDENAO , KOHNO HIROAKI , SHITARA KENYA , SUGIMOTO SEIJI , FURUYA AKIKO
IPC分类号： C07K16/22 , G01N33/574 , C12N5/12 , C12N5/16 , G01N33/53
摘要： A method of judging leukemia, pre-leukemia or an aleukemic malignant blood disease characterized by comprising quantifying stem cell growth factor (SCGF); a method of discriminating leukemia from pre-leukemia or an aleukemi c malignant blood disease; a method of discriminating aplastic anemia from myelodysplastic syndrome; a method of judging delayed take in hematopoietic stem cells after transplantation of the hematopoietic stem cells; and a meth od of judging graft versus host disease. It is also possible to provide a diagnostic for leukemia, pre-leukemia or an aleukemic malignant blood diseas e and a diagnostic for delayed take in hematopoietic stem cells after transplantation of the hematopoietic stem cells or graft versus host disease (GVHD) each containing as the active ingredient an antibody reacting with st em cell growth factor (SCGF).

4. 发明专利

AU2006323706A8 Genetically recombinant anti-PERP antibody 未知
公开(公告)号：AU2006323706A8
公开(公告)日：2008-05-22
申请号：AU2006323706
申请日：2006-12-06
申请人： JAPAN AS REPRESENTED BY PRESIDENT OF NAT CANCER CENTER , KYOWA HAKKO KOGYO CO LTD
发明人： HOSAKA EMI , OCHIAI ATSUSHI , NAKAMURA KAZUYASU , OHKI YUJI , FURUYA AKIKO
IPC分类号： C12N15/09 , A61K39/395 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
摘要： An antibody which binds to a polypeptide encoded by human PERP (p53 apoptosis effector related to PMP-22) gene which is considered to be related to incidence of cancer or the like is desired. The present invention provides a gene recombinant antibody which has no consensus sequence of an N-linked sugar chain in a variable region, specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by the PERP gene and binds to the extracellular region. The antibody is useful for treatment of various diseases expressing a polypeptide encoded by the PERP gene.

5. 发明专利

JP2006169263A Assay of peg-modified human granulocyte colony stimulating factor 审中-公开
标题翻译： PEG改性人粒细胞集落刺激因子的测定
公开(公告)号：JP2006169263A
公开(公告)日：2006-06-29
申请号：JP2006065190
申请日：2006-03-10
申请人： Kyowa Hakko Kogyo Co Ltd , 協和醗酵工業株式会社
发明人： HANAI NOBUO , FURUYA AKIKO , YAMAZAKI MOTOO , KOBAYASHI SATOSHI , KUWABARA TAKASHI
IPC分类号： C07K16/24 , C12P21/08 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To provide an assay of PEG-modified human granulocyte colony stimulating factor (G-CSF) or its derivative by preparing a monoclonal antibody reacting with G-CSF or its derivative and PEG-modified G-CSF or its derivative and using the prepared.
SOLUTION: The monoclonal antibody reacting with a PEG-modified G-CSF or its derivative ND28 is selected by immunizing nonhuman animal with G-CSF, its derivative ND28 or partial peptide of ND28 and examining reactivity of the obtained monoclonal antibody to PEG-modified G-CSF or its derivative ND28. The method for assaying PEG-modified G-CSF or its derivative comprises an immunoassay using an antibody specifically reacting with antibody reacting with G-CSF or its derivative and PEG-modified G-CSF or its derivative and a monoclonal antibody reacting with G-CSF or its derivative and unreacting with PEG-modified G-CSF or its derivative.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：通过制备与G-CSF或其衍生物和PEG修饰的G-CSF反应的单克隆抗体或其衍生物和PEG修饰的G-CSF或其衍生物，提供PEG修饰的人粒细胞集落刺激因子（G-CSF）或其衍生物的测定法其衍生和使用准备。解决方案：通过用G-CSF，其衍生物ND28或ND28的部分肽免疫非人动物，并检测所获得的单克隆抗体对PEG的反应性，选择与PEG修饰的G-CSF或其衍生物ND28反应的单克隆抗体改性G-CSF或其衍生物ND28。用于测定PEG修饰的G-CSF或其衍生物的方法包括使用与G-CSF或其衍生物和PEG修饰的G-CSF或其衍生物反应的抗体特异性反应的抗体的免疫测定和与G-CSF反应的单克隆抗体或其衍生物并与PEG修饰的G-CSF或其衍生物不反应。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2008261764A Measuring method of kinase inhibitor 审中-公开
标题翻译：激酶抑制剂的测定方法
公开(公告)号：JP2008261764A
公开(公告)日：2008-10-30
申请号：JP2007105436
申请日：2007-04-13
申请人： Kyowa Hakko Kogyo Co Ltd , 協和醗酵工業株式会社
发明人： SHIOZU YUKIMASA , ISHII KENICHI , SHIMIZU MAKIKO , FURUYA AKIKO , KUWABARA TAKASHI , MAEDA HIROSHI , OHASHI RUI
IPC分类号： G01N33/574 , C07K16/18
摘要： PROBLEM TO BE SOLVED: To provide a method of measuring a kinase inhibitor contained in a biological sample using the biological sample containing the kinase inhibitor and a cell for developing target kinase, an immunological measuring method for measuring the kinase inhibitor, and a reagent, kit, or the like for immunological measurement.
SOLUTION: This measuring method of the kinase inhibitor contained in the biological sample includes a process (a) of bringing the biological sample into contact with the cell for developing the kinase working as the target of the kinase inhibitor, and a process (b) of measuring the substrate of the kinase as the target existing inside the cell and/or the phosphorylation level of kinase on the downstream side of the kinase as the target.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供使用含有激酶抑制剂的生物样品和用于发展靶标激酶的细胞的生物样品中测定激酶抑制剂的方法，用于测定激酶抑制剂的免疫测定方法和试剂，试剂盒等进行免疫测定。解决方案：生物样品中所含的激酶抑制剂的测量方法包括使生物样品与细胞接触以开发用作激酶抑制剂靶标的激酶的方法（a） b）测量激酶的底物作为存在于细胞内的靶标和/或激酶下游侧的激酶的磷酸化水平作为靶标。版权所有（C）2009，JPO＆INPIT

7. 发明专利

JP2003310276A SUBSTANCE BLOCKING SIGNAL TRANSDUCTION MOLECULE TO KDR/ Flk-1 HAVING PHOSPHORYLATED TYROSINE AT 1214 POSITION 审中-公开
标题翻译：物理阻塞信号传输分子到具有1214位置的磷酸化酪氨酸的KDR / Flk-1
公开(公告)号：JP2003310276A
公开(公告)日：2003-11-05
申请号：JP2002129072
申请日：2002-04-30
申请人： Kyowa Hakko Kogyo Co Ltd , Masashi Shibuya , 協和醗酵工業株式会社 , 正史澁谷
发明人： SHIBUYA MASASHI , FURUYA AKIKO , SHIDARA KIYONARI
IPC分类号： G01N33/50 , A61K35/76 , A61K39/395 , A61K45/00 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/99 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/48 , G01N33/15
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To obtain a substance that blocks intracellular signal transduction to KDR/Flk-1 and inhibits cell proliferation caused by VEGF. SOLUTION: An antibody that specifically recognizes KDR/Flk-1 having phosphorylated tyrosine at 1214 position not only can specifically detect the KDR/Flk-1 having phosphorylated tyrosine at 1214 position, but also can block the signal transduction to the KDR/Flk-1, when the antibody is injected into endothelial cell and can suppress the VEGF (vascular endotherial growth factor)- dependent cell proliferation. COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：获得阻断细胞内信号转导至KDR / Flk-1并抑制由VEGF引起的细胞增殖的物质。解决方案：特异性识别在1214位具有磷酸化酪氨酸的KDR / Flk-1的抗体不仅可以特异性地检测到在1214位具有磷酸化酪氨酸的KDR / Flk-1，而且可以阻断信号转导到KDR / Flk-1，当抗体注入内皮细胞并能抑制VEGF（血管内皮生长因子）依赖性细胞增殖。版权所有（C）2004，JPO

8. 发明专利

JP2005308757A Peg human granulocyte colony stimulating factor assay 有权
标题翻译： PEG人造粒组织刺激因子测定
公开(公告)号：JP2005308757A
公开(公告)日：2005-11-04
申请号：JP2005154801
申请日：2005-05-27
申请人： Kyowa Hakko Kogyo Co Ltd , 協和醗酵工業株式会社
发明人： HANAI NOBUO , FURUYA AKIKO , YAMAZAKI MOTOO , KOBAYASHI SATOSHI , KUWABARA TAKASHI
IPC分类号： G01N33/53 , C07K16/24 , C12N15/02 , C12P21/08 , G01N33/543 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To highly sensitively determine PEG human granulocyte colony stimulating factor or its derivative only.
SOLUTION: An assay for PEG human granulocyte colony stimulating factor or its derivative by an immunologic measurement method using PEG human granulocyte colony stimulating factor or its derivative, antibody for reacting with PEG human granulocyte colony stimulating factor or its derivative and monoclonal antibody for specifically reacting with human granulocyte colony stimulating factor or its derivative and not reacting with PEG human granulocyte colony stimulating factor or its derivative.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：高度敏感地确定PEG人类粒细胞集落刺激因子或其衍生物。
解决方案：使用PEG人粒细胞集落刺激因子或其衍生物，通过免疫测定方法测定PEG人粒细胞集落刺激因子或其衍生物，与PEG人粒细胞集落刺激因子或其衍生物和单克隆抗体反应的抗体特异性地与人粒细胞集落刺激因子或其衍生物反应，而不与PEG人粒细胞集落刺激因子或其衍生物反应。版权所有（C）2006，JPO＆NCIPI

9. 发明专利

JP2003310275A Gene recombinant antibody against human insulin-like growth factor 审中-公开
标题翻译：基因重组抗人类胰岛素样生长因子
公开(公告)号：JP2003310275A
公开(公告)日：2003-11-05
申请号：JP2002129047
申请日：2002-04-30
申请人： Kyowa Hakko Kogyo Co Ltd , 協和醗酵工業株式会社
发明人： SHIDARA KIYONARI , NAKAMURA KAZUYASU , FURUYA AKIKO , NIWA RINHEI , OKI YUJI , HANAI NOBUO
IPC分类号： C12N15/09 , A61K39/395 , A61P3/10 , A61P43/00 , C07K16/26 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
摘要： PROBLEM TO BE SOLVED: To obtain a gene recombinant antibody or its antibody fragments, for example, a hominized antibody that strongly bonds to hIGF-I to inhibit its functions in order to effectively treating a variety of diseases including cancers relating to the hIGF. SOLUTION: This invention provides the gene recombinant antibody that specifically bonds to hIGF-I, does not recognize the primary sequence epitope of hIGF-I but recognizes the three-dimensional structure of human hIGF-I and its antibody fragments and further provides a diagnostic agent, a prophylactic agent and a therapeutic agent containing the antibody for diseases, e.g. cancer. COPYRIGHT: (C)2004,JPO

10. 发明专利

JP2005089354A Antibody selectively recognizing phosphorylated beta-catenin 审中-公开
标题翻译：抗体选择性识别磷酸化谷氨酸蛋白酶
公开(公告)号：JP2005089354A
公开(公告)日：2005-04-07
申请号：JP2003323624
申请日：2003-09-16
申请人： Kyowa Hakko Kogyo Co Ltd , National Cancer Center-Japan , 協和醗酵工業株式会社 , 国立がんセンター総長
发明人： OCHIAI ATSUSHI , SHIDARA KIYONARI , FURUYA AKIKO
IPC分类号： G01N33/50 , A61K39/395 , A61P35/00 , C07K16/18 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , G01N33/15 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a diagnostic agent for diagnosing the development, metastasis or infiltration of cancer, and a treating agent for inhibiting the development, metastasis, growth or infiltration of cancer. SOLUTION: An antibody which selectively recognizes β-catenin whose tyrosine residue at the 86th-position or the 254th-position of a specific amino acid sequence is phosphorylated and its immunoreactive segment are disclosed. The diagnostic agent for diagnosing the development, metastasis or infiltration of cancer has them as active ingredients, and the treating agent for inhibiting the development, metastasis, infiltration or growth of cancer has them as active ingredients. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供用于诊断癌症的发展，转移或浸润的诊断剂，以及用于抑制癌症的发展，转移，生长或浸润的治疗剂。解决方案：公开了选择性识别特定氨基酸序列的第86位或第254位的酪氨酸残基被磷酸化的β-连环蛋白的抗体及其免疫反应性区段。用于诊断癌症的发展，转移或浸润的诊断剂具有它们作为活性成分，并且用于抑制癌症的发育，转移，浸润或生长的治疗剂具有它们作为活性成分。版权所有（C）2005，JPO＆NCIPI

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