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JP2008261764A Measuring method of kinase inhibitor 审中-公开
标题翻译：激酶抑制剂的测定方法
公开(公告)号：JP2008261764A
公开(公告)日：2008-10-30
申请号：JP2007105436
申请日：2007-04-13
申请人： Kyowa Hakko Kogyo Co Ltd , 協和醗酵工業株式会社
发明人： SHIOZU YUKIMASA , ISHII KENICHI , SHIMIZU MAKIKO , FURUYA AKIKO , KUWABARA TAKASHI , MAEDA HIROSHI , OHASHI RUI
IPC分类号： G01N33/574 , C07K16/18
摘要： PROBLEM TO BE SOLVED: To provide a method of measuring a kinase inhibitor contained in a biological sample using the biological sample containing the kinase inhibitor and a cell for developing target kinase, an immunological measuring method for measuring the kinase inhibitor, and a reagent, kit, or the like for immunological measurement.
SOLUTION: This measuring method of the kinase inhibitor contained in the biological sample includes a process (a) of bringing the biological sample into contact with the cell for developing the kinase working as the target of the kinase inhibitor, and a process (b) of measuring the substrate of the kinase as the target existing inside the cell and/or the phosphorylation level of kinase on the downstream side of the kinase as the target.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供使用含有激酶抑制剂的生物样品和用于发展靶标激酶的细胞的生物样品中测定激酶抑制剂的方法，用于测定激酶抑制剂的免疫测定方法和试剂，试剂盒等进行免疫测定。解决方案：生物样品中所含的激酶抑制剂的测量方法包括使生物样品与细胞接触以开发用作激酶抑制剂靶标的激酶的方法（a） b）测量激酶的底物作为存在于细胞内的靶标和/或激酶下游侧的激酶的磷酸化水平作为靶标。版权所有（C）2009，JPO＆INPIT

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