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1. 发明申请

WO2010066342A1 QUETIAPINE COMPOSITION 审中-公开
标题翻译： QUETIAPINE组合物
公开(公告)号：WO2010066342A1
公开(公告)日：2010-06-17
申请号：PCT/EP2009/008431
申请日：2009-11-26
申请人： KRKA , PAVLI, Matej , ZADNIK, Jernej , VRECER, Franc , PISEK, Robert , BAUMGARTNER, Sasa , DREU, Rok , PLANINSEK, Odon
发明人： PAVLI, Matej , ZADNIK, Jernej , VRECER, Franc , PISEK, Robert , BAUMGARTNER, Sasa , DREU, Rok , PLANINSEK, Odon
IPC分类号： A61K9/20 , A61K31/554
CPC分类号： A61K9/2027 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/554
摘要： Pharmaceutical composition comprising a solid matrix system of quetiapine or its salt and a nonswellable anionic polymer.
摘要翻译：药物组合物，其包含喹硫平或其盐的固体基质体系和不可聚合的阴离子聚合物。

2. 发明申请

WO2010012490A1 QUETIAPINE COMPOSITION 审中-公开
标题翻译： QUETIAPINE组合物
公开(公告)号：WO2010012490A1
公开(公告)日：2010-02-04
申请号：PCT/EP2009/005573
申请日：2009-07-31
申请人： KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO , PAVLI, Matej , DREU, Rok , BAUMGARTNER, Sasa , PLANINSEK, Odon , PISEK, Robert , VRECER, Franc , VRBINC, Miha
发明人： PAVLI, Matej , DREU, Rok , BAUMGARTNER, Sasa , PLANINSEK, Odon , PISEK, Robert , VRECER, Franc , VRBINC, Miha
IPC分类号： A61K9/20 , A61K31/554
CPC分类号： A61K9/205 , A61K9/1641 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K31/554
摘要： In the present invention novel sustained release pharmaceutical composition is described comprising quetiapine and carrageenan.
摘要翻译：在本发明中，描述了包含喹硫平和角叉菜胶的新型缓释药物组合物。

3. 发明申请

WO2010030252A2 STERICALLY STABILISED DISPERSION OF A HYBRID INORGANIC- ORGANIC MATERIAL IN OIL AS A PREPARATION FOR PROTECTION AGAINST UV RAYS AND A PROCESS OF PREPARATION THEREOF 审中-公开
标题翻译：作为防紫外线防护的制剂及其制备方法，油中杂多无机有机材料的非均匀稳定化分散体
公开(公告)号：WO2010030252A2
公开(公告)日：2010-03-18
申请号：PCT/SI2009/000031
申请日：2009-07-20
申请人： KEMIJSKI INSTITUT , UKMAR, Tina , GODEC, Aljaz , MAVER, Uros , GENORIO, Bostjan , BELE, Marjan , PLANINSEK, Odon , GABERSCEK, Miran , JAMNIK, Janko
发明人： UKMAR, Tina , GODEC, Aljaz , MAVER, Uros , GENORIO, Bostjan , BELE, Marjan , PLANINSEK, Odon , GABERSCEK, Miran , JAMNIK, Janko
IPC分类号： A61K8/04 , A61K8/29 , A61Q17/04
CPC分类号： A61K8/29 , A61K8/0241 , A61K8/361 , A61K2800/623 , A61K2800/651 , A61Q17/04
摘要： The subject of the invention is a sterically stabilised dispersion of a hybrid inorganic-organic material in oil as a preparation for the protection against harmful effects of UV rays. The present invention refers to a new cosmetic material on the basis of composites of hybrid inorganic-organic coatings on TiO 2 nanocrystalline particles or another metallic oxide with increased dispersibility in organic vehicles and decreased formation of free radicals. The basic nanocrystalline particles of TiO 2 and the inorganic coating from the bridged silane are prepared by the sol-gel process. Molecules of an organic steric stabiliser are then covalently bound to the coating of the bridged silane, said stabiliser being selected from one of the following groups of compounds: higher fatty acids, linear polymers, cross-linked polymers, branched polymers and dendritic polymers. The presence of the steric stabiliser prevents the TiO 2 particles to agglomerate, improves dispersibility in organic vehicles, increases water resistance of the preparation and allows the use of high concentrations of oily suspensions that provide for a high factor of protection against harmful effects of UV rays.
摘要翻译：本发明的主题是作为防止紫外线有害影响的制剂的油中混合无机 - 有机材料的空间稳定的分散体。本发明涉及一种新的化妆品材料，其基于TiO 2纳米晶颗粒上的混合无机 - 有机涂层或在有机载体中具有增加的分散性的另一种金属氧化物的复合材料，并减少了自由基的形成。通过溶胶 - 凝胶法制备TiO 2的基本纳米晶粒和桥接硅烷的无机涂层。然后将有机空间稳定剂的分子共价结合到桥连硅烷的涂层上，所述稳定剂选自以下化合物之一：高级脂肪酸，线性聚合物，交联聚合物，支化聚合物和树枝状聚合物。空间稳定剂的存在防止TiO 2颗粒附聚，改善有机载体中的分散性，增加制剂的耐水性，并允许使用高浓度的油性悬浮液，其提供高的紫外线有害影响的保护因子。

4. 发明申请

WO2007114797A1 POROUS TABLETS FOR SUBSEQUENT FILLING WITH ACTIVE PHARMACEUTICAL INGREDIENT 审中-公开
标题翻译：用于后续充填活性药物成分的多孔片
公开(公告)号：WO2007114797A1
公开(公告)日：2007-10-11
申请号：PCT/SI2007/000013
申请日：2007-03-21
申请人： IGC Center d.o.o. , PLANINSEK, Odon
发明人： PLANINSEK, Odon
IPC分类号： A61K9/20
CPC分类号： A61K9/2095 , A61K9/2009 , A61K9/2018 , A61K9/2054
摘要： Bases of porous tablets for subsequent filling with active pharmaceutical ingredient are made with known processes and are composed only of excipients used in pharmacy that are not soluble in organic solvents, in contact with these solvent do not disintegrate, and are then filled by use of organic solvent solution of active pharmaceutical ingredient and then dried. Excipients are lactose and/or SiO 2 and/or with SiO 2 modified microcrystalline cellulose in different proportions. Organic solvents in which active pharmaceutical ingredient is dissolved are heptane, isobutyl acetate, isopropyl acetate, methyl acetate, 3-methyl -1-butanol, methylethylketone, methylisobutylketone, 2-methyl-l-propanol, pentane, 1/pentanol, 1- propanol, 2-propanol, propyl acetate, acetic acid, acetone, anisole, 1-butanol, 2-butanol, buthyl acetate, tert-butylmethyl ether, cumene, dimethyl sulphoxide, ethanol, ethyl acetate, ethyl ether, ethyl formate, formic acid, acetonitrile, chlorobenzene, chloroform, cyclohexane 1,2- dichloroethene, dichloromethane, 1,2-dimetoxyethane, N,N-dimethylacetamide, N5N- dimethylformamide, 1,4-dioxane, 2-etoxyethanol, ethyleneglycol, formamide, hexane, methanol, 2-methohyethanol, methylcyclohexane, N-methylpzrrolidone, nitromethane, pyridine, tetrahydrofuran, toluene, xylene or mixtures of two or more of these listed liquids Tablet bases are immersed into surplus of organic solution of active pharmaceutical ingredient. This solution can be added into each tablet separately usindg appropriate dosing device preferentially pipette in the way that tablet absorbs whole amount of solution added.
摘要翻译：用于随后用活性药物成分填充的多孔片剂的基底是用已知方法制备的，并且仅由药剂中不溶于有机溶剂的赋形剂组成，与这些溶剂接触不分解，然后通过使用有机物溶剂溶液，然后干燥。赋形剂是不同比例的乳糖和/或SiO 2和/或SiO 2修饰的微晶纤维素。溶解活性药物成分的有机溶剂为庚烷，乙酸异丁酯，乙酸异丙酯，乙酸甲酯，3-甲基-1-丁醇，甲基乙基酮，甲基异丁基酮，2-甲基-1-丙醇，戊烷，1 /戊醇，1-丙醇，2-丙醇，乙酸丙酯，乙酸，丙酮，苯甲醚，1-丁醇，2-丁醇，乙酸丁酯，叔丁基甲基醚，枯烯，二甲基亚砜，乙醇，乙酸乙酯，乙醚，甲酸乙酯，甲酸，乙腈，氯苯，氯仿，环己烷1,2-二氯乙烯，二氯甲烷，1,2-二甲氧基乙烷，N，N-二甲基乙酰胺，N，N-二甲基甲酰胺，1,4-二恶烷，2-乙氧基乙醇，乙二醇，甲酰胺，己烷，甲醇，甲基环己烷，N-甲基吡咯烷酮，硝基甲烷，吡啶，四氢呋喃，甲苯，二甲苯或这些列出的液体中的两种或更多种的混合物片剂基底浸入过量的活性药物成分的有机溶液中。该溶液可以分别加入每个片剂中，以适当的剂量装置优先移液，以片剂吸收全部溶液的方式吸收。

5. 发明授权

EP2262486B1 QUETIAPINE COMPOSITION 有权
标题翻译：奎组成
公开(公告)号：EP2262486B1
公开(公告)日：2013-01-02
申请号：EP09777586.0
申请日：2009-07-31
申请人： KRKA, Tovarna Zdravil, D.D., Novo Mesto
发明人： PAVLI, Matej , DREU, Rok , BAUMGARTNER, Sasa , PLANINSEK, Odon , PISEK, Robert , VRECER, Franc , VRBINC, Miha
IPC分类号： A61K9/20 , A61K31/554
CPC分类号： A61K9/205 , A61K9/1641 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K31/554

6. 发明公开

EP2355804A1 QUETIAPINE COMPOSITION 审中-公开
标题翻译：奎ZUSAMMENSETZUNG
公开(公告)号：EP2355804A1
公开(公告)日：2011-08-17
申请号：EP09771502.3
申请日：2009-11-26
申请人： KRKA
发明人： PAVLI, Matej , ZADNIK, Jernej , VRECER, Franc , PISEK, Robert , BAUMGARTNER, Sasa , DREU, Rok , PLANINSEK, Odon
IPC分类号： A61K9/20 , A61K31/554
CPC分类号： A61K9/2027 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/554
摘要： Pharmaceutical composition comprising a solid matrix system of quetiapine or its salt and a nonswellable anionic polymer.

7. 发明公开

EP2262486A1 QUETIAPINE COMPOSITION 有权
标题翻译： QUETIAPIN-ZUSAMMENSETZUNG
公开(公告)号：EP2262486A1
公开(公告)日：2010-12-22
申请号：EP09777586.0
申请日：2009-07-31
申请人： KRKA, tovarna zdravil, d.d., Novo mesto
发明人： PAVLI, Matej , DREU, Rok , BAUMGARTNER, Sasa , PLANINSEK, Odon , PISEK, Robert , VRECER, Franc , VRBINC, Miha
IPC分类号： A61K9/20 , A61K31/554
CPC分类号： A61K9/205 , A61K9/1641 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K31/554
摘要： In the present invention novel sustained release pharmaceutical composition is described comprising quetiapine and carrageenan.
摘要翻译：在本发明中，描述了包含喹硫平和角叉菜胶的新型缓释药物组合物。

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