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1. 发明申请

WO2007114797A1 POROUS TABLETS FOR SUBSEQUENT FILLING WITH ACTIVE PHARMACEUTICAL INGREDIENT 审中-公开
标题翻译：用于后续充填活性药物成分的多孔片
公开(公告)号：WO2007114797A1
公开(公告)日：2007-10-11
申请号：PCT/SI2007/000013
申请日：2007-03-21
申请人： IGC Center d.o.o. , PLANINSEK, Odon
发明人： PLANINSEK, Odon
IPC分类号： A61K9/20
CPC分类号： A61K9/2095 , A61K9/2009 , A61K9/2018 , A61K9/2054
摘要： Bases of porous tablets for subsequent filling with active pharmaceutical ingredient are made with known processes and are composed only of excipients used in pharmacy that are not soluble in organic solvents, in contact with these solvent do not disintegrate, and are then filled by use of organic solvent solution of active pharmaceutical ingredient and then dried. Excipients are lactose and/or SiO 2 and/or with SiO 2 modified microcrystalline cellulose in different proportions. Organic solvents in which active pharmaceutical ingredient is dissolved are heptane, isobutyl acetate, isopropyl acetate, methyl acetate, 3-methyl -1-butanol, methylethylketone, methylisobutylketone, 2-methyl-l-propanol, pentane, 1/pentanol, 1- propanol, 2-propanol, propyl acetate, acetic acid, acetone, anisole, 1-butanol, 2-butanol, buthyl acetate, tert-butylmethyl ether, cumene, dimethyl sulphoxide, ethanol, ethyl acetate, ethyl ether, ethyl formate, formic acid, acetonitrile, chlorobenzene, chloroform, cyclohexane 1,2- dichloroethene, dichloromethane, 1,2-dimetoxyethane, N,N-dimethylacetamide, N5N- dimethylformamide, 1,4-dioxane, 2-etoxyethanol, ethyleneglycol, formamide, hexane, methanol, 2-methohyethanol, methylcyclohexane, N-methylpzrrolidone, nitromethane, pyridine, tetrahydrofuran, toluene, xylene or mixtures of two or more of these listed liquids Tablet bases are immersed into surplus of organic solution of active pharmaceutical ingredient. This solution can be added into each tablet separately usindg appropriate dosing device preferentially pipette in the way that tablet absorbs whole amount of solution added.
摘要翻译：用于随后用活性药物成分填充的多孔片剂的基底是用已知方法制备的，并且仅由药剂中不溶于有机溶剂的赋形剂组成，与这些溶剂接触不分解，然后通过使用有机物溶剂溶液，然后干燥。赋形剂是不同比例的乳糖和/或SiO 2和/或SiO 2修饰的微晶纤维素。溶解活性药物成分的有机溶剂为庚烷，乙酸异丁酯，乙酸异丙酯，乙酸甲酯，3-甲基-1-丁醇，甲基乙基酮，甲基异丁基酮，2-甲基-1-丙醇，戊烷，1 /戊醇，1-丙醇，2-丙醇，乙酸丙酯，乙酸，丙酮，苯甲醚，1-丁醇，2-丁醇，乙酸丁酯，叔丁基甲基醚，枯烯，二甲基亚砜，乙醇，乙酸乙酯，乙醚，甲酸乙酯，甲酸，乙腈，氯苯，氯仿，环己烷1,2-二氯乙烯，二氯甲烷，1,2-二甲氧基乙烷，N，N-二甲基乙酰胺，N，N-二甲基甲酰胺，1,4-二恶烷，2-乙氧基乙醇，乙二醇，甲酰胺，己烷，甲醇，甲基环己烷，N-甲基吡咯烷酮，硝基甲烷，吡啶，四氢呋喃，甲苯，二甲苯或这些列出的液体中的两种或更多种的混合物片剂基底浸入过量的活性药物成分的有机溶液中。该溶液可以分别加入每个片剂中，以适当的剂量装置优先移液，以片剂吸收全部溶液的方式吸收。

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