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1. 发明申请

WO2006066147A2 AMBRUTICIN VS COMPOUNDS 审中-公开
标题翻译： AMBRUTICIN VS化合物
公开(公告)号：WO2006066147A2
公开(公告)日：2006-06-22
申请号：PCT/US2005045806
申请日：2005-12-16
申请人： KOSAN BIOSCIENCES INC , TIAN ZONG-QIANG , MYLES DAVID C , WANG ZHAN , XU YUAN , JULIEN BRYAN , RODRIGUEZ EDUARDO , SHIMAZU MARK , BUCHANAN GREG O , KATZ LEONARD
发明人： TIAN ZONG-QIANG , MYLES DAVID C , WANG ZHAN , XU YUAN , JULIEN BRYAN , RODRIGUEZ EDUARDO , SHIMAZU MARK , BUCHANAN GREG O , KATZ LEONARD
IPC分类号： C07D307/20
CPC分类号： C07D309/14 , C07D309/22 , C07D405/06 , C07D405/12 , C07D407/08 , C07D407/12 , C07D417/12
摘要： Antifungal compounds represented by formula I where R 1 , R 2 , R 3 and R 4 are as defined herein. Isolated or purified naturally occurring 20,21-dihydro ambruticin compounds. The invention also provides Sorangium cellulosum
摘要翻译：由式I表示的抗真菌化合物，其中R 1，R 2，R 3和R 4如本文所定义。分离或纯化的天然存在的20,21-二氢氨苄青霉素化合物。本发明还提供了丝兰纤维素

2. 发明公开

EP1885243A4 METHODS AND APPARATUS FOR IMAGING WITH MAGNETIC INDUCTION 审中-公开
标题翻译：方法及装置与磁感应成像
公开(公告)号：EP1885243A4
公开(公告)日：2014-05-21
申请号：EP06759547
申请日：2006-05-10
申请人： UNIV MINNESOTA , HE BIN , XU YUAN , LI XU
发明人： HE BIN , XU YUAN , LI XU
IPC分类号： A61B5/00 , A61B8/00 , G01R33/48
CPC分类号： G01R33/4808 , A61B5/0093 , A61B8/00

3. 发明专利

CA2902122A1 IMPROVED SYNTHETIC APERTURE IMAGING METHODS AND SYSTEMS 未知
公开(公告)号：CA2902122A1
公开(公告)日：2016-03-01
申请号：CA2902122
申请日：2015-08-31
申请人： XU YUAN , KOLIOS MICHAEL C , GONG PING , LI YING
发明人： XU YUAN , KOLIOS MICHAEL C , GONG PING , LI YING
IPC分类号： G01S13/90
摘要： The invention generally relates to the field of synthetic aperture imaging. In particular, the invention relates to systems and methods for generating synthetic transmit aperture ("STA") signals and processing synthetic aperture imaging ("SAI") signals for improved signal-to-noise ratio ("SNR") and spatial resolution. This generally relates to a method to improve the signal-noise-ratio (SNR) of array signals by both encoding the transmission from multiple array elements with waveform modifications and time delays and encoding the receivers into output channels and decoding the measured signals at the selected output channels to estimate the equivalent received signals of a receiver as if only one transmitting element were fired individually in each transmission event. SAI techniques are subsequently applied to the equivalent SAI signals to obtain improved images.

4. 发明申请

WO2012118675A3 WETTABLE SILICONE HYDROGEL CONTACT LENSES 审中-公开
标题翻译：可湿式水胶接触镜
公开(公告)号：WO2012118675A3
公开(公告)日：2014-04-24
申请号：PCT/US2012026215
申请日：2012-02-23
申请人： COOPERVISION INT HOLDING CO LP , LIU YUWEN , CHEN CHARLIE , FRANCIS CHARLES A , GE JUNHAO , XU YUAN , YAO LI , BACK ARTHUR , ZHENG YING
发明人： LIU YUWEN , CHEN CHARLIE , FRANCIS CHARLES A , GE JUNHAO , XU YUAN , YAO LI , BACK ARTHUR , ZHENG YING
IPC分类号： C08G77/04 , G02C7/04
CPC分类号： G02C7/04 , B65B5/04 , G02B1/043 , C08L83/12 , C08L33/08 , C08L33/10
摘要： Ophthalmic ally acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (I): wherein m, n, R1 and R2 are as defined herein, the first siloxane monomer having a number average molecular weight of from 400 daltons to 700 daltons; and a second siloxane monomer having a number average molecular weight greater than 7,000 daltons; wherein a total amount of siloxane monomers present in the polymerizable composition is from 30 unit parts to 50 unit parts; the lenses also include units derived from at least one hydrophilic amide monomer having one N-vinyl group that is present in the polymerizable composition in an amount from 30 to 60 unit parts. The lenses have ophthalmically acceptably wettable lens surfaces when fully hydrated.
摘要翻译：描述了眼科盟友可接受的可湿性硅氧水凝胶隐形眼镜。透镜衍生自包含由式（I）表示的第一硅氧烷单体的可聚合组合物：其中m，n，R 1和R 2如本文所定义，第一硅氧烷单体的数均分子量为400道尔顿至700道尔顿 ; 和数均分子量大于7,000道尔顿的第二硅氧烷单体; 其中存在于聚合性组合物中的硅氧烷单体的总量为30单位份〜50单位份; 透镜还包括衍生自至少一种具有一个N-乙烯基的亲水性酰胺单体的单元，该单体存在于可聚合组合物中的量为30至60单位份。当完全水合时，镜片具有眼科可接受的可润湿透镜表面。

5. 发明公开

EP1831204A4 AMBRUTICIN VS COMPOUNDS 审中-公开
标题翻译： Ambruticin VS CONNECTIONS
公开(公告)号：EP1831204A4
公开(公告)日：2009-10-21
申请号：EP05854506
申请日：2005-12-16
申请人： KOSAN BIOSCIENCES INC
发明人： TIAN ZONG-QIANG , MYLES DAVID C , WANG ZHAN , XU YUAN , JULIEN BRYAN , RODRIGUEZ EDUARDO , SHIMAZU MARK , BUCHANAN GREG O , KATZ LEONARD
IPC分类号： C07D407/08 , A61K31/351 , C12N1/21 , C12P17/06
CPC分类号： C07D309/14 , C07D309/22 , C07D405/06 , C07D405/12 , C07D407/08 , C07D407/12 , C07D417/12

6. 发明申请

WO2012118684A3 SILICONE HYDROGEL CONTACT LENSES 审中-公开
标题翻译：硅胶水镜接触镜
公开(公告)号：WO2012118684A3
公开(公告)日：2013-12-12
申请号：PCT/US2012026228
申请日：2012-02-23
申请人： COOPERVISION INT HOLDING CO LP , LIU YUWEN , HONG YE , GE JUNHAO , XU YUAN , CHEN CHARLIE , FRANCIS CHARLES A , YAO LI , BACK ARTHUR
发明人： LIU YUWEN , HONG YE , GE JUNHAO , XU YUAN , CHEN CHARLIE , FRANCIS CHARLES A , YAO LI , BACK ARTHUR
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , C08F226/00 , C08F236/20 , C08F283/065 , C08F283/126 , C08J11/02 , C08L51/085 , C08L83/04 , C08L101/14
摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including a first siloxane monomer represented by formula (3): wherein m of formula (3) represents one integer from 3 to 10, n of formula (3) represents one integer from 1 to 10, R1 of formula (3) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (3) is independently either a hydrogen atom or a methyl group; and at least one vinyl ether-containing cross-linking agent are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described. In one example, the batches of silicone hydrogel contact lenses are dimensionally stable, and the method of making is a method of making dimensionally stable silicone hydrogel contact lenses.
摘要翻译：衍生自包含由式（3）表示的第一硅氧烷单体的可聚合组合物的聚合性组合物的硅氧水凝胶隐形眼镜：式（3）的m表示3〜10的整数，式（3）的n表示1〜 10，式（3）的R 1为碳原子数1〜4的烷基，式（3）的各R 2独立地为氢原子或甲基。和至少一种含乙烯基醚的交联剂。还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。在一个示例中，硅胶水凝胶隐形眼镜的批次是尺寸稳定的，并且制造方法是制备尺寸稳定的硅酮水凝胶隐形眼镜的方法。

7. 发明申请

WO2012106121A3 FORMING A TEMPLATE WITH DISCRETE DOMAINS 审中-公开
标题翻译：形成具有离散域的模板
公开(公告)号：WO2012106121A3
公开(公告)日：2012-10-18
申请号：PCT/US2012021781
申请日：2012-01-18
申请人： SEAGATE TECHNOLOGY LLC , XU YUAN , LEE KIM Y , HU WEI , WAGO KOICHI , KUO DAVID S , CHAUHAN SUNDEEP
发明人： XU YUAN , LEE KIM Y , HU WEI , WAGO KOICHI , KUO DAVID S , CHAUHAN SUNDEEP
IPC分类号： G11B5/62
CPC分类号： G11B5/84 , G11B5/746 , G11B5/855 , Y10T428/24479 , Y10T428/24802
摘要： A method for nano-patterning includes imprinting features in a resist with an imprint mold to form one or more topographic surface patterns on the imprinted resist. A block copolymer ("BCP") material is deposited on the imprinted resist, wherein a molecular dimension Lo of the BCP material correlates by an integer multiple to a spacing dimension of the one or more topographic surface patterns on the imprinted resist. The deposited BCP is annealed and at least a portion of the annealed BCP is removed, forming a template having discrete domains.
摘要翻译：纳米图案的方法包括在抗蚀剂中用压印模具压印特征以在印刷抗蚀剂上形成一个或多个形貌表面图案。在印刷抗蚀剂上沉积嵌段共聚物（“BCP”）材料，其中BCP材料的分子尺寸Lo与印迹抗蚀剂上的一个或多个形貌表面图案的间隔尺寸相关。将沉积的BCP退火，并且去除退火的BCP的至少一部分，形成具有离散区域的模板。

8. 发明申请

WO2012118685A8 SILICONE HYDROGEL CONTACT LENSES 审中-公开
标题翻译：硅胶水镜接触镜
公开(公告)号：WO2012118685A8
公开(公告)日：2013-01-31
申请号：PCT/US2012026230
申请日：2012-02-23
申请人： COOPERVISION INT HOLDING CO LP , LIU YUWEN , CHEN CHARLIE , GE JUNHAO , ZHENG YING , XU YUAN , YAO LI , BACK ARTHUR
发明人： LIU YUWEN , CHEN CHARLIE , GE JUNHAO , ZHENG YING , XU YUAN , YAO LI , BACK ARTHUR
IPC分类号： B65B55/02 , G02C7/04
CPC分类号： G02B1/043 , C08L51/085 , C08L83/04 , C08L101/14
摘要： Silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including 30-60 unit parts by weight of a hydrophilic monomer(s) having one N-vinyl group; 1 to 30 unit parts by weight of a first siloxane monomer component comprising a siloxane monomer of formula (1) as described herein or a siloxane monomer of formula (2) as described herein or a siloxane monomer of formula (3) as described herein or any combination thereof; and 10 to 39 unit parts by weight of a second siloxane monomer component comprising 3-[tris (trimethylsilyloxy) silyl] propyl methacrylate (TRIS), or MCS-M11, or both; where the polymerizable composition is free of ?,?-dimethylacrylamide (DMA); and a total amount of siloxane monomers present in the polymerizable composition is from 15 to 40 unit parts by weight. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.
摘要翻译：描述了硅酮水凝胶隐形眼镜。透镜衍生自包含30-60单位重量份具有一个N-乙烯基的亲水性单体的可聚合组合物; 1至30单位重量份的包含本文所述的式（1）的硅氧烷单体的第一硅氧烷单体组分或如本文所述的式（2）的硅氧烷单体或本文所述的式（3）的硅氧烷单体或式其任何组合; 和10至39单位重量份的包含3- [三（甲硅烷基氧基）甲硅烷基]丙基丙烯酸酯（TRIS）或MCS-M11的第二硅氧烷单体组分或两者; 其中可聚合组合物不含α，α-二甲基丙烯酰胺（DMA）; 存在于聚合性组合物中的硅氧烷单体的总量为15〜40单位份。还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

9. 发明申请

WO2012118686A2 SILICONE HYDROGEL CONTACT LENSES 审中-公开
标题翻译：硅胶水镜接触镜
公开(公告)号：WO2012118686A2
公开(公告)日：2012-09-07
申请号：PCT/US2012026231
申请日：2012-02-23
申请人： COOPERVISION INT HOLDING CO LP , CHEN CHARLIE , LIU YUWEN , XU YUAN , ZHENG YING , GE JUNHAO , YAO LI , BACK ARTHUR
发明人： CHEN CHARLIE , LIU YUWEN , XU YUAN , ZHENG YING , GE JUNHAO , YAO LI , BACK ARTHUR
IPC分类号： B65B55/02 , G02C7/04
CPC分类号： G02B1/043 , C08L51/085 , C08L83/04 , C08L101/14
摘要： Silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including 30-60 unit parts by weight of a hydrophilic monomer(s) having one N-vinyl group, 10 to 50 unit parts by weight of 2-hydroxyethyl methacrylate (HEMA), and a first siloxane monomer component comprising a siloxane monomer of formula (1) as described herein or a siloxane monomer of formula (2) as described herein or a siloxane monomer of formula (3) as described herein or any combination thereof, where the total amount of siloxane monomer(s) present in the polymerizable composition is from 15 to 40 unit parts by weight. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.
摘要翻译：描述了硅酮水凝胶隐形眼镜。透镜衍生自可聚合组合物，其包含30-60单位重量份的具有一个N-乙烯基的亲水性单体，10-50单位重量份的甲基丙烯酸2-羟乙酯（HEMA）和第一个硅氧烷单体组分，其包含本文所述的式（1）的硅氧烷单体或本文所述的式（2）的硅氧烷单体或本文所述的式（3）的硅氧烷单体或其任何组合，其中硅氧烷单体的总量存在于聚合性组合物中的重量比为15〜40单位份。还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

10. 发明申请

WO2007002293A3 AZAINDAZOLE COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：阿扎达唑化合物和使用方法
公开(公告)号：WO2007002293A3
公开(公告)日：2007-03-08
申请号：PCT/US2006024313
申请日：2006-06-22
申请人： CHEMOCENTRYX INC , ZHANG PENGLIE , PENNELL ANDREW M K , WRIGHT JOHN J KIM , CHEN WEI , LELETI MANMOHAN R , LI YANDONG , LI LIANFA , XU YUAN
发明人： ZHANG PENGLIE , PENNELL ANDREW M K , WRIGHT JOHN J KIM , CHEN WEI , LELETI MANMOHAN R , LI YANDONG , LI LIANFA , XU YUAN
IPC分类号： A61K31/496 , C07D487/06
CPC分类号： C07D487/04 , C07D471/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要翻译：提供的化合物作为CCR1受体的强效拮抗剂，并具有体内抗炎活性。这些化合物通常是芳基哌嗪衍生物并且可用于药物组合物，治疗CCR1介导的疾病的方法以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。

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