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1. 发明申请

WO2009093872A3 NOVEL DIAMINE COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCERS CONTAINING SAME 审中-公开
标题翻译：新型DIAMINE化合物或其药学上可接受的盐，其制备方法和用于治疗含有其的癌症的药物组合物
公开(公告)号：WO2009093872A3
公开(公告)日：2009-11-05
申请号：PCT/KR2009000375
申请日：2009-01-23
申请人： KOREA RES INST OF BIOSCIENCE , SEOUL PHARMA CO LTD , IND ACADEMIC COOP , HAN GYOONHEE , YANG JEE SUN , NAM MIHEE , LEE CHUL HO , SONG DOONA , WON MISUN , CHUNG KYUNG-SOOK , KIM DONG-MYUNG , YOO HYANG-SOOK , KIM HWAN MOOK , PARK SONG-KYU , LEE KIHO , LEE CHANG WOO , KO WONJIN , RYOO BYUNG-HWAN , CHOI NAM-SONG , JEONG YONG-MI
发明人： HAN GYOONHEE , YANG JEE SUN , NAM MIHEE , LEE CHUL HO , SONG DOONA , WON MISUN , CHUNG KYUNG-SOOK , KIM DONG-MYUNG , YOO HYANG-SOOK , KIM HWAN MOOK , PARK SONG-KYU , LEE KIHO , LEE CHANG WOO , KO WONJIN , RYOO BYUNG-HWAN , CHOI NAM-SONG , JEONG YONG-MI
IPC分类号： C07C211/62
CPC分类号： C07C311/05 , C07C233/36 , C07C233/43 , C07C311/08
摘要： The present invention relates to a novel diamine compound or pharmaceutically acceptable salts thereof, method for preparing same, and a pharmaceutical composition for treating cancers containing same. The compound of the present invention exhibits superior effects of suppressing growth of tumor cells, and therefore can be valuable in treating cancer disease.
摘要翻译：本发明涉及新型二胺化合物或其药学上可接受的盐，其制备方法和用于治疗含有其的癌症的药物组合物。本发明的化合物表现出抑制肿瘤细胞生长的优异效果，因此在治疗癌症方面是有价值的。

2. 发明申请

WO2012053787A3 ARYLOXY PHENOXY ACRYLIC COMPOUND HAVING HIF-1 INHIBITION ACTIVITY, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：具有HIF-1抑制活性的芳氧基苯氧基丙烯酸化合物，其制备方法以及含有该化合物作为活性成分的药物组合物
公开(公告)号：WO2012053787A3
公开(公告)日：2012-07-26
申请号：PCT/KR2011007710
申请日：2011-10-17
申请人： KOREA RES INST OF BIOSCIENCE , UNIV DONGGUK IND ACAD COOP , LEE KYEONG , WON MI SUN , KIM HWAN MOOK , PARK SONG KYU , LEE KIHO , LEE KI HOON , LEE CHANG WOO , LEE JUNG JOON , CHUNG KYUNG SOOK , KIM BO KYUNG , JIN YINGLAN , LEE SEUNG-HEE
发明人： LEE KYEONG , WON MI SUN , KIM HWAN MOOK , PARK SONG KYU , LEE KIHO , LEE KI HOON , LEE CHANG WOO , LEE JUNG JOON , CHUNG KYUNG SOOK , KIM BO KYUNG , JIN YINGLAN , LEE SEUNG-HEE
IPC分类号： C07C235/38 , A61K31/167 , A61P35/00 , C07C231/02
CPC分类号： A61K31/5375 , A61K9/0019 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/167 , A61K31/196 , A61K31/24 , A61K31/34 , A61K31/40 , A61K31/417 , A61K31/4409 , C07C233/07 , C07C235/28 , C07C311/16 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D295/088
摘要： The present invention relates to a compound having HIF-1 inhibition activity, to a method for preparing same, and to a pharmaceutical composition containing same as an active ingredient. The compound of the present invention exhibits anticancer activity by inhibiting the activity of HIF-1, which is a transcription factor that plays a significant role in cancer cell growth and metastasis, and does not indicate non-selective, cytotoxic anti-tumour activity. Accordingly, the compound or a pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumours such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
摘要翻译：本发明涉及具有HIF-1抑制活性的化合物，其制备方法，以及含有该化合物作为有效成分的药物组合物。本发明化合物通过抑制作为在癌细胞生长和转移中起重要作用的转录因子HIF-1的活性而显示出抗癌活性，并且不表示非选择性的细胞毒性抗肿瘤活性。因此，本发明的化合物或其药学上可接受的盐可以抑制HIF-1活性，因此可以用作结肠癌，肝癌，胃癌，乳癌等实体瘤的治疗剂。另外，根据本发明的化合物或其药学上可接受的盐可以用作用于糖尿病性视网膜病或关节炎的治疗剂的活性成分，其在HIF-1引起的低氧诱导的VEGF表达增加时可能变得更差。

3. 发明申请

WO2010140835A3 NOVEL PYRIDONE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PRODUCING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR TREATING CANCER 审中-公开
标题翻译：新颖的吡咯烷酮化合物或其药学上可接受的盐，其生产方法和含有其的药物组合物用于治疗癌症
公开(公告)号：WO2010140835A3
公开(公告)日：2011-03-24
申请号：PCT/KR2010003539
申请日：2010-06-01
申请人： UNIV YONSEI IACF , KOREA RES INST OF BIOSCIENCE , BIORUNX , HAN GYOONHEE , CHOI EUNHYUN , LEE CHULHO , PARK JUNG EUN , CHO MISUN , SEO JEONGJEA , KIM HWAN MOOK , PARK SONG KYU , LEE KIHO , LEE CHANG WOO , LEE KI HOON , KIM HYUN-JUNG
发明人： HAN GYOONHEE , CHOI EUNHYUN , LEE CHULHO , PARK JUNG EUN , CHO MISUN , SEO JEONGJEA , KIM HWAN MOOK , PARK SONG KYU , LEE KIHO , LEE CHANG WOO , LEE KI HOON , KIM HYUN-JUNG
IPC分类号： C07D211/34 , C07D211/74
CPC分类号： C07D213/64 , C07D401/06 , C07D405/06 , C07D409/06
摘要： The present invention relates to novel pyridone compounds or pharmaceutically acceptable salts thereof, a method for producing the same and a pharmaceutical composition containing the same for treating cancer. The compounds according to the present invention utilize the superior effects of the RUNX activity found in the HDAC inhibitor for inhibiting tumor cell growth, and are thus useful for treating cancer.
摘要翻译：本发明涉及新颖的吡啶酮化合物或其药学上可接受的盐，其制备方法和含有其的治疗癌症的药物组合物。根据本发明的化合物利用HDAC抑制剂中发现的RUNX活性的优异效果来抑制肿瘤细胞生长，因此可用于治疗癌症。

4. 发明申请

WO2010016675A3 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING INFLAMMATORY DISEASES CONTAINING EXTRACTS OF THE IMMATURE FRUIT OF RHUS SUCCEDANEA AS ACTIVE INGREDIENTS 审中-公开
标题翻译：用于预防和治疗含有作为活性成分的芸苔属植物提取物的炎症性疾病的药物组合物
公开(公告)号：WO2010016675A3
公开(公告)日：2010-05-14
申请号：PCT/KR2009004187
申请日：2009-07-28
申请人： KOREA RES INST OF BIOSCIENCE , KIM HWAN MOOK , KANG JONG SOON , PARK SONG-KYU , LEE KIHO , LEE KI HOON , LEE CHANG WOO
发明人： KIM HWAN MOOK , KANG JONG SOON , PARK SONG-KYU , LEE KIHO , LEE KI HOON , LEE CHANG WOO
IPC分类号： A61K36/22 , A23L33/00 , A61K35/00 , A61K36/00
CPC分类号： A61K36/22
摘要： The present invention relates to an anti-inflammatory composition containing extracts of the immature fruit of Rhus succedanea as active ingredients. The extracts of the immature fruit of Rhus succedanea of the present invention exhibit anti-inflammatory effects through inhibiting the generation of nitrogen oxide (NO), inhibiting the expression of inducible nitric oxide synthase (iNOS), and inhibiting the activity and the expression inhibition activity of interleukin-1ß(IL-1ß) which is pro-inflammatory cytokine, and has no cytotoxicity. Therefore, the present invention can be valuably used in medicines for preventing and treating inflammatory diseases, in health food, or in functional feed.
摘要翻译：本发明涉及含有作为有效成分的玫瑰果的未成熟果实的提取物的抗炎组合物。本发明的苦参碱的未成熟果实的提取物通过抑制氮氧化物（NO）的产生，抑制诱导型一氧化氮合酶（iNOS）的表达，抑制活性和表达抑制活性而表现出抗炎作用的白介素-1β（IL-1β），其是促炎细胞因子，并且没有细胞毒性。因此，本发明可以有效地用于预防和治疗炎性疾病，保健食品或功能性饲料中的药物。

5. 发明申请

WO2007081091A8 RHODANDSE DERIVARIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：罗丹明衍生物，其制备方法和含有其的药物组合物
公开(公告)号：WO2007081091A8
公开(公告)日：2007-11-22
申请号：PCT/KR2006005343
申请日：2006-12-08
申请人： KOREA RES INST OF BIOSCIENCE , KOREA RES INST CHEM TECH , RYU SEONG EON , KIM SEUNG JUN , JEONG DAE GWIN , LEE SANG HYEUP , JUNG SUK KYEONG , KIM HWAN MOOK , PARK SONG KYU , LEE KI HO , LEE CHANG WOO , CHOI JOONG-KWON , AHN JIN HEE
发明人： RYU SEONG EON , KIM SEUNG JUN , JEONG DAE GWIN , LEE SANG HYEUP , JUNG SUK KYEONG , KIM HWAN MOOK , PARK SONG KYU , LEE KI HO , LEE CHANG WOO , CHOI JOONG-KWON , AHN JIN HEE
IPC分类号： C07D277/06 , A61K31/426 , A61P3/04 , A61P3/10 , A61P35/00
CPC分类号： C07D277/20 , C07D417/12
摘要： Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTPlB, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PPl and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity fliereof is modulated.
摘要翻译：本文公开了绕丹宁衍生物，其制备方法和含有它们的药物组合物。罗丹明衍生物对PTPlB，Prl-3，LAR，CD45，Cdc25A，Cdc25B，Cdc25C，Yop，PP1和VHR等蛋白磷酸酶（PPase）具有抑制活性，可用于预防和治疗PPase引起的疾病包括自身免疫疾病，糖尿病，葡萄糖不耐受受损，胰岛素抵抗，肥胖，癌症等。

6. 发明申请

WO2011043630A3 COMPOSITION FOR PREVENTING AND TREATING OBESITY DISEASES CONTAINING HIGHLY WATER-SOLUBLE 2-HYDROXYPROPYL-?-CYCLODEXTRIN AS ACTIVE INGREDIENT 审中-公开
公开(公告)号：WO2011043630A3
公开(公告)日：2011-10-13
申请号：PCT/KR2010006912
申请日：2010-10-08
申请人： SONG HO BIOMED CO LTD , HAN GYOON-HEE , CHOI YONG SEOK , HAN SANG-BAE , LEE JONG HO , KIM HWAN MOOK , PARK SONG-KYU , LEE KIHO , KANG JONG SOON , LEE KI HOON , LEE CHANG WOO
发明人： HAN GYOON-HEE , CHOI YONG SEOK , HAN SANG-BAE , LEE JONG HO , KIM HWAN MOOK , PARK SONG-KYU , LEE KIHO , KANG JONG SOON , LEE KI HOON , LEE CHANG WOO
IPC分类号： A61K31/724 , A61P3/00 , A61P3/04
CPC分类号： A61K31/724 , A23L29/35 , A23L33/10 , A23V2002/00 , A23V2200/328 , A23V2200/332 , A23V2250/5112
摘要： The present invention relates to a composition for preventing and treating obesity containing highly water-soluble ß-cyclodextrin derivatives as an active ingredient. More specifically, the composition containing highly water-soluble ß-cyclodextrin derivatives, particularly 2-hydroxypropyl-ß-cyclodextrin (HP-ß-CD, HPBCD), inhibits the weight increase induced by a high fat diet, inhibits appetite through the decrease of food intake, reduces body fat, reduces the weight of a liver, and remarkably inhibits the rapid increase of blood glucose induced by the intake of glucose and maltose on an empty stomach, thereby enabling helpful use for preventing and treating obesity, preventing and treating various diseases induced by obesity and inhibiting the rapid increase of blood sugar after meals.

7. 发明申请

WO2011043630A2 COMPOSITION FOR PREVENTING AND TREATING OBESITY DISEASES CONTAINING HIGHLY WATER-SOLUBLE 2-HYDROXYPROPYL-?-CYCLODEXTRIN AS ACTIVE INGREDIENT 审中-公开
标题翻译：用于预防和治疗含有高水溶性2-羟基丙酸 - β-环糊精作为活性成分的肥胖症的组合物
公开(公告)号：WO2011043630A2
公开(公告)日：2011-04-14
申请号：PCT/KR2010006912
申请日：2010-10-08
申请人： SONG HO BIOMED CO LTD , HAN GYOON-HEE , CHOI YONG SEOK , HAN SANG-BAE , LEE JONG HO , KIM HWAN MOOK , PARK SONG-KYU , LEE KIHO , KANG JONG SOON , LEE KI HOON , LEE CHANG WOO
发明人： HAN GYOON-HEE , CHOI YONG SEOK , HAN SANG-BAE , LEE JONG HO , KIM HWAN MOOK , PARK SONG-KYU , LEE KIHO , KANG JONG SOON , LEE KI HOON , LEE CHANG WOO
IPC分类号： A61K31/724 , A61P3/00 , A61P3/04
CPC分类号： A61K31/724 , A23L29/35 , A23L33/10 , A23V2002/00 , A23V2200/328 , A23V2200/332 , A23V2250/5112
摘要： The present invention relates to a composition for preventing and treating obesity containing highly water-soluble ß-cyclodextrin derivatives as an active ingredient. More specifically, the composition containing highly water-soluble ß-cyclodextrin derivatives, particularly 2-hydroxypropyl-ß-cyclodextrin (HP-ß-CD, HPBCD), inhibits the weight increase induced by a high fat diet, inhibits appetite through the decrease of food intake, reduces body fat, reduces the weight of a liver, and remarkably inhibits the rapid increase of blood glucose induced by the intake of glucose and maltose on an empty stomach, thereby enabling helpful use for preventing and treating obesity, preventing and treating various diseases induced by obesity and inhibiting the rapid increase of blood sugar after meals.
摘要翻译：本发明涉及用于预防和治疗含有高度水溶性β-环糊精衍生物作为活性成分的肥胖症的组合物。更具体地，含有高度水溶性的β-环糊精衍生物，特别是2-羟丙基-β-环糊精（HP-β-CD，HPBCD）的组合物抑制高脂肪饮食引起的体重增加，通过降低食物摄取，减少体脂肪，减轻肝脏的重量，并且显着抑制空腹时摄入葡萄糖和麦芽糖引起的血糖的快速增加，从而有助于预防和治疗肥胖症，预防和治疗各种各样的肥胖引起的疾病和饭后血糖快速增加。

8. 发明专利

CA2661131A1 NEW HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN ATOMS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR TREATMENT OF CANCER 未知
公开(公告)号：CA2661131A1
公开(公告)日：2008-02-14
申请号：CA2661131
申请日：2007-08-10
申请人： SEOUL PHARMA CO LTD , KOREA RES INST OF BIOSCIENCE
发明人： YANG JEE SUN , YOO HYANG SOOK , KIM DONG MYUNG , HONG SUNG HEE , CHOI EUN HYUN , HAN GYOON HEE , LEE CHANG WOO , CHOI YOUN WOONG , JEONG YONG MI , MIN BYUNG GU , CHUNG KYUNG SOOK , WON MI SUN , LEE KI HO , KIM HWAN MOOK , PARK SONG KYU , KIM MYUNG SOOK
IPC分类号： C07D295/185 , A61P35/00 , C07D241/04 , C07D243/08
摘要： The present invention relates to new heterocyclic compounds containing ni trogen atoms or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and a phar¬ maceutical composition comprising the same for treatment of cancer. The compounds according to the present invention i nduce DNA damage due to reactive oxygen species to activate c-abl and p53, i nduce RhoB to generate apoptosis, and induce cell death by down-regulating B cl2 involved in cell survival, which is generated by dysregulated signals vi a the mitochondria pathway, thereby inhibiting tumor cell growth and inducin g apoptosis. Accordingly, the composition according to the present invention can be used to treat cancer.

9. 发明公开

KR20070093574A PHARMACEUTICAL COMPOSITION COMPRISING SILYMARIN FOR PREVENTION AND TREATMENT OF IRRITANT CONTACT DERMATITIS 审中-公开
标题翻译：包含SILYMARIN的药物组合物用于预防和治疗刺激性接触剂量
公开(公告)号：KR20070093574A
公开(公告)日：2007-09-19
申请号：KR20060023580
申请日：2006-03-14
申请人： KOREA RES INST OF BIOSCIENCE
发明人： KIM HWAN MOOK , PARK SONG KYU , KANG JONG SOON , HAN MI HWA , LEE KI HO , HAN SANG BAE , LEE KI HOON , LEE CHANG WOO
IPC分类号： A61K31/357 , A61K8/49 , A61P17/00 , A61Q19/00
CPC分类号： A61K31/357
摘要： A composition comprising silymarin is provided to inhibit irritant contact dermatitis by inhibiting increase of the thickness of ear, increase of the moisture content of the ear, increase of lymph node weight and expression of TNF-alpha. A pharmaceutical composition for preventing and treating irritant contact dermatitis comprises silymarin or main ingredients thereof such as silybin, silidianin and silicristin. The composition further comprises a pharmaceutically acceptable carrier, an excipient and a diluent. The functional cosmetics of irritant contact dermatitis comprises silymarin or main ingredients thereof such as silybin, silidianin and silicristin and is in the form of skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutritive lotion, massage cream, nutritive cream, moisture cream, hand cream, essence, nutritive essence, pack, soap, shampoo, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, emulsion, press powder, or loose powder.
摘要翻译：提供包含水飞蓟素的组合物，通过抑制耳朵的厚度增加，耳朵的水分含量增加，淋巴结重量的增加和TNF-α的表达来抑制刺激性接触性皮炎。用于预防和治疗刺激性接触性皮炎的药物组合物包括水飞蓟素或其主要成分，例如水飞蓟
宾，硅胶石和硅胶。组合物还包含药学上可接受的载体，赋形剂和稀释剂。刺激性接触性皮炎的功能性化妆品包括水飞蓟马或其主要成分，如水飞蓟宾，硅藻土和硅胶，并且是皮肤洗剂，皮肤柔软剂，皮肤调色剂，涩味剂，洗剂，乳液，湿润剂，营养洗剂，按摩膏，营养霜，护肤霜，护手霜，精华，营养精华，包装，肥皂，洗发水，清洁泡沫，清洁乳液，清洁霜，身体乳液，身体清洁剂，乳液，压粉或松散粉末。

10. 发明公开

KR20090040809A METHOD OF SCREENING APOPTOSIS INDUCING ANTICANCER REAGENTS USING RHOB PROMOTER REPORTER SYSTEM 有权
标题翻译：使用RHOB PROMOTER报告系统筛选诱导抗原试剂的方法
公开(公告)号：KR20090040809A
公开(公告)日：2009-04-27
申请号：KR20070106337
申请日：2007-10-22
申请人： KOREA RES INST OF BIOSCIENCE
发明人： WON MI SUN , CHUNG KYUNG SOOK , CHOI SHIN JUNG , PARK SU HYEON , KIM HWAN MOOK , PARK SONG KYU , HAN GYOON HEE , AHAN JI WON , SONG KYUNG BIN , LEE SEUNG GOO , HA JAE SEOK
IPC分类号： G01N33/48
摘要： A method of screening apoptosis-inducing anticancer reagents by using a RhoB promoter reporter system is provided to fine drug which inhibits the growth of tumor cell and induces the apoptosis, therefore, a therapeutic agent can be developed. A screening system of an improvement material of RhoB gene expression comprises (i) nucleotide encoding a RhoB promoter; and (ii) host cell which contains nucleotide encoding luciferase or cyanogen fluorescence protein(CFP) and is transformed to the plasmid which does not encode the other promoter or enhancers.
摘要翻译：提供了通过使用RhoB启动子报告系统筛选凋亡诱导抗癌试剂的方法，其抑制肿瘤细胞生长并诱导细胞凋亡的细菌，因此可以开发治疗剂。 RhoB基因表达改良材料的筛选系统包括（i）编码RhoB启动子的核苷酸; 和（ii）含有编码荧光素酶或氰基荧光蛋白（CFP）的核苷酸的宿主细胞，并转化到不编码其他启动子或增强子的质粒。

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