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1. 发明申请

WO2012053787A3 ARYLOXY PHENOXY ACRYLIC COMPOUND HAVING HIF-1 INHIBITION ACTIVITY, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：具有HIF-1抑制活性的芳氧基苯氧基丙烯酸化合物，其制备方法以及含有该化合物作为活性成分的药物组合物
公开(公告)号：WO2012053787A3
公开(公告)日：2012-07-26
申请号：PCT/KR2011007710
申请日：2011-10-17
申请人： KOREA RES INST OF BIOSCIENCE , UNIV DONGGUK IND ACAD COOP , LEE KYEONG , WON MI SUN , KIM HWAN MOOK , PARK SONG KYU , LEE KIHO , LEE KI HOON , LEE CHANG WOO , LEE JUNG JOON , CHUNG KYUNG SOOK , KIM BO KYUNG , JIN YINGLAN , LEE SEUNG-HEE
发明人： LEE KYEONG , WON MI SUN , KIM HWAN MOOK , PARK SONG KYU , LEE KIHO , LEE KI HOON , LEE CHANG WOO , LEE JUNG JOON , CHUNG KYUNG SOOK , KIM BO KYUNG , JIN YINGLAN , LEE SEUNG-HEE
IPC分类号： C07C235/38 , A61K31/167 , A61P35/00 , C07C231/02
CPC分类号： A61K31/5375 , A61K9/0019 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/167 , A61K31/196 , A61K31/24 , A61K31/34 , A61K31/40 , A61K31/417 , A61K31/4409 , C07C233/07 , C07C235/28 , C07C311/16 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D295/088
摘要： The present invention relates to a compound having HIF-1 inhibition activity, to a method for preparing same, and to a pharmaceutical composition containing same as an active ingredient. The compound of the present invention exhibits anticancer activity by inhibiting the activity of HIF-1, which is a transcription factor that plays a significant role in cancer cell growth and metastasis, and does not indicate non-selective, cytotoxic anti-tumour activity. Accordingly, the compound or a pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumours such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
摘要翻译：本发明涉及具有HIF-1抑制活性的化合物，其制备方法，以及含有该化合物作为有效成分的药物组合物。本发明化合物通过抑制作为在癌细胞生长和转移中起重要作用的转录因子HIF-1的活性而显示出抗癌活性，并且不表示非选择性的细胞毒性抗肿瘤活性。因此，本发明的化合物或其药学上可接受的盐可以抑制HIF-1活性，因此可以用作结肠癌，肝癌，胃癌，乳癌等实体瘤的治疗剂。另外，根据本发明的化合物或其药学上可接受的盐可以用作用于糖尿病性视网膜病或关节炎的治疗剂的活性成分，其在HIF-1引起的低氧诱导的VEGF表达增加时可能变得更差。

2. 发明专利

ES2653965T3 Nuevos compuestos como inhibidores de HIF-1alfa y proceso de fabricación de los mismos 未知
公开(公告)号：ES2653965T3
公开(公告)日：2018-02-09
申请号：ES12837558
申请日：2012-09-27
申请人： UNIV DONGGUK IND ACAD COOP , KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY
发明人： LEE KYEONG , WON MI SUN , KIM HWAN MOOK , PARK SONG KYU , LEE KI HO , LEE CHANG WOO , KIM BO KYUNG , BAN HYUN SEUNG , CHUNG KYUNG SOOK , RAVI NAIK
IPC分类号： C07C235/18 , A61K31/165 , A61K31/495 , A61K31/4985 , A61K31/5375 , A61P35/00 , C07C231/02 , C07C235/20 , C07C235/22 , C07D241/04 , C07D279/12 , C07D295/073 , C07D295/104 , C07D295/108 , C07D295/182 , C07D295/185 , C07D307/46 , C07D487/04
摘要： Un compuesto representado por la Fórmula I, o una sal, hidrato o solvato farmacéuticamente aceptable del mismo**Fórmula** en la que, R1 representa hidrógeno, metilo, fluoro o cloro; R2 representa hidrógeno o metilo; R3 representa, **Fórmula** Ra representa dimetilo, ciclopropilo, N,N-dimetilaminoetilo o 2-furanilmetilo; Rb representa hidrógeno, (S)-metilo o (R)-metilo; Rc representa hidrógeno, metilo, isopropilo, terc-butoxicarbonilo (Boc), 4-trifluorometilbencilo, hidroxietilo o propinilo; Rd representa **Fórmula** Re representa hidrógeno o hidroxilo; n representa 1, 2 o 3.

3. 发明公开

EP3053601A4 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING CANCER, CONTAINING CYB5R3 GENE OR PROTEIN AS ACTIVE INGREDIENT 有权转让
标题翻译： CYB5R3基因或蛋白质作为活性物质预防和治疗癌症的药物组合物
公开(公告)号：EP3053601A4
公开(公告)日：2016-08-10
申请号：EP14851311
申请日：2014-09-30
申请人： KOREA RES INST OF BIOSCIENCE
发明人： WON MI SUN , BAN HYUN SEUNG , KIM BO KYUNG , NAM SOON WOO , LEE KYEONG , LEE YOUNG-JU , LEE HONG-SUB , KIM DONG UK , PARK KI CHEOL , OH KYOUNG-JIN , IM JOO-YOUNG
IPC分类号： A61K48/00 , A61K38/16 , A61K38/17 , A61K38/44 , A61P35/00 , C12N9/02
CPC分类号： A61K38/44 , A61K48/005 , C12N7/00 , C12N9/004 , C12N2710/10043 , C12N2710/10071 , C12Y106/02002 , G01N33/57492 , G01N2333/90209

4. 发明申请

WO2012148181A3 COMPOSITION FOR THE CONTROLLED-RELEASE OF DRUGS 审中-公开
标题翻译：用于控制释放药物的组合物
公开(公告)号：WO2012148181A3
公开(公告)日：2012-12-20
申请号：PCT/KR2012003223
申请日：2012-04-26
申请人： KOREA UNITED PHARM INC , CHOI YOUN-WOONG , CHO SANG MIN , MIN BYUNG GU , PARK JIN HA , KIM BO KYUNG
发明人： CHOI YOUN-WOONG , CHO SANG MIN , MIN BYUNG GU , PARK JIN HA , KIM BO KYUNG
IPC分类号： A61K9/22 , A61K9/20 , A61K47/30 , A61K47/38
CPC分类号： A61K9/2054 , A61K9/2013 , A61K9/2027
摘要： The present invention relates to a composition for the controlled-release of drugs. More particularly, the composition for the controlled-release of drugs according to the present invention expands the capacity for the controlled-release of a matrix-type polymer for controlled-release via a carbomer in which said polymer for controlled-release forms a basic frame and in which sol-gel transition occurs in accordance with a pH level. The composition of the present invention is characterized in that it comprises: a solubilizing agent for the event the drug to be released is highly insoluble, and a disintegrating agent for sufficient initial release. The composition for the controlled-release of drugs according to the present invention uses a carbomer which maintains the controlled-release of conventional matrix structures having polymers for controlled-release and which has sol-gel transition properties, thus preventing a sudden release of a drug caused by a collapse of the matrix structure during a late stage of elution. In addition, the composition of the present invention uses a solubilizing agent to solve the problem of a highly insoluble drug failing to dissolve even after being released, and also uses a disintegrating agent to improve the speed of the initial release, which is the limiting factor in controlled-release preparations.
摘要翻译：本发明涉及用于药物控制释放的组合物。更具体地说，根据本发明的用于药物控制释放的组合物通过卡波姆扩大了用于控制释放的基质型聚合物的释放能力，其中所述控释聚合物形成基本框架并且其中根据pH水平发生溶胶 - 凝胶转变。本发明的组合物的特征在于，它包括：用于释放药物高度不溶性的增溶剂，以及用于充分初始释放的崩解剂。根据本发明的用于药物控制的组合物使用卡波姆，其维持具有用于控制释放的聚合物的常规基质结构的控制释放，并且具有溶胶 - 凝胶转变特性，从而防止药物的突然释放由洗脱后期的基体结构的崩溃引起的。此外，本发明的组合物使用增溶剂来解决即使在剥离后不能溶解的高度不溶性药物的问题，并且还使用崩解剂来提高初始释放的速度，这是限制因素在控释制剂中。

5. 发明公开

KR20180019011A 효과적인 마의 갈변방지 공정 审中-公开
标题翻译：防止薯Brown褐变反应的工艺
公开(公告)号：KR20180019011A
公开(公告)日：2018-02-22
申请号：KR20180010171
申请日：2018-01-26
申请人： KIM WON SOO , PARK JEONG SOO , KIM LEE KYUNG , KIM BO KYUNG
发明人： KIM WON SOO , PARK JEONG SOO , KIM BO KYUNG , KIM LEE KYUNG
IPC分类号： A23B7/10 , A23B7/154 , A23B7/157 , A23L3/3571 , A23L5/41 , A23L19/10
CPC分类号： Y02A40/943 , A23B7/10 , A23B7/154 , A23B7/157 , A23L3/3571 , A23L5/41 , A23L19/10 , A23V2002/00 , A23V2200/048 , A23V2200/06 , A23V2250/21 , A23V2300/38
摘要： 본발명은마의갈변방지공정에관한것으로, 보다상세하게는, 마의갈변방지를위한기능성첨가제조성물로마를처리하는갈변방지방법, 그리고, 효과적인갈변방지를위해전처리공정을더 포함하거나, 산미완화제를포함하여처리하는마의갈변방지방법에관한것이다. 본갈변방지공정에따르면, 마상태그대로장기보존, 보관, 저장을용이하게해주어다양한마의 2차가공을가능하게하는효과가있다.
摘要翻译：它涉及到本发明的褐变防止过程Eunma，更具体地，还包括用于褐变防止方法的预处理步骤，用于处理对于镇褐变预防功能性添加剂组合物，罗马和，有效褐变预防或包括酸度润肤本发明涉及防止大麻褐变的方法。根据抗褐变步骤，haejueo促进镇状态长期存储，存储和存储具有使得各种麻二次加工的效果。

6. 发明公开

KR20060020697A ANTOMATIC KEYBOARD 审中-公开
标题翻译： ANTOMATIC键盘
公开(公告)号：KR20060020697A
公开(公告)日：2006-03-06
申请号：KR20060007627
申请日：2006-01-25
申请人： KIM BO KYUNG
发明人： KIM BO KYUNG
IPC分类号： G06F3/02
CPC分类号： H03K3/64
摘要： 본 제품은 일반 키보드 상단에 설치되어 지정한 숫자나 글자를 반복적으로 눌러주는 장치로서 시간 조절이 가능하며 여러 개를 조합 하여 단어나 숫자를 일정한 시간에 반복 출력하도록 하게 하는 장치이다 별도의 프로그램 설치나 컴퓨터의 사향에 상관없이 어느 컴퓨터에서도 사용이 가능함으로 개인이나 산업체에서 컴퓨터로 특정한 작업 또는 온라인게임에서도 사용 할 수 있다
릴레이구동방법,오토키보드,자동키보드,반복입력,타이머키보드,

7. 发明公开

KR20180019010A 마의 갈변방지를 위한 기능성 조성물 审中-公开
标题翻译：为组成山药褐变反应预防
公开(公告)号：KR20180019010A
公开(公告)日：2018-02-22
申请号：KR20180010168
申请日：2018-01-26
申请人： KIM WON SOO , PARK JEONG SOO , KIM LEE KYUNG , KIM BO KYUNG
发明人： KIM WON SOO , PARK JEONG SOO , KIM BO KYUNG , KIM LEE KYUNG
IPC分类号： A23B7/14 , A01N3/00 , A23B7/08
CPC分类号： Y02A40/943 , A23B7/14 , A01N3/00 , A23B7/08 , A23V2200/048 , A23V2200/306 , A23V2200/328 , A23V2250/036 , A23V2250/6402 , A23V2250/6416 , A23V2250/6418 , A23V2250/642
摘要： 본발명은마의갈변방지를위한기능성첨가제조성물에관한것이다. 보다구체적으로, 당알코올, 유기산, 산도조절제및 복합추출물을유효성분으로포함하는마의갈변방지용조성물에관한것이다. 본기능성첨가제조성물은갈변방지기능을효과적으로발휘하면서도원료마 자체의형태와식감을최대한그대로유지하면서장기보관및 저장을용이하게해주어, 다양한형태로 2차가공을가능하게하는효과가있다.
摘要翻译：本发明涉及用于防止本发明Eunma的褐变的功能性添加剂组合物。更具体地说，本发明涉及包含糖醇，有机酸，所述pH控制剂和化合物提取物作为活性成分的抗褐变麻组合物。功能添加剂组合物，同时有效地发挥，同时保持尽可能的形状和原料本身的质地，镇防止褐变功能haejueo便于长期存储和存储，存在允许以各种形式的二次加工的效果。

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