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1. 发明申请

WO2009069064A1 IMPLANTABLE THERAPEUTIC SUBSTANCE DELIVERY DEVICE 审中-公开
标题翻译：可植入的治疗物质输送装置
公开(公告)号：WO2009069064A1
公开(公告)日：2009-06-04
申请号：PCT/IB2008/054922
申请日：2008-11-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , IORDANOV, Ventzeslav, P. , KRIJNSEN, Hendrika, C. , VAN BRUGGEN, Michel, P., B. , JANNER, Anna-Maria
发明人： IORDANOV, Ventzeslav, P. , KRIJNSEN, Hendrika, C. , VAN BRUGGEN, Michel, P., B. , JANNER, Anna-Maria
IPC分类号： A61M5/142 , F16H39/34
CPC分类号： A61M5/14276 , A61M5/14236 , A61M2005/1726 , A61M2205/3523 , F04C2/165 , F04C11/008 , F04C13/008
摘要： An implantable therapeutic substance delivery pump is typically implanted into a patient at a location appropriate for the therapy that interferes as little as practicable with patient activity such as subcutaneous in the lower abdomen. The invention refers to an implantable therapeutic substance delivery device (1) comprising a therapeutic substance reservoir (3), and a pump (4) configured to pump a therapeutic substance from the reservoir to an outlet (22). The pump has a power rotor (41) and two parallel idler rotors (42) adjacent to the power rotor. The idler rotors have screw threads which intermesh with a screw thread (43) in the power rotor wherein the idler rotors and power rotor are encased in an enclosure (51) dimensioned to allow axial rotation of the rotors.
摘要翻译：植入式治疗物质输送泵通常植入适合于治疗的位置处的患者中，该位置尽可能少地干扰患者活动，例如在下腹部皮下。本发明涉及包括治疗物质储存器（3）的可植入治疗物质输送装置（1）和构造成将治疗物质从储存器泵送到出口（22）的泵（4）。泵具有与动力转子相邻的动力转子（41）和两个平行惰轮转子（42）。空转转子具有与动力转子中的螺纹（43）相互啮合的螺纹，其中惰轮转子和动力转子被封装在尺寸适于允许转子轴向旋转的外壳（51）中。

2. 发明申请

WO2008044186A2 ENVIRONMENTAL STATE DETECTION WITH HYDROGEL BASED FULLY INTEGRATED TRANSDUCER DEVICE 审中-公开
标题翻译：基于氢化物的全集成传感器设备的环境状态检测
公开(公告)号：WO2008044186A2
公开(公告)日：2008-04-17
申请号：PCT/IB2007/054078
申请日：2007-10-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , IORDANOV, Ventzeslav, P. , VAN BRUGGEN, Michel, P., B. , KRIJNSEN, Hendrika, C. , JANNER, Anna-Maria
发明人： IORDANOV, Ventzeslav, P. , VAN BRUGGEN, Michel, P., B. , KRIJNSEN, Hendrika, C. , JANNER, Anna-Maria
IPC分类号： G01N33/50
CPC分类号： G01N21/77 , A61B5/0031 , A61B5/0071 , A61B5/0084 , A61B5/01 , A61B5/14539 , G01N2021/7723
摘要： It is described a hydrogel based transducer device for detecting an environmental state, in particular for detecting an environmental state within a biological material. The transducer device (300) comprises a base element (302), a radiation source (305), which is formed at the base element (302) and which is adapted to emit electromagnetic radiation (306), an optical element (325), which is arranged at the base element (302) and which is adapted to interact with the electromagnetic radiation (306). The transducer device (300) further comprises a radiation detector (350), which is adapted to receive the electromagnetic radiation (326) having interacted with the optical element (325), and a hydrogel material (340), which is mechanically coupled to the optical element (325) and which is adapted to change its volume when getting into contact with an environmental material of the transducer device (300) such that the spatial position of the optical element (325) is changed. The base element (302), the radiation source (305) and the radiation detector (350) are formed integrally from an electronic substrate material.
摘要翻译：描述了用于检测环境状态的基于水凝胶的换能器装置，特别是用于检测生物材料内的环境状态。换能器装置（300）包括基座元件（302），辐射源（305），其形成在基座元件（302）处并适于发射电磁辐射（306），光学元件（325）其布置在基座元件（302）处并且适于与电磁辐射（306）相互作用。换能器装置（300）还包括辐射检测器（350），其适于接收与光学元件（325）相互作用的电磁辐射（326），以及水凝胶材料（340），其被机械耦合到光学元件（325），并且适于在与所述换能器装置（300）的环境材料接触时改变其体积，使得所述光学元件（325）的空间位置改变。基底元件（302），辐射源（305）和辐射检测器（350）由电子基底材料一体地形成。

3. 发明申请

WO2008012725A2 A DRUG DELIVERY SYSTEM WITH THERMOSWITCHABLE MEMBRANES 审中-公开
标题翻译：具有热交换膜的药物递送系统
公开(公告)号：WO2008012725A2
公开(公告)日：2008-01-31
申请号：PCT/IB2007/052809
申请日：2007-07-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN BRUGGEN, Michel, P., B. , KRIJNSEN, Hendrika, C. , IORDANOV, Ventzeslav, P. , JANNER, Anna-Maria
发明人： VAN BRUGGEN, Michel, P., B. , KRIJNSEN, Hendrika, C. , IORDANOV, Ventzeslav, P. , JANNER, Anna-Maria
IPC分类号： A61K9/00 , A61M31/00 , A61M35/00
CPC分类号： A61M37/00 , A61M2037/0007
摘要： The present invention provides a device for controlled release of molecules. The device is particularly suitable for controlled release of therapeutic drugs to a patient. The device includes a housing with an opening for release of the molecules from the housing. The housing also comprises a reservoir for containing the molecules, in particular therapeutic drugs. The reservoir is arranged in the housing to allow release of the molecules through the opening. The device also comprises at least one thermoswitchable membrane and at least one heating element for at least partially heating the membrane. The device is configured for modulating the release of the molecules at the opening by heating the membrane, using the heating element. Optionally, the device further comprises a pressure element for providing pressurized release of the molecules from the device. In this way, the drug can be delivered to a patient in a pulsatile fashion. The present invention also provides a method for modulating the release of molecules, using such a device.
摘要翻译：本发明提供了一种控制释放分子的装置。该装置特别适合于向患者控制释放治疗药物。该装置包括具有用于从壳体释放分子的开口的壳体。壳体还包括用于容纳分子的储存器，特别是治疗药物。储存器布置在壳体中以允许分子通过开口释放。该装置还包括至少一个热敏开关膜和至少一个用于至少部分加热膜的加热元件。该装置被配置用于通过使用加热元件加热膜来调节开口处分子的释放。可选地，该装置还包括用于提供来自装置的分子的加压释放的压力元件。以这种方式，药物可以以脉冲方式递送给患者。本发明还提供了一种使用这种装置来调节分子释放的方法。

4. 发明申请

WO2008122926A1 HYDROGEL BASED DEVICE FOR DETECTING AN ENVIRONMENTAL STATE 审中-公开
标题翻译：用于检测环境状态的基于HYDROGEL的设备
公开(公告)号：WO2008122926A1
公开(公告)日：2008-10-16
申请号：PCT/IB2008/051224
申请日：2008-04-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , IORDANOV, Ventzeslav, P. , KRIJNSEN, Hendrika, C. , VAN BRUGGEN, Michel, P., B. , JANNER, Anna-Maria , KURT, Ralph
发明人： IORDANOV, Ventzeslav, P. , KRIJNSEN, Hendrika, C. , VAN BRUGGEN, Michel, P., B. , JANNER, Anna-Maria , KURT, Ralph
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/0008 , A61B5/0031 , A61B5/4839
摘要： The invention relates to a transducer device (100,200,300,400) for detecting an environmental state or a change in the environmental state, in particular for detecting an environmental state within a biological material. The transducer device (100,200,300,400) comprises a channel (2,22,51) comprising a fluid, a hydrogel material (1,21,51), which is adapted to change its volume when getting into contact with an environmental material and/or when detecting an environmental change, and which is mechanically coupled to the channel (2,22,51) such that the volume of the channel (2,22,51) changes when the volume of the hydrogel material (1,21,51) changes. The transducer device (100,200,300,400) further comprises a sensor (11,12,25,35), which is adapted to generate a signal upon detection of the change of a physical property of the fluid that is induced by the volume change of the channel (2,22,51). By applying the transducer device (100,200,300,400) according to the invention within a bodily lumen, an accurate monitoring of physiological parameters, for which the hydrogel material (1,21,51) is sensitive, within the bodily lumen is possible. It is also possible to apply the transducer device (100,200,300,400) outside of the bodily lumen, for example to monitor the blood of a patient outside the bodily lumen.
摘要翻译：本发明涉及用于检测环境状态或环境状态变化的换能器装置（100,200,300,400），特别是用于检测生物材料内的环境状态。所述换能器装置（100,200,300,400）包括包含流体的通道（2,22,51），水凝胶材料（1,21,51），其适于在与环境材料接触时改变其体积，和/或检测环境变化，并且其机械耦合到通道（2,22,51），使得当水凝胶材料（1,21,51）的体积变化时，通道（2,22,51）的体积改变。换能器装置（100,200,300,400）还包括传感器（11,12,25,35），其适于在检测到由通道的体积变化引起的流体的物理特性的变化时产生信号（ 2,22,51）。通过将根据本发明的换能器装置（100,200,300,400）应用于体腔内，可以精确地监测身体内水凝胶材料（1,21,51）敏感的生理参数。也可以将换能器装置（100,200,300,400）应用于体腔外，例如监测患者体外的血液。

5. 发明申请

WO2008099356A2 DRUG DELIVERY DEVICE 审中-公开
标题翻译：药物递送装置
公开(公告)号：WO2008099356A2
公开(公告)日：2008-08-21
申请号：PCT/IB2008/050526
申请日：2008-02-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KRIJNSEN, Hendrika, C. , JANNER, Anna-maria , IORDANOV, Ventzeslav, P. , VAN BRUGGEN, Michel, P., B.
发明人： KRIJNSEN, Hendrika, C. , JANNER, Anna-maria , IORDANOV, Ventzeslav, P. , VAN BRUGGEN, Michel, P., B.
IPC分类号： A61M5/142
CPC分类号： A61M5/142 , A61M5/1723 , A61M2005/14208
摘要： The invention relates to a method and a device(10) for supplying a substance (e.g. a drug) to a physiological system(1) (e.g. a patient) during a predetermined time period (e.g. 24 hours). The amounts(u) of substance that have to be administered are determined in such a way that the predicted concentration of the substance, which is predicted with a pharmacokinetic model, matches a target concentration(c tar ) within the predetermined time period according to some optimization criterion. The optimization may particularly minimize the overall difference between target and predicted concentration during the time period. In a preferred embodiment, parameters of the pharmacokinetic model are individually adjusted to the associated patient.
摘要翻译：本发明涉及在预定时间段（例如24小时）内向物理系统（1）（例如患者）提供物质（例如药物）的方法和装置（10）。确定必须给药的物质的量（u），使得以药物动力学模型预测的物质的预测浓度与预定时间段内的目标浓度（c tar）相符合优化标准。优化可以特别地在时间段内最小化目标和预测浓度之间的总体差异。在优选的实施方案中，药代动力学模型的参数被单独调整到相关患者。

6. 发明申请

WO2009053914A1 IMPLANTABLE DRUG DELIVERY SYSTEM 审中-公开
标题翻译：可植入药物输送系统
公开(公告)号：WO2009053914A1
公开(公告)日：2009-04-30
申请号：PCT/IB2008/054357
申请日：2008-10-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , IORDANOV, Ventzeslav, P. , KRIJNSEN, Hendrika, C. , VAN BRUGGEN, Michel, P., B. , JANNER, Anna-Maria
发明人： IORDANOV, Ventzeslav, P. , KRIJNSEN, Hendrika, C. , VAN BRUGGEN, Michel, P., B. , JANNER, Anna-Maria
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61M5/172 , A61M2205/3507
摘要： An implantable drug delivery system is provided, comprising a reservoir for comprising a drug to be delivered, a pump (27) for delivering the drug to a patient, an actuator (22) for operating the pump, a monitoring sensor (12) for monitoring a performance of the system and a power source (13, 23) for providing power to the system. The system comprises at least two separate units. An actuator unit (20) comprises an actuator controller (21) and the actuator (22), the actuator controller (21) being arranged to control the actuator (22). A sensor unit (10) comprises a sensor controller (11) and the monitoring sensor (12), the sensor controller (11) being arranged for switching off the actuator unit (20) in dependence of the monitored performance.
摘要翻译：提供了一种可植入药物递送系统，包括用于包含待输送药物的储存器，用于将药物输送给患者的泵（27），用于操作泵的致动器（22），用于监测的监测传感器该系统的性能和用于向系统提供电力的电源（13,23）。该系统包括至少两个单独的单元。致动器单元（20）包括致动器控制器（21）和致动器（22），致动器控制器（21）被布置成控制致动器（22）。传感器单元（10）包括传感器控制器（11）和监测传感器（12），所述传感器控制器（11）被布置成根据所监视的性能来关闭致动器单元（20）。

7. 发明申请

WO2008078287A1 SELF-LEARNING DRUG DELIVERY SYSTEM 审中-公开
标题翻译：自学药物递送系统
公开(公告)号：WO2008078287A1
公开(公告)日：2008-07-03
申请号：PCT/IB2007/055219
申请日：2007-12-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KRIJNSEN, Hendrika, C. , IORDANOV, Ventzeslav, P. , JANNER, Anna-Maria , VAN BRUGGEN, Michel, P., B.
发明人： KRIJNSEN, Hendrika, C. , IORDANOV, Ventzeslav, P. , JANNER, Anna-Maria , VAN BRUGGEN, Michel, P., B.
IPC分类号： A61M5/172 , A61M5/14 , A61M5/142
CPC分类号： A61M5/1723 , A61M2005/1405 , A61M2005/14208 , A61M2205/52
摘要： Self-learning process for automatically adjusting a dosage (2) of a substance administered to a person (P) by a drug delivery device, a drug delivery device in which a dosage (2) of a substance is adjusted by such a self-learning process, and a drug delivery system comprising such a drug delivery device. Pain is experienced differently at certain times of day due to the origin causing the symptoms. Therefore, the medication providing pain relief should be adjusted accordingly. The invention is to anticipate the pain experience and to deliver pain relief medication in such a way that the quality of life is improved by an appropriate timing of the right amount of medication and by an appropriate timing of turning off the medication so as to reduce side effects.
摘要翻译：用于通过药物递送装置自动调节给予人（P）的物质的剂量（2）的自学习过程，其中通过这种自学习调节物质的剂量（2）的药物递送装置方法和包含这种药物递送装置的药物递送系统。由于原因导致症状，疼痛在一天的某些时间有不同的体验。因此，提供疼痛缓解的药物应相应调整。本发明是为了预测疼痛经验并且以这样的方式提供止痛药物，即通过合适的药物量的适当时机和关闭药物的适当时机来改善生活质量，以减少侧面效果。

8. 发明申请

WO2008117214A1 AUTOMATIC DRUG ADMINISTRATION WITH REDUCED POWER CONSUMPTION 审中-公开
标题翻译：具有降低功耗的自动药物管理
公开(公告)号：WO2008117214A1
公开(公告)日：2008-10-02
申请号：PCT/IB2008/051065
申请日：2008-03-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KRIJNSEN, Hendrika, C. , IORDANOV, Ventzeslav, P. , JANNER, Anna, M. , VAN BRUGGEN, Michel, P., B.
发明人： KRIJNSEN, Hendrika, C. , IORDANOV, Ventzeslav, P. , JANNER, Anna, M. , VAN BRUGGEN, Michel, P., B.
IPC分类号： A61M5/172 , A61M5/142
CPC分类号： A61M5/1723 , A61M5/142 , A61M2205/8212 , A61M2230/63 , G06F19/00
摘要： It is described a drug delivery system (100) that is adapted to infuse at least one drug in a profile related to the status of a patient. The system comprises sensors (110), dedicated electronics (140) and software to monitor the patient's activity and maintain control over the drug-release profile. A control unit (120) of the system (100) is adapted to temporarily set at least one component (110, 120, 150) of the system (100) in an idle mode (265). This will result in particular in a reduction of power required by the system (100). The described system (100) enables a personalized treatment of patients by monitoring their individual activity status and coupling this information to a drug delivery following appropriate delivery profiles. The system (100) may be provided with a memory in order to store a time dependence of activity data. This time dependence may be used by physicians to monitor, support and adapt their therapy for the patients. The system (100) may be realized as a closed- loop system for monitoring and treatment of various diseases such as hemophilia A and Parkinson.
摘要翻译：描述了适于在与患者的状态相关的轮廓中注入至少一种药物的药物递送系统（100）。该系统包括传感器（110），专用电子设备（140）和用于监视患者活动并维持对药物释放特征的控制的软件。系统（100）的控制单元（120）适于将系统（100）的至少一个组件（110,120,150）临时设置为空闲模式（265）。这将特别导致系统（100）所需的功率的降低。所描述的系统（100）能够通过监测患者的个体活动状态来对患者进行个性化治疗，并将该信息与适当的递送概况相关联地传递给药物递送。系统（100）可以设置有存储器，以便存储活动数据的时间依赖性。这种时间依赖可以由医生使用来监测，支持和适应患者的治疗。系统（100）可以实现为用于监测和治疗诸如血友病A和帕金森病等各种疾病的闭环系统。

9. 发明申请

WO2010023622A1 DRUG MIXING DEVICE AND DRUG DELIVERY DEVICE 审中-公开
标题翻译：药物混合装置和药物递送装置
公开(公告)号：WO2010023622A1
公开(公告)日：2010-03-04
申请号：PCT/IB2009/053728
申请日：2009-08-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN BRUGGEN, Michel, P., B. , EVERAERTS, Fransciscus, J., L. , KRIJNSEN, Hendrika, C. , IORDANOV, Ventzeslav, P.
发明人： VAN BRUGGEN, Michel, P., B. , EVERAERTS, Fransciscus, J., L. , KRIJNSEN, Hendrika, C. , IORDANOV, Ventzeslav, P.
IPC分类号： A61M5/142 , A61M5/14 , H01M8/00
CPC分类号： A61M5/14276 , A61M5/1409 , A61M2205/8268 , H01M8/04156 , H01M8/22 , H01M2250/00
摘要： A drug mixing device (10, 20, 40, 60) and a drug delivery device (20, 40, 60) are provided. Both devices (10, 20, 40, 60) are capable of hydrating a solid drug. The drug deliverydevice (10, 20, 40, 60) is further arranged for delivering the hydrated drug to a deliverysite in a human or animal body. The devices (10, 20, 40, 60) comprise a drug compartment (12) for comprising the solid drug and oxygen, a fuel compartment (11) for comprising a hydrogen rich fluid and a proton exchange membrane (13) being situated in between the drug compartment (12) and the fuel compartment (11). An anode electrode (15, 51) is provided in the fuel compartment (11) and a cathode electrode (14, 52) in the drug compartment(12). An electronic circuit (17) couples the anode electrode (15, 51) to the cathode electrode (14, 52), such that water is produced at the cathode electrode (14, 52) for hydrating the solid drug.
摘要翻译：提供药物混合装置（10,20,40,60）和药物输送装置（20,40,60）。两种装置（10,20,40,60）都能够固化固体药物。药物递送装置（10,20,40,60）还被布置成将水合药物递送到人体或动物体内的分泌物。装置（10,20,40,60）包括用于包含固体药物和氧气的药物隔室（12），用于包含富氢液体和位于其间的质子交换膜（13）的燃料室（11）药物隔间（12）和燃料室（11）。阳极电极（15,51）设置在燃料室（11）和药物室（12）中的阴极电极（14,52）。电子电路（17）将阳极电极（15,51）耦合到阴极电极（14,52），使得在阴极电极（14,52）处产生水以固化固体药物。

10. 发明申请

WO2009144625A1 IMPLANTABLE DRUG DELIVERY DEVICE WITH DOSAGE CONTROL 审中-公开
标题翻译：具有剂量控制的可植入药物递送装置
公开(公告)号：WO2009144625A1
公开(公告)日：2009-12-03
申请号：PCT/IB2009/052096
申请日：2009-05-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , IORDANOV, Ventzeslav, P. , VAN BRUGGEN, Michel, P., B. , KRIJNSEN, Hendrika, C. , EVERAERTS, Fransciscus, J., L.
发明人： IORDANOV, Ventzeslav, P. , VAN BRUGGEN, Michel, P., B. , KRIJNSEN, Hendrika, C. , EVERAERTS, Fransciscus, J., L.
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61M5/16881 , A61M2005/1726 , A61M2205/3507
摘要： An implantable drug delivery device (10, 30) is provided, comprising a reservoir(14) for storing reservoirfluid and a plurality of capsules (20), the capsules (20) comprising medicine, the outer surface of the capsules (20) being made of a water degradable materialthat does not dissolve in the reservoirfluid. The device (10, 30) further comprises an actuator (13) for initiating release of a capsule (20) of the pluralityofcapsules (20) from the 5 device (10, 30), a valve (17) for controlling the release of the capsule (20) and processing electronics (12) being arranged for controlling the actuator (13) and the valve (17).
摘要翻译：提供了可植入药物输送装置（10,30），其包括用于储存储存器流体的储存器（14）和多个胶囊（20），所述胶囊（20）包括药物，所述胶囊（20）的外表面被制成的水可降解材料，不溶于储液器。装置（10,30）还包括用于启动从5装置（10,30）释放多个胶囊（20）的胶囊（20）的致动器（13），用于控制所述多个胶囊（20）的释放的阀（17）胶囊（20）和处理电子器件（12）被布置用于控制致动器（13）和阀（17）。

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